The Immune Response To Implanted Materials And Devices

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The Immune Response to Implanted Materials and Devices

Bruna Corradetti
The Immune Response to Implanted Materials and Devices Book PDF

Author : Bruna Corradetti
Publisher : Springer
Page : 241 pages
File Size : 44,5 Mb
Release : 2016-11-30
Category : Technology & Engineering
ISBN : 9783319454337

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The Immune Response to Implanted Materials and Devices by Bruna Corradetti Pdf

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Immunomodulatory Biomaterials

Stephen F. Badylak,Jennifer Elisseeff
Immunomodulatory Biomaterials Book PDF

Author : Stephen F. Badylak,Jennifer Elisseeff
Publisher : Woodhead Publishing
Page : 296 pages
File Size : 55,6 Mb
Release : 2021-07-30
Category : Medical
ISBN : 9780128214565

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Immunomodulatory Biomaterials by Stephen F. Badylak,Jennifer Elisseeff Pdf

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Biomaterials and Immune Response

Nihal Engin Vrana
Biomaterials and Immune Response Book PDF

Author : Nihal Engin Vrana
Publisher : CRC Press
Page : 249 pages
File Size : 47,6 Mb
Release : 2018-07-20
Category : Medical
ISBN : 9781351377560

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Biomaterials and Immune Response by Nihal Engin Vrana Pdf

The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area

Biomaterials and Immune Response

Nihal Engin Vrana
Biomaterials and Immune Response Book PDF

Author : Nihal Engin Vrana
Publisher : Unknown
Page : 0 pages
File Size : 51,6 Mb
Release : 2023-09-25
Category : Electronic
ISBN : 1032653027

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Biomaterials and Immune Response by Nihal Engin Vrana Pdf

This book focuses on the role of the immune system in biomaterial applications. In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial immune system in

Host Response to Biomaterials

Stephen F Badylak
Host Response to Biomaterials Book PDF

Author : Stephen F Badylak
Publisher : Academic Press
Page : 460 pages
File Size : 44,8 Mb
Release : 2015-05-08
Category : Technology & Engineering
ISBN : 9780128005002

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Host Response to Biomaterials by Stephen F Badylak Pdf

Host Response to Biomaterials: The Impact of Host Response on Biomaterial Selection explains the various categories of biomaterials and their significance for clinical applications, focusing on the host response to each biomaterial. It is one of the first books to connect immunology and biomaterials with regard to host response. The text also explores the role of the immune system in host response, and covers the regulatory environment for biomaterials, along with the benefits of synthetic versus natural biomaterials, and the transition from simple to complex biomaterial solutions. Fields covered include, but are not limited to, orthopaedic surgery, dentistry, general surgery, neurosurgery, urology, and regenerative medicine. Explains the various categories of biomaterials and their significance for clinical applications Contains a range of extensive coverage, including, but not limited to, orthopedic, surgery, dental, general surgery, neurosurgery, lower urinary tract, and regenerative medicine Includes regulations regarding combination devices

Safety of Silicone Breast Implants

Institute of Medicine,Committee on the Safety of Silicone Breast Implants
Safety of Silicone Breast Implants Book PDF

Author : Institute of Medicine,Committee on the Safety of Silicone Breast Implants
Publisher : National Academies Press
Page : 559 pages
File Size : 53,8 Mb
Release : 2000-01-06
Category : Medical
ISBN : 9780309132756

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Safety of Silicone Breast Implants by Institute of Medicine,Committee on the Safety of Silicone Breast Implants Pdf

The Dow Corning case raised serious questions about the safety of silicone breast implants and about larger issues of medical device testing and patient education. Safety of Silicone Breast Implants presents a well-documented, thoughtful exploration of the safety of these devices, drawing conclusions from the available research base and suggesting further questions to be answered. This book also examines the sensitive issues surrounding women's decisions about implants. In reaching conclusions, the committee reviews: The history of the silicone breast implant and the development of its chemistry. The wide variety of U.S.-made implants and their regulation by the Food and Drug Administration. Frequency and consequences of local complications from implants. The evidence for and against links between implants and autoimmune disorders, connective tissue disease, neurological problems, silicone in breast milk, or a proposed new syndrome. Evidence that implants may be associated with lower frequencies of breast cancer. Safety of Silicone Breast Implants provides a comprehensive, well-organized review of the science behind one of the most significant medical controversies of our time.

An Introduction to Tissue-Biomaterial Interactions

Kay C. Dee,David A. Puleo,Rena Bizios
An Introduction to Tissue Biomaterial Interactions Book PDF

Author : Kay C. Dee,David A. Puleo,Rena Bizios
Publisher : John Wiley & Sons
Page : 250 pages
File Size : 53,9 Mb
Release : 2003-04-14
Category : Science
ISBN : 9780471461128

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An Introduction to Tissue-Biomaterial Interactions by Kay C. Dee,David A. Puleo,Rena Bizios Pdf

An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body’s wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today’s and tomorrow’s implantable biomedical devices.

