The Amide Linkage

Author : Arthur Greenberg,Curt M. Breneman,Joel F. Liebman
Publisher : John Wiley & Sons
Page : 672 pages
File Size : 48,8 Mb
Release : 2002-11-11
Category : Science
ISBN : 0471420255

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The Amide Linkage by Arthur Greenberg,Curt M. Breneman,Joel F. Liebman Pdf

An authoritative reference to an important and ubiquitous chemical linkage The amide linkage is one of the most fundamental and widespread chemical bonds in nature, underlying the properties of a vast array of organic molecules, polymers, and materials, including peptides and proteins. Arthur Greenberg, Curt Breneman, and Joel Liebman's peerless text provides comprehensive coverage of the experimental, structural, and computational findings that shed light on the chemical and physical properties of the amide linkage, as well as its emerging applications in materials and biotechnology. Chapters in The Amide Linkage highlight how this chemical bond factors in the design of enzyme inhibitors, cyclic peptides, antibacterial agents, and emerging nanotechnology applications. This one-of-a-kind study also: * Discusses selected aspects of chemical reactions, structure, bonding, and energetics of the amide bond, including amide rotational barriers, stereochemistry, complexation, spectroscopy, and thermochemistry * Presents specific applications to supramolecular and stereospecific synthesis * Discusses key aspects of peptide and protein chemistry-such as molecular recognition, conformation, and folding-in terms of the amide linkage * Includes chapters contributed by numerous eminent chemists and biochemists Organic, medicinal, polymer, and physical chemists, as well as biochemists and materials scientists, will find The Amide Linkage to be an invaluable addition to their professional libraries.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 46,6 Mb
Release : 2000
Category : Amides
ISBN : OCLC:1345495031

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The Amide Linkage by Anonim Pdf

Author : Michal Szostak
Publisher : MDPI
Page : 466 pages
File Size : 45,5 Mb
Release : 2019-07-12
Category : Science
ISBN : 9783039212033

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Amide Bond Activation by Michal Szostak Pdf

The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.

Author : Michal Szostak
Publisher : John Wiley & Sons
Page : 533 pages
File Size : 40,5 Mb
Release : 2022-10-10
Category : Science
ISBN : 9783527348312

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Amide Bond Activation by Michal Szostak Pdf

Amide Bond Activation Comprehensive resource on the pivotal role of the amide bond in organic synthesis This book provides the reader with insight into the advances that have taken place in the field of amide bond activation. It focuses on both the fundamental structural properties of the amide bond and the synthetic reactions mediated by transition-metals. By discussing amide bond activation in terms of modern organic synthesis, the reader is provided with a thorough overview of the area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds. Sample topics discussed within the work include: Cross-coupling of amides Amide bond activation by twisting and nitrogen pyramidalization Electrophilic amide bond functionalization Transition metal-catalyzed radical reactions of amides Amide bond esterification, hydrolysis and transamidation Classical bridged lactams and anomeric amides Computational studies of amide C-N bond activation Cross-coupling of esters by C-O activation The book is immensely valuable to synthetic chemists in academia and the pharmaceutical industry who wish to gain an in-depth understanding of the concept of amide bond activation.

Author : Michal Szostak
Publisher : Unknown
Page : 466 pages
File Size : 44,9 Mb
Release : 2019
Category : Chemistry
ISBN : 3039212044

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Amide Bond Activation by Michal Szostak Pdf

The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N-C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 42,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Arnold David Marcus
Publisher : Unknown
Page : 266 pages
File Size : 52,5 Mb
Release : 1954
Category : Electronic
ISBN : WISC:89086014420

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A Kinetic Study of the Hydrolysis of Chloramphenicol at Its Amide Linkage by Arnold David Marcus Pdf

Author : Brian C. Smith
Publisher : CRC Press
Page : 282 pages
File Size : 51,5 Mb
Release : 2018-02-06
Category : Science
ISBN : 9781351438377

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Infrared Spectral Interpretation by Brian C. Smith Pdf

This author's second volume introduces basic principles of interpreting infrared spectral data, teaching its readers to make sense of the data coming from an infrared spectrometer. Contents include spectra and diagnostic bands for the more common functional groups as well as chapters on polyester spectra and interpretation aids. Discussions include: Science of infrared interpretation Light and molecular vibrations How and why molecules absorb infrared radiation Peak heights, intensities, and widths Hydrocarbons, carbonyl groups, and molecules with C-N bonds Polymers and inorganic molecules The use of atlases, library searching, spectral subtraction, and the Internet in augmenting interpretation Each chapter presents an introduction to the nomenclature and structure of a specific functional group and proceeds with the important diagnostic bands for each group. Infrared Spectral Interpretation serves both novices and experienced practitioners in this field. The author maintains a website and blog with supplemental material. His training course schedule is also available online.

