The Drug Hunters

The Drug Hunters Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of The Drug Hunters book. This book definitely worth reading, it is an incredibly well-written.

The Drug Hunters

Donald R. Kirsch,Ogi Ogas
The Drug Hunters Book PDF

Author : Donald R. Kirsch,Ogi Ogas
Publisher : Simon and Schuster
Page : 328 pages
File Size : 49,8 Mb
Release : 2016-12-13
Category : Science
ISBN : 9781628727197

Get Book

The Drug Hunters by Donald R. Kirsch,Ogi Ogas Pdf

The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

The Drug Hunters

Donald R. Kirsch,Ogi Ogas
The Drug Hunters Book PDF

Author : Donald R. Kirsch,Ogi Ogas
Publisher : Arcade
Page : 304 pages
File Size : 42,5 Mb
Release : 2018-10-16
Category : Science
ISBN : 1628729864

Get Book

The Drug Hunters by Donald R. Kirsch,Ogi Ogas Pdf

The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes of drug hunters from the US, UK, Germany, and other nations. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

The Body Hunters

Sonia Shah
The Body Hunters Book PDF

Author : Sonia Shah
Publisher : New Press, The
Page : 257 pages
File Size : 53,5 Mb
Release : 2012-03-13
Category : Medical
ISBN : 9781595588319

Get Book

The Body Hunters by Sonia Shah Pdf

Hailed by John le Carré as “an act of courage on the part of its author” and singled out for praise by the leading medical journals in the United States and the United Kingdom, The Body Hunters uncovers the real-life story behind le Carré's acclaimed novel The Constant Gardener and the feature film based on it. "A trenchant exposé . . . meticulously researched and packed with documentary evidence" (Publishers Weekly), Sonia Shah's riveting journalistic account shines a much-needed spotlight on a disturbing new global trend. Drawing on years of original research and reporting in Africa and Asia, Shah examines how the multinational pharmaceutical industry, in its quest to develop lucrative drugs, has begun exporting its clinical research trials to the developing world, where ethical oversight is minimal and desperate patients abound. As the New England Journal of Medicine notes, “it is critical that those engaged in drug development, clinical research and its oversight, research ethics, and policy know about these stories,” which tell of an impossible choice being faced by many of the world's poorest patients—be experimented upon or die for lack of medicine.

Kinetics of Enzyme Action

Ross L. Stein
Kinetics of Enzyme Action Book PDF

Author : Ross L. Stein
Publisher : John Wiley & Sons
Page : 322 pages
File Size : 49,7 Mb
Release : 2011-08-08
Category : Science
ISBN : 9781118084403

Get Book

Kinetics of Enzyme Action by Ross L. Stein Pdf

Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.

Beautiful Things

Hunter Biden
Beautiful Things Book PDF

Author : Hunter Biden
Publisher : Simon and Schuster
Page : 272 pages
File Size : 54,5 Mb
Release : 2021-04-06
Category : Biography & Autobiography
ISBN : 9781982151119

Get Book

Beautiful Things by Hunter Biden Pdf

Hunter Biden recounts his descent into substance abuse and his tortuous path to sobriety. The story ends with where Hunter is today

Ten Drugs

Thomas Hager
Ten Drugs Book PDF

Author : Thomas Hager
Publisher : Abrams
Page : 342 pages
File Size : 55,6 Mb
Release : 2019-03-05
Category : Medical
ISBN : 9781683355311

Get Book

Ten Drugs by Thomas Hager Pdf

“The stories are skillfully told and entirely entertaining . . . An expert, mostly feel-good book about modern medicine” from the award-winning author (Kirkus Reviews, starred review). Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine. Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book. “[An] absorbing new book.” —The New York Times Book Review “[A] well-written and engaging chronicle.” —The Wall Street Journal “Lucidly informative and compulsively readable.” —Publishers Weekly “Entertaining [and] insightful.” —Booklist “Well-written, well-researched and fascinating to read Ten Drugs provides an insightful look at how drugs have shaped modern medical practices. Towards the end of the book Hager writes that he ‘came away surprised by some of the things he had learned.’ I had the very same reaction.” —Penny Le Couteur, coauthor of Napoleon’s Buttons: How 17 Molecules Changed History

Drug-Drug Interactions

A. David Rodrigues
Drug Drug Interactions Book PDF

Author : A. David Rodrigues
Publisher : CRC Press
Page : 769 pages
File Size : 47,8 Mb
Release : 2019-01-03
Category : Medical
ISBN : 9780849375941

Get Book

Drug-Drug Interactions by A. David Rodrigues Pdf

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes

Drug Discovery with Privileged Building Blocks

Jie Jack Li,Minmin Yang
Drug Discovery with Privileged Building Blocks Book PDF

Author : Jie Jack Li,Minmin Yang
Publisher : Unknown
Page : 424 pages
File Size : 50,6 Mb
Release : 2021
Category : Drug development
ISBN : 1032041730

Get Book

Drug Discovery with Privileged Building Blocks by Jie Jack Li,Minmin Yang Pdf

Drug Discovery with Privileged Building Blocks traces back PharmaBlockʹs founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to molecules' biological activities but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and regular analysis of new building block structures in the latest researches has proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists and veteran medicinal chemists find it useful as well.