Biomaterials in Regenerative Medicine and the Immune System

Laura Santambrogio
Biomaterials in Regenerative Medicine and the Immune System Book PDF

Author : Laura Santambrogio
Publisher : Springer
Page : 280 pages
File Size : 40,8 Mb
Release : 2015-09-04
Category : Technology & Engineering
ISBN : 9783319180458

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Biomaterials in Regenerative Medicine and the Immune System by Laura Santambrogio Pdf

The generation of tridimensional tissues, assembled from scaffolding materials populated with biologically functional cells, is the great challenge and hope of tissue bioengineering and regenerative medicine. The generation of biomaterials capable of harnessing the immune system has been particularly successful. This book provides a comprehensive view of how immune cells can be manipulated to suppresses inflammation, deliver vaccines, fight cancer cells, promote tissue regeneration or inhibit blood clotting and bacterial infections by functionally engineered biomaterials. However, long-lived polymers, such as those employed in orthopedic surgery or vascular stents, can often induce an immune reaction to their basic components. As a result, this book is also an important step towards coming to understand how to manipulate biomaterials to optimize their beneficial effects and downplay detrimental immune responses.

Biomaterials, Artificial Organs and Tissue Engineering

L Hench,J. Jones
Biomaterials Artificial Organs and Tissue Engineering Book PDF

Author : L Hench,J. Jones
Publisher : Elsevier
Page : 298 pages
File Size : 43,9 Mb
Release : 2005-09-27
Category : Science
ISBN : 9781845690861

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Biomaterials, Artificial Organs and Tissue Engineering by L Hench,J. Jones Pdf

Maintaining quality of life in an ageing population is one of the great challenges of the 21st Century. This book summarises how this challenge is being met by multi-disciplinary developments of specialty biomaterials, devices, artificial organs and in-vitro growth of human cells as tissue engineered constructs. Biomaterials, Artificial Organs and Tissue Engineering is intended for use as a textbook in a one semester course for upper level BS, MS and Meng students. The 25 chapters are organized in five parts: Part one provides an introduction to living and man-made materials for the non-specialist; Part two is an overview of clinical applications of various biomaterials and devices; Part three summarises the bioengineering principles, materials and designs used in artificial organs; Part four presents the concepts, cell techniques, scaffold materials and applications of tissue engineering; Part five provides an overview of the complex socio-economic factors involved in technology based healthcare, including regulatory controls, technology transfer processes and ethical issues. Comprehensive introduction to living and man-made materials Looks at clinical applications of various biomaterials and devices Bioengineering principles, materials and designs used in artificial organs are summarised

Biological Performance of Materials

Jonathan Black
Biological Performance of Materials Book PDF

Author : Jonathan Black
Publisher : CRC Press
Page : 526 pages
File Size : 48,8 Mb
Release : 2005-12-20
Category : Medical
ISBN : 0849339596

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Biological Performance of Materials by Jonathan Black Pdf

Bioengineers need a thorough grounding in biocompatibility - the biological performance of materials. Until now, there were no publications suitable for a neophyte in the field; prior publications were either not comprehensive or focused on rather narrow interests. Drawing on the author's 35 years of experience as a teacher, researcher, and consultant in biomaterials science and engineering (BSE), Biological Performance of Materials: Fundamentals of Biocompatibility, Fourth Edition focuses primarily on principles of biological performance at a relatively fundamental level, analyzing interactions between living organisms and nonliving materials used in medical devices - the subject that sets BSE apart as a distinct field of investigation. Following an introductory section, the book is divided into three sections: the material response to biological systems, host response to biomaterials, and test methods for determining biological response in vitro as well as in animal models and clinical settings. Supplemental "Interparts" summarize the physical properties of commonly used metallic, polymeric, and ceramic biomaterials. They also provide a guide to understanding the clinical performance of implanted biomaterials.

Concepts and Design of Materials Nanoarchitectonics

Omar Azzaroni,Katsuhiko Ariga
Concepts and Design of Materials Nanoarchitectonics Book PDF

Author : Omar Azzaroni,Katsuhiko Ariga
Publisher : Royal Society of Chemistry
Page : 521 pages
File Size : 47,7 Mb
Release : 2022-02-09
Category : Science
ISBN : 9781788019620

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Concepts and Design of Materials Nanoarchitectonics by Omar Azzaroni,Katsuhiko Ariga Pdf

The concept of nanoarchitechtonics was introduced to describe the correct manipulation of nanoscale materials in the creation of nano-devices and applications. Nanoarchitectonics has begun to spread into many fields including nanostructured materials synthesis, supramolecular assembly, nanoscale structural fabrications, materials hybridizations, materials and structures for energy and environmental sciences, device and physical application, and bio- and medical applications. Following on from the 2012 title Manipulation of Nanoscale Materials, Concepts and Design of Materials Nanoarchitectonics covers the introductory features underlying the field, presenting a unifying overview of the theoretical aspects and emerging applications that are changing the capability to understand and design advanced functional materials. Edited by pioneers of the field, this book will appeal to researchers working in nanoscience, materials science, supramolecular chemistry, physical chemistry and organic chemistry, as well as graduate students in these areas.

