The Characteristics Of Pediatric Soft Tissue Sarcomas Recent Advances In Management And Treatment
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The Characteristics of Pediatric Soft Tissue Sarcomas: Recent Advances in Management and Treatment by Jilong Yang,Shunbin Xiong Pdf
Sarcomas are forms of cancer that comprise tumors of the connective and structural tissue of the body and mainly affect children and young adults. Pediatric soft tissue sarcomas (STS) are a heterogeneous group of malignant tumors constituting about 7% of all cancer cases. Rhabdomyosarcomas (RMS) constitute about half of all soft tissue sarcomas in children, the rest being constituted by non- rhabdomyosarcoma soft tissue sarcomas (NRSTS). The estimated 5-year survival rate is around 65.6% in children and young adults, Rhabdomyosarcoma being as low as 59.2% in some cases.
Sarcomas of Bone and Soft Tissues in Children and Adolescents by Carola A. S. Arndt Pdf
This book is a comprehensive and up-to-date compendium on all aspects of sarcomas of bone and soft tissues in childhood and adolescence. After introductory chapters on the history, epidemiology, and biology of pediatric sarcomas, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. The pathology and biology of this diverse group of tumors are extensively reviewed. Promising new treatment approaches are discussed, and strategies for the development of new agents are appraised. The major common pediatric sarcomas, including osteosarcoma, Ewing sarcoma, rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcoma, are covered in detail. The authors are internationally recognized experts who offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of childhood and adolescent sarcomas and will prove invaluable to specialists, generalists, and trainees alike.
Treatment of Soft Tissue Sarcomas by H.M. Pinedo,J. Verweij Pdf
One of the major advances of the last decade concerning the treatment of patients with soft tissue sarcomas is that an increased number of patients are being discussed in multidisciplinary teams prior to the initial treatment. The present volume on soft tissue sarcomas in the series Cancer Treatment and Research reflects the multidisciplinary approach with a focus on recent developments. The availability of new histopathologic techniques has reduced the number of unclassified sarcomas and has furhter increased the importance of the histo pathologist in providing estimates of the prognosis of the patient as well as data for the planning of treatment strategy. Further data for this strategy will be provided by diagnostic imaging. In this field, the role of magnetic reson ance imaging has been further defined. Of utmost importance is the recent trend toward consensus in staging. The modification of the staging system of the American Joint Commission for Cancer Staging and End Results Report ing brings the possibility of a single staging system within reach in the next decade. As surgery still provides the only chance for cure, the importance of being the most sparing as possible is obvious. For this reason, radiotherapy has been applied with success. The introduction of relatively new radiation tech niques is therefore being observed with interest.
Pediatric and Adolescent Osteosarcoma by Norman Jaffe,Oyvind S. Bruland,Stefan Bielack Pdf
Pediatric and Adolescent Osteosarcoma provides a historical review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in Epidemiology and Etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age group, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of radiation therapy. The volume concludes with a review of differences and similarities in the management of osteosarcoma in adults as compared to pediatrics / adolescents and new laboratory and animal investigations currently in progress to develop effective diagnostic and therapeutic approaches to improve the outcome. In essence the scope and intensive coverage of the book provides a historical perspective of the advances made over the past 30 years and emerging concepts and prospects for new diagnostic and therapeutic approaches. This is based upon past experiences and new discoveries. It also provides a unique opportunity for pediatric and adult medical oncologists, physicians in training, orthopedic surgeons, pathologists, radiologists, radiotherapists, oncology nurses and allied professionals involved in the care of pediatric/adolescent patients with osteosarcoma to become acquainted with prevailing methods of treatment and new and evolving concepts and developments.
