The Gene

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The Gene

Siddhartha Mukherjee
The Gene Book PDF

Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
Page : 624 pages
File Size : 53,9 Mb
Release : 2016-05-17
Category : Medical
ISBN : 9781476733531

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The Gene by Siddhartha Mukherjee Pdf

The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

The Gene

Siddhartha Mukherjee
The Gene Book PDF

Author : Siddhartha Mukherjee
Publisher : Random House
Page : 608 pages
File Size : 50,7 Mb
Release : 2016-06-02
Category : Science
ISBN : 9781448181162

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The Gene by Siddhartha Mukherjee Pdf

** NEW YORK TIMES NUMBER ONE BESTSELLER ** The Gene is the story of one of the most powerful and dangerous ideas in our history from the author of The Emperor of All Maladies. The story begins in an Augustinian abbey in 1856, and takes the reader from Darwin’s groundbreaking theory of evolution, to the horrors of Nazi eugenics, to present day and beyond - as we learn to “read” and “write” the human genome that unleashes the potential to change the fates and identities of our children. Majestic in its scope and ambition, The Gene provides us with a definitive account of the epic history of the quest to decipher the master-code that makes and defines humans – and paints a fascinating vision of both humanity’s past and future. For fans of Sapiens by Yuval Noah Harari, A Brief History of Time by Stephen Hawking and Being Mortal by Atul Gwande. ‘Siddhartha Mukherjee is the perfect person to guide us through the past, present, and future of genome science’ Bill Gates ‘A thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time...Read this book and steel yourself for what comes next’ Sunday Times

The Gene

Siddhartha Mukherjee
The Gene Book PDF

Author : Siddhartha Mukherjee
Publisher : Penguin UK
Page : 560 pages
File Size : 55,9 Mb
Release : 2016-05-17
Category : Literary Collections
ISBN : 9789386057051

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The Gene by Siddhartha Mukherjee Pdf

Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856, where a monk stumbles on the idea of a ‘unit of heredity’. It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. Above all, this is a story driven by human ingenuity and obsessive minds–from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. This is an epic, moving history of a scientific idea being brought to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history–the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to ‘read’ and ‘write’ the human genome–unleashing the potential to change the fates and identities of our children. Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity–and a vision of both humanity’s past and future.

The Gene

Siddhartha Mukherjee
The Gene Book PDF

Author : Siddhartha Mukherjee
Publisher : Random House
Page : 610 pages
File Size : 48,5 Mb
Release : 2016
Category : Genes
ISBN : 9781847922632

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The Gene by Siddhartha Mukherjee Pdf

Selected as a Book of the Year by The New York Times, The Economist, Independent, Observer and Mail on Sunday THE NEW YORK TIMES NUMBER ONE BESTSELLER BBC RADIO 4 BOOK OF THE WEEK 'Dramatic and precise... [A] thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time... He is a natural storyteller... A page-turner... Read this book and steel yourself for what comes next' Bryan Appleyard, Sunday Times The Gene is the story of one of the most powerful and dangerous ideas in our history, from bestselling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history - the story of Mukherjee's own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to "read" and "write" the human genome - unleashing the potential to change the fates and identities of our children. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a 'unit of heredity'. It intersects with Darwin's theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds - from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity - and a vision of both humanity's past and future.

The Laws of Medicine

Siddhartha Mukherjee
The Laws of Medicine Book PDF

Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
Page : 96 pages
File Size : 55,5 Mb
Release : 2015-10-13
Category : Medical
ISBN : 9781476784854

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The Laws of Medicine by Siddhartha Mukherjee Pdf

Essential, required reading for doctors and patients alike: A Pulitzer Prize-winning author and one of the world’s premiere cancer researchers reveals an urgent philosophy on the little-known principles that govern medicine—and how understanding these principles can empower us all. Over a decade ago, when Siddhartha Mukherjee was a young, exhausted, and isolated medical resident, he discovered a book that would forever change the way he understood the medical profession. The book, The Youngest Science, forced Dr. Mukherjee to ask himself an urgent, fundamental question: Is medicine a “science”? Sciences must have laws—statements of truth based on repeated experiments that describe some universal attribute of nature. But does medicine have laws like other sciences? Dr. Mukherjee has spent his career pondering this question—a question that would ultimately produce some of most serious thinking he would do around the tenets of his discipline—culminating in The Laws of Medicine. In this important treatise, he investigates the most perplexing and illuminating cases of his career that ultimately led him to identify the three key principles that govern medicine. Brimming with fascinating historical details and modern medical wonders, this important book is a fascinating glimpse into the struggles and Eureka! moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee’s signature eloquence and passionate prose, The Laws of Medicine is a critical read, not just for those in the medical profession, but for everyone who is moved to better understand how their health and well-being is being treated. Ultimately, this book lays the groundwork for a new way of understanding medicine, now and into the future.

