The Cannabinoid Receptors

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The Endocannabinoid System

Eric Murillo-Rodríguez
The Endocannabinoid System Book PDF

Author : Eric Murillo-Rodríguez
Publisher : Academic Press
Page : 256 pages
File Size : 49,7 Mb
Release : 2017-05-12
Category : Nature
ISBN : 9780128096673

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The Endocannabinoid System by Eric Murillo-Rodríguez Pdf

The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy examines the cellular, biochemical, genetic, and therapeutic aspects of the endocannabinoid system. The chapters cover significant conceptual advances in the endocannabinoid field and shed light on the many brain disorders in which this biological system is involved. Written by world-leading experts in the field, the topics covered in this book will have a positive impact on the area of molecular biology, including, but not limited to, cell biology, neuroscience, pharmacology, signaling, disease mechanisms, and therapeutics. Provides an introduction to endocannabinoids in the central nervous system and an overview to their functions in the brain Presents information on neurobiological and cellular studies on the role of the cannabinoid signaling system and its implications in human diseases Includes well-written overviews of the basics of endocannabinoid system structure and function Contains well-illustrated material, with diagrams, charts, and tables Explores compelling case studies and their application to chapters written by experts

The Cannabinoid Receptors

Patricia H. Reggio
The Cannabinoid Receptors Book PDF

Author : Patricia H. Reggio
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 55,6 Mb
Release : 2008-11-09
Category : Medical
ISBN : 9781597455039

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The Cannabinoid Receptors by Patricia H. Reggio Pdf

As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream. In The Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part of The Receptors TM series, this volume highlights its receptor with the most thorough, focused and essential information available. Comprehensive and cutting-edge, The Cannabinoid Receptors serves as an ideal guidebook to what continues to be a fascinating and vital field.

Marijuana and Medicine

Institute of Medicine
Marijuana and Medicine Book PDF

Author : Institute of Medicine
Publisher : National Academies Press
Page : 288 pages
File Size : 50,7 Mb
Release : 1999-07-10
Category : Medical
ISBN : 9780309071550

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Marijuana and Medicine by Institute of Medicine Pdf

The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicineâ€"the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.

Phytocannabinoids

A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi
Phytocannabinoids Book PDF

Author : A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi
Publisher : Springer
Page : 131 pages
File Size : 45,6 Mb
Release : 2017-01-24
Category : Science
ISBN : 9783319455419

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Phytocannabinoids by A. Douglas Kinghorn,Heinz Falk,Simon Gibbons,Jun'ichi Kobayashi Pdf

The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science. The focus is on natural product cannabinoids which have been demonstrated to act at specific receptor targets in the CNS.

A Psychiatrist's View of Marijuana

Timmen Cermak
A Psychiatrist s View of Marijuana Book PDF

Author : Timmen Cermak
Publisher : Cambridge University Press
Page : 257 pages
File Size : 53,8 Mb
Release : 2020-04-02
Category : Medical
ISBN : 9781108735735

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A Psychiatrist's View of Marijuana by Timmen Cermak Pdf

An essential guide covering the scientific knowledge and communication skills required to deliver objective patient advice about marijuana use.

Cannabinoids in Health and Disease

Rosaria Meccariello,Rosanna Chianese
Cannabinoids in Health and Disease Book PDF

Author : Rosaria Meccariello,Rosanna Chianese
Publisher : BoD – Books on Demand
Page : 260 pages
File Size : 51,8 Mb
Release : 2016-06-15
Category : Medical
ISBN : 9789535124290

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Cannabinoids in Health and Disease by Rosaria Meccariello,Rosanna Chianese Pdf

This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use of cannabinoids and on the targeting of endocannabinoid system as new therapeutic strategy for the prevention and treatment of human diseases. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding in the field of cannabinoids.

Translational Pain Research

Lawrence Kruger,Alan R Light
Translational Pain Research Book PDF

Author : Lawrence Kruger,Alan R Light
Publisher : CRC Press
Page : 432 pages
File Size : 44,6 Mb
Release : 2009-11-24
Category : Health & Fitness
ISBN : 9781439812105

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Translational Pain Research by Lawrence Kruger,Alan R Light Pdf

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

Handbook of Cannabis and Related Pathologies

Victor R Preedy
Handbook of Cannabis and Related Pathologies Book PDF

Author : Victor R Preedy
Publisher : Academic Press
Page : 1382 pages
File Size : 41,9 Mb
Release : 2016-12-31
Category : Medical
ISBN : 9780128008270

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Handbook of Cannabis and Related Pathologies by Victor R Preedy Pdf

Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment is the first book to take an interdisciplinary approach to the understanding of cannabis use and misuse. Recent worldwide trends toward decriminalizing marijuana for medical use have increased legal use of the drug and recreational use remains high, making cannabis one of the most commonly used drugs. Cannabis has a wide range of adverse neurological effects, and use and abuse can lead to physical, social, and psychopathological issues that are multifarious and complex. Effective understanding and treatment requires knowledge of the drug’s effects from across scientific disciplines. This book provides an overview of the biological and pharmacological components of the cannabis plant, outlines its neurological, social, and psychopathological effects, assists in the diagnosis and screening for use and dependency, and aids researchers in developing effective treatments for cannabis-related issues and disorders. Fully illustrated, with contributions from internationally recognized experts, it is the go-to resource for neuroscientists, pharmacologists, pathologists, public-health workers, and any other researcher who needs an in-depth and cross-disciplinary understanding of cannabis and its effects. Comprehensive chapters include an abstract, key facts, mini dictionary of terms, and summary points Presents illustrations with at least six figures, tables, and diagrams per chapter Provides a one-stop-shopping synopsis of everything to do with cannabis and its related pathology, from chemicals and cells, individuals and communities, and diagnosis and treatment Offers an integrated and informed synopsis of the complex issues surrounding cannabis as a substance, its use, and its misuse

Cannabinoids and Neuropsychiatric Disorders

Eric Murillo-Rodriguez,S. R. Pandi-Perumal,Jaime M. Monti
Cannabinoids and Neuropsychiatric Disorders Book PDF

Author : Eric Murillo-Rodriguez,S. R. Pandi-Perumal,Jaime M. Monti
Publisher : Springer Nature
Page : 163 pages
File Size : 54,9 Mb
Release : 2020-12-17
Category : Science
ISBN : 9783030573690

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Cannabinoids and Neuropsychiatric Disorders by Eric Murillo-Rodriguez,S. R. Pandi-Perumal,Jaime M. Monti Pdf

This volume highlights the recent advances in the understanding of the endocannabinoid system and the likely benefit from the therapeutic effects of cannabinoid treatment in a variety of health issues. Archeological evidence has shown that Cannabis has a long history of use for multiple purposes, including the treatment of medical conditions. The primary active constituent of the hemp plant Cannabis sativa, delta 9-tetrahydrocannabinol (Δ9-THC), causes euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration and impairment of memory, among other effects. Despite these undesirable effects, signaling is mostly inhibitory and suggests a putative role for cannabinoids as therapeutic agents by managing several diseases where inhibition of neurotransmitter release would be beneficial. The themes of this book have been edited and written by world-leaders in the field, The contents of the volume aims at readers from a range of academic and professional disciplines, such as biomedicine, several areas of biology, neurology, clinical medicine and pharmacy.

Cannabinoids in Neurologic and Mental Disease

Liana Fattore
Cannabinoids in Neurologic and Mental Disease Book PDF

Author : Liana Fattore
Publisher : Academic Press
Page : 499 pages
File Size : 51,5 Mb
Release : 2015-01-23
Category : Medical
ISBN : 9780124171244

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Cannabinoids in Neurologic and Mental Disease by Liana Fattore Pdf

The application of cannabis sativa for the treatment of neurologic and mental disease is expanding. Cannabinoids in Neurologic and Mental Disease collects and presents for the first time recent research involving the use of pharmacological cannabinoids for the treatment of neurodegenerative and neuroinflammatory disease. The neurologic application of cannabinoid therapy builds upon psychiatric and psychological use for the treatment of a variety of core mental disorders. This comprehensive reference on the known uses of cannabinoids will be useful for clinical neurologists, neuroscience and clinical neuroscience researchers, clinical psychologists and psychiatrists and the general medical community. A comprehensive reference on the clinical uses of cannabinoids for treating major neurologic and mental diseases Detailed coverage of cannabinoid use for neuroinflammatory and neurodegenerative disease including Multiple Sclerosis, Epilepsy, Huntington's disease, Parkinson's disease, and Alzheimer's disease Detailed coverage of cannabinoid use for major psychiatric and psychological diseases and disorders including schizophrenia, bipolar disorders, Tourette's syndrome, and post-traumatic stress disorder (PTSD)

Cannabinoids and the Brain

Linda A. Parker
Cannabinoids and the Brain Book PDF

Author : Linda A. Parker
Publisher : MIT Press
Page : 249 pages
File Size : 54,8 Mb
Release : 2018-09-25
Category : Science
ISBN : 9780262536608

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Cannabinoids and the Brain by Linda A. Parker Pdf

A review of the scientific evidence on the effects of cannabinoids on brain and behavioral functioning, with an emphasis on potential therapeutic use. The cannabis plant has been used for recreational and medicinal purposes for more than 4,000 years, but the scientific investigation into its effects has only recently yielded useful results. In this book, Linda Parker offers a review of the scientific evidence on the effects of cannabinoids on brain and behavioral functioning, with an emphasis on potential therapeutic uses. Parker describes the discovery of tetrahydocannbinol (THC), the main psychoactive component of cannabis, and the further discovery of cannabinoid receptors in the brain. She explains that the brain produces chemicals similar to THC, which act on the same receptors as THC, and shows that the endocannabinoid system is involved in all aspects of brain functioning. Parker reports that cannabis contains not only the psychoactive compound THC, but also other compounds of potential therapeutic benefit, and that one of them, cannabidiol (CBD), shows promise for the treatment of pain, anxiety, and epilepsy. Parker reviews the evidence on cannabinoids and anxiety, depression, mood, sleep, schizophrenia, learning and memory, addiction, sex, appetite and obesity, chemotherapy-induced nausea, epilepsy, and such neurodegenerative disorders as multiple sclerosis and Alzheimer's Disease. Each chapter also links the scientific evidence to historical and anecdotal reports of the medicinal use of cannabis. As debate about the medical use of marijuana continues, Parker's balanced and objective review of the fundamental science and potential therapeutic effects of cannabis is especially timely.