Management of Soft Tissue Sarcoma by Murray F. Brennan,Cristina R. Antonescu,Kaled M. Alektiar,Robert G. Maki Pdf
Management of Soft Tissue Sarcoma, 2nd Edition provides the most comprehensive analysis of demographics and natural history currently available for these lesions, based on the authors’ experience with over 10,000 patients. Sections regarding radiation therapy not found in the previous text have been expanded, as have updates on molecular characteristics of sarcomas and chemotherapy studies published since the prior edition. Clinical and molecular diagnoses are addressed, and tumor histopathology is employed as the basis of treatment recommendations including surgery, radiation and systemic therapy. This is the first book to provide specific chemotherapy opinions for every sarcoma subtype. Written by four world-renowned experts, this book gives a practical, up-to-date approach to managing the many subtypes of adult soft tissue sarcoma. Reviews from the first edition: “This is an impressive book. Written by a surgeon, a pathologist and an oncologist, the book draws heavily on the Memorial Sloan-Kettering Cancer Center soft tissue sarcoma (STS) database. ... it is a book that should be in the library of any sarcoma unit and will appeal to the sub-specialist in Orthopaedic Oncology.” (Robert U. Ashford, European Journal of Orthopaedic Surgery & Traumatology, Vol. 24, 2014) “The book is laid out in 27 chapters, with an impressive inclusion of a wide array of sarcoma histology. One of the real strengths of the book is the quality and number of images, figures, tables, and graphs. ... The overall outline of the text is well done. ... This book is a unique and important addition to the sarcoma literature. ... this edtion should find itself on every medical oncologist’s bookshelf ... .” (Larry C. Daugherty and Sanjay P. Bagaria, Journal of Radiation Oncology, Vol. 3, 2014)
Author : Martin M. Malawer,Paul H. Sugarbaker Publisher : Springer Science & Business Media Page : 618 pages File Size : 46,5 Mb Release : 2006-02-24 Category : Medical ISBN : 9780306484070
Musculoskeletal Cancer Surgery by Martin M. Malawer,Paul H. Sugarbaker Pdf
Steven A. Rosenberg, MD In the past two decades significant progress has quality of life. The use of local radiation therapy has occurred, in the management of patients with mus- had a profound impact on the ability to achieve local loskeletal cancers, that has improved both the survival control. Cooperation between surgeons and radiation and the quality of life of afflicted patients. Changes in therapists often results in the tailoring of surgical p- the management of these patients have mirrored cedures to maximize the combined application of these trends in the entire field of oncology. two effective treatment modalities. Although impact on The most significant change has been improvement overall survival has not been demonstrated due to the in the surgical techniques for the resection of musculo- addition of radiation therapy, important advances in skeletal cancers based on a detailed understanding of improving the quality of life of patients receiving this the anatomic features of each particular tumor site, as combined-modality treatment have been evident. well as an appreciation of the natural biology that affects A third change impacting on the survival of patients the local spread of these tumors. The current volume of with musculoskeletal cancers has been the aggressive Musculoskeletal Cancer Surgery: Treatment of Sarcomas and resection of metastatic deposits.
Essentials of Surgical Pediatric Pathology by Marta C. Cohen,Irene Scheimberg Pdf
Essentials of Surgical Pediatric Pathology is a clear and practical yet comprehensive guide for trainee pediatric pathologists and non-pediatric pathologists. Each chapter corresponds to one of the main subspecialties, such as dermatopathology, head and neck pathology, and system pathology. Practical guidance is given on handling pediatric specimens and the authors highlight the ways in which common conditions present differently in adults and children. Other chapters cover conditions typical of childhood, including soft tissue tumors and blue round cell tumors. The chapters begin with a brief clinical presentation, followed by a clear macroscopical and histological description of the principal pathologies seen in children. Up-to-date genetic and immunohistochemical information is provided, and the book includes hundreds of high-quality color images. Written and edited by leading international experts in the field, this is an essential resource for trainee pediatric pathologists, as well as general pathologists who may encounter pediatric cases.
Robert O. Greer,Robert E. Marx,Sherif Said,Lori D. Prok
Author : Robert O. Greer,Robert E. Marx,Sherif Said,Lori D. Prok Publisher : Cambridge University Press Page : 607 pages File Size : 45,6 Mb Release : 2017-07-06 Category : Medical ISBN : 9781316613993
Author : John R. Goldblum,Sharon W. Weiss,Andrew L. Folpe Publisher : Elsevier Health Sciences Page : 1173 pages File Size : 48,6 Mb Release : 2013-10-11 Category : Medical ISBN : 9781455737635
Enzinger and Weiss's Soft Tissue Tumors E-Book by John R. Goldblum,Sharon W. Weiss,Andrew L. Folpe Pdf
Enzinger and Weiss's Soft Tissue Tumors is your essential medical reference on the diagnosis of tumors of the skeletal muscles, connective tissue, fat, and related structures. No other source matches Enzinger and Weiss’s scope and depth of coverage in this complex and challenging area of surgical pathology, and no other text contains as much practical information on differential diagnosis. Microscopic findings are correlated with the latest developments in molecular biology, cytogenetics, and immunohistochemistry, providing you with a comprehensive and integrated approach to the evaluation of soft tissue specimens. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compare what you see under the microscope to nearly 2,000 superb images that capture the appearance of a complete range of pathological entities and help you relate their characteristics to their specific classifications. Apply the latest knowledge on FNA biopsy, molecular biology, and cytogenetics. Make rapid and effective decisions with the aid of extensive algorithms, and access information at a glance with abundant tables and graphs. Take advantage of all of the essential clinical and prognostic data on soft tissue tumors that are necessary to formulate complete sign-out reports. Navigate through the book quickly thanks to summary outlines at the beginning of each chapter, a color-coded page design, and a consistent approach to every entity. Apply the latest advances in surgical pathology thanks to major updates on recently identified pathological entities such as soft tissue angiofibroma and CIC-related sarcomas; coverage of the newest molecular diagnostic techniques and immunohistochemical and molecular genetic features of soft tissue tumors; new chapters on GIST and soft tissue tumors showing melanocytic differentiation; and more. Effortlessly find the information you need with a chapter organization based on the newest surgical pathology concepts and classifications of soft tissue tumors.
Soft Tissue and Bone Tumours by WHO Classification of Tumours Editorial Board Pdf
PLEASE NOTE: Text has been accidentally deleted from page 54 of this book. Please refer to the corrigenda (PDF file) posted on the Stylus Publishing web site or email [email protected] for an updated, printable page. ****When not purchasing directly from the official sales agents of the WHO, especially at online bookshops, please note that there have been issues with counterfeited copies. Buy only from known sellers and if there are quality issues, please contact the seller for a refund.***** Soft Tissue and Bone Tumours is the third volume in the 5th edition of the WHO series on the classification of human tumours. This series (also known as the WHO Blue Books) is regarded as the gold standard for the diagnosis of tumours and comprises a unique synthesis of histopathological diagnosis with digital and molecular pathology. These authoritative and concise reference books provide indispensable international standards for anyone involved in the care of patients with cancer or in cancer research, underpinning individual patient treatment as well as research into all aspects of cancer causation, prevention, therapy, and education. This volume will be of particular interest to pathologists, oncologists, surgeons, and epidemiologists who manage or research soft tissue and bone tumours. Sections are included on all recognized neoplasms of the soft tissue and bone, as well as on genetic tumour syndromes affecting these sites. Since the previous edition, there have been changes based on recent molecular and genetic information, with impact on clinical practice.
