The Antibody Enigma

Author : Thomas Kindt
Publisher : Springer Science & Business Media
Page : 281 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468446760

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The Antibody Enigma by Thomas Kindt Pdf

The Antibody Enigma is a somewhat personal view of the antibody diversity question from two investigators who have spent the past 18 years trying to penetrate the enigma. It is not and was not meant to be an all-embracing comprehensively referenced review of the subject of antibody diversity. Because of the subjective viewpoint, there are un doubtedly omissions of data that others consider to be seminal, and if we have offended anyone by omitting their own contribution we sin cerelyapologize. We have lived with "The Enigma" on and off for the past two years. It has been both hard work and good fun but, above all, it has been a learning experience. There were several difficult decisions to make in putting together the final text, but perhaps the most difficult was de ciding upon a stopping point. The field of antibody diversity is presently enjoying an unparalleled expansion of information, and because of this it was very tempting to await further developments in hopes of tying up as many loose ends as possible. This was decided against for several reasons; the major factor was that the project was growing burdensome for both of us. From a more objective point of view this appears to be a reasonable time to stop our exposition.

Author : Anthony R. Rees
Publisher : Oxford Medical Histories
Page : 385 pages
File Size : 49,9 Mb
Release : 2015
Category : Medical
ISBN : 9780199646579

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The Antibody Molecule by Anthony R. Rees Pdf

'The Antibody Molecule' is a beautifully illustrated review of the remarkable developments within immunology from the discovery of the antibody molecule to its exploitation in medicine and the scientists and pioneers who were involved. This engaging and authoritative history will appeal to a wide audience

Author : Eric Reid,G.M.W. Cook,D.J. Morre
Publisher : Springer Science & Business Media
Page : 359 pages
File Size : 49,6 Mb
Release : 2013-03-09
Category : Science
ISBN : 9781468450064

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Investigation and Exploitation of Antibody Combining Sites by Eric Reid,G.M.W. Cook,D.J. Morre Pdf

Author : Anonim
Publisher : Academic Press
Page : 452 pages
File Size : 42,9 Mb
Release : 1993-11-17
Category : Medical
ISBN : 0080859356

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Antibodies in Cell Biology by Anonim Pdf

Antibodies in Cell Biology focuses on a new generation of protocols aimed at the cell biologist. This laboratory manual features systems and techniques that are especially relevant for modern problems. The contributing authors have been carefully chosen for their specific expertise, and have provided detailed protocols, recipes, and troubleshooting guides in each chapter. The book is designed for any researcher or student who needs to use antibodies in cell biology and related research areas. Practical applications and future emphases of antibodies, including: Light microscopic immunolocalization of antigens Gold particles in immunoelectron microscopy Special methods of fixation and permeabilization Microinjection of antibodies into living cells Antibodies to identify cDNA clones Antisense antibody strategies

Author : James W. Goding
Publisher : Elsevier
Page : 513 pages
File Size : 51,5 Mb
Release : 1996-02-26
Category : Science
ISBN : 9780080536958

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Monoclonal Antibodies by James W. Goding Pdf

Monoclonal Antibodies now have applications in virtually all areas of biology and medicine, and much of the world's biotechnology industry has its foundations in the exploitation of this technology. The Third Edition of this well established book meets the needs of both newcomers to the area and experienced researchers, by providing an integrated treatment of both the production and application of monoclonal antibodies. As in previous editions, detailed and critical accounts of the theory, production, purification, fragmentation, storage and radiolabelling of monoclonal antibodies are given, along with descriptions of their use in antigen characterization, affinity chromatography and immunofluorescence. The present volume has been comprehensively updated to cover recent rapid advances, particularly with respect to the applications of molecular biology, the use of antibodies in closing and heterologous expression of genes, immunohistology and phage display libraries. Since the previous edition, there has been a growing trend towards the replacement of procedures using radioactive isotopes, and the current edition incorporates these newer technologies. The text is oriented towards problems solving, and makes it easy to adapt each procedure to individual needs. Extensive cross-referencing, a glossary and a comprehensive index make this book an essential reference. This book will be vital both for laboratories already producing or using monoclonal antibodies, and for workers in many disciplines who are contemplating their use. Provides an integrated treatment of both the production and application of monoclonals in cell biology, biochemistry, and immunology Gives detailed and critical accounts of the theory, production, purification, storage, and relabelling of monoclonals, and their use in antigen characterization, affinity chromorography, and immunofluroscence Comprehensively updated to cover the rapid advances that have occurred since the publication of the Second Edition