The Selfish Gene

Richard Dawkins
The Selfish Gene Book PDF

Author : Richard Dawkins
Publisher : Oxford University Press, USA
Page : 372 pages
File Size : 47,5 Mb
Release : 1989
Category : Medical
ISBN : 0192860925

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The Selfish Gene by Richard Dawkins Pdf

Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science

The Gene Book

Sarah Adelaide Crawford
The Gene Book Book PDF

Author : Sarah Adelaide Crawford
Publisher : Cognella Academic Publishing
Page : 128 pages
File Size : 40,8 Mb
Release : 2018-06-28
Category : Electronic
ISBN : 1516545249

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The Gene Book by Sarah Adelaide Crawford Pdf

The Gene Book: Explorations in the Code of Life is designed to introduce undergraduate college students to foundational concepts in genetics. The text provides in-depth coverage of the essential principles of genetics, from Mendel to molecular gene therapy, and reads like a story, guiding readers through each of these areas in an interesting, engaging, and enlightening way. Milestone scientific discoveries introduce conceptual topics in each of the 10 chapters. The significance of each genetics paradigm is reinforced by the meaningful research context in which it is placed, whether the focus is single gene inheritance of disorders such as PKU and cystic fibrosis, or more complex genetic phenomena. Chromosomes, cell division, and cytogenetic disorders, including Down Syndrome and leukemia, are presented in a riveting historical context. In addition, the principles of molecular genetics are a major focus of this book. Students learn about the double helix, DNA replication, gene expression, mutation, natural selection, genomics, and the tools of molecular DNA analysis. Approachable and effective, The Gene Book is a highly readable comprehensive text on genetics principles designed to highlight essential concepts that make up their very core. The text is well suited to undergraduate genetics courses and can also be used as a primer for more advanced undergraduate and graduate courses in medical or molecular genetics.

The Selfish Gene

Richard Dawkins
The Selfish Gene Book PDF

Author : Richard Dawkins
Publisher : Oxford University Press
Page : 544 pages
File Size : 42,9 Mb
Release : 2016-05-26
Category : Science
ISBN : 9780191093067

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The Selfish Gene by Richard Dawkins Pdf

The million copy international bestseller, critically acclaimed and translated into over 25 languages. As influential today as when it was first published, The Selfish Gene has become a classic exposition of evolutionary thought. Professor Dawkins articulates a gene's eye view of evolution - a view giving centre stage to these persistent units of information, and in which organisms can be seen as vehicles for their replication. This imaginative, powerful, and stylistically brilliant work not only brought the insights of Neo-Darwinism to a wide audience, but galvanized the biology community, generating much debate and stimulating whole new areas of research. Forty years later, its insights remain as relevant today as on the day it was published. This 40th anniversary edition includes a new epilogue from the author discussing the continuing relevance of these ideas in evolutionary biology today, as well as the original prefaces and foreword, and extracts from early reviews. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.

Above the Gene, Beyond Biology

Jan Baedke
Above the Gene Beyond Biology Book PDF

Author : Jan Baedke
Publisher : University of Pittsburgh Press
Page : 296 pages
File Size : 49,6 Mb
Release : 2018-07-20
Category : Science
ISBN : 9780822983408

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Above the Gene, Beyond Biology by Jan Baedke Pdf

Epigenetics is currently one of the fastest-growing fields in the sciences. Epigenetic information not only controls DNA expression but links genetic factors with the environmental experiences that influence the traits and characteristics of an individual. What we eat, where we work, and how we live affects not only the activity of our genes but that of our offspring as well. This discovery has imposed a revolutionary theoretical shift on modern biology, especially on evolutionary theory. It has helped to uncover the developmental processes leading to cancer, obesity, schizophrenia, alcoholism, and aging, and to facilitate associated medial applications such as stem cell therapy and cloning. Above the Gene, Beyond Biology explores how biologists in this booming field investigate and explain living systems. Jan Baedke offers the first comprehensive philosophical discussion of epigenetic concepts, explanations, and methodologies so that we can better understand this “epigenetic turn” in the life sciences from a philosophical perspective.

