The Biology Of Human Longevity

Author : Caleb E. Finch
Publisher : Elsevier
Page : 640 pages
File Size : 44,8 Mb
Release : 2010-07-28
Category : Medical
ISBN : 0080545947

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The Biology of Human Longevity by Caleb E. Finch Pdf

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

Author : James R. Carey
Publisher : Princeton University Press
Page : 305 pages
File Size : 54,5 Mb
Release : 2021-01-12
Category : Science
ISBN : 9780691224084

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Longevity by James R. Carey Pdf

Despite our deep interest in mortality, little is known about why some individuals live to middle age and others to extreme old age. Life span, mortality, and aging present some of the most profound mysteries in biology. In Longevity, James Carey draws on unprecedented data to develop a biological and demographic framework for identifying the key factors that govern aging, life span, and mortality in humans and other animals. Carey presents the results of a monumental, twelve-year, National Institute on Aging-funded research project on the determinants of longevity using data from the life tables of five million Mediterranean fruit flies, the most comprehensive set of life table studies ever on the mortality dynamics of a single species. He interprets the fruit fly data within the context of human aging and the aging process in general to identify the determinants of mortality. Three key themes emerge: the absence of species-specific life span limits, the context-specific nature of the mortality rate, and biodemographic linkages between longevity and reproduction. A powerful foundation for the emerging field of biodemography and a rich framework for considering the future of human life span, Longevity will be an indispensable resource for readers from a range of fields including population biology, demography, gerontology, ecology, evolutionary biology, and medical research.

Author : Lewis D. Solomon
Publisher : Routledge
Page : 220 pages
File Size : 47,5 Mb
Release : 2017-12-02
Category : Political Science
ISBN : 9781351475594

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The Quest for Human Longevity by Lewis D. Solomon Pdf

"Many scientists today are working to retard the aging process in humans so as to increase both life expectancy and the quality of life. Over the past decade impressive results have been achieved in targeting the mechanisms and pathways of aging. In The Quest for Human Longevity, Lewis D. Solomon considers these scientific studies by exploring the principal biomedical anti-aging techniques. The book also considers cutting edge research on mental enhancements and assesses the scientific doubts of skeptics. The Quest for Human Longevity is also about business. Solomon examines eight corporations pursuing various age-related interventions, profiling their scientific founders and top executives, and examining personnel, intellectual property, and financing for each firm. Academic scientists form the link between research and commerce. Solomon notes that the involvement of university scientists and researchers follows one of two models. The first is a traditional model in which scientists leave academia to work for a corporation or remain in academia and obtain business support for their research. The second is a modern model in which scientists use their intellectual property as a catalyst for acquiring equity interests in the firms they organize. Critics have pointed to the dangers of commercialized science, but Solomon's analysis, on balance, finds that the benefits outweigh the costs and that problems of secrecy and conflicts of interest can be addressed. If scientists succeed in unlocking the secrets of aging and developing drugs or therapies that will allow us to live decades longer, the consequences for society will include profound social, political, economic, and ethical questions. Solomon deals with the public policy aspects of significant life extension and looks at the conflict between those who advocate the acceptance of mortality and the partisans of life. The Quest for Human Longevity will be of interest to policymakers, sociologists, scientists, and studen"

Author : Raymond C. Valentine,David L. Valentine
Publisher : CRC Press
Page : 259 pages
File Size : 46,5 Mb
Release : 2014-09-18
Category : Medical
ISBN : 9781466594876

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Human Longevity by Raymond C. Valentine,David L. Valentine Pdf

More than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman’s famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membrane oxidation introduced in this book. This concept is consistent with recent discoveries showing that mitochondria-targeted antioxidants prevent Huntington’s disease, Parkinson’s disease, and traumatic brain disease in animal models of neurodegeneration. This book explores a unified theory of aging based on bioenergetics. It covers a variety of topics including an introduction to the science of human aging, the Darwinian selection of membranes enabling longevity, a revised mitochondrial membrane hypothesis of aging, and various mechanisms that protect human mitochondrial membranes, thereby enabling longevity.

