The G Protein Coupled Receptors Handbook

Author : Lakshmi A. Devi
Publisher : Springer Science & Business Media
Page : 412 pages
File Size : 41,8 Mb
Release : 2008-03-01
Category : Medical
ISBN : 9781592599196

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The G Protein-Coupled Receptors Handbook by Lakshmi A. Devi Pdf

A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.

Author : Stephen J. Peroutka
Publisher : CRC Press
Page : 372 pages
File Size : 47,6 Mb
Release : 1993-10-20
Category : Medical
ISBN : 0849383218

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Handbook of Receptors and Channels by Stephen J. Peroutka Pdf

The cloning, sequencing, and expression of a variety of membrane receptors and channels indicate the existence of at least four "superfamilies" of molecular structures that mediate signal transduction. Presently, more than 400 receptors have been cloned and sequenced. The Handbook of Receptors and Channels is the first handbook series to present the enormous amount of new molecular biological receptor data in a practical and useful format. Each volume in this remarkable series will focus on a specific molecular superfamily of receptors. Complete amino acid sequence information on all cloned receptors, as well as relevant pharmacological information, will be included. Furthermore, the format for each of the volumes will be consistent to allow for easy comparisons of different molecular subtypes for a given transmitter. G Protein-Coupled Receptors is the first volume in this new handbook series. Topics covered in future volumes include:

Author : Amy Sojka MS
Publisher : Lulu.com
Page : 40 pages
File Size : 55,8 Mb
Release : 2024-06-01
Category : Electronic
ISBN : 9781329400108

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G Protein-Coupled Receptor Guidebook by Amy Sojka MS Pdf

Author : Marta Filizola
Publisher : Unknown
Page : 327 pages
File Size : 43,7 Mb
Release : 2015
Category : Medical
ISBN : 1493929143

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G Protein-coupled Receptors in Drug Discovery by Marta Filizola Pdf

This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical, and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists, and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.--

Author : Kenneth H. Lundstrom,Mark L. Chiu
Publisher : CRC Press
Page : 376 pages
File Size : 49,8 Mb
Release : 2005-07-11
Category : Medical
ISBN : 9781420028218

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G Protein-Coupled Receptors in Drug Discovery by Kenneth H. Lundstrom,Mark L. Chiu Pdf

The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs

Author : Tobias Langenhan,Torsten Schöneberg
Publisher : Springer
Page : 403 pages
File Size : 45,6 Mb
Release : 2016-11-09
Category : Medical
ISBN : 9783319415239

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Adhesion G Protein-coupled Receptors by Tobias Langenhan,Torsten Schöneberg Pdf

Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.

Author : Andrea Strasser,Hans-Joachim Wittmann
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 55,7 Mb
Release : 2012-08-13
Category : Medical
ISBN : 9789400745964

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Modelling of GPCRs by Andrea Strasser,Hans-Joachim Wittmann Pdf

G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is – in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book “Modelling of GPCRs – a practical handbook” is focussed onto a practical introduction into molecular modelling of GPCRs. This book is very useful for beginners in GPCR modelling, but also addresses the advanced GPCR modeller: On the one hand, the book introduces principles of GPCR modelling, including extensive examples. On the other hand, detailed outlooks onto advanced GPCR modelling techniques are presented. Furthermore, the book includes important data, like information about crystal structures in a summarized manner or amino acid sequences, which are essential for GPCR modelling in general. Due to an increase in efficacy and data handling most modellers use LINUX as operating system. To address this, a summary of most important LINUX commands with examples is presented within the book.

Author : David Poyner,Mark Wheatley
Publisher : John Wiley & Sons
Page : 310 pages
File Size : 52,9 Mb
Release : 2009-12-11
Category : Science
ISBN : 9780470749227

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G Protein-Coupled Receptors by David Poyner,Mark Wheatley Pdf

G-Protein Coupled Receptors (GPCRs) are not only the largest protein family in the human genome but are also the single biggest target for therapeutic agents. Research into GPCRs is therefore growing at a fast pace and the range of techniques that can be applied to GPCRs is vast and continues to grow. This book provides an invaluable bench-side guide into the best and most up-to-date techniques for current and future research on GPCRs. With contributions from leading international authorities, this book equips readers with clear and detailed protocols for both well-known and up-and-coming techniques along with hints and tips for success. All the methods have been tried and tested by leading international research labs and are presented in easy-to-follow stages along with a useful overview of each technique. This book is an essential resource for all researchers in molecular biology, biochemistry, pharmacology and for graduate students.

Author : Anonim
Publisher : Academic Press
Page : 332 pages
File Size : 51,7 Mb
Release : 2019-01-05
Category : Science
ISBN : 9780128151082

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G Protein-Coupled Receptors by Anonim Pdf

G-Protein-Coupled Receptors, Part B, 2nd Edition, Volume 149, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers Optical Approaches for Visualization of Arrestin Binding to Muscarinic Receptors, Luciferase Reporter Assay for Unlocking Ligand-mediated Signaling of GPCRs, Assays to Measure GPCR Dependent Cellular Migration, Characterization of the Frizzled GPCRs, Binding Assays for Bradykinin and Angiotensin Receptors, Detection of Misfolded Rhodopsin Aggregates in Cells, Measuring GPCR Ubiquitination and Trafficking, Culture of Primary Neurons and its Use in Studying GPCR Trafficking, and much more. Covers the increasingly appreciated cell biology field of G-protein-coupled receptors Includes both established and new technologies Contributed by experts in the field

Author : Jesús Giraldo,Jean-Philippe Pin
Publisher : Royal Society of Chemistry
Page : 522 pages
File Size : 48,6 Mb
Release : 2011
Category : Medical
ISBN : 9781849731836

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G Protein-coupled Receptors by Jesús Giraldo,Jean-Philippe Pin Pdf

G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. The book lies between the fields of chemical biology, molecular pharmacology, and medicinal chemistry.