Author : Arthur M. Silverstein
Publisher : Elsevier
Page : 445 pages
File Size : 54,7 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780080925837

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A History of Immunology by Arthur M. Silverstein Pdf

This is a professional-level intellectual history of the development of immunology from about 1720 to about 1970. Beginning with the work and insights of the early immunologists in the 18th century, Silverstein traces the development of the major ideas which have formed immunology down to the maturation of the discipline in the decade following the Second World War. Emphasis is placed on the philosophic and sociologic climate of the scientific milieu in which immunology has developed, providing a background to the broad culture of the discipline. A professional-level intellectual history of the development of immunology from about 1720 to 1970, with emphasis placed on the social climate of the scientific milieu in which modern immunology evolved Written by an author very well known both as a historian of medical science and for his substantial research contributions to the immunopathology of the eye The only complete history of immunology available

Author : M.G. Ord,L.A. Stocken
Publisher : Elsevier
Page : 345 pages
File Size : 49,9 Mb
Release : 1997-05-16
Category : Science
ISBN : 0080532217

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Further Milestones in Biochemistry by M.G. Ord,L.A. Stocken Pdf

The contributors to this text, who are all biochemists who worked during the 1950s and 60s, describe what appears to them to be the conceptually significant developments in biochemistry since the mid 1950s and how these were achieved. Their aim is to make their subjects intelligible to other scientists not expert in their field.

Author : Klaus Eichmann
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 46,5 Mb
Release : 2006-01-16
Category : Medical
ISBN : 9783764374136

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Köhler's Invention by Klaus Eichmann Pdf

Georges Köhler was one of the most prominent German scientists of recent history. In 1984, at an age of 38, he received the Nobel Prize in Physiology or Medicine, together with N.K. Jerne and C. Milstein, for inventing the technique for generating monoclonal antibodies. This method and its subsequent applications had an enormous impact on basic research, medicine and the biotech industry. In the same year, Köhler became one of the directors of the Max-Planck-Institute of Immunobiology in Freiburg; his unfortunate premature death in 1995 set an end to his extraordinary career. Prof. Klaus Eichmann, who had invited Köhler to become his codirector, is one of the people who were closest to him. This scientific biography commemorates the 10th anniversary of Köhler's untimely death. Köhler's scientific achievements are explained in a way to make them understandable for the general public and discussed in the historical context of immunological research.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1044 pages
File Size : 51,6 Mb
Release : 2024-06-06
Category : Medicine
ISBN : STANFORD:36105214548971

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : Alfred I. Tauber,Scott H. Podolsky
Publisher : Harvard University Press
Page : 532 pages
File Size : 49,6 Mb
Release : 2000
Category : Antibody diversity
ISBN : 0674001826

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The Generation of Diversity by Alfred I. Tauber,Scott H. Podolsky Pdf

This book is an intellectual history of the major theoretical problem in immunology and its resolution in the post-World War II period. In recent years immunology has been one of the most exciting--and successful--fields of biomedical research; this book provides essential background for understanding the conceptual conflicts occurring in the field.

