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Author : Sarah S. Richardson Publisher : University of Chicago Press Page : 319 pages File Size : 54,9 Mb Release : 2021-11-05 Category : Medical ISBN : 9780226544809
Introduction: The Maternal Imprint -- Sex Equality in Heredity -- Prenatal Culture -- Germ Plasm Hygiene -- Maternal Effects -- Race, Birth Weight, and the Biosocial Body -- Fetal Programming -- It's the Mother! -- Epilogue: Gender and Heredity in the Postgenomic Moment.
Introduction to Epigenetics by Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz Pdf
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Graham J. Burton,David J. P. Barker,Ashley Moffett,Kent Thornburg
Author : Graham J. Burton,David J. P. Barker,Ashley Moffett,Kent Thornburg Publisher : Cambridge University Press Page : 267 pages File Size : 48,6 Mb Release : 2010-12-16 Category : Medical ISBN : 9781139494229
The Placenta and Human Developmental Programming by Graham J. Burton,David J. P. Barker,Ashley Moffett,Kent Thornburg Pdf
Developmental programming is a rapidly advancing discipline of great importance to basic scientists and health professionals alike. This text integrates, for the first time, contributions from world experts to explore the role of the placenta in developmental programming. The book considers the materno-fetal supply line, and how perturbations of placental development impact on its functional capacity. Chapters examine ways in which environmental, immunological and vascular insults regulate expression of conventional and imprinted genes, along with their impact on placental shape and size, transport, metabolism and endocrine function. Research in animal models is integrated with human clinical and epidemiological data, and questions for future research are identified. Transcripts of discussions between the authors allow readers to engage with controversial issues. Essential reading for researchers in placental biology and developmental programming, as well as specialists and trainees in the wider field of reproductive medicine.
Author : Sarah S. Richardson Publisher : University of Chicago Press Page : 320 pages File Size : 46,7 Mb Release : 2013-12-13 Category : Science ISBN : 9780226084718
Human genomes are 99.9 percent identical—with one prominent exception. Instead of a matching pair of X chromosomes, men carry a single X, coupled with a tiny chromosome called the Y. Tracking the emergence of a new and distinctive way of thinking about sex represented by the unalterable, simple, and visually compelling binary of the X and Y chromosomes, Sex Itself examines the interaction between cultural gender norms and genetic theories of sex from the beginning of the twentieth century to the present, postgenomic age. Using methods from history, philosophy, and gender studies of science, Sarah S. Richardson uncovers how gender has helped to shape the research practices, questions asked, theories and models, and descriptive language used in sex chromosome research. From the earliest theories of chromosomal sex determination, to the mid-century hypothesis of the aggressive XYY supermale, to the debate about Y chromosome degeneration, to the recent claim that male and female genomes are more different than those of humans and chimpanzees, Richardson shows how cultural gender conceptions influence the genetic science of sex. Richardson shows how sexual science of the past continues to resonate, in ways both subtle and explicit, in contemporary research on the genetics of sex and gender. With the completion of the Human Genome Project, genes and chromosomes are moving to the center of the biology of sex. Sex Itself offers a compelling argument for the importance of ongoing critical dialogue on how cultural conceptions of gender operate within the science of sex.
The Imprinted Brain sets out a radical new theory of the mind and mental illness based on the recent discovery of genomic imprinting. Imprinted genes are those from one parent that, in that parent's interest, are expressed in an offspring rather than the diametrically opposed genes from the other parent. For example, a higher birth weight may represent the dominance of the father's genes in leading to a healthy child, whereas a lower birth weight is beneficial to the mother's immediate wellbeing, and the imprint of the mother's genes will result in a smaller baby. According to this view, a win for the father's genes may result in autism, whereas one for the mother's may result in psychosis. A state of equilibrium - normality - is the most likely outcome, with a no-win situation of balanced expression. Imprinted genes typically produce symptoms that are opposites of each other, and the author uses psychiatric case material to show how many of the symptoms of psychosis can be shown to be the mental mirror-images of those of autism. Combining psychiatry with insights from modern genetics and cognitive science, Christopher Badcock explains the fascinating imprinted brain theory to the reader in a thorough but accessible way. This new theory casts some intriguing new light on other topics as diverse as the nature of genius, the appeal of detective fiction, and the successes - and failures - of psychoanalysis. This thought-provoking book is a must-read for anyone with an interest in autism, psychiatry, cognitive science or psychology in general.
