The Fragment Of Water

Author : Ben Hale
Publisher : Unknown
Page : 332 pages
File Size : 43,9 Mb
Release : 2018-08-10
Category : Electronic
ISBN : 1945580135

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The Fragment of Water by Ben Hale Pdf

Born of magic in the final days of war, Draeken's power is near absolute-until his soul shatters, leaving five fragments. Each possesses a single magic, and a consciousness of his own. Trained by the Hauntress, they secretly quell threats throughout the kingdoms, and their mastery grows with every passing age. But their time of unity has come, for a dangerous new foe has arrived.Long thought extinct, the ancient race of krey has returned to Lumineia, and they seek dominion over what they had lost. With an Eternal at his side, the fragment of Water is sent north in search of their lair. But in the ruins of an abandoned temple he will discover a darker truth. Kept secret since the Dawn of Magic, the Order of Ancients has members hidden among thieves, assassins, and even kings. After a millennia of waiting they rise . . . from anonymity to war.

Author : Dmitri G Fedorov
Publisher : World Scientific
Page : 326 pages
File Size : 44,7 Mb
Release : 2023-02-17
Category : Science
ISBN : 9789811263644

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Complete Guide To The Fragment Molecular Orbital Method In Gamess: From One Atom To A Million, At Your Service by Dmitri G Fedorov Pdf

The fragment molecular orbital (FMO) method is a fast linear-scaling quantum-mechanical method employed by chemists and physicists all over the world. It provides a wealth of properties of fragments from quantum-chemical calculations, a bottomless treasure pit for data mining and machine learning. However, there is no user-friendly description of its usage in the widely employed quantum-chemical open-source software GAMESS, nor is there any book covering the usage of GAMESS in general. This leaves very many interested users to their own devices to get through a variety of problems with very cryptic descriptions of keywords in the program manual and no guide whatsoever as to what options should be set for particular scientific tasks. This book is the panacea to many frustrations.The main focus of the book is to build a solid bridge connecting FMO users to GAMESS, by giving a helpful introduction of various FMO methods as needed for particular problems found in computational chemistry, and describing in detail how to do these simulations and understand the results from the output of the program. The book also covers parallelization strategies for attaining high parallel efficiency in massively parallel computations, and provides means to analyze performance and design a solution for overcoming performance bottlenecks. A special section is devoted to dealing with problems in executing GAMESS, arising from computational environment and user errors. Finally, 14 carefully selected types of applications are discussed in detail, describing the input keywords and explaining where to find the main results in the text-based output.

Author : Dmitri Fedorov,Kazuo Kitaura
Publisher : CRC Press
Page : 304 pages
File Size : 44,9 Mb
Release : 2009-05-14
Category : Science
ISBN : 9781420078497

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The Fragment Molecular Orbital Method by Dmitri Fedorov,Kazuo Kitaura Pdf

Answering the need to facilitate quantum-chemical calculations of systems with thousands of atoms, Kazuo Kitaura and his coworkers developed the Fragment Molecular Orbital (FMO) method in 1999. Today, the FMO method can be applied to the study of whole proteins and protein-ligand interactions, and is extremely effective in calculating the propertie

Author : Joyce Hibbert
Publisher : Dundurn
Page : 269 pages
File Size : 41,7 Mb
Release : 1985-01-01
Category : History
ISBN : 9781554881697

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Fragments of War by Joyce Hibbert Pdf

The young girl from the Ottawa Valley who served as a nurse in North Africa with only a helmet of fresh water a day, the teenage soldier from Fredericton who stole pig swill to survive in a Hong Kong prisoner of war camp, the English woman who survived the sinking of the Athenia to become a war-bride, and an Alberta airman who crashed off the icy coast of Greenland, these are but only four of the thirty compelling personal accounts of war experiences. Many private photographs from their own albums illustrate these stories, which reflect the world wide aspect of the war from the Indian Ocean to the North Atlantic, from Poland to the Middle East, and the varied activities and duties of these young men and women. Their hardships, their adventures, frustrations, fears, joys and romances are chronicled in a poignant and often humorous manner.

Author : Warren Fahy
Publisher : Delacorte Press
Page : 386 pages
File Size : 51,5 Mb
Release : 2009-06-16
Category : Fiction
ISBN : 9780440338574

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Fragment by Warren Fahy Pdf

Aboard a long-range research vessel, in the vast reaches of the South Pacific, the cast and crew of the reality show Sealife believe they have found a ratings bonanza. For a director dying for drama, a distress call from Henders Island—a mere blip on any radar—might be just the ticket. Until the first scientist sets foot on Henders—and the ultimate test of survival begins. For when they reach the island’s shores, the scientists are utterly unprepared for what they find—creatures unlike any ever recorded in natural history. This is not a lost world frozen in time; this is Earth as it might have looked after evolving on a separate path for half a billion years—a fragment of a lost continent, with an ecosystem that could topple ours like a house of cards.

Author : Yuji Mochizuki,Shigenori Tanaka,Kaori Fukuzawa
Publisher : Springer Nature
Page : 606 pages
File Size : 40,5 Mb
Release : 2021-01-04
Category : Science
ISBN : 9789811592355

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Recent Advances of the Fragment Molecular Orbital Method by Yuji Mochizuki,Shigenori Tanaka,Kaori Fukuzawa Pdf

This book covers recent advances of the fragment molecular orbital (FMO) method, consisting of 5 parts and a total of 30 chapters written by FMO experts. The FMO method is a promising way to calculate large-scale molecular systems such as proteins in a quantum mechanical framework. The highly efficient parallelism deserves being considered the principal advantage of FMO calculations. Additionally, the FMO method can be employed as an analysis tool by using the inter-fragment (pairwise) interaction energies, among others, and this feature has been utilized well in biophysical and pharmaceutical chemistry. In recent years, the methodological developments of FMO have been remarkable, and both reliability and applicability have been enhanced, in particular, for non-bio problems. The current trend of the parallel computing facility is of the many-core type, and adaptation to modern computer environments has been explored as well. In this book, a historical review of FMO and comparison to other methods are provided in Part I (two chapters) and major FMO programs (GAMESS-US, ABINIT-MP, PAICS and OpenFMO) are described in Part II (four chapters). dedicated to pharmaceutical activities (twelve chapters). A variety of new applications with methodological breakthroughs are introduced in Part IV (six chapters). Finally, computer and information science-oriented topics including massively parallel computation and machine learning are addressed in Part V (six chapters). Many color figures and illustrations are included. Readers can refer to this book in its entirety as a practical textbook of the FMO method or read only the chapters of greatest interest to them.

Author : William Alexander
Publisher : Unknown
Page : 412 pages
File Size : 47,7 Mb
Release : 1875
Category : Electronic
ISBN : UOM:39015030972353

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Pyrology by William Alexander Pdf

Author : William Alexander Ross
Publisher : Unknown
Page : 402 pages
File Size : 50,5 Mb
Release : 1875
Category : Analytical chemistry
ISBN : NLS:V000664236

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Pyrology, Or Fire Chemistry, Etc by William Alexander Ross Pdf

Author : Lawrence C. Kuo
Publisher : Academic Press
Page : 662 pages
File Size : 50,6 Mb
Release : 2011-03-09
Category : Medical
ISBN : 9780123812742

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Fragment Based Drug Design by Lawrence C. Kuo Pdf

There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits. Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD

Author : Anonim
Publisher : Unknown
Page : 506 pages
File Size : 55,7 Mb
Release : 1869
Category : Electronic
ISBN : BSB:BSB10613980

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The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science by Anonim Pdf

Author : Mark Lemon
Publisher : Unknown
Page : 322 pages
File Size : 44,8 Mb
Release : 1888
Category : Christmas stories, English
ISBN : UGA:32108003587832

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The Small House Over the Water by Mark Lemon Pdf

Author : John Muter
Publisher : Unknown
Page : 288 pages
File Size : 42,5 Mb
Release : 1898
Category : Electronic
ISBN : UOM:39015031074332

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A Short Manual of Analytical Chemistry, Qualitative and Quantitative--inorganic and Organic. Following the Course of Instruction Given in the Laboratories of the South London School of Pharmacy by John Muter Pdf

Author : Anonim
Publisher : Unknown
Page : 724 pages
File Size : 44,7 Mb
Release : 1881
Category : Electronic
ISBN : UOM:39015047760577

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Cincinnati Medical Advance by Anonim Pdf

Author : Thomas G. Davies,Marko Hyvönen
Publisher : Springer Science & Business Media
Page : 235 pages
File Size : 55,5 Mb
Release : 2012-01-23
Category : Science
ISBN : 9783642275395

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Fragment-Based Drug Discovery and X-Ray Crystallography by Thomas G. Davies,Marko Hyvönen Pdf

Introduction to Fragment-Based Drug Discovery, by Daniel A. Erlanson Fragment Screening Using X-Ray Crystallography, by Thomas G. Davies and Ian J. Tickle Hsp90 Inhibitors and Drugs from Fragment and Virtual Screening, by Stephen Roughley, Lisa Wright, Paul Brough, Andrew Massey and Roderick E. Hubbard Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors, by Daniel F. Wyss, Yu-Sen Wang, Hugh L. Eaton, Corey Strickland, Johannes H. Voigt, Zhaoning Zhu and Andrew W. Stamford Combining Biophysical Screening and X-Ray Crystallography for Fragment-Based Drug Discovery, by Michael Hennig, Armin Ruf and Walter Huber Targeting Protein–Protein Interactions and Fragment-Based Drug Discovery, by Eugene Valkov, Tim Sharpe, May Marsh, Sandra Greive and Marko Hyvönen Fragment Screening and HIV Therapeutics, by Joseph D. Bauman, Disha Patel and Eddy Arnold Fragment-Based Approaches and Computer-Aided Drug Discovery, by Didier Rognan

Author : Steven Howard,Chris Abell
Publisher : Royal Society of Chemistry
Page : 314 pages
File Size : 48,5 Mb
Release : 2015-07-03
Category : Medical
ISBN : 9781849739085

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Fragment-Based Drug Discovery by Steven Howard,Chris Abell Pdf

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.