Biomaterials Science

William R Wagner,Shelly E. Sakiyama-Elbert,Guigen Zhang,Michael J. Yaszemski
Biomaterials Science Book PDF

Author : William R Wagner,Shelly E. Sakiyama-Elbert,Guigen Zhang,Michael J. Yaszemski
Publisher : Academic Press
Page : 1612 pages
File Size : 53,5 Mb
Release : 2020-05-23
Category : Medical
ISBN : 9780128161388

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Biomaterials Science by William R Wagner,Shelly E. Sakiyama-Elbert,Guigen Zhang,Michael J. Yaszemski Pdf

The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine.This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for most chapters

Service Characteristics of Biomedical Materials and Implants

Andrew W. Batchelor,Margam Chandrasekaran
Service Characteristics of Biomedical Materials and Implants Book PDF

Author : Andrew W. Batchelor,Margam Chandrasekaran
Publisher : Imperial College Press
Page : 260 pages
File Size : 43,8 Mb
Release : 2004
Category : Medical
ISBN : 9781860945366

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Service Characteristics of Biomedical Materials and Implants by Andrew W. Batchelor,Margam Chandrasekaran Pdf

A wide variety of materials is being used in biomedical engineering for various functions. This includes a range of ceramics, polymers and metallic materials for implants and medical devices. A major question is how these materials will perform inside the body, which is very sensitive to alien materials.

Biomaterials Associated Infection

Fintan Moriarty,Sebastian A.J. Zaat,Henk J. Busscher
Biomaterials Associated Infection Book PDF

Author : Fintan Moriarty,Sebastian A.J. Zaat,Henk J. Busscher
Publisher : Springer Science & Business Media
Page : 564 pages
File Size : 49,5 Mb
Release : 2012-09-29
Category : Technology & Engineering
ISBN : 9781461410317

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Biomaterials Associated Infection by Fintan Moriarty,Sebastian A.J. Zaat,Henk J. Busscher Pdf

Biomaterials associated infection (BAI) is one of the most common complications associated with implantation of any biomaterial regardless of form or function. These infections usually involve bacterial colonization and biofilm formation on the biomaterial itself, rendering the infection impervious to antimicrobials and host defenses. In addition, it is becoming increasingly clear that infection of the surrounding tissues also plays an important role in BAI, and that the infection may be influenced by the composition and design of the implanted biomaterial. In this book, worldwide leaders in the field address this critical problem in the translation of biomaterials research into clinical practice. The book begins with an emphasis on the latest research in the pathogenesis of BAI from microbiological, immunological, and materials science perspectives. The current state of the art in antimicrobial activation of biomaterials through surface modification and the incorporation of antimicrobial agents is then discussed. In the concluding chapters, successful translation of a selection of antimicrobial technologies from preclinical research into clinical use is described alongside a discussion of the utility of these devices and perspectives for future development. This book is essential reading for researchers and clinicians who are interested in understanding the fundamentals of BAI, the latest in antimicrobial materials research, and the state of the art in clinically available antimicrobial containing medical devices.

Biomaterials and Medical Devices

Ferdyansyah Mahyudin,Hendra Hermawan
Biomaterials and Medical Devices Book PDF

Author : Ferdyansyah Mahyudin,Hendra Hermawan
Publisher : Springer
Page : 242 pages
File Size : 52,8 Mb
Release : 2016-02-26
Category : Technology & Engineering
ISBN : 9783319148458

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Biomaterials and Medical Devices by Ferdyansyah Mahyudin,Hendra Hermawan Pdf

This book presents an introduction to biomaterials with the focus on the current development and future direction of biomaterials and medical devices research and development in Indonesia. It is the first biomaterials book written by selected academic and clinical experts experts on biomaterials and medical devices from various institutions and industries in Indonesia. It serves as a reference source for researchers starting new projects, for companies developing and marketing products and for governments setting new policies. Chapter one covers the fundamentals of biomaterials, types of biomaterials, their structures and properties and the relationship between them. Chapter two discusses unconventional processing of biomaterials including nano-hybrid organic-inorganic biomaterials. Chapter three addresses biocompatibility issues including in vitro cytotoxicity, genotoxicity, in vitro cell models, biocompatibility data and its related failure. Chapter four describes degradable biomaterial for medical implants, which include biodegradable polymers, biodegradable metals, degradation assessment techniques and future directions. Chapter five focuses on animal models for biomaterial research, ethics, care and use, implantation study and monitoring and studies on medical implants in animals in Indonesia. Chapter six covers biomimetic bioceramics, natural-based biocomposites and the latest research on natural-based biomaterials in Indonesia. Chapter seven describes recent advances in natural biomaterial from human and animal tissue, its processing and applications. Chapter eight discusses orthopedic applications of biomaterials focusing on most common problems in Indonesia, and surgical intervention and implants. Chapter nine describes biomaterials in dentistry and their development in Indonesia.