In Quest of Tomorrow's Medicines

Jürgen Drews
In Quest of Tomorrow s Medicines Book PDF

Author : Jürgen Drews
Publisher : Springer Science & Business Media
Page : 282 pages
File Size : 46,6 Mb
Release : 2003-01-14
Category : Business & Economics
ISBN : 0387955429

Get Book

In Quest of Tomorrow's Medicines by Jürgen Drews Pdf

An eminent scientist talks about the pharmaceutical industry, biotechnology and the future of drug research. In the course of our busy, technologically-driven lives, it is taken for granted that we respond to minor fluctuations in our health by taking pills -- pills for headache and for toothache; sleeping pills and tranquilizers; pills to lower fever, quiet coughs, and clear the sinuses; medicines to reduce appetite; preparations to relieve heartburn; and many more. In the war against serious disease, medicines are an indispensable weapon in the physician's arsenal: they save lives, or at least prolong them and make them more bearable. Despite the important role that pharmaceuticals play in our lives, few of us know where medicines come from or how the pharmaceutical industry discovers and develops new drugs. Jurgen Drews, an acclaimed leader in the pharmaceutical industry, tells the fascinating story of drug discovery and development from his years of successfully leading internatnional research teams at Hoffman-LaRoche. Drews traces the history of modern drug development from pharmacies, chemical companies, and individual entrepeneurs in Switzerland, Germany and the U.S. to the mega-corporations that dot the landscape of Europe, Japan and America. He describes the process by which new drugs are tested and brought to market, including a provacative look at how AIDS activism stimulated the approval process in the US. Drews' commentary on the role of clinical trials -- the time involved and their cost -- is sobering testimony to the complexity of bringing innovation to the marketplace. In the final two chapters of "In Quest of Tomorrow's Medicines", Drews offers an important and critical analysis of research in the the pharmaceutical industry, pointing to strategies that work and management practices that impede progress. Drews' comments on the impact that the growing relationship between the biotechnology industry and university-sponsored research will have ont he pharmaceutical industry makes provocative reading for pharmaceutical researchers, managers and investors. "In Quest of Tomorrow's Medicines" in written in clear, thoughtful language for people in the pharmaceutical and biotechnology industries, as well as policy makers, industry analysts and observers.

Twelve

Nick McDonell
Twelve Book PDF

Author : Nick McDonell
Publisher : Grove/Atlantic, Inc.
Page : 215 pages
File Size : 42,9 Mb
Release : 2010-07-06
Category : Fiction
ISBN : 9781555846879

Get Book

Twelve by Nick McDonell Pdf

New York Times Notable Book: “An exceptional, assured debut [that] captures the zeitgeist of confused adolescents and a sick culture post-Columbine.”—Hartford Courant A national bestseller that inspired a major motion picture, this chilling novel follows prep school dropout White Mike through the week between Christmas and New Year’s 1999, as he deals an alluring new drug to his privileged peers on Manhattan’s Upper East Side. The kids of Twelve have it all; Chris and Claude and Hunter and Laura have the best, and most, of everything, but are constantly looking for something more exotic, and more dangerous. But Twelve is not a coming-of-age story, because these kids never had a childhood—their parents are off on holiday in Bali or business in Brussels, leaving hired help to look the other way as the kids stay home alone in their multimillion-dollar town houses, partying, surrounded by drugs and sex—and, in the end, much worse. “Renders Manhattan’s cosseted Upper East Side with both the casual authority of an insider and the wry distance of an observer…impressive.”—Jennifer Egan, The New York Times Book Review “Riveting in its no-holds-barred depiction of teenage nihilism.”—Jon Land, Providence Journal

Drug Discovery

Hany El-Shemy
Drug Discovery Book PDF

Author : Hany El-Shemy
Publisher : BoD – Books on Demand
Page : 528 pages
File Size : 49,5 Mb
Release : 2013-01-23
Category : Medical
ISBN : 9789535109068

Get Book

Drug Discovery by Hany El-Shemy Pdf

Natural products are a constant source of potentially active compounds for the treatment of various disorders. The Middle East and tropical regions are believed to have the richest supplies of natural products in the world. Plant derived secondary metabolites have been used by humans to treat acute infections, health disorders and chronic illness for tens of thousands of years. Only during the last 100 years have natural products been largely replaced by synthetic drugs. Estimates of 200 000 natural products in plant species have been revised upward as mass spectrometry techniques have developed. For developing countries the identification and use of endogenous medicinal plants as cures against cancers has become attractive. Books on drug discovery will play vital role in the new era of disease treatment using natural products.