Author : M.-F. Schulz-Aellen
Publisher : Springer Science & Business Media
Page : 291 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461220060

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Aging and Human Longevity by M.-F. Schulz-Aellen Pdf

The proportion of elderly people continues to increase in the western world-nearly a quarter of the population will be over 65 years by the year 2050. Since aging is accompanied by an increase in diseases and by a deterioration in well-being, finding solutions to these social, medical and psychological problems is necessarily a major goal for society. Scientists and medical practitioners are therefore faced with the urgent task of increasing basic knowledge of the biological processes that cause aging. More resources must be put into this research in order to achieve better understanding of the cellular mechanisms that underlie the differences in life span between species and to answer the difficult questions of why some individuals age more quickly than others, and why some develop liver problems, some have heart problems, and others brain problems. The results of such a wide program of research will provide important information about the causes of many life-threatening and/ or debilitating diseases of old age; it will help find ways to prevent some of the ailments that result from aging, and it may well lead to discoveries enabling the prolongation of human life.

Author : David W. E. Smith
Publisher : Oxford University Press, USA
Page : 200 pages
File Size : 51,9 Mb
Release : 1993
Category : Health & Fitness
ISBN : UOM:39015029855874

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Human Longevity by David W. E. Smith Pdf

This absorbing, balanced account of human longevity draws together information from the fields of medicine, biology, demography, epidemiology, gerontology, and sociology. It describes the history and present status of human longevity and deals in logical sequence with the questions this subject raises. The book illustrates how life expectancy has increased in most countries due, in part, to changing causes of death. It examines the biological determinants of longevity and analyzes social and behavioral factors that may reduce longevity. The book covers the reasons why women live longer than men. It asks why the maximum human life span is nearly twice that of any other warm-blooded animal and much longer than required for reproductive success, and it discusses factors that were involved in the evolution of longevity. It presents predictable increases in human life expectancy and explores the possibility that the maximum human life expectancy may become even longer. Accessible, comprehensive, and original, this book provides a multidisciplinary synthesis of ideas and conclusions about human longevity. It will have wide appeal to professionals in the many areas concerned with longevity as well as lay readers.

Author : Marie-Françoise Schulz-Aellen
Publisher : Birkhauser
Page : 283 pages
File Size : 40,7 Mb
Release : 1997-01-01
Category : Aging
ISBN : 3764339640

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Aging and Human Longevity by Marie-Françoise Schulz-Aellen Pdf

This book combines a scientific and medical description of aging with a critical review of ways to prolong life. The first part gives an overview of the complex biological mechanisms of aging and of the consequences of tissue and system aging in humans. The role of genetic and environmental factors that influence the rate of aging in several species is discussed. The second part of this book evaluates the various means, including life styles, behavioral variables, medical interventions and vitamin supplementation, that may slow down the physiological and psychological effects of aging. Biotechnology and gene therapy are also becoming a part of medical interventions to prolong life. This book is aimed at readers with some knowledge of biology and medicine, as well as to a larger audience eager to know more about how to live a healthy, happy and productive life in their old age.

Author : Marie-Francoise Schulz-Aellen
Publisher : Birkhäuser
Page : 0 pages
File Size : 55,8 Mb
Release : 1997
Category : Science
ISBN : 1461224489

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Aging and Human Longevity by Marie-Francoise Schulz-Aellen Pdf

The proportion of elderly people continues to increase in the western world-nearly a quarter of the population will be over 65 years by the year 2050. Since aging is accompanied by an increase in diseases and by a deterioration in well-being, finding solutions to these social, medical and psychological problems is necessarily a major goal for society. Scientists and medical practitioners are therefore faced with the urgent task of increasing basic knowledge of the biological processes that cause aging. More resources must be put into this research in order to achieve better understanding of the cellular mechanisms that underlie the differences in life span between species and to answer the difficult questions of why some individuals age more quickly than others, and why some develop liver problems, some have heart problems, and others brain problems. The results of such a wide program of research will provide important information about the causes of many life-threatening and/ or debilitating diseases of old age; it will help find ways to prevent some of the ailments that result from aging, and it may well lead to discoveries enabling the prolongation of human life.

