The Initiation Of Dna Replication

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 45,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Dan S Ray
Publisher : Elsevier
Page : 628 pages
File Size : 50,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323139007

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The Initiation of DNA Replication by Dan S Ray Pdf

The Initiation of DNA Replication contains the proceedings of the 1981 ICN-UCLA Symposia on Structure and DNA-Protein Interactions of Replication Origins, held in Salt Lake City, Utah on March 8-13, 1981. The papers explore the initiation of DNA replication and address relevant topics such as whether there are specific protein recognition sites within an origin; how many proteins interact at an origin and whether they interact in a specific temporal sequence; or whether origins can be subdivided into distinct functional domains. The specific biochemical steps in DNA chain initiation and how they are catalyzed are also discussed. This book is organized into six sections and comprised of 41 chapters. The discussion begins by analyzing the replication origin region of the Escherichia coli chromosome and the precise location of the region carrying autonomous replicating function. A genetic map of the replication and incompatibility regions of the resistance plasmids R100 and R1 is described, and several gene products produced in vivo or in vitro from the replication region are considered. The sections that follow focus on the DNA initiation determinants of bacteriophage M13 and of chimeric derivatives carrying foreign replication determinants; suppressor loci in E. coli; and enzymes and proteins involved in initiation of phage and bacterial chromosomes. The final chapters examine the origins of eukaryotic replication. This book will be of interest to scientists, students, and researchers in fields ranging from microbiology and molecular biology to biochemistry, molecular genetics, and physiology.

Author : Samantha Fowler,Rebecca Roush,James Wise
Publisher : Unknown
Page : 618 pages
File Size : 41,9 Mb
Release : 2018-01-07
Category : Science
ISBN : 9888407457

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Concepts of Biology by Samantha Fowler,Rebecca Roush,James Wise Pdf

Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

Author : Daniel L. Kaplan
Publisher : Unknown
Page : 128 pages
File Size : 53,7 Mb
Release : 2016
Category : Cytology
ISBN : 331924695X

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The Initiation of DNA Replication in Eukaryotes by Daniel L. Kaplan Pdf

Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

Author : Jelena Kusic-Tisma
Publisher : BoD – Books on Demand
Page : 322 pages
File Size : 42,6 Mb
Release : 2011-09-26
Category : Medical
ISBN : 9789533072593

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Fundamental Aspects of DNA Replication by Jelena Kusic-Tisma Pdf

DNA replication, the process of copying one double stranded DNA molecule to produce two identical copies, is at the heart of cell proliferation. This book highlights new insights into the replication process in eukaryotes, from the assembly of pre-replication complex and features of DNA replication origins, through polymerization mechanisms, to propagation of epigenetic states. It also covers cell cycle control of replication initiation and includes the latest on mechanisms of replication in prokaryotes. The association between genome replication and transcription is also addressed. We hope that readers will find this book interesting, helpful and inspiring.

Author : Hisao Masai,Marco Foiani
Publisher : Springer
Page : 581 pages
File Size : 44,6 Mb
Release : 2018-01-22
Category : Science
ISBN : 9789811069550

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DNA Replication by Hisao Masai,Marco Foiani Pdf

This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

Author : John A. Bryant
Publisher : CRC Press
Page : 199 pages
File Size : 49,5 Mb
Release : 2018-01-18
Category : Science
ISBN : 9781351088411

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Dna Replication In Plants by John A. Bryant Pdf

This texts discusses DNA replication in plants including chapters on; functional chromosomal structure, the biochemistry of DNA replication, Control of DNA replication, Replication of plant organelle DNA, replication of DNA viruses in plants, and DNA damage, repair, and mutagenesis.

Author : Daniel L. Kaplan
Publisher : Springer
Page : 563 pages
File Size : 50,6 Mb
Release : 2016-02-11
Category : Medical
ISBN : 9783319246963

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The Initiation of DNA Replication in Eukaryotes by Daniel L. Kaplan Pdf

​Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

Author : Nina Parker,OpenStax,Mark Schneegurt,AnhHue Thi Tu,Brian M. Forster,Philip Lister
Publisher : Unknown
Page : 1301 pages
File Size : 53,8 Mb
Release : 2016-05-30
Category : Microbiology
ISBN : 1938168143

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Microbiology by Nina Parker,OpenStax,Mark Schneegurt,AnhHue Thi Tu,Brian M. Forster,Philip Lister Pdf

"Microbiology covers the scope and sequence requirements for a single-semester microbiology course for non-majors. The book presents the core concepts of microbiology with a focus on applications for careers in allied health. The pedagogical features of the text make the material interesting and accessible while maintaining the career-application focus and scientific rigor inherent in the subject matter. Microbiology's art program enhances students' understanding of concepts through clear and effective illustrations, diagrams, and photographs. Microbiology is produced through a collaborative publishing agreement between OpenStax and the American Society for Microbiology Press. The book aligns with the curriculum guidelines of the American Society for Microbiology."--BC Campus website.