Don't Eat This If You're Taking That

Madelyn Fernstrom,John Fernstrom
Don t Eat This If You re Taking That Book PDF

Author : Madelyn Fernstrom,John Fernstrom
Publisher : Simon and Schuster
Page : 200 pages
File Size : 41,9 Mb
Release : 2015-10-20
Category : Health & Fitness
ISBN : 9781632209252

Get Book

Don't Eat This If You're Taking That by Madelyn Fernstrom,John Fernstrom Pdf

NBC Today Show nutrition and health guru Madelyn Fernstrom presents the ultimate guide to food and medicine interaction. While no one wants to take medication to treat diabetes, high blood pressure, heart disease, or other ailments, for millions of people, this is a daily reality. Seven out of ten Americans take prescription drugs. But when it comes to food and medicine interactions, what you don’t know can harm your health. Don’t Eat This If You’re Taking That takes the mystery out of food and medications, providing an easy-to-use guide for anyone taking a medication—short term or long term—that indicates foods to avoid that can interfere with the action of the medication. Readers can easily find a medication, see what foods to avoid, and make some smart swaps. Small diet changes learned from this book can have big health payoffs! An added bonus in each chapter is a Dietary Supplements Alert box, providing the most up-to-date information on interactions with vitamins, minerals, and other dietary supplements. We all believe a diet rich in colorful fruits and vegetables, lean proteins, whole grains, and low-fat dairy products is the path to healthy eating, right? Not always. Consumers can easily personalize their healthiest eating plan to work with not against their medications.

Hunting Marco Polo

Paul Eddy,Sara Walden
Hunting Marco Polo Book PDF

Author : Paul Eddy,Sara Walden
Publisher : Little, Brown Medical Division
Page : 302 pages
File Size : 52,9 Mb
Release : 1991
Category : Social Science
ISBN : 0316210560

Get Book

Hunting Marco Polo by Paul Eddy,Sara Walden Pdf

Chronicles DEA agent Craig Lovato's pursuit of Howard Marks, a graduate of Oxford and a former British intelligence agent who for twenty years smuggled drugs into America

Manhunters

Steve Murphy,Javier F. Peña
Manhunters Book PDF

Author : Steve Murphy,Javier F. Peña
Publisher : St. Martin's Press
Page : 352 pages
File Size : 49,5 Mb
Release : 2019-11-12
Category : True Crime
ISBN : 9781250202901

Get Book

Manhunters by Steve Murphy,Javier F. Peña Pdf

For the first time, legendary DEA operatives Steve Murphy and Javier F. Peña tell the true story of how they helped put an end to one of the world’s most infamous narco-terrorists in Manhunters: How We Took Down Pablo Escobar—the subject of the hit Netflix series, Narcos. Colombian drug lord Pablo Escobar’s brutal Medellín Cartel was responsible for trafficking tons of cocaine to North America and Europe in the 1980s and ’90s. The nation became a warzone as his sicarios mercilessly murdered thousands of people—competitors, police, and civilians—to ensure he remained Colombia’s reigning kingpin. With billions in personal income, Pablo Escobar bought off politicians and lawmen, and became a hero to poorer communities by building houses and sports centers. He was nearly untouchable despite the efforts of the Colombian National Police to bring him to justice. But Escobar was also one of America’s most wanted, and the Drug Enforcement Administration was determined to see him pay for his crimes. Agents Steve Murphy and Javier F. Peña were assigned to the Bloque de Búsqueda, the joint Colombian-U.S. taskforce created to end Escobar’s reign of terror. For eighteen months, between July 1992 and December 1993, Steve and Javier lived and worked beside Colombian authorities, finding themselves in the crosshairs of sicarios targeting them for the $300,000 bounty Escobar placed on each of their heads. Undeterred, they risked the dangers, relentlessly and ruthlessly separating the drug lord from his resources and allies, and tearing apart his empire, leaving him underground and on the run from enemies on both sides of the law. Manhunters presents Steve and Javier’s history in law enforcement from their rigorous physical training and their early DEA assignments in Miami and Austin to the Escobar mission in Medellin, Colombia—living far from home and serving as frontline soldiers in the never ending war on drugs that continues to devastate America.

Drug-like Properties: Concepts, Structure Design and Methods

Li Di,Edward H Kerns
Drug like Properties Concepts Structure Design and Methods Book PDF

Author : Li Di,Edward H Kerns
Publisher : Elsevier
Page : 549 pages
File Size : 46,5 Mb
Release : 2010-07-26
Category : Science
ISBN : 9780080557618

Get Book

Drug-like Properties: Concepts, Structure Design and Methods by Li Di,Edward H Kerns Pdf

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint