The Dynamics Of Living Systems

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The Dynamics of Living Systems

Thomas Lecuit
The Dynamics of Living Systems Book PDF

Author : Thomas Lecuit
Publisher : Collège de France
Page : 32 pages
File Size : 49,6 Mb
Release : 2020-11-16
Category : Science
ISBN : 9782722605602

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The Dynamics of Living Systems by Thomas Lecuit Pdf

How can we explain the fundamental paradox of living matter, which combines stability and robustness of form with constant internal dynamics? It is not only the genetic information contained in every cell, but also numerous stochastic biomolecular processes that are at work in morphogenesis. In addition, the shaping of an organism is driven by mechanical forces that operate within and between cells, across tissues and organs. The dynamics of morphogenesis is a self-organized process that emerges from biological control and physical constraints at all scales. Its study is currently bringing together a fast-growing interdisciplinary community that observes, analyses and models living organisms.

Dynamics of Biological Systems

Michael Small
Dynamics of Biological Systems Book PDF

Author : Michael Small
Publisher : CRC Press
Page : 286 pages
File Size : 45,5 Mb
Release : 2011-08-25
Category : Mathematics
ISBN : 9781439853368

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Dynamics of Biological Systems by Michael Small Pdf

From the spontaneous rapid firing of cortical neurons to the spatial diffusion of disease epidemics, biological systems exhibit rich dynamic behaviour over a vast range of time and space scales. Unifying many of these diverse phenomena, Dynamics of Biological Systems provides the computational and mathematical platform from which to understand the underlying processes of the phenomena. Through an extensive tour of various biological systems, the text introduces computational methods for simulating spatial diffusion processes in excitable media, such as the human heart, as well as mathematical tools for dealing with systems of nonlinear ordinary and partial differential equations, such as neuronal activation and disease diffusion. The mathematical models and computer simulations offer insight into the dynamics of temporal and spatial biological systems, including cardiac pacemakers, artificial electrical defibrillation, pandemics, pattern formation, flocking behaviour, the interaction of autonomous agents, and hierarchical and structured network topologies. Tools from complex systems and complex networks are also presented for dealing with real phenomenological systems. With exercises and projects in each chapter, this classroom-tested text shows students how to apply a variety of mathematical and computational techniques to model and analyze the temporal and spatial phenomena of biological systems. MATLAB® implementations of algorithms and case studies are available on the author’s website.

Self-Organized Biological Dynamics and Nonlinear Control

Jan Walleczek
Self Organized Biological Dynamics and Nonlinear Control Book PDF

Author : Jan Walleczek
Publisher : Cambridge University Press
Page : 444 pages
File Size : 49,9 Mb
Release : 2006-04-20
Category : Science
ISBN : 9781139427593

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Self-Organized Biological Dynamics and Nonlinear Control by Jan Walleczek Pdf

The growing impact of nonlinear science on biology and medicine is fundamentally changing our view of living organisms and disease processes. This book introduces the application to biomedicine of a broad range of interdisciplinary concepts from nonlinear dynamics, such as self-organization, complexity, coherence, stochastic resonance, fractals and chaos. It comprises 18 chapters written by leading figures in the field and covers experimental and theoretical research, as well as the emerging technological possibilities such as nonlinear control techniques for treating pathological biodynamics, including heart arrhythmias and epilepsy. This book will attract the interest of professionals and students from a wide range of disciplines, including physicists, chemists, biologists, sensory physiologists and medical researchers such as cardiologists, neurologists and biomedical engineers.

The Physics of Living Systems

Fabrizio Cleri
The Physics of Living Systems Book PDF

Author : Fabrizio Cleri
Publisher : Springer
Page : 620 pages
File Size : 42,8 Mb
Release : 2016-10-08
Category : Science
ISBN : 9783319306476

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The Physics of Living Systems by Fabrizio Cleri Pdf

In this book, physics in its many aspects (thermodynamics, mechanics, electricity, fluid dynamics) is the guiding light on a fascinating journey through biological systems, providing ideas, examples and stimulating reflections for undergraduate physics, chemistry and life-science students, as well as for anyone interested in the frontiers between physics and biology. Rather than introducing a lot of new information, it encourages young students to use their recently acquired knowledge to start seeing the physics behind the biology. As an undergraduate textbook in introductory biophysics, it includes the necessary background and tools, including exercises and appendices, to form a progressive course. In this case, the chapters can be used in the order proposed, possibly split between two semesters. The book is also an absorbing read for researchers in the life sciences who wish to refresh or go deeper into the physics concepts gleaned in their early years of scientific training. Less physics-oriented readers might want to skip the first chapter, as well as all the "gray boxes" containing the more formal developments, and create their own á-la-carte menu of chapters.

