The Future Of The Oocyte

Author : John Eppig,Christa Hegele-Hartung
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 40,9 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9783662049600

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The Future of the Oocyte by John Eppig,Christa Hegele-Hartung Pdf

Since the first successful transfer of an in vitro fertilised human egg in 1976, modern endocrinology, genetics, and assisted reproductive technologies have opened new frontiers of research with the aim to treat infertile women. In this workshop we set out to promote an interdisciplinary discussion between experts from various fields of basic, company-based and clinical research related to folliculogenesis and oocyte development. The aim of this workshop was to present, discuss and assess novel approaches in mammalian folliculogenesis and oocyte development that may have an impact on fertility/ infertility in the near or distant future. Key issues were the understanding of new modulators of folliculogenesis and regulators of cytoplasmic as well as meiotic oocyte maturation, modern technologies, the aging oocyte and pathogenetic mechanisms of infertility.

Author : Lucy van de Wiel
Publisher : NYU Press
Page : 378 pages
File Size : 54,8 Mb
Release : 2020-12-15
Category : Social Science
ISBN : 9781479803620

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Freezing Fertility by Lucy van de Wiel Pdf

Welcomed as liberation and dismissed as exploitation, egg freezing (oocyte cryopreservation) has rapidly become one of the most widely-discussed and influential new reproductive technologies of this century. In Freezing Fertility, Lucy van de Wiel takes us inside the world of fertility preservation—with its egg freezing parties, contested age limits, proactive anticipations and equity investments—and shows how the popularization of egg freezing has profound consequences for the way in which female fertility and reproductive aging are understood, commercialized and politicized. Beyond an individual reproductive choice for people who may want to have children later in life, Freezing Fertility explores how the rise of egg freezing also reveals broader cultural, political and economic negotiations about reproductive politics, gender inequities, age normativities and the financialization of healthcare. Van de Wiel investigates these issues by analyzing a wide range of sources—varying from sparkly online platforms to heart-breaking court cases and intimate autobiographical accounts—that are emblematic of each stage of the egg freezing procedure. By following the egg’s journey, Freezing Fertility examines how contemporary egg freezing practices both reflect broader social, regulatory and economic power asymmetries and repoliticize fertility and aging in ways that affect the public at large. In doing so, the book explores how the possibility of egg freezing shifts our relation to the beginning and end of life.

Author : Catherine Waldby
Publisher : Duke University Press
Page : 238 pages
File Size : 53,7 Mb
Release : 2019-04-15
Category : Social Science
ISBN : 9781478005568

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The Oocyte Economy by Catherine Waldby Pdf

In recent years increasing numbers of women from wealthy countries have turned to egg donation, egg freezing, and in vitro fertilization to become pregnant, especially later in life. This trend has created new ways of using, exchanging, and understanding oocytes—the reproductive cells specific to women. In The Oocyte Economy Catherine Waldby draws on 130 interviews---with scientists, clinicians, and women who have either donated or frozen their oocytes or received those of another woman---to trace how the history of human oocytes' perceived value intersects with the biological and social life of women. Demonstrating how oocytes have come to be understood as discrete and scarce biomedical objects open to valuation, management, and exchange, Waldby examines the global market for oocytes and the power dynamics between recipients and the often younger and poorer donors. With this exploration of the oocyte economy and its contemporary biopolitical significance, Waldby rethinks the relationship between fertility, gendered experience, and biomedical innovation.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research
Publisher : National Academies Press
Page : 112 pages
File Size : 48,6 Mb
Release : 2007-03-22
Category : Medical
ISBN : 9780309179607

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Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Institute of Medicine,Board on Health Sciences Policy,Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research Pdf