The Sports Gene

David Epstein
The Sports Gene Book PDF

Author : David Epstein
Publisher : Penguin
Page : 352 pages
File Size : 41,7 Mb
Release : 2013-08-01
Category : Sports & Recreation
ISBN : 9781101622636

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The Sports Gene by David Epstein Pdf

The New York Times bestseller – with a new afterword about early specialization in youth sports – by the author of Range: Why Generalists Triumph in a Specialized World. The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training? In this controversial and engaging exploration of athletic success and the so-called 10,000-hour rule, David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving it. Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.

Understanding Genetics

Genetic Alliance,New York-Mid-Atlantic Consortium for Genetic and Newborn Screening Services
Understanding Genetics Book PDF

Author : Genetic Alliance,New York-Mid-Atlantic Consortium for Genetic and Newborn Screening Services
Publisher : Lulu.com
Page : 104 pages
File Size : 44,9 Mb
Release : 2009
Category : Biology
ISBN : 9780982162217

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Understanding Genetics by Genetic Alliance,New York-Mid-Atlantic Consortium for Genetic and Newborn Screening Services Pdf

The purpose of this manual is to provide an educational genetics resource for individuals, families, and health professionals in the New York - Mid-Atlantic region and increase awareness of specialty care in genetics. The manual begins with a basic introduction to genetics concepts, followed by a description of the different types and applications of genetic tests. It also provides information about diagnosis of genetic disease, family history, newborn screening, and genetic counseling. Resources are included to assist in patient care, patient and professional education, and identification of specialty genetics services within the New York - Mid-Atlantic region. At the end of each section, a list of references is provided for additional information. Appendices can be copied for reference and offered to patients. These take-home resources are critical to helping both providers and patients understand some of the basic concepts and applications of genetics and genomics.

Who is the Scientist-Subject?

Esha Shah
Who is the Scientist Subject Book PDF

Author : Esha Shah
Publisher : Taylor & Francis
Page : 247 pages
File Size : 43,9 Mb
Release : 2018-05-20
Category : Philosophy
ISBN : 9780429953170

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Who is the Scientist-Subject? by Esha Shah Pdf

This book explores two disparate sets of debates in the history and philosophy of the life sciences: the history of subjectivity in shaping objective science and the history of dominance of reductionism in molecular biology. It questions the dominant conception of the scientist-subject as a neo-Kantian ideal self – that is, the scientist as a unified and wilful, self-determined, self-regulated, active and autonomous, rational subject wilfully driven by social and scientific ethos – in favour of a narrative that shows how the microcosm of reductionism is sustained, adopted, questioned, or challenged in the creative struggles of the scientist-subject. The author covers a century-long history of the concept of the gene as a series of "pioneering moments" through an engagement with life-writings of eminent scientists to show how their ways of being and belonging relate with the making of the science. The scientist-self is theorized as fundamentally a feeling, experiencing, and suffering subject split between the conscious and unconscious and constitutive of personality aspects that are emotional/psychological, "situated" (cultural and ideological), metaphysical, intersubjective, and existential at the same time. An engaging interdisciplinary interpretation of the dominance of reductionism in genetic science, this book will be of major interest to scholars and researchers of science, history, and philosophy alike.

Inventing the Thrifty Gene

Travis Hay
Inventing the Thrifty Gene Book PDF

Author : Travis Hay
Publisher : Univ. of Manitoba Press
Page : 208 pages
File Size : 50,6 Mb
Release : 2021-09-10
Category : History
ISBN : 9780887559389

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Inventing the Thrifty Gene by Travis Hay Pdf

Though First Nations communities in Canada have historically lacked access to clean water, affordable food, and equitable health care, they have never lacked access to well-funded scientists seeking to study them. Inventing the Thrifty Gene examines the relationship between science and settler colonialism through the lens of “Aboriginal diabetes” and the thrifty gene hypothesis, which posits that Indigenous peoples are genetically predisposed to type 2 diabetes and obesity due to their alleged hunter-gatherer genes. Hay’s study begins with Charles Darwin’s travels and his observations on the Indigenous peoples he encountered, setting the imperial context for Canadian histories of medicine and colonialism. It continues in the mid-twentieth century with a look at nutritional experimentation during the long career of Percy Moore, the medical director of Indian Affairs (1946–1965). Hay then turns to James Neel’s invention of the thrifty gene hypothesis in 1962 and Robert Hegele’s reinvention and application of the hypothesis to Sandy Lake First Nation in northern Ontario in the 1990s. Finally, Hay demonstrates the way in which settler colonial science was responded to and resisted by Indigenous leadership in Sandy Lake First Nation, who used monies from the thrifty gene study to fund wellness programs in their community. Inventing the Thrifty Gene exposes the exploitative nature of settler science with Indigenous subjects, the flawed scientific theories stemming from faulty assumptions of Indigenous decline and disappearance, as well as the severe inequities in Canadian health care that persist even today.

The Meanings of the Gene

Celeste Michelle Condit
The Meanings of the Gene Book PDF

Author : Celeste Michelle Condit
Publisher : Univ of Wisconsin Press
Page : 348 pages
File Size : 43,7 Mb
Release : 1999
Category : Genetics
ISBN : 0299163644

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The Meanings of the Gene by Celeste Michelle Condit Pdf

The Meanings of the Gene is a compelling look at societal hopes and fears about genetics in the course of the twentieth century. The work of scientists and doctors in advancing genetic research and its applications has been accompanied by plenty of discussion in the popular press—from Good Housekeeping and Forbes to Ms. and the Congressional Record—about such topics as eugenics, sterilization, DNA, genetic counseling, and sex selection. By demonstrating the role of rhetoric and ideology in public discussions about genetics, Condit raises the controversial question, Who shapes decisions about genetic research and its consequences for humans—scientists, or the public? Analyzing hundreds of stories from American magazines—and, later, television news—from the 1910s to the 1990s, Condit identifies three central and enduring public worries about genetics: that genes are deterministic arbiters of human fate; that genetics research can be used for discriminatory ends; and that advances in genetics encourage perfectionistic thinking about our children. Other key public concerns that Condit highlights are the complexity of genetic decision-making and potential for invasion of privacy; conflict over the human genetic code and experimentation with DNA; and family genetics and reproductive decisions. Her analysis reveals a persistent debate in the popular media between themes of genetic determinism (such as eugenics) and more egalitarian views that place genes within the complexity of biological and social life. The Meanings of the Gene offers an insightful view of our continuing efforts to grapple with our biological natures and to define what it means, and will mean in the future, to be human.

The Century of the Gene

Evelyn Fox KELLER
The Century of the Gene Book PDF

Author : Evelyn Fox KELLER
Publisher : Harvard University Press
Page : 194 pages
File Size : 47,7 Mb
Release : 2009-06-30
Category : Science
ISBN : 9780674039438

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The Century of the Gene by Evelyn Fox KELLER Pdf

In a book that promises to change the way we think and talk about genes and genetic determinism, Evelyn Fox Keller, one of our most gifted historians and philosophers of science, provides a powerful, profound analysis of the achievements of genetics and molecular biology in the twentieth century, the century of the gene. Not just a chronicle of biology’s progress from gene to genome in one hundred years, The Century of the Gene also calls our attention to the surprising ways these advances challenge the familiar picture of the gene most of us still entertain. Keller shows us that the very successes that have stirred our imagination have also radically undermined the primacy of the gene—word and object—as the core explanatory concept of heredity and development. She argues that we need a new vocabulary that includes concepts such as robustness, fidelity, and evolvability. But more than a new vocabulary, a new awareness is absolutely crucial: that understanding the components of a system (be they individual genes, proteins, or even molecules) may tell us little about the interactions among these components. With the Human Genome Project nearing its first and most publicized goal, biologists are coming to realize that they have reached not the end of biology but the beginning of a new era. Indeed, Keller predicts that in the new century we will witness another Cambrian era, this time in new forms of biological thought rather than in new forms of biological life.