Models of Life

Kim Sneppen
Models of Life Book PDF

Author : Kim Sneppen
Publisher : Cambridge University Press
Page : 353 pages
File Size : 50,5 Mb
Release : 2014-10-02
Category : Science
ISBN : 9781107061903

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Models of Life by Kim Sneppen Pdf

An overview of current models of biological systems, reflecting the major advances that have been made over the past decade.

Artificial Life IV

Rodney Allen Brooks,Pattie Maes
Artificial Life IV Book PDF

Author : Rodney Allen Brooks,Pattie Maes
Publisher : MIT Press
Page : 462 pages
File Size : 53,8 Mb
Release : 1994
Category : Computers
ISBN : 0262521903

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Artificial Life IV by Rodney Allen Brooks,Pattie Maes Pdf

This book brings together contributions to the Fourth Artificial Life Workshop, held at the Massachusetts Institute of Technology in the summer of 1994.

Physical Models of Living Systems

Philip Nelson
Physical Models of Living Systems Book PDF

Author : Philip Nelson
Publisher : Macmillan Higher Education
Page : 384 pages
File Size : 48,7 Mb
Release : 2015-03-06
Category : Science
ISBN : 9781319036904

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Physical Models of Living Systems by Philip Nelson Pdf

Written for intermediate-level undergraduates pursuing any science or engineering major, Physical Models of Living Systems helps students develop many of the competencies that form the basis of the new MCAT2015. The only prerequisite is first-year physics. With the more advanced "Track-2" sections at the end of each chapter, the book can be used in graduate-level courses as well.

Modeling Complex Living Systems

N. Bellomo
Modeling Complex Living Systems Book PDF

Author : N. Bellomo
Publisher : Springer Science & Business Media
Page : 229 pages
File Size : 51,8 Mb
Release : 2008
Category : Mathematics
ISBN : 9780817645106

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Modeling Complex Living Systems by N. Bellomo Pdf

Develops different mathematical methods and tools to model living systems. This book presents material that can be used in such real-world applications as immunology, transportation engineering, and economics. It is of interest to those involved in modeling complex social systems and living matter in general.

Understanding the Dynamics of Biological Systems

Werner Dubitzky,Jennifer Southgate,Hendrik Fuß
Understanding the Dynamics of Biological Systems Book PDF

Author : Werner Dubitzky,Jennifer Southgate,Hendrik Fuß
Publisher : Springer Science & Business Media
Page : 238 pages
File Size : 45,9 Mb
Release : 2011-01-07
Category : Science
ISBN : 9781441979643

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Understanding the Dynamics of Biological Systems by Werner Dubitzky,Jennifer Southgate,Hendrik Fuß Pdf

This book is intended as a communication platform to bridge the cultural, conceptual, and technological gap among the key systems biology disciplines of biology, mathematics, and information technology. To support this goal, contributors were asked to adopts an approach that appeals to audiences from different backgrounds.

Quantitative Biology: Dynamics of Living Systems

Noriko Hiroi,Viji M. Draviam,Tetsuya J. Kobayashi,Akira Funahashi,Chun-Biu Li,Douglas B. Murray,Hiroaki Takagi,Ziya Kalay,Rinshi S. Kasai,Jason Edward Shoemaker,Akatsuki Kimura,Naoki A. Irie
Quantitative Biology Dynamics of Living Systems Book PDF

Author : Noriko Hiroi,Viji M. Draviam,Tetsuya J. Kobayashi,Akira Funahashi,Chun-Biu Li,Douglas B. Murray,Hiroaki Takagi,Ziya Kalay,Rinshi S. Kasai,Jason Edward Shoemaker,Akatsuki Kimura,Naoki A. Irie
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 50,5 Mb
Release : 2017-07-24
Category : Electronic book
ISBN : 9782889452132

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Quantitative Biology: Dynamics of Living Systems by Noriko Hiroi,Viji M. Draviam,Tetsuya J. Kobayashi,Akira Funahashi,Chun-Biu Li,Douglas B. Murray,Hiroaki Takagi,Ziya Kalay,Rinshi S. Kasai,Jason Edward Shoemaker,Akatsuki Kimura,Naoki A. Irie Pdf

With the emergence of Systems Biology, there is a greater realization that the whole behavior of a living system may not be simply described as the sum of its elements. To represent a living system using mathematical principles, practical quantities with units are required. Quantities are not only the bridge between mathematical description and biological observations; they often stand as essential elements similar to genome information in genetics. This important realization has greatly rejuvenated research in the area of Quantitative Biology. Because of the increased need for precise quantification, a new era of technological development has opened. For example, spatio-temporal high-resolution imaging enables us to track single molecule behavior in vivo. Clever artificial control of experimental conditions and molecular structures has expanded the variety of quantities that can be directly measured. In addition, improved computational power and novel algorithms for analyzing theoretical models have made it possible to investigate complex biological phenomena. This research topic is organized on two aspects of technological advances which are the backbone of Quantitative Biology: (i) visualization of biomolecules, their dynamics and function, and (ii) generic technologies of model optimization and numeric integration. We have also included articles highlighting the need for new quantitative approaches to solve some of the long-standing cell biology questions. In the first section on visualizing biomolecules, four cutting-edge techniques are presented. Ichimura et al. provide a review of quantum dots including their basic characteristics and their applications (for example, single particle tracking). Horisawa discusses a quick and stable labeling technique using click chemistry with distinct advantages compared to fluorescent protein tags. The relatively small physical size, stability of covalent bond and simple metabolic labeling procedures in living cells provides this type of technology a potential to allow long-term imaging with least interference to protein function. Obien et al. review strategies to control microelectrodes for detecting neuronal activity and discuss techniques for higher resolution and quality of recordings using monolithic integration with on-chip circuitry. Finally, the original research article by Amariei et al. describes the oscillatory behavior of metabolites in bacteria. They describe a new method to visualize the periodic dynamics of metabolites in large scale cultures populations. These four articles contribute to the development of quantitative methods visualizing diverse targets: proteins, electrical signals and metabolites. In the second section of the topic, we have included articles on the development of computational tools to fully harness the potential of quantitative measurements through either calculation based on specific model or validation of the model itself. Kimura et al. introduce optimization procedures to search for parameters in a quantitative model that can reproduce experimental data. They present four examples: transcriptional regulation, bacterial chemotaxis, morphogenesis of tissues and organs, and cell cycle regulation. The original research article by Sumiyoshi et al. presents a general methodology to accelerate stochastic simulation efforts. They introduce a method to achieve 130 times faster computation of stochastic models by applying GPGPU. The strength of such accelerated numerical calculation are sometimes underestimated in biology; faster simulation enables multiple runs and in turn improved accuracy of numerical calculation which may change the final conclusion of modeling study. This also highlights the need to carefully assess simulation results and estimations using computational tools.

Modelling the Dynamics of Biological Systems

Erik Mosekilde,Ole G. Mouritsen
Modelling the Dynamics of Biological Systems Book PDF

Author : Erik Mosekilde,Ole G. Mouritsen
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642792908

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Modelling the Dynamics of Biological Systems by Erik Mosekilde,Ole G. Mouritsen Pdf

The development of a proper description of the living world today stands as one of the most significant challenges to physics. A variety of new experimental techniques in molecular biology, microbiol ogy, physiology and other fields of biological research constantly expand our knowledge and enable us to make increasingly more detailed functional and structural descriptions. Over the past decades, the amount and complexity of available information have multiplied dramatically, while at the same time our basic understanding of the nature of regulation, behavior, morphogenesis and evolution in the living world has made only modest progress. A key obstacle is clearly the proper handling of the available data. This requires a stronger emphasis on mathematical modeling through which the consistency of the adopted explanations can be checked, and general princi ples may be extracted. As an even more serious problem, however, it appears that the proper physical concepts for the development of a theoretically oriented biology have not hitherto been available. Classical mechanics and equilibrium thermody namics, for instance, are inappropriate and useless in some of the most essen tial biological contexts. Fortunately, there is now convincing evidence that the concepts and methods of the newly developed fields of nonlinear dynam ics and complex systems theory, combined with irreversible thermodynamics and far-from-equilibrium statistical mechanics will enable us to move ahead with many of these problems.

Models of Life

Kim Sneppen
Models of Life Book PDF

Author : Kim Sneppen
Publisher : Cambridge University Press
Page : 128 pages
File Size : 42,6 Mb
Release : 2014-10-02
Category : Science
ISBN : 9781316061657

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Models of Life by Kim Sneppen Pdf

Reflecting the major advances that have been made in the field over the past decade, this book provides an overview of current models of biological systems. The focus is on simple quantitative models, highlighting their role in enhancing our understanding of the strategies of gene regulation and dynamics of information transfer along signalling pathways, as well as in unravelling the interplay between function and evolution. The chapters are self-contained, each describing key methods for studying the quantitative aspects of life through the use of physical models. They focus, in particular, on connecting the dynamics of proteins and DNA with strategic decisions on the larger scale of a living cell, using E. coli and phage lambda as key examples. Encompassing fields such as quantitative molecular biology, systems biology and biophysics, this book will be a valuable tool for students from both biological and physical science backgrounds.

Nonlinear Electrodynamics in Biological Systems

W. Adey
Nonlinear Electrodynamics in Biological Systems Book PDF

Author : W. Adey
Publisher : Springer Science & Business Media
Page : 589 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461327899

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Nonlinear Electrodynamics in Biological Systems by W. Adey Pdf

The past half century has seen an extraordinary growth in the fields of cellular and molecular biology. From simple morphologi cal concepts of cells as the essential units of living matter there has been an ever-sharper focus on functional organization of living systems, with emphasis on molecular dynamics. Thus, life forms have come to be defined increasingly in terms of metabolism, growth, reproduction and responses to environmental perturbations. Since these properties occur in varying degrees in systems below the level of cellular organization, there has been a blurring of older models that restricted the concepts of life to cellular systems. At the same time, a search has begun for elemental as pects of molecular and atomic behavior that might better define properties common to all life forms. This search has led to an examination of nonlinear behavior in biological macromolecules, whether in response to electrical or chemical stimulation, for example, or as a means of signaling along a molecular chain, or as a means of energy transfer. Experimental knowledge in this area has grown rapidly in the past decade, and in some respects has outstripped theoretical models adequate to ex plain these new observations. Nevertheless, it can be claimed that there is now an impressive body of experiments implicating non linear, nonequilibrium processes as fundamental steps in sequential operations of biological systems.

The Dynamics of Biological Systems

Arianna Bianchi,Thomas Hillen,Mark A. Lewis,Yingfei Yi
The Dynamics of Biological Systems Book PDF

Author : Arianna Bianchi,Thomas Hillen,Mark A. Lewis,Yingfei Yi
Publisher : Springer Nature
Page : 267 pages
File Size : 47,6 Mb
Release : 2019-10-02
Category : Mathematics
ISBN : 9783030225834

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The Dynamics of Biological Systems by Arianna Bianchi,Thomas Hillen,Mark A. Lewis,Yingfei Yi Pdf

The book presents nine mini-courses from a summer school, Dynamics of Biological Systems, held at the University of Alberta in 2016, as part of the prestigious seminar series: Séminaire de Mathématiques Supérieures (SMS). It includes new and significant contributions in the field of Dynamical Systems and their applications in Biology, Ecology, and Medicine. The chapters of this book cover a wide range of mathematical methods and biological applications. They - explain the process of mathematical modelling of biological systems with many examples, - introduce advanced methods from dynamical systems theory, - present many examples of the use of mathematical modelling to gain biological insight - discuss innovative methods for the analysis of biological processes, - contain extensive lists of references, which allow interested readers to continue the research on their own. Integrating the theory of dynamical systems with biological modelling, the book will appeal to researchers and graduate students in Applied Mathematics and Life Sciences.

Leading from the Roots

Kathleen E. Allen
Leading from the Roots Book PDF

Author : Kathleen E. Allen
Publisher : Morgan James Publishing
Page : 207 pages
File Size : 48,8 Mb
Release : 2018-06-05
Category : Business & Economics
ISBN : 9781683508502

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Leading from the Roots by Kathleen E. Allen Pdf

Can we design organizations in a way that creates a space where employees, the organization, and the larger community all thrive? And if so, where can we go for inspiration to help us achieve this goal? In a time of volatile and complex uncertainty, it is time to learn the lessons that nature has compiled from 3.8 billion years of research and development. Nature is an interdependent, dynamic and living system – just like today’s organizations and communities. Kathleen Allen uses nature as a model, mentor, and muse to rethink how leadership is practiced today. Leading from the Roots takes nature as a source of inspiration to help organizations see a new way of leading and designing workplace structure, applying the generous framework found in mature ecologies to human organizations. Kathleen Allen helps shift assumptions, practices, structures, and processes of organizations to become more resilient and nourishing for all, and, along the way, design the way out of workplace dysfunction and drama. “Leading from the Roots provides a powerful new way of thinking about organizations as living systems and delivers practical leadership frameworks for individuals to learn how to unleash the energy and create innovative, effective teams. -Anne Boneparte, CEO Appthority This book is a must read for organizational leaders who are not only committed to their mission, but equally to creating a workplace that attracts and retains the brightest and the best professionals fully enabled to meet that mission. -Caryl Stern, President & CEO UNICEF USA