The Drug Hunters

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The Drug Hunters

Donald R. Kirsch,Ogi Ogas
The Drug Hunters Book PDF

Author : Donald R. Kirsch,Ogi Ogas
Publisher : Simon and Schuster
Page : 328 pages
File Size : 45,8 Mb
Release : 2016-12-13
Category : Science
ISBN : 9781628727197

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The Drug Hunters by Donald R. Kirsch,Ogi Ogas Pdf

The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

The Body Hunters

Sonia Shah
The Body Hunters Book PDF

Author : Sonia Shah
Publisher : New Press, The
Page : 257 pages
File Size : 40,7 Mb
Release : 2012-03-13
Category : Medical
ISBN : 9781595588319

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The Body Hunters by Sonia Shah Pdf

Hailed by John le Carré as “an act of courage on the part of its author” and singled out for praise by the leading medical journals in the United States and the United Kingdom, The Body Hunters uncovers the real-life story behind le Carré's acclaimed novel The Constant Gardener and the feature film based on it. "A trenchant exposé . . . meticulously researched and packed with documentary evidence" (Publishers Weekly), Sonia Shah's riveting journalistic account shines a much-needed spotlight on a disturbing new global trend. Drawing on years of original research and reporting in Africa and Asia, Shah examines how the multinational pharmaceutical industry, in its quest to develop lucrative drugs, has begun exporting its clinical research trials to the developing world, where ethical oversight is minimal and desperate patients abound. As the New England Journal of Medicine notes, “it is critical that those engaged in drug development, clinical research and its oversight, research ethics, and policy know about these stories,” which tell of an impossible choice being faced by many of the world's poorest patients—be experimented upon or die for lack of medicine.

Kinetics of Enzyme Action

Ross L. Stein
Kinetics of Enzyme Action Book PDF

Author : Ross L. Stein
Publisher : John Wiley & Sons
Page : 322 pages
File Size : 47,7 Mb
Release : 2011-08-08
Category : Science
ISBN : 9781118084403

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Kinetics of Enzyme Action by Ross L. Stein Pdf

Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.

Beautiful Things

Hunter Biden
Beautiful Things Book PDF

Author : Hunter Biden
Publisher : Simon and Schuster
Page : 272 pages
File Size : 45,7 Mb
Release : 2021-04-06
Category : Biography & Autobiography
ISBN : 9781982151119

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Beautiful Things by Hunter Biden Pdf

Hunter Biden recounts his descent into substance abuse and his tortuous path to sobriety. The story ends with where Hunter is today

Ten Drugs

Thomas Hager
Ten Drugs Book PDF

Author : Thomas Hager
Publisher : Abrams
Page : 342 pages
File Size : 41,7 Mb
Release : 2019-03-05
Category : Medical
ISBN : 9781683355311

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Ten Drugs by Thomas Hager Pdf

“The stories are skillfully told and entirely entertaining . . . An expert, mostly feel-good book about modern medicine” from the award-winning author (Kirkus Reviews, starred review). Behind every landmark drug is a story. It could be an oddball researcher’s genius insight, a catalyzing moment in geopolitical history, a new breakthrough technology, or an unexpected but welcome side effect discovered during clinical trials. Piece together these stories, as Thomas Hager does in this remarkable, century-spanning history, and you can trace the evolution of our culture and the practice of medicine. Beginning with opium, the “joy plant,” which has been used for 10,000 years, Hager tells a captivating story of medicine. His subjects include the largely forgotten female pioneer who introduced smallpox inoculation to Britain, the infamous knockout drops, the first antibiotic, which saved countless lives, the first antipsychotic, which helped empty public mental hospitals, Viagra, statins, and the new frontier of monoclonal antibodies. This is a deep, wide-ranging, and wildly entertaining book. “[An] absorbing new book.” —The New York Times Book Review “[A] well-written and engaging chronicle.” —The Wall Street Journal “Lucidly informative and compulsively readable.” —Publishers Weekly “Entertaining [and] insightful.” —Booklist “Well-written, well-researched and fascinating to read Ten Drugs provides an insightful look at how drugs have shaped modern medical practices. Towards the end of the book Hager writes that he ‘came away surprised by some of the things he had learned.’ I had the very same reaction.” —Penny Le Couteur, coauthor of Napoleon’s Buttons: How 17 Molecules Changed History

Drug Discovery with Privileged Building Blocks

Jie Jack Li,Minmin Yang
Drug Discovery with Privileged Building Blocks Book PDF

Author : Jie Jack Li,Minmin Yang
Publisher : Unknown
Page : 424 pages
File Size : 48,6 Mb
Release : 2021
Category : Drug development
ISBN : 1032041730

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Drug Discovery with Privileged Building Blocks by Jie Jack Li,Minmin Yang Pdf

Drug Discovery with Privileged Building Blocks traces back PharmaBlockʹs founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to molecules' biological activities but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and regular analysis of new building block structures in the latest researches has proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists and veteran medicinal chemists find it useful as well.