Author : Wayne R. Leifert
Publisher : Humana Press
Page : 0 pages
File Size : 47,9 Mb
Release : 2009-06-09
Category : Medical
ISBN : 1603273166

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G Protein-Coupled Receptors in Drug Discovery by Wayne R. Leifert Pdf

The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a multitude of physiological processes. The GPCRs represent one of the largest superfamilies in the human genome and are a significant target for bioactive and drug discovery programs. It is estimated that greater than 50% of all drugs, including those in development, currently target GPCRs. Many of the characterized GPCRs have known ligands; however, approximately 20% of GPCRs are described as orphan GPCRs, apparent GPCRs that share the generic high-level structure charact- istic of GPCRs but whose endogenous ligand is not known. Therefore, it is expected that the field of GPCR drug discovery and development will greatly expand in the coming years with emphasis on new generations of drugs against GPCRs with unique therapeuticuseswhichmayincludedrugssuchasallostericregulators,inverseagonists, and identification of orphan GPCR ligands. AswelearnmoreaboutthemolecularsignalingcascadesfollowingGPCRactivation, we acquire a better appreciation of the complexity of cell signaling and as a result, also acquire a vast array ofnew molecularmethods toinvestigate these andother processes. Thegeneralaimofthisbookistoprovideresearcherswitharangeofprotocolsthatmay be useful in their GPCR drug discovery programs. It is also the basis for the devel- ment of future assays in this field. Therefore, the range of topics covered and the appropriate methodological approaches in GPCR drug discovery are reflected in this book. Itisinterestingtonotethatfuturedirectionsindrugdiscoverywillrequireinput and collaboration from a plethora of fields of research. As such, this book will likely be of interest to scientists involved in such fields as molecular biology, pharmacology, biochemistry, cellular signaling, and bio-nanotechnology.

Author : Anonim
Publisher : Academic Press
Page : 502 pages
File Size : 54,5 Mb
Release : 2016-02-26
Category : Science
ISBN : 9780128036129

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G Protein-Coupled Receptors by Anonim Pdf

G-Protein-Coupled Receptors: Signaling, Trafficking, and Regulation, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in G-Protein-Coupled Receptors, and includes sections on such topics signaling, trafficking and regulation. Covers the increasingly appreciated cell biology field of G-protein-coupled receptors Includes both established and new technologies Contributed by experts in the field Covers topics such as signaling, trafficking, and regulation

Author : Richard R. Neubig
Publisher : Academic Press
Page : 408 pages
File Size : 50,7 Mb
Release : 2011-09-19
Category : Medical
ISBN : 9780123859525

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Pharmacology of G Protein Coupled Receptors by Richard R. Neubig Pdf

G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors. It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones. In addition, emerging drug targets such as receptor families for fatty acids, carboxylic acids, lipid mediators, etc. are included. Final chapters cover novel mechanisms of signal regulation through PDZ domains and RGS proteins. This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists. The present volume explores the modern experimental and conceptual framework for drug discovery for G protein coupled receptors It explores advances in structure determination and structure-based drug design as well as new concepts of allosteric modulation, functional selectivity/biased agonism, and pharmacological chaperones This volume will bring an up-to-date perspective on the G protein coupled receptor field to both academic and industry scientists

Author : Craig W. Stevens
Publisher : Humana Press
Page : 0 pages
File Size : 55,8 Mb
Release : 2011-07-15
Category : Medical
ISBN : 1617791784

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Methods for the Discovery and Characterization of G Protein-Coupled Receptors by Craig W. Stevens Pdf

The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies. In Methods for the Discovery and Characterization of G Protein-Coupled Receptors, experts in the field present the very latest on the methods and technology used to characterize and discover novel mechanisms of GPCRs which, in many cases, can be used directly to design experiments for the reader’s particular GPCR of interest and their specific avenue of investigation. Divided into four convenient sections, this detailed volume covers GPCRs in the genome, trafficking of GPCRs, GPCRs on the membrane, as well as the regulation of these key receptors. Chapters also feature an important section called “Future Directions” which gives the reader an insight into advances soon to be realized in each area. Written for the popular Neuromethods series, this book contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Methods for the Discovery and Characterization of G Protein-Coupled Receptors serves as an ideal guide for scientists determined to further our knowledge of crucially important set of receptors.

Author : Anonim
Publisher : Academic Press
Page : 260 pages
File Size : 47,6 Mb
Release : 2017-10-02
Category : Science
ISBN : 9780128133200

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G Protein-Coupled Receptors by Anonim Pdf

G Protein Coupled Receptors, Second Edition, Volume 143, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. It contains a wide array of topics about the G protein coupled receptors, as well as updates of chapters from the first edition. Contains contributions from experts in the field from across the world Covers a wide array of topics on G protein coupled receptors Includes analysis based topics