Author : Ellen Fanning,Rolf Knippers,Ernst-L. Winnacker
Publisher : Springer Science & Business Media
Page : 260 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642770401

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DNA Replication and the Cell Cycle by Ellen Fanning,Rolf Knippers,Ernst-L. Winnacker Pdf

Provided here is an easily accessible introduction to the mechanisms of DNA replication, regulation and the biochemistry of cell cycle control. An overview of this rapidly developing field is presented to orient the reader, followed by a series of contributions by leading researchers summarizing recent results on selected topics, such as protein phosporylation, tumor suppressor genes, and signal transduction in prokaryotic and eucaryotic systems. The reader will gain an overview of our current understanding of DNA replication and the cell cycle, and a selection of useful recent references for further reading.

Author : Alan Kolber
Publisher : Springer Science & Business Media
Page : 457 pages
File Size : 46,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468421248

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Mechanism and Regulation of DNA Replication by Alan Kolber Pdf

1 - Chromosome Replication in Procaryotes.- Enzymatic Aspects of Chromosome Replication in E. coli.- Escherichia coli DNA Polymerase II and III.- Initiation of DNA Synthesis.- In vitro Replication of DNA.- The Role of ATP in Chromosome Replication Studied in Toluenized Escherichia coli.- Membrane Protein Components and DNA Synthesis in Escherichia coli.- A Possible Common Role for DNA Polymerase I and Exonuclease V in Escherichia coli.- The Joining of DNA Duplexes at Their Base-Paired Ends.- The Attachment of the Bacterial Chromosome to the Cell Membrane.- DNA Replication in Bacteriophage and.

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 53,5 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

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Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Author : Patrick Hughes,Ellen Fanning,Masamichi Kohiyama
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642769887

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DNA Replication: The Regulatory Mechanisms by Patrick Hughes,Ellen Fanning,Masamichi Kohiyama Pdf

DNA replication is a key event in the cell cycle. Although our knowledge is far from complete and many elusive regulatory mechanisms still remain beyondour grasp, many enzymes and a multiplicity of biochemical mechanisms involved have been discovered. Recent findings in E. coli have confirmed and yet surpassed the original hypothesis of F. Jacob. In yeast and higher eucaryotes, the apparent redundancy in putative origins and initiators has made an estimation of the importance of each identified element difficult to access. In spite of well established methodologies - which are also described in the book - the origin identification in mammalian chromosomes is still a controversial subject. On the other hand, considerable advances have been made in our understanding of virus DNA replication and this continues to deepen and broaden our understanding of the controls of cellular DNA replication.

Author : David Scott Pederson,Nicholas H. Heintz
Publisher : R. G. Landes
Page : 132 pages
File Size : 42,9 Mb
Release : 1994
Category : DNA replication
ISBN : UOM:39015032140892

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Transcription Factors and DNA Replication by David Scott Pederson,Nicholas H. Heintz Pdf

Initiation of DNA synthesis: a general model from studies with prokaryotes. Regulatory transcription factors and the initiation of transcription in eucaryotic cells. Replication origins and the initiation of DNA synthesis in mammalian cells and the viruses. DNA replication in yeast. Transcription factors and control of DNA replication.

Author : Ulrich Huebscher
Publisher : Springer Science & Business Media
Page : 542 pages
File Size : 44,7 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781468487305

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Proteins Involved in DNA Replication by Ulrich Huebscher Pdf

This book collects the Proceedings of a workshop sponsored by the European Molecular Biology Organization (EMBO) entitled "Pro teins Involved in DNA Replication" which was held September 19 to 23,1983 at Vitznau, near Lucerne, in Switzerland. The aim of this workshop was to review and discuss the status of our knowledge on the intricate array of enzymes and proteins that allow the replication of the DNA. Since the first discovery of a DNA polymerase in Escherichia coli by Arthur Kornberg twenty eight years ago, a great number of enzymes and other proteins were des cribed that are essential for this process: different DNA poly merases, DNA primases, DNA dependent ATPases, helicases, DNA liga ses, DNA topoisomerases, exo- and endonucleases, DNA binding pro teins and others. They are required for the initiation of a round of synthesis at each replication origin, for the progress of the growing fork, for the disentanglement of the replication product, or for assuring the fidelity of the replication process. The number, variety and ways in which these proteins inter act with DNA and with each other to the achievement of replication and to the maintenance of the physiological structure of the chromo somes is the subject of the contributions collected in this volume. The presentations and discussions during this workshop reinforced the view that DNA replication in vivo can only be achieved through the cooperation of a high number of enzymes, proteins and other cofactors.