Twelve

Nick McDonell
Twelve Book PDF

Author : Nick McDonell
Publisher : Grove/Atlantic, Inc.
Page : 215 pages
File Size : 40,6 Mb
Release : 2010-07-06
Category : Fiction
ISBN : 9781555846879

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Twelve by Nick McDonell Pdf

New York Times Notable Book: “An exceptional, assured debut [that] captures the zeitgeist of confused adolescents and a sick culture post-Columbine.”—Hartford Courant A national bestseller that inspired a major motion picture, this chilling novel follows prep school dropout White Mike through the week between Christmas and New Year’s 1999, as he deals an alluring new drug to his privileged peers on Manhattan’s Upper East Side. The kids of Twelve have it all; Chris and Claude and Hunter and Laura have the best, and most, of everything, but are constantly looking for something more exotic, and more dangerous. But Twelve is not a coming-of-age story, because these kids never had a childhood—their parents are off on holiday in Bali or business in Brussels, leaving hired help to look the other way as the kids stay home alone in their multimillion-dollar town houses, partying, surrounded by drugs and sex—and, in the end, much worse. “Renders Manhattan’s cosseted Upper East Side with both the casual authority of an insider and the wry distance of an observer…impressive.”—Jennifer Egan, The New York Times Book Review “Riveting in its no-holds-barred depiction of teenage nihilism.”—Jon Land, Providence Journal

Drugs

Rick Ng
Drugs Book PDF

Author : Rick Ng
Publisher : John Wiley & Sons
Page : 368 pages
File Size : 40,8 Mb
Release : 2011-09-20
Category : Science
ISBN : 9781118210703

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Drugs by Rick Ng Pdf

"Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs." —Doody's Reviews, May 2009 "The second edition of a book that offers a user-friendly step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of preclinical trials." —Chemistry World, February 2009 The new edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes for pharmaceutical products. Concise and easy to read, the book quickly introduces basic concepts, then moves on to discuss target selection and the drug discovery process for both small and large molecular drugs. This second edition features many key enhancements, including Key Points, Chapter Summary, and Review Questions in each chapter, Answers to Review Questions provided in a book-end appendix, and one or two carefully selected "mini" case studies in each chapter. Richly illustrated throughout with over ninety figures and tables, this important book also includes helpful listings of current FDA and European guidelines and a special section on regulatory authority and processes in China. It is an indispensable resource for pharmaceutical industry and academic researchers, pharmaceutical managers and executives, healthcare clinicians, policymakers, regulators, and lobbyists with an interest in drug development. It is also an excellent textbook for students in pharmacy, science, and medicine courses.

Manhunters

Steve Murphy,Javier F. Peña
Manhunters Book PDF

Author : Steve Murphy,Javier F. Peña
Publisher : St. Martin's Press
Page : 352 pages
File Size : 44,7 Mb
Release : 2019-11-12
Category : True Crime
ISBN : 9781250202901

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Manhunters by Steve Murphy,Javier F. Peña Pdf

For the first time, legendary DEA operatives Steve Murphy and Javier F. Peña tell the true story of how they helped put an end to one of the world’s most infamous narco-terrorists in Manhunters: How We Took Down Pablo Escobar—the subject of the hit Netflix series, Narcos. Colombian drug lord Pablo Escobar’s brutal Medellín Cartel was responsible for trafficking tons of cocaine to North America and Europe in the 1980s and ’90s. The nation became a warzone as his sicarios mercilessly murdered thousands of people—competitors, police, and civilians—to ensure he remained Colombia’s reigning kingpin. With billions in personal income, Pablo Escobar bought off politicians and lawmen, and became a hero to poorer communities by building houses and sports centers. He was nearly untouchable despite the efforts of the Colombian National Police to bring him to justice. But Escobar was also one of America’s most wanted, and the Drug Enforcement Administration was determined to see him pay for his crimes. Agents Steve Murphy and Javier F. Peña were assigned to the Bloque de Búsqueda, the joint Colombian-U.S. taskforce created to end Escobar’s reign of terror. For eighteen months, between July 1992 and December 1993, Steve and Javier lived and worked beside Colombian authorities, finding themselves in the crosshairs of sicarios targeting them for the $300,000 bounty Escobar placed on each of their heads. Undeterred, they risked the dangers, relentlessly and ruthlessly separating the drug lord from his resources and allies, and tearing apart his empire, leaving him underground and on the run from enemies on both sides of the law. Manhunters presents Steve and Javier’s history in law enforcement from their rigorous physical training and their early DEA assignments in Miami and Austin to the Escobar mission in Medellin, Colombia—living far from home and serving as frontline soldiers in the never ending war on drugs that continues to devastate America.