Author : Thomas Soderqvist
Publisher : Yale University Press
Page : 387 pages
File Size : 52,8 Mb
Release : 2008-10-01
Category : Biography & Autobiography
ISBN : 9780300128710

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Science as Autobiography by Thomas Soderqvist Pdf

This biography probes the unusual mind, the dramatic life, and the outstanding scientific work of Danish-born immunologist Niels Jerne (1911–1994). Jerne’s Nobel Prize-winning achievements in the field of immunology place him in the pantheon of great twentieth-century biomedical theorists, yet his life is perhaps even more interesting than his science. Science as Autobiography tells Jerne’s story, weaving together a narrative of his life experiences, emotional life, and extraordinarily creative scientific work. A legendary figure who preferred an afternoon of conversation in a Paris wine bar to work in the laboratory, Jerne was renowned for his unparalleled powers of concentration and analytical keenness as well as his dissonant personal life. The book explores Jerne the man and scientist, making the fascinating argument that his life experience and view of himself became a metaphorical resource for the construction of his theories. The book also probes the moral issues that surrounded Jerne’s choice to sacrifice his family in favor of scientific goals and the pursuit of excellence.

Author : Anonim
Publisher : Academic Press
Page : 501 pages
File Size : 41,8 Mb
Release : 1994-07-06
Category : Medical
ISBN : 0080578322

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Advances in Immunology by Anonim Pdf

A Leader in Immunology

Author : Frank Putnam
Publisher : Elsevier
Page : 432 pages
File Size : 45,6 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323161749

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The Plasma Proteins V5 by Frank Putnam Pdf

The Plasma Proteins: Structure, Function, and Genetic Control, Second Edition, Volume V explores the contribution of molecular biology and gene cloning approaches to the advancement of plasma protein structure, function, and genomic organization studies. This volume is composed of five chapters and begins with a discussion on the DNA sequences and chromosomal location of plasma protein genes, specifically the cloning and sequencing of immunoglobulin genes. These topics are followed by a discussion on the advances in relation to discovered genetic variants present either as normal phenotypes or in dyslipoproteinemic states associated with cardiovascular disease. A chapter highlights the application of molecular biology techniques to the study of gene structure and the translational and maturation steps of every major plasma apolipoprotein. Another chapter emphasizes the unique features of protein structure and the conformational changes that characterize the assembly of macromolecular complexes in plasma and on cell surfaces. The concluding chapter provides a comprehensive review of the integration of molecular biology, physiology, and pathology of plasma proteins and their response in inflammation. This book will be of great value to molecular biologists, physiologists, pathologists, and clinicians.

Author : Klaus D. Elgert
Publisher : John Wiley & Sons
Page : 738 pages
File Size : 45,8 Mb
Release : 2009-09-08
Category : Medical
ISBN : 9780470081570

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Immunology by Klaus D. Elgert Pdf

Blends biology, clinical science, genetics, and molecular biology of the immune system to provide a complete account of our knowledge of immunology New features include full-color artwork and design, over 50 new figures, and text that has been completely revised to reflect the very latest references Incorporates a variety of pedagogical aids to assist students in the learning process, including chapter outlines, objectives, and summaries, as well as a self-evaluation section

Author : M. Benczur,Anna Erdei,A. Falus,G. Füst,G.A. Medgyesi,G.G. Petranyi,Eva Rajnavölgyi
Publisher : Springer
Page : 926 pages
File Size : 55,6 Mb
Release : 2013-12-21
Category : Medical
ISBN : 9783642514791

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Progress in Immunology Vol. VIII by M. Benczur,Anna Erdei,A. Falus,G. Füst,G.A. Medgyesi,G.G. Petranyi,Eva Rajnavölgyi Pdf

At this congress there were again numereous reports of progress in immunology. The new technologies are continuing to have an immense impact: gene isolation, mutation, transfection and expression, protein structure andpeptide synthesis, cell cloning, hybridization and monoclonal antibodies, CD serology, SCID and transgenic mice, modern immunomodulation and vaccines. A trmendous mass of data has accumulated over the last years. The reports are up-to-date and outstanding,to a degree no journal will ever achieve, and the results are presented in a concise and lucid way. This report will serve as a guideline for the years to came, because it is a treasure trove of explorations, making it exciting reading. This progress presents outstanding contributions. Immunology is exhibited at its best: an exciting research area and a rewarding subject to study for the benefit of mankind - today more than ever.