Endocannabinoid Signaling

Mauro Maccarrone
Endocannabinoid Signaling Book PDF

Author : Mauro Maccarrone
Publisher : Humana
Page : 0 pages
File Size : 53,9 Mb
Release : 2016-06-01
Category : Medical
ISBN : 1493935372

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Endocannabinoid Signaling by Mauro Maccarrone Pdf

This volume encompasses all major methodologies to interrogate endocannabinoid systems (ECS) and endocannabinoids (eCBs) signaling. With increasing interest towards the manifold activities of eCBs, this book discusses the chemical, biochemical, and molecular biological assays, and activity of distinct elements of the ECS. These include membrane, nuclear receptors, biosynthetic and hydrolytic enzymes, and membrane transporters and oxidative enzymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Timely and cutting edge, Endocannabinoid Signaling: Methods and Protocols is a valuable resource and will help chemists, drug designers, biochemists, molecular biologists, cell biologists, pharmacologists, and (electro) physiologists navigate the mare magnum of endocannabinoid research.

EndoCANNABINOIDS

Mary E. Abood,Roger Gene Sorensen,Nephi Stella
EndoCANNABINOIDS Book PDF

Author : Mary E. Abood,Roger Gene Sorensen,Nephi Stella
Publisher : Springer Science & Business Media
Page : 286 pages
File Size : 43,6 Mb
Release : 2013
Category : Cannabinoids
ISBN : 9781461446682

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EndoCANNABINOIDS by Mary E. Abood,Roger Gene Sorensen,Nephi Stella Pdf

The cloning of two G protein-coupled cannabinoid receptors, termed CB1 and CB2, in the early 1990s has stimulated and facilitated research conducted on the physiological function of cannabinoid actions in the brain and throughout the body. In the twenty years since the identification of these two receptors, endogenous ligands (endocannabinoids) for these receptors have been identified, their biosynthetic and metabolic pathways have been discerned, and their functional and regulatory action for signalling through CB1 and CB2 receptors have been described. More recently, it has become has become evident that cannabinoids exert actions at non-CB1, non-CB2 receptors. Much less is understood about these actions. Many of these novel?targets? are in the process of being characterized functionally and physiologically, and the therapeutic value of targeting these non-CB1, non-CB2 receptors is being evaluated. The purpose of this volume is to present the current knowledge on the atypical actions of cannabinoids on these new targets. This book is intended as a scientific resource for cannabinoid researchers carrying out animal and human experiments, and for those who are interested in learning about future directions in cannabinoid research. Additionally, this book may be of value to investigators currently working outside the field of cannabinoid research who have an interest in learning about these compounds and their atypical cannabinoid signalling. This book provides insight into the potential medical application of cannabinoids and their therapeutic development for the treatment of human disease.

Cannabinoids and the Brain

Attila Köfalvi
Cannabinoids and the Brain Book PDF

Author : Attila Köfalvi
Publisher : Springer Science & Business Media
Page : 583 pages
File Size : 53,6 Mb
Release : 2007-12-22
Category : Medical
ISBN : 9780387743493

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Cannabinoids and the Brain by Attila Köfalvi Pdf

Endocannabinoids have tremendous therapeutic potential. This book introduces readers to our current understanding of the neurobiology of endocannabinoids and related systems, detailing their pathophysiological role and therapeutic potential. Authors, experienced clinical investigators, present and analyze results of recent clinical trials as well as the development of new therapeutic strategies and medicines.

Recent Advances in Cannabinoid Physiology and Pathology

Anna N. Bukiya
Recent Advances in Cannabinoid Physiology and Pathology Book PDF

Author : Anna N. Bukiya
Publisher : Springer
Page : 167 pages
File Size : 47,6 Mb
Release : 2019-07-22
Category : Science
ISBN : 9783030217372

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Recent Advances in Cannabinoid Physiology and Pathology by Anna N. Bukiya Pdf

The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems. Cannabinoids also play a central role in developmental physiology, management of pain, and shaping of human behaviour. Recent movements towards legalization of marijuana use have bolstered scientific interest in the cannabinoid field and led to research efforts that would unveil multi-faceted effects and mechanisms of cannabinoid presence in different organs and at various stages of development. This book summarizes the recent advances in the field of cannabinoid research at multiple levels of resolution. It spans from systemic effects of cannabinoids on development, physiological function, and prevalent pathophysiological conditions to mechanisms that govern cannabinoid interaction with their relevant protein targets at atomic resolution. This book will be of interest to a specialized audience in the fields of biochemistry, pharmacology and developmental biology but alsoto a wider readership with interest in general physiology and cannabinoid signalling in biological systems.