It is widely understood that stem cell treatments have the potential to revolutionize medicine. Because of this potential, in 2004 California voters approved Proposition 71 to set up a 10-year, $3 billion program to fund research on stem cells. Under the direction of the California Institute for Regenerative Medicine, this program will pay to build facilities for stem cell research and will fund doctors and scientists to carry out research with the ultimate goal of helping to develop therapies based on stem cells. For this research to move forward, however, will require a steady supply of stem cells, particularly human embryonic stem cells. Those stem cells are collected from developing human embryos created from eggs-or oocytes-harvested from the ovaries of female donors. Thus much of the promise of stem cells depends on women choosing to donate oocytes to the research effort. The oocyte donation process is not without risk, however. Donors are given doses of hormones to trigger the production of more eggs than would normally be produced, and this hormone treatment can have various side effects. Once the eggs have matured in the ovary, they must be retrieved via a surgical procedure that is typically performed under anesthesia, and both the surgery and the anesthesia carry their own risks. Furthermore, given the very personal nature of egg donation, the experience may carry psychological risks for some women as well. With this in mind, in 2006 the California Institute for Regenerative Medicine contracted with the National Academies to organize a workshop that would bring together experts from various areas to speak about the potential risks of oocyte donation and to summarize what is known and what needs to be known about this topic. The Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research was formed to plan the workshop, which was held in San Francisco on September 28, 2006. This report is a summary and synthesis of that workshop.

Author : David K. Gardner,Botros R. M. B. Rizk,Tommaso Falcone
Publisher : Cambridge University Press
Page : 363 pages
File Size : 49,8 Mb
Release : 2011-03-31
Category : Medical
ISBN : 9781139501040

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Human Assisted Reproductive Technology by David K. Gardner,Botros R. M. B. Rizk,Tommaso Falcone Pdf

Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice offers a collection of concise, practical review articles on cutting-edge topics within reproductive medicine. Each article presents a balanced view of clinically relevant information and looks ahead to how practice will change over the next five years. The clinical section discusses advances in reproductive surgery and current use of robotic surgery for tubal reversal and removal of fibroids. It looks into the refinement of surgical procedures for fertility preservation purposes. Chapters also discuss non-invasive diagnosis of endometriosis with proteomics technology, new concepts in ovarian stimulation and in the management of polycystic ovary syndrome, and evidence-based ART. The embryology section discusses issues ranging from three-dimensional in-vitro ovarian follicle culture, and morphometric and proteomics analysis of embryos, to oocyte and embryo cyropreservation. This forward-looking volume of review articles is key reading for reproductive medicine physicians, gynecologists, reproductive endocrinologists, urologists and andrologists.

Author : Alan O. Trounson,Roger G. Gosden
Publisher : Cambridge University Press
Page : 384 pages
File Size : 55,5 Mb
Release : 2003-07-10
Category : Medical
ISBN : 0521799589

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Biology and Pathology of the Oocyte by Alan O. Trounson,Roger G. Gosden Pdf

The human oocyte or egg is the rarest and most rapidly ageing cell in the body, and yet one that is essential for fertility. This book is about the development, biology and pathology of the oocyte, and new technologies to manipulate, enhance, and control fertility. These technologies are paving the way for overcoming infertility, avoiding inherited diseases, and creating genetically engineered animals from embryo stem cells and cloning. This progress would have been impossible without the myriad of scientific and technical developments covered in this book, including the ability to manipulate and fertilize oocytes in vitro. World-leading experts have contributed to the first book for many years on basic and applied science of the egg, its clinical manipulation, and its pivotal role in reproductive medicine and biology. It will be an essential reference for scientists and clinicians in reproductive medicine and animal breeding technology, and everyone involved in treating infertility.

Author : T.A. Dettlaff,Sergei G. Vassetzky
Publisher : Springer Science & Business Media
Page : 456 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468406825

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Oocyte Growth and Maturation by T.A. Dettlaff,Sergei G. Vassetzky Pdf