Author : Society for the Study of Human Biology
Publisher : Cambridge University Press
Page : 298 pages
File Size : 49,6 Mb
Release : 1986-03-20
Category : Science
ISBN : 0521304857

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The Biology of Human Ageing by Society for the Study of Human Biology Pdf

This book discusses the findings of a joint symposium held in 1984 to consider human ageing and longevity from an interdisciplinary point of view.

Author : Anonim
Publisher : Greenwood
Page : 232 pages
File Size : 40,5 Mb
Release : 1987-03-18
Category : Health & Fitness
ISBN : STANFORD:36105040571973

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Human Longevity From Antiquity to the Modern Lab by Anonim Pdf

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Author : Matt Kaeberlein,George Martin
Publisher : Academic Press
Page : 576 pages
File Size : 52,9 Mb
Release : 2015-08-20
Category : Medical
ISBN : 9780124116207

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Handbook of the Biology of Aging by Matt Kaeberlein,George Martin Pdf

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Author : Cameron Diaz
Publisher : Unknown
Page : 0 pages
File Size : 51,5 Mb
Release : 2016
Category : Aging
ISBN : 000813961X

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The Longevity Book: The Biology of Resilience Privilege of Time and the New by Cameron Diaz Pdf

Author : Roger B. McDonald
Publisher : Garland Science
Page : 828 pages
File Size : 40,7 Mb
Release : 2019-06-07
Category : Science
ISBN : 9780429638190

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Biology of Aging by Roger B. McDonald Pdf

Biology of Aging, Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging, longevity, and age-related disease. Intended for undergraduate biology students, it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph.D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California, Davis. Dr. McDonald’s research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan, and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at [email protected]. Related Titles Ahmad, S. I., ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody, H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras, P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)

Author : Giuseppina Rose,Mette Sørensen,Serena Dato
Publisher : MDPI
Page : 118 pages
File Size : 55,8 Mb
Release : 2019-10-28
Category : Science
ISBN : 9783039216789

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Genetic Determinants of Human Longevity by Giuseppina Rose,Mette Sørensen,Serena Dato Pdf

In the last two decades, due to the continuous increase of lifespans in Western societies, and the consequent growing of the elderly population, have witnessed an increase in the number of studies on biological and molecular factors able to promote healthy aging and reach longevity. The study of the genetic component of human longevity demonstrated that it accounts for 25% of intra population phenotype variance. The efforts made to characterize the genetic determinants suggested that the maintenance of cellular integrity, inflammation, oxidative stress response, DNA repair, as well as the use of nutrients, represent the most important pathways correlated with a longer lifespan. However, although a plethora of variants were indicated to be associated with human longevity, only very few were successfully replicated in different populations, probably because of population specificity, missing heritability as well as a complex interaction among genetic factors with lifestyle and cultural factors, which modulate the individual chance of living longer. Thus, many challenges remain to be addressed in the search for the genetic components of human longevity. This Special Issue is aimed to unify the progress in the analysis of the genetic determinants of human longevity, to take stock of the situation and point to future directions of the field. We invite submissions for reviews, research articles, short-communications dealing with genetic association studies in human longevity, including all types of genetic variation, as well as the characterization of longevity-related genes.

Author : S.I. Rattan
Publisher : Springer
Page : 0 pages
File Size : 48,5 Mb
Release : 2010-12-25
Category : Science
ISBN : 9048163110

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Modulating Aging and Longevity by S.I. Rattan Pdf

After decades of systematic collection of data describing age-related changes in organisms, organs, tissues, cells and macromolecules, biogerontologists are now in a position to construct general principles of ageing and explore various possibilities of intervention using rational approaches. While not giving serious consideration to the claims made by charlatans, it cannot be ignored that several researchers are making genuine attempts to test and develop various means of intervention for the prevention and treatment of age-related diseases, for regaining the functional abilities and for prolonging the lifespan of experimental organisms. This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence.