The Environment Animal Human Web A One Health View Of Toxicological Risk Analysis

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The Environment-Animal-Human Web: A "One Health" View of Toxicological Risk Analysis

Chiara Frazzoli,Alberto Mantovani
The Environment Animal Human Web A One Health View of Toxicological Risk Analysis Book PDF

Author : Chiara Frazzoli,Alberto Mantovani
Publisher : Unknown
Page : 0 pages
File Size : 52,5 Mb
Release : 2019
Category : Electronic
ISBN : OCLC:1368438099

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The Environment-Animal-Human Web: A "One Health" View of Toxicological Risk Analysis by Chiara Frazzoli,Alberto Mantovani Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

The Environment-Animal-Human Web: A “One Health” View of Toxicological Risk Analysis

Chiara Frazzoli,Alberto Mantovani
The Environment Animal Human Web A One Health View of Toxicological Risk Analysis Book PDF

Author : Chiara Frazzoli,Alberto Mantovani
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 48,6 Mb
Release : 2019-04-09
Category : Electronic
ISBN : 9782889457915

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The Environment-Animal-Human Web: A “One Health” View of Toxicological Risk Analysis by Chiara Frazzoli,Alberto Mantovani Pdf

One Health (OH) is the conceptual and operational framework that links environment, food-producing organisms and human health. OH is a developing field, that deals with the multifaceted web of feed-backs and interactions among its components. In order to avoid “drowning into complexity”, priority issues should be identified, either for research and for risk analysis. To date OH approaches have frequently pivoted on infectious agents shared among animals and humans and the related problems, such as antibiotic resistance. Nevertheless, the OH scenarios include, and should increasingly include, environment-and-health problems. Food and environment do interact. Environment influences the living organisms that produce human food and, in the meanwhile, food production outputs influence the environmental quality; as for foods of animal origin, feed materials and practices are driving components of the environment-food interactions. In this book, we aimed at highlighting the importance of environment, chemical exposures and toxicological issues in the field of OH, as well as the need for multidisciplinary integration in order to support OH approaches into diseases prevention and health promotion.

Challenges in Endocrine Disruptor Toxicology and Risk Assessment

Alberto Mantovani,Alexandra Fucic
Challenges in Endocrine Disruptor Toxicology and Risk Assessment Book PDF

Author : Alberto Mantovani,Alexandra Fucic
Publisher : Royal Society of Chemistry
Page : 539 pages
File Size : 52,8 Mb
Release : 2020-12-08
Category : Science
ISBN : 9781839160837

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Challenges in Endocrine Disruptor Toxicology and Risk Assessment by Alberto Mantovani,Alexandra Fucic Pdf

Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.

Animals as Sentinels of Environmental Health Hazards

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Animals as Monitors of Environmental Hazards
Animals as Sentinels of Environmental Health Hazards Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Animals as Monitors of Environmental Hazards
Publisher : National Academies Press
Page : 173 pages
File Size : 41,8 Mb
Release : 1991-02-01
Category : Science
ISBN : 9780309040464

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Animals as Sentinels of Environmental Health Hazards by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Animals as Monitors of Environmental Hazards Pdf

Studying animals in the environment may be a realistic and highly beneficial approach to identifying unknown chemical contaminants before they cause human harm. Animals as Sentinels of Environmental Health Hazards presents an overview of animal-monitoring programs, including detailed case studies of how animal health problemsâ€"such as the effects of DDT on wild bird populationsâ€"have led researchers to the sources of human health hazards. The authors examine the components and characteristics required for an effective animal-monitoring program, and they evaluate numerous existing programs, including in situ research, where an animal is placed in a natural setting for monitoring purposes.

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

Aristidis M. Tsatsakis
Toxicological Risk Assessment and Multi System Health Impacts from Exposure Book PDF

Author : Aristidis M. Tsatsakis
Publisher : Elsevier
Page : 684 pages
File Size : 45,7 Mb
Release : 2021-08-01
Category : Medical
ISBN : 9780323853583

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Toxicological Risk Assessment and Multi-System Health Impacts from Exposure by Aristidis M. Tsatsakis Pdf

Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

One Health

Ronald M. Atlas,Stanley Maloy
One Health Book PDF

Author : Ronald M. Atlas,Stanley Maloy
Publisher : John Wiley & Sons
Page : 332 pages
File Size : 55,5 Mb
Release : 2020-07-24
Category : Medical
ISBN : 9781555818432

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One Health by Ronald M. Atlas,Stanley Maloy Pdf

Emerging infectious diseases are often due to environmental disruption, which exposes microbes to a different niche that selects for new virulence traits and facilitates transmission between animals and humans. Thus, health of humans also depends upon health of animals and the environment – a concept called One Health. This book presents core concepts, compelling evidence, successful applications, and remaining challenges of One Health approaches to thwarting the threat of emerging infectious disease. Written by scientists working in the field, this book will provide a series of "stories" about how disruption of the environment and transmission from animal hosts is responsible for emerging human and animal diseases. Explains the concept of One Health and the history of the One Health paradigm shift. Traces the emergence of devastating new diseases in both animals and humans. Presents case histories of notable, new zoonoses, including West Nile virus, hantavirus, Lyme disease, SARS, and salmonella. Links several epidemic zoonoses with the environmental factors that promote them. Offers insight into the mechanisms of microbial evolution toward pathogenicity. Discusses the many causes behind the emergence of antibiotic resistance. Presents new technologies and approaches for public health disease surveillance. Offers political and bureaucratic strategies for promoting the global acceptance of One Health.

Toxicity Testing for Assessment of Environmental Agents

National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents
Toxicity Testing for Assessment of Environmental Agents Book PDF

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents
Publisher : National Academies Press
Page : 271 pages
File Size : 42,7 Mb
Release : 2006-05-07
Category : Nature
ISBN : 9780309100922

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Toxicity Testing for Assessment of Environmental Agents by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Toxicity Testing and Assessment of Environmental Agents Pdf

Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establish tolerances for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Because the number of regulations that require toxicity testing is growing, EPA called for a comprehensive review of established and emerging toxicity-testing methods and strategies. This interim report reviews current toxicity-testing methods and strategies and near-term improvements in toxicity-testing approaches proposed by EPA and others. It identifies several recurring themes and questions in the various reports reviewed. The final report will present a long-range vision and strategic plan to advance the practices of toxicity testing and human health assessment of environmental contaminants.

Human Risk Assessment

M V Roloff
Human Risk Assessment Book PDF

Author : M V Roloff
Publisher : CRC Press
Page : 216 pages
File Size : 50,8 Mb
Release : 2020-10-28
Category : Medical
ISBN : 9781000162875

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Human Risk Assessment by M V Roloff Pdf

This book explores the factors which are critical in the selection of an appropriate animal species for toxicology studies and the subsequent extrapolation of the data to humans. It provides some future directions for risk assessment activities at the Environmental Protection Agency.

One Health: The Human-Animal-Environment Interfaces in Emerging Infectious Diseases

John S. Mackenzie,Martyn Jeggo,Peter Daszak,Juergen A. Richt
One Health The Human Animal Environment Interfaces in Emerging Infectious Diseases Book PDF

Author : John S. Mackenzie,Martyn Jeggo,Peter Daszak,Juergen A. Richt
Publisher : Springer Science & Business Media
Page : 238 pages
File Size : 54,7 Mb
Release : 2013-11-22
Category : Medical
ISBN : 9783642358463

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One Health: The Human-Animal-Environment Interfaces in Emerging Infectious Diseases by John S. Mackenzie,Martyn Jeggo,Peter Daszak,Juergen A. Richt Pdf

One Health is an emerging concept that aims to bring together human, animal, and environmental health. Achieving harmonized approaches for disease detection and prevention is difficult because traditional boundaries of medical and veterinary practice must be crossed. In the 19th and early 20th centuries this was not the case—then researchers like Louis Pasteur and Robert Koch and physicians like William Osler and Rudolph Virchow crossed the boundaries between animal and human health. More recently Calvin Schwabe revised the concept of One Medicine. This was critical for the advancement of the field of epidemiology, especially as applied to zoonotic diseases. The future of One Health is at a crossroads with a need to more clearly define its boundaries and demonstrate its benefits. Interestingly the greatest acceptance of One Health is seen in the developing world where it is having significant impacts on control of infectious diseases.

Building Confidence in New Evidence Streams for Human Health Risk Assessment

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Variability and Relevance of Current Laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods (NAMs) for use in Human Health Risk Assessment
Building Confidence in New Evidence Streams for Human Health Risk Assessment Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Variability and Relevance of Current Laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods (NAMs) for use in Human Health Risk Assessment
Publisher : Unknown
Page : 0 pages
File Size : 43,8 Mb
Release : 2023-08-25
Category : Science
ISBN : 0309700779

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Building Confidence in New Evidence Streams for Human Health Risk Assessment by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Board on Environmental Studies and Toxicology,Committee on Variability and Relevance of Current Laboratory Mammalian Toxicity Tests and Expectations for New Approach Methods (NAMs) for use in Human Health Risk Assessment Pdf

As part of its core mission, the U.S. Environmental Protection Agency (EPA) is tasked with assessing the hazards and risks to human health from exposure to pollutants. While some pollutants are well studied, there are little or no data on the potential health effects for many thousands of chemicals that can make their way into the environment, such as PFAS. EPA still relies on laboratory mammalian studies as the foundation of most human health risk assessments, which are limited by high costs, long timelines, and other concerns. New approach methods (NAMs) in toxicology, for example new in vivo and in vitro strategies and computational systems biology, offer opportunities to inform timely decision-making when no data are available from laboratory mammalian toxicity tests or epidemiological studies. NAMs may also help inform efforts to protect susceptible and vulnerable populations by characterizing subtle health perturbations, better encompassing genetic diversity, and accounting for nonchemical stressors. While the promise and need for NAMs is clear, many barriers to their use remain. This report aims to bridge the gap between the potential of NAMs and their practical application in human health risk assessment. Building Confidence in New Evidence Streams for Human Health Risk Assessment draws lessons learned from laboratory mammalian toxicity tests to help inform approaches for building scientific confidence in NAMs and for incorporating such data into risk assessment and decision-making. Overall, the report recommendations aim to ensure a seamless handoff from the evaluation of NAM-based testing strategies in the laboratory to the incorporation of NAM data into modern, systematic-review-based risk assessments.

One Health

Meththika Vithanage,Majeti Narasimha Vara Prasad
One Health Book PDF

Author : Meththika Vithanage,Majeti Narasimha Vara Prasad
Publisher : John Wiley & Sons
Page : 500 pages
File Size : 55,6 Mb
Release : 2023-07-19
Category : Technology & Engineering
ISBN : 9781119867302

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One Health by Meththika Vithanage,Majeti Narasimha Vara Prasad Pdf

A balanced and multidisciplinary exploration of the One Health concept In One Health: Human, Animal, and Environment Triad, a team of distinguished researchers introduces and explains the concept of One Health by providing an overview of the One Health idea from the perspective of diverse disciplines, from earth and environmental science to ecology and conservation to veterinary and human medicine. The authors also present case studies demonstrating the real-world challenges and opportunities of this interdisciplinary approach to sustainable human well-being. Readers will find insightful discussions of the interactions between chemical pollutants and water, soil, and the atmosphere, as well as detailed examinations of sustainable food supply, waste management, and pathogen control, backed up by extensive reference data. One Health: Human, Animal, and Environment Triad also includes: The emergence and re-emergence of zoonoses and other infectious diseases The behavior of microplastics in soil and water Organic farming and its influence on soil health The role of light for human well-being Perfect for researchers interested in global health, ecological health, medical geology, toxicology, epidemiology, and zoonotic diseases, One Health: Human, Animal, and Environment Triad will also benefit professionals with an interest in public health and other public services, resource conservation, waste management, and the circular economy.

Understanding Risk to Wildlife from Exposures to Per- and Polyfluorinated Alkyl Substances (PFAS)

Mark S. Johnson,Michael J. Quinn Jr.,Marc A. Williams,Allison M. Narizzano
Understanding Risk to Wildlife from Exposures to Per and Polyfluorinated Alkyl Substances PFAS Book PDF

Author : Mark S. Johnson,Michael J. Quinn Jr.,Marc A. Williams,Allison M. Narizzano
Publisher : CRC Press
Page : 176 pages
File Size : 41,6 Mb
Release : 2021-04-22
Category : Technology & Engineering
ISBN : 9781000375862

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Understanding Risk to Wildlife from Exposures to Per- and Polyfluorinated Alkyl Substances (PFAS) by Mark S. Johnson,Michael J. Quinn Jr.,Marc A. Williams,Allison M. Narizzano Pdf

Understanding Risk to Wildlife from Exposures to Per- and Polyfluorinated Alkyl Substances (PFAS) provides the most recent summary of toxicity data relevant to mammals, birds, reptiles, and amphibians, and provides values for use in risk assessment applications. Predicting the bioaccumulation of PFAS in terrestrial wildlife (including humans) has proven to be extremely complex. As a group, PFAS act differently than traditional non-ionic organic molecules, where PFAS can break down and reform, whereas some are demonstrated to be extremely persistent. Where sufficient data are provided, this book establishes toxicity reference values (TRVs), which are derived to assist in characterizing environmental sources of contamination and making risk-based decisions. Features: Provides toxicity reference values (TRVs) for vertebrates (mammals, birds, amphibians) for PFAS, where sufficient data are available, and includes objective supporting background information. Assigns a level of confidence to each TRV to provide the risk assessor with an understanding of the relative uncertainty associated with each value. Presents toxicity data in the formats of scatter diagrams and tables for quick review and assessment. Provides TRVs relevant for screening and decision making This book serves as a useful aid for risk assessors and managers in those industries that have sites contaminated with PFAS, consultants tasked with evaluating risks at such sites, and staff at regulatory agencies at various governmental levels, who need to know how much contamination is considered safe for wildlife. It will also appeal to researchers with an interest in filling the gaps in the current toxicological data for PFAS exposure.

Global Applications of One Health Practice and Care

Yasobant, Sandul,Saxena, Deepak
Global Applications of One Health Practice and Care Book PDF

Author : Yasobant, Sandul,Saxena, Deepak
Publisher : IGI Global
Page : 306 pages
File Size : 41,8 Mb
Release : 2019-03-01
Category : Medical
ISBN : 9781522563051

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Global Applications of One Health Practice and Care by Yasobant, Sandul,Saxena, Deepak Pdf

Many factors have changed interactions between people, animals, and our environment including the emergence and reemergence of diseases such as swine flu, rabies, and diphtheria. By practicing the concept of one health, which relates the close interactions between people, animals, and our environment to overall health, a solution for global wellbeing can be found. Global Applications of One Health Practice and Care provides in-depth research on the concept of one health and the ability to achieve universal health by connecting human health with animal health and a safe environment. Featuring coverage on a broad range of topics such as holism health, drug resistance, and parasitic zoonoses, this book is ideally designed for policy planners, program managers, public health practitioners, animal health specialists, environmentalists, researchers, and academicians seeking current research on achieving better public health outcomes.

Beyond One Health

John A. Herrmann,Yvette J. Johnson-Walker
Beyond One Health Book PDF

Author : John A. Herrmann,Yvette J. Johnson-Walker
Publisher : John Wiley & Sons
Page : 368 pages
File Size : 51,9 Mb
Release : 2018-03-06
Category : Medical
ISBN : 9781119194514

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Beyond One Health by John A. Herrmann,Yvette J. Johnson-Walker Pdf

Tackling One Health from a multi-disciplinary perspective, this book offers in-depth insight into how our health and the health of every living creature and our ecosystem are all inextricably connected. Presents critical population health topics, written by an international group of experts Addresses the technical aspects of the subject Offers potential policy solutions to help mitigate current threats and prevent additional threats from occurring

Animals, Health, and Society

Craig Stephen
Animals Health and Society Book PDF

Author : Craig Stephen
Publisher : CRC Press
Page : 325 pages
File Size : 55,9 Mb
Release : 2020-12-22
Category : Medical
ISBN : 9781000285468

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Animals, Health, and Society by Craig Stephen Pdf

CHOICE Recommended title 2022 This timely book reframes the historic narrative of people, animals, and nature as risks to each other, to one where we think about health as a shared capacity. This new narrative promotes the positive contributions made to health across species and generations and addresses growing calls to shift from a reactive to proactive approach in One Health. Editor Craig Stephen takes the reader on a tour of the situations wherein we can all, regardless of our job description, work across species, sectors, and generations to motivate action. Perspectives and methods from a variety of fields and experts are shared and adapted to promote collaborative understanding of and action on determinants of health at the animal-society interface. Case studies demonstrate that the principles and practices presented are feasible, empowering people to make choices that concurrently benefit the health of animals, societies, and ecosystems. The first book to adapt and explain health promotion, harm reduction, and health equity issues in a One Health context, and in terms of animal health, this is necessary reading for students of and practitioners working in planetary health, conservation, ecohealth, public health, health promotion, veterinary medicine, and animal welfare.