Studies of oogenesis occupy an important place in current in vestigations in developmental biology. Today no one has any doubt whatsoever that oogenesis is not just the prelude to development, but is development itself, and a very essential part of it. These words of an eminent Soviet scientist, B. L. As taurov , taken by T. B. Aizenshtadt as an epigraph to her chapter in this book, make a good epigraph for the entire book. It is now clear that during oogenesis not only vast reserves of ribosomes and mitochondria, of yolk, carbohydrates, and lipids, and of enzymes for protein and nucleic acid synthesis and for carbohydrate and fat metabolism (which ensures the energy supply and metabolism of the oocyte and the developing embryo) are formed, but also long-lived mRNA and proteins are synthesized, which determine both the completion of oocyte maturation and the initial stages of embryonic development. In the last 15-20 years, the use of molecular biology methods, electron microscopy, autoradiography, and microsurgical methods of experimental embryology in studying the pre-embryonic development of animals has greatly increased our knowledge of oogenesis. This has led to the need to systematize the data obtained, to reinter pret old ideas, and to review the results obtained by new research trends which have emerged in the last few years and which are of general biological interest. Such a task was undertaken in the book Sovremennye Problemy Oogeneza (Current Problems of Oogenesis), published in 1977 (in Russian).

Author : Patrick J. Babin,Joan Cerdà,Esther Lubzens
Publisher : Springer Science & Business Media
Page : 513 pages
File Size : 53,9 Mb
Release : 2007-08-20
Category : Nature
ISBN : 9781402062339

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The Fish Oocyte by Patrick J. Babin,Joan Cerdà,Esther Lubzens Pdf

This book addresses the growing needs in deciphering the biological processes associated with fish reproduction, in view of the growth of aquaculture and the dwindling natural stocks of commercially important fish. It presents a comprehensive overview on egg production in fish, from the standpoint of the oocyte. With this view in mind, the book includes chapters on oocyte development (oogenesis), hormonal regulation and hormone receptors, formation of the egg envelopes, growth, accumulation of nutrients and maternal transcripts, maturation, hydration, ovulation and fertilization. A special emphasis is placed on using state-of-the-art tools including electron microscopy for discerning the ultra-structure of the follicle and genomic/proteomic tools to fully understand biological basis of fish reproduction. Studies on promoting oocyte maturation, ovulation and spawning in farmed fish and preservation of fish oocytes at low temperatures are also included. The book will appeal to University lecturers, students, research scientists and those associated with culture of fish in freshwater or marine aquaculture.

Author : Dmitry M. Kissin,G. David Adamson,Georgina Chambers,Christian De Geyter
Publisher : Cambridge University Press
Page : 255 pages
File Size : 50,7 Mb
Release : 2019-07-04
Category : Health & Fitness
ISBN : 9781108498586

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Assisted Reproductive Technology Surveillance by Dmitry M. Kissin,G. David Adamson,Georgina Chambers,Christian De Geyter Pdf

Offers a comprehensive guide to assisted reproductive technology surveillance, describing its history, global variations, and best practices.

Author : Gabor Kovacs,Anthony Rutherford,David K. Gardner
Publisher : Cambridge University Press
Page : 402 pages
File Size : 52,8 Mb
Release : 2019-01-09
Category : Medical
ISBN : 9781108668460

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How to Prepare the Egg and Embryo to Maximize IVF Success by Gabor Kovacs,Anthony Rutherford,David K. Gardner Pdf

This comprehensive review of the factors that affect the harvesting and preparation of oocytes and the management of embryos will allow practitioners to make evidence-based decisions for successful IVF. The book reviews and re-considers the value of strategies and outcomes in the management of fertility and conception rates, centred on the production of oocytes, and successful development of the embryo. Authored by leading experts in the field, chapters engage with treatments and strategies that affect the production of oocytes and embryos, optimizing outcomes in the management of female fertility, conception rates, and live births. This vital guide covers controlled ovarian hyperstimulation, the role of AMH in determining ovarian reserve, and primary stimulation agents and the use of adjuncts. Integral for all clinicians and embryologists working in reproductive medicine units, readers are provided with evidence-based, comprehensive advice and review of all factors affecting the management of oocytes and the embryo that are vital for successful IVF cycles.