Author : Robert J. Ouellette,J. David Rawn
Publisher : Academic Press
Page : 496 pages
File Size : 41,8 Mb
Release : 2015-02-13
Category : Science
ISBN : 9780128026342

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Principles of Organic Chemistry by Robert J. Ouellette,J. David Rawn Pdf

Class-tested and thoughtfully designed for student engagement, Principles of Organic Chemistry provides the tools and foundations needed by students in a short course or one-semester class on the subject. This book does not dilute the material or rely on rote memorization. Rather, it focuses on the underlying principles in order to make accessible the science that underpins so much of our day-to-day lives, as well as present further study and practice in medical and scientific fields. This book provides context and structure for learning the fundamental principles of organic chemistry, enabling the reader to proceed from simple to complex examples in a systematic and logical way. Utilizing clear and consistently colored figures, Principles of Organic Chemistry begins by exploring the step-by-step processes (or mechanisms) by which reactions occur to create molecular structures. It then describes some of the many ways these reactions make new compounds, examined by functional groups and corresponding common reaction mechanisms. Throughout, this book includes biochemical and pharmaceutical examples with varying degrees of difficulty, with worked answers and without, as well as advanced topics in later chapters for optional coverage. Incorporates valuable and engaging applications of the content to biological and industrial uses Includes a wealth of useful figures and problems to support reader comprehension and study Provides a high quality chapter on stereochemistry as well as advanced topics such as synthetic polymers and spectroscopy for class customization

Author : V. Nenajdenko
Publisher : John Wiley & Sons
Page : 615 pages
File Size : 44,5 Mb
Release : 2012-06-04
Category : Science
ISBN : 9783527652556

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Isocyanide Chemistry by V. Nenajdenko Pdf

The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.

Author : Yan Guo Shi,Jin Long Zuo
Publisher : Trans Tech Publications Ltd
Page : 2450 pages
File Size : 52,8 Mb
Release : 2011-01-20
Category : Technology & Engineering
ISBN : 9783038135746

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Environmental Biotechnology and Materials Engineering by Yan Guo Shi,Jin Long Zuo Pdf

Volume is indexed by Thomson Reuters CPCI-S (WoS). This collection of peer-reviewed papers provided a forum within which researchers, educators, engineers and government officials - involved in the general areas of Environmental Biotechnology and Materials Engineering - could disseminate their latest research results and exchange views on possible future research directions. The 473 most outstanding papers were carefully selected from among the total of 783 submitted works and are presented in this special collection, which covers a wide range of issues related to the state-of-the-art of the progress, made in environmental biotechnology and materials engineering, with regard to the understanding and optimization of various types of treatment process.

Author : Chung Eun Ha,N. V. Bhagavan
Publisher : Academic Press
Page : 600 pages
File Size : 44,8 Mb
Release : 2011-01-28
Category : Science
ISBN : 9780080916880

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Essentials of Medical Biochemistry by Chung Eun Ha,N. V. Bhagavan Pdf

Expert biochemist N.V. Bhagavan’s new work condenses his successful Medical Biochemistry texts along with numerous case studies, to act as an extensive review and reference guide for both students and experts alike. The research-driven content includes four-color illustrations throughout to develop an understanding of the events and processes that are occurring at both the molecular and macrolecular levels of physiologic regulation, clinical effects, and interactions. Using thorough introductions, end of chapter reviews, fact-filled tables, and related multiple-choice questions, Bhagavan provides the reader with the most condensed yet detailed biochemistry overview available. More than a quick survey, this comprehensive text includes USMLE sample exams from Bhagavan himself, a previous coauthor. Clinical focus emphasizing relevant physiologic and pathophysiologic biochemical concepts Interactive multiple-choice questions to prep for USMLE exams Clinical case studies for understanding basic science, diagnosis, and treatment of human diseases Instructional overview figures, flowcharts, and tables to enhance understanding

Author : Greg T. Hermanson
Publisher : Academic Press
Page : 1233 pages
File Size : 48,9 Mb
Release : 2010-07-26
Category : Science
ISBN : 9780080568720

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Bioconjugate Techniques by Greg T. Hermanson Pdf

Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions

Author : Pierre H. Dixneuf,Christian Bruneau
Publisher : Springer
Page : 401 pages
File Size : 45,8 Mb
Release : 2014-10-18
Category : Science
ISBN : 9783319084824

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Ruthenium in Catalysis by Pierre H. Dixneuf,Christian Bruneau Pdf

The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics in pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors.

Author : Alan J. Barrett,J. Fred Woessner,Neil D. Rawlings
Publisher : Elsevier
Page : 1182 pages
File Size : 40,8 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080984155

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Handbook of Proteolytic Enzymes, Volume 1 by Alan J. Barrett,J. Fred Woessner,Neil D. Rawlings Pdf

Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.