The Comprehensive Sourcebook Of Bacterial Protein Toxins

Author : Joseph E. Alouf,Daniel Ladant,Michel R. Popoff
Publisher : Academic Press
Page : 1200 pages
File Size : 54,5 Mb
Release : 2015-05-29
Category : Science
ISBN : 9780128005897

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The Comprehensive Sourcebook of Bacterial Protein Toxins by Joseph E. Alouf,Daniel Ladant,Michel R. Popoff Pdf

The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them. Focused chapters on toxin applications and common properties or general features of toxins.

Author : John H. Freer,Joseph E. Alouf
Publisher : Unknown
Page : 750 pages
File Size : 44,7 Mb
Release : 1999
Category : Bacterial proteins
ISBN : UOM:39015048833282

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The Comprehensive Sourcebook of Bacterial Protein Toxins by John H. Freer,Joseph E. Alouf Pdf

The Comprehensive Sourcebook of Bacterial Protein Toxins, Second Edition provides an up-to-date description of the great advances made in our understanding of the structure, genetics, cellular, and molecular mechanisms of action of bacterial protein toxins over the past decade. This work follows and expands on the First Edition, with 70% totally new content and full-color illustrations. Molecular biology, microbiology, immunology, cell biology, protein engineering, structural biochemistry, and clinical research in infectious diseases are brought together to provide a complete overview of the field.

Author : Joseph E. Alouf,Daniel Ladant,Michel R. Popoff
Publisher : Elsevier
Page : 0 pages
File Size : 43,6 Mb
Release : 2015-06-05
Category : Science
ISBN : 0128001887

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The Comprehensive Sourcebook of Bacterial Protein Toxins by Joseph E. Alouf,Daniel Ladant,Michel R. Popoff Pdf

The Comprehensive Sourcebook of Bacterial Protein Toxins, Fourth Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content.

Author : Joseph E. Alouf,John H. Freer
Publisher : Unknown
Page : 540 pages
File Size : 48,7 Mb
Release : 1991
Category : Medical
ISBN : UOM:39015024930649

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Sourcebook of Bacterial Protein Toxins by Joseph E. Alouf,John H. Freer Pdf

Written by an international team of leading scientists, this volume draws together a wealth of information on the structure, regulation, and activity of bacterial protein toxins. A comprehensive sourcebook on bacterial toxins, Sourcebook of Bacterial Protein Toxins is the first book designed to draw together current knowledge on these toxins. The 22 chapters of this book have been written by 44 internationally known specialists who have significantly contributed to the progress in the domains covered. This book will appeal to a wide readership, including microbiologists, biochemists, cell biologists, and physicians. It will also arouse the interest of students and scientists in other disciplines who see the power of these fascinating biological agents, either as exquisitely specific probes of cellular processes or as extremely potent agents of infectious disease.

Author : Solomon Kadis
Publisher : Elsevier
Page : 433 pages
File Size : 49,8 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323150514

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Bacterial Protein Toxins V2A by Solomon Kadis Pdf

Microbial Toxins, A Comprehensive Treatise, Volume IIA: Bacterial Protein Toxins provides a comprehensive discussion of various aspects of bacterial toxins. The book's 10 chapters discuss the following: botulinum toxin; tetanus toxin; Clostridium perfringens toxins types A, B, C, D, and E; cholera toxins; the exotoxin of Shigella dysenteriae; protein toxins from Bordetella pertussis; Salmonella typhimurium and Escherichia coli neurotoxins; toxins of Proteus mirabilis; and Listeria monocytogenes toxin. Each chapter covers the nature of the toxin, toxin production and purification, and mode of action.

Author : Alistair J. Lax
Publisher : Cambridge University Press
Page : 268 pages
File Size : 55,9 Mb
Release : 2011-04-28
Category : Science
ISBN : 1139443593

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Bacterial Protein Toxins by Alistair J. Lax Pdf

Bacterial toxins that act inside cells interact very specifically with key components of the cell and some even manipulate the cell in subtle ways for their own purposes. These potent toxins, described in this 2005 book, will be of interest to both microbiologists and cell biologists. Some of these toxins are conventional multidomain toxins that are self-programmed to enter cells. Others are delivered by type III mechanisms, often as a package of potent molecules. The molecular targets for all these toxins mediate signal transduction and the cell cycle to regulate the crucial processes of cell growth, cell division and differentiation. Thus these potent toxins are not only responsible for disease, but also provide a powerful set of tools with which to interrogate the biology of the cell. In addition such toxins may act directly to promote carcinogenesis and hence their study is also of interest in a wider context.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 53,7 Mb
Release : 1971
Category : Electronic
ISBN : OCLC:712470623