Author : Jacques Donnez,S. Samuel Kim
Publisher : Cambridge University Press
Page : 569 pages
File Size : 51,7 Mb
Release : 2011-02-03
Category : Medical
ISBN : 9781139496124

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Principles and Practice of Fertility Preservation by Jacques Donnez,S. Samuel Kim Pdf

The specialty of fertility preservation offers patients with cancer, who are rendered infertile by chemo- and radiotherapy, the opportunity to realize their reproductive potential. This gold-standard publication defines the specialty. The full range of techniques and scientific concepts is covered in detail, and the author team includes many of the world's leading experts in the field. The book opens with introductions to fertility preservation in both cancer and non-cancer patients, followed by cancer biology, epidemiology and treatment, and reproductive biology and cryobiology. Subsequent sections cover fertility preservation strategies in males and females, including medical/surgical procedures, ART, cryopreservation and transplantation of both ovarian tissue and the whole ovary, and in-vitro follicle growth and maturation. Concluding chapters address future technologies, as well as ethical, legal and religious issues. Richly illustrated throughout, this is a key resource for all clinicians specializing in reproductive medicine, gynecology, oncology, hematology, endocrinology and infertility.

Author : Ri-Cheng Chian,Patrick Quinn
Publisher : Cambridge University Press
Page : 287 pages
File Size : 52,8 Mb
Release : 2010-05-13
Category : Medical
ISBN : 9780521517782

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Fertility Cryopreservation by Ri-Cheng Chian,Patrick Quinn Pdf

Protecting the reproductive potential of young patients undergoing cancer therapy is increasingly important. With modern treatment protocols, 80% of patients can be expected to survive. It has been estimated that up to one in 250 young adults will be a survivor of childhood cancer in the future; infertility, however, may be a consequence. As a wide range of fertility preservation methods are increasingly offered by clinicians, this systematic and comprehensive textbook dealing with the cryobiology, technology and clinical approach to this therapy will be essential reading to infertility specialists, embryologists, oncologists, cryobiologists, ObGyns, andrologists, and urologists with an interest in fertility preservation. Fertility Cryopreservation reviews all the techniques of this increasingly important field within reproductive medicine. It covers the basic principles of pertinent cryobiology, and contains major sections on the different therapies available, written by international specialists combining experience from both academic centers and commercial industries.

Author : Ying Cheong,Togas Tulandi,Tin-Chiu Li
Publisher : Cambridge University Press
Page : 235 pages
File Size : 51,6 Mb
Release : 2018-09-20
Category : Health & Fitness
ISBN : 9781316645185

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Practical Problems in Assisted Conception by Ying Cheong,Togas Tulandi,Tin-Chiu Li Pdf

Practical and effective; this book supports challenging clinical and laboratory issues that the IVF practitioner faces all day, every day.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 48,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Mark V. Sauer
Publisher : Springer Science & Business Media
Page : 427 pages
File Size : 45,8 Mb
Release : 2013-03-01
Category : Health & Fitness
ISBN : 9781447123927

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Principles of Oocyte and Embryo Donation by Mark V. Sauer Pdf

The versatility of oocyte and embryo donation has proven to be extremely valuable to both patients and doctors engaged in reproductive medicine. Originally thought to be applicable only to a rather small subset of infertile women, today busy practices commonly recommend the procedure and it is estimated that nearly all of the 400 or more IVF programs in the United States provide these services. Oocyte and embryo donation has established itself as a mainstay procedure within assisted reproductive care, and the breadth, depth and complexity of practice is deserving of focused attention. Much has changed within the field of oocyte and embryo donation since the publication of the first edition of Principles of Oocyte and Embryo Donation in 1998, thus the need for a completely updated and more expansive text. The second edition of this book provides an overview of the major issues affecting men and women engaged in the practice of oocyte and embryo donation. A primary emphasis has been placed on defining the standards of practice that have evolved over the past 30 years, clearly stating the outcomes expected from adhering to these established protocols. Details of both the basic science and the clinical medicine are presented together and attention is also focused on the non-reproductive aspects inherent to this unique method of assisted reproduction that involves opinions from lawyers, ethicists, mental health care professionals and theologians. Oocyte and embryo donation requires a working knowledge of the medicine, the law and the ethics that underlies its foundation. This book is intended to serve as a complete and comprehensive reference for all health care professionals that provide services related to egg donation, reproductive endocrinologists, obstetrician- gynecologists, and fellows and residents entering the fertility field.