Bone and Soft Tissue Pathology by Andrew L. Folpe, MD,Carrie Y. Inwards, MD Pdf
Bone and Soft Tissue Pathology: A Volume in the Diagnostic Pathology Series, by Andrew L. Folpe, MD and Carrie Y. Inwards, MD, packs today's most essential bone and soft tissue pathology know-how into a compact, high-yield format! The book's pragmatic, well-organized approach-complemented by abundant full-color, high-quality illustrations and at-a-glance tables-makes it easy to access the information you need to quickly and accurately identify pathology specimens. Best of all, Expert Consult functionality provides online access to the full text of the book, downloadable illustrations for your personal use, and more. The result is a practical, affordable reference for study and review as well as for everyday clinical practice. Includes access to the complete contents online, fully searchable, downloadable illustrations for your personal use, and more, allowing you to consult the text a quick, convenient manner. Reviews normal histology before examining abnormal findings, enabling you to conveniently compare their characteristics in one place at one time. Covers both neoplastic and non-neoplastic conditions of bone and soft tissue to equip you to meet a wide range of diagnostic challenges. Uses a consistent, user-friendly format to explore each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations...making it easy to locate specific information on a particular entity. Features abundant boxes and tables throughout that enhance the presentation and accessibility of the material. Offers nearly 1,000 full-color, high-quality illustrations that demonstrate the key features of a wide variety of pathologic lesions to facilitate greater accuracy in identification of specimens. The Foundations in Diagnostic Pathology Series answers the call for fresh, affordable, and easy-to-use guidance. Each region-specific volume provides all of the most essential information on the pathologic entities encountered in practice. Series Editor: John R. Goldblum, MD, FACP, FASCP, FACG Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Sarcomas by Jonathan C. Trent, MD, PhD,Andrew E. Rosenberg, MD,Raphael Pollock, MD,Thomas F. Delaney, MD Pdf
Sarcomas: Evidence-Based Diagnosisand Management is the most comprehensive clinical reference on sarcomas available to oncologists and trainees. Presenting a compilation of the current knowledge of specific soft tissue and bone sarcomas, this accessible resource on diagnosis and management is the most practical in the market. Led by the world’s foremost sarcomas experts in medical oncology, surgical oncology, radiation oncology, gynecologic oncology, orthopedic surgery, radiology, and pathology, the book addresses the general principles of each major medical discipline, provides details on each major sarcoma subtype, and presents the evidence for standard frontline, adjuvant, and novel treatment approaches such as immunotherapy, cellular therapies, and more. The book begins with general principles of diagnosis and management for each discipline in the field, covering specialties from medical oncology to radiology. Following the chapters on general principles, are chapters characterizing the most prevalent subtypes of sarcoma including their estimated incidence, common presenting symptoms, diagnostic approach, radiographic features and essential imaging, key diagnostic features, molecular characteristics, approaches to treatment, recommended follow up, the metastatic potential as well as evidence-based therapeutic approaches. Each chapter ends with a summary of caveats, clinical pearls, pitfalls, and solutions as well as a case study from the clinician’s point of view. The book ends with chapters focusing on new approaches to treatment and the development of therapeutics to combat sarcoma using immunotherapy, cellular therapy, and interventional radiology. Numerous tables and disease-based images support the text and provide key information for quick reference. Presenting detailed evidence and authoritative clinical guidance throughout, Sarcomas is a “one-stop” guide for any clinician diagnosing, treating, or managing patients suffering from these heterogenous diseases. Key Features: Provides the standards of care and evidence base for treatment of each major sarcoma subtype Covers all new treatment paradigms and FDA approvals Includes numerous quick reference tables and high-quality color images Presents over 20 practical case studies from leading clinicians in the field
Modern Soft Tissue Pathology by Markku Miettinen Pdf
This book comprehensively covers modern soft tissue pathology and includes both tumors and non-neoplastic entities. Soft tissues make up a large bulk of the human body, and they are susceptible to a wide range of diseases. Many soft-tissue tumors are biologically very aggressive, and the chance of them metastasizing to vital organs is quite high. In recent years, the outlook for soft-tissue cancers has brightened dramatically due to the increased accuracy of the pathologist's tools. All methods of diagnosis are covered here, with an emphasis on the newest immunoassays and other genetic, molecular, and immunologic diagnostic modalities. This book's systematic description of benign and malignant primary soft tissue tumors with didactic, comprehensive panels of illustrations allows the reader to formulate a complete understanding of the morphology of tumor entities at one glance. The book covers both the most common tumor entities and more unusual diseases using more than 1,500 color images, making it a resource for beginning and senior pathologists.