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Bacterial protein toxins by Anonim Pdf

Author : Thomas C. Montie
Publisher : Elsevier
Page : 569 pages
File Size : 51,8 Mb
Release : 2013-09-11
Category : Science
ISBN : 9780323163224

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Bacterial Protein Toxins V3 by Thomas C. Montie Pdf

Bacterial Protein Toxins V3

Author : K. Aktories,I. Just
Publisher : Springer Science & Business Media
Page : 748 pages
File Size : 40,6 Mb
Release : 2000-04-26
Category : Medical
ISBN : 3540661255

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Bacterial Protein Toxins by K. Aktories,I. Just Pdf

With contributions by numerous experts

Author : Rino Rappuoli,Cesare Montecucco
Publisher : OUP Oxford
Page : 278 pages
File Size : 50,8 Mb
Release : 1997-05-29
Category : Medical
ISBN : 9780191547287

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Guidebook to Protein Toxins and Their Use in Cell Biology by Rino Rappuoli,Cesare Montecucco Pdf

Many bacteria, animals, and plants produce toxins that can prove lethal to other organisms. Toxins are a form of "biological warfare" that helps their producer to survive and so confer an evolutionary advantage. They display an extraordinary range of complexity, from the formic acid provided by ants to bacterial proteins composed of thousands of amino acids. This Guidebook considers the more complex protein and peptide toxins and groups them according to their mode of action. Topics covered include: membrane-permeabilizing toxins; toxins affecting signal transduction and protein synthesis; cytoskeleton-affecting toxins; toxins affecting the immune and inflammatory response. This class of biomolecules will be of interest to a wide range of researchers in cell biology, neuroscience, and toxicology.

Author : Otto Holst
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 53,5 Mb
Release : 2008-02-05
Category : Science
ISBN : 9781592590520

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Bacterial Toxins by Otto Holst Pdf

The interest of investigators across a broad spectrum of scientific dis- plines has been steadily stimulated by the field of bacterial toxin research, an area that makes use of a large variety of biological, chemical, physicochemical, and medically oriented approaches. Researchers studying bacterial toxins need to be acquainted with all these disciplines in order to work effectively in the field. To date, there has been no published collection offering detailed descr- tions of the techniques and methods needed by researchers operating across the field’sdiverse areas. The present volume Bacterial Toxins: Methods and Pro- cols, is intended to fill this gap. Bacterial Toxins: Methods and Protocols consists of two sections: one on protein toxins (15 chapters) and one on endotoxins (5 chapters). Each s- tion is introduced by an overview article (Chapters 1 and 16). The protocols collected represent state-of-the-art techniques that each have high impact on future bacterial toxin research. All methods are described by authors who have regularly been using the protocol in their own laboratories. Included in each chapter is a brief introduction to the method being described.

Author : Klaus Aktories
Publisher : John Wiley & Sons
Page : 334 pages
File Size : 46,8 Mb
Release : 2008-09-26
Category : Science
ISBN : 9783527614608

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Bacterial Toxins by Klaus Aktories Pdf

This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.

Author : Holger Barth
Publisher : MDPI
Page : 125 pages
File Size : 50,5 Mb
Release : 2018-07-09
Category : Electronic
ISBN : 9783038424307

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Novel Pharmacological Inhibitors for Bacterial Protein Toxins by Holger Barth Pdf

This book is a printed edition of the Special Issue "Novel Pharmacological Inhibitors for Bacterial Protein Toxins" that was published in Toxins

Author : Holger Barth
Publisher : Springer
Page : 256 pages
File Size : 51,8 Mb
Release : 2017-12-01
Category : Medical
ISBN : 9783319588933

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Uptake and Trafficking of Protein Toxins by Holger Barth Pdf

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as multivalent and heterocyclic molecules that specifically block the toxins’ translocation channels. This volume offers an up-to-date resource for scientists.

Author : Gianfranco Menestrina,M. Dalla Sera
Publisher : CRC Press
Page : 360 pages
File Size : 47,6 Mb
Release : 2003-01-30
Category : Medical
ISBN : 9780203986646

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Pore-forming Peptides and Protein Toxins by Gianfranco Menestrina,M. Dalla Sera Pdf

Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell function. The discovery of this cellular interaction has