Hunting Marco Polo

Paul Eddy,Sara Walden
Hunting Marco Polo Book PDF

Author : Paul Eddy,Sara Walden
Publisher : Little, Brown Medical Division
Page : 302 pages
File Size : 47,9 Mb
Release : 1991
Category : Social Science
ISBN : 0316210560

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Hunting Marco Polo by Paul Eddy,Sara Walden Pdf

Chronicles DEA agent Craig Lovato's pursuit of Howard Marks, a graduate of Oxford and a former British intelligence agent who for twenty years smuggled drugs into America

Fear and Loathing in Las Vegas (Harper Perennial Modern Classics)

Hunter S. Thompson
Fear and Loathing in Las Vegas Harper Perennial Modern Classics Book PDF

Author : Hunter S. Thompson
Publisher : HarperCollins UK
Page : 240 pages
File Size : 55,6 Mb
Release : 2014-10-16
Category : Biography & Autobiography
ISBN : 9780007596713

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Fear and Loathing in Las Vegas (Harper Perennial Modern Classics) by Hunter S. Thompson Pdf

‘We were somewhere around Barstow on the edge of the desert when the drugs began to take hold. I remember saying something like, “I feel a bit lightheaded; maybe you should drive ...”’

The Diamond Hunters

Wilbur Smith
The Diamond Hunters Book PDF

Author : Wilbur Smith
Publisher : Bonnier Publishing Fiction Ltd.
Page : 235 pages
File Size : 42,7 Mb
Release : 2018-01-01
Category : Fiction
ISBN : 9781785765919

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The Diamond Hunters by Wilbur Smith Pdf

An action-packed thriller of family, business and betrayal - perfect for fans of Succession - by global sensation Wilbur Smith. 'A master storyteller' - Sunday Times 'Wilbur Smith is one of those benchmarks against whom others are compared' - The Times 'No one does adventure quite like Smith' - Daily Mirror Some people will never have enough . . . Johnny Lance was taken in by the Van Der Byls when he was an orphaned boy, and his life has been dedicated to making his adoptive father proud. But his efforts have been in vain, his father loathes him and, in his dying breath, makes one final demand of his biological son, the jealous and vengeful Benedict: to destroy his half-brother. When Johnny is tricked by Benedict into losing his entire fortune to the Van Der Byls company, he becomes a laughingstock. Benedict's sister, the smart and beautiful Tracey, loves Johnny and buys him a concession in the diamond rich seabeds of the South-West African Coast. But the obsessive Benedict has been shaped at his father's hand and will do anything to finish what he started. Even if it means destroying everything . . .

The Ultimate Beginner's Guide to Buying Street Drugs

Hunter Mays
The Ultimate Beginner s Guide to Buying Street Drugs Book PDF

Author : Hunter Mays
Publisher : Createspace Independent Publishing Platform
Page : 40 pages
File Size : 48,7 Mb
Release : 2016-08-23
Category : Electronic
ISBN : 1537191985

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The Ultimate Beginner's Guide to Buying Street Drugs by Hunter Mays Pdf

A personal memoir and guide to buying street drugs... The Ultimate Beginner's Guide to Buying Street Drugs comes straight from an experienced brain-abusing drug user seeking to shed some light on the drug world. In this brief guide, you will learn everything from the types of drugs out on the streets to where to make a purchase. This is the real deal.

Managing the Drug Discovery Process

Walter Moos,Susan Miller,Stephen Munk,Barbara Munk
Managing the Drug Discovery Process Book PDF

Author : Walter Moos,Susan Miller,Stephen Munk,Barbara Munk
Publisher : Woodhead Publishing
Page : 536 pages
File Size : 42,7 Mb
Release : 2016-11-08
Category : Medical
ISBN : 9780081006320

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Managing the Drug Discovery Process by Walter Moos,Susan Miller,Stephen Munk,Barbara Munk Pdf

Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological, and infrastructural. Since drug research can be a high-risk, high-payoff industry, it is important to researchers to effectively and strategically manage the drug discovery process. This book takes a closer look at increasing pre-approval costs for new drugs and examines not only why these increases occur, but also how they can be overcome to ensure a robust pharmacoeconomic future. Written in an engaging manner and including memorable insights, this book is aimed at redirecting the drug discovery process to make it more efficient and cost-effective in order to achieve the goal of saving countless more lives through science. A valuable and compelling resource, this is a must-read for all students and researchers in academia and the pharmaceutical industry. Considers drug discovery in multiple R&D venues, including big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable

Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set

Anonim
Burger s Medicinal Chemistry Drug Discovery and Development 8 Volume Set Book PDF

Author : Anonim
Publisher : John Wiley & Sons
Page : 6057 pages
File Size : 43,7 Mb
Release : 2021-04-20
Category : Science
ISBN : 9781119530305

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Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set by Anonim Pdf

Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.