Author : Claire L. Wendland Publisher : University of Chicago Press Page : 365 pages File Size : 50,7 Mb Release : 2022-04-22 Category : History ISBN : 9780226816883
"Partial Stories takes readers to Malawi, where roughly one in twenty women can expect to die of a pregnancy or childbirth complication, despite decades of safe-motherhood programs. The stories of these mothers are told in hospitals and villages, by chiefs and doctors, herbalists and nurses, epidemiologists and healers, and competing explanations proliferate. The mothers' stories are used by elders for technical education and moral instruction at a coming-of-age-ritual, a district hospital's mortality review, and in the reflected glow of a computer screen at an international conference. After orienting readers to urban Malawi's context of therapeutic pluralism and material scarcity, Claire Wendland discusses the ways various experts account for maternal death, showing how their diverse explanations reflect competing visions of the past and shared concerns about social change. She looks to a series of pregnancy-related deaths in order to consider bodies as biosocial phenomena, shaped from before birth by history and social inequality. Wendland reveals an uneven therapeutic landscape that pushes experts to improvise, clinically and ethically. Their creative, essential, and sometimes deadly improvisations ask us to reconsider the "best practice" dogmas of global health and transnational research, as well as the nature of medical authority and expertise. Wendland demonstrates how strategies of legitimation render care more dangerous and knowledge more partial than it might otherwise be"--
Author : Alison Sharrock,Alison Keith Publisher : University of Toronto Press Page : 395 pages File Size : 55,7 Mb Release : 2020 Category : History ISBN : 9781487532017
Maternal Conceptions in Classical Literature and Philosophy by Alison Sharrock,Alison Keith Pdf
This book explores motherhood in Greek and Roman literature, focusing on images of mothers and their relationships with their children across a variety of genres.
Maternal Immunization by Elke Leuridan,Marta Nunes,Chrissie Jones Pdf
Immunization during pregnancy with currently recommended vaccines prevents infection in the mother, the unborn fetus, and the young infant, and there is an increasing focus from different stakeholders to use this approach for other infections of importance to protect these vulnerable groups. The aim of this Maternal Immunization book is to provide a contemporary overview of vaccines used in pregnancy (and the lactation period), with emphasis on aspects of importance for the target groups, namely, rationale for the use of vaccines in pregnancy, safety, immunogenicity (immunology), timing to vaccinate, repeat doses, protective effects in the mother, fetus, and infant, and public acceptance and implementation, of existing and of future vaccines. Provides an overview of a quickly evolving topic. This will benefit the reader who wishes to rapidly become informed and up-to-date with new developments in this field Suitable to a broad audience: scientific researchers, obstetricians, gynecologists, neonatologists, vaccinators, pediatricians, students, and industry. Maternal vaccination impacts a wide range of specialists Allows health care professionals/researchers to gain insight into other aspects of vaccination in pregnancy outside of their specialism Is coauthored by specialists from multiple disciplines, providing a diverse view of the subject, increasing its interest and appeal Creates awareness of the current developments in this area of medicine and of the potential of maternal vaccination to improve the health of mothers and infants worldwide
The intersection of motherhood and creative life is explored in these writings on mothering that turn the spotlight from the child to the mother herself. Here, in memoirs, testimonials, diaries, essays, and fiction, mothers describe first-hand the changes brought to their lives by pregnancy, childbirth, and mothering. Many of the writers articulate difficult and socially unsanctioned maternal anger and ambivalence. In Mother Reader, motherhood is scrutinized for all its painful and illuminating subtleties, and addressed with unconventional wisdom and candor. What emerges is a sense of a community of writers speaking to and about each other out of a common experience, and a compilation of extraordinary literature never before assembled in a single volume.
Genomic imprinting allows scientists to trace genes to the parent of origin. This volume presents a collection of 13 papers by David Haig (organisimic and evolutionary biology, Harvard U.) on genomic imprinting. He argues that our paternally and maternally active genes do not work in cooperation with each other and in fact are in competition. Each paper is followed by commentary by the author, providing background information and discussing developments since its publication. Annotation copyrighted by Book News Inc., Portland, OR.
Perinatal Genetics by Mary E Norton,Jeffrey A. Kuller,Lorraine Dugoff Pdf
Get a quick, expert overview of the fast-changing field of perinatal genetics with this concise, practical resource. Drs. Mary Norton, Jeffrey A. Kuller, Lorraine Dugoff, and George Saade fully cover the clinically relevant topics that are key to providers who care for pregnant women and couples contemplating pregnancy. It’s an ideal resource for Ob/Gyn physicians, maternal-fetal medicine specialists, and clinical geneticists, as well as midwives, nurse practitioners, and other obstetric providers. Provides a comprehensive review of basic principles of medical genetics and genetic counseling, molecular genetics, cytogenetics, prenatal screening options, chromosomal microarray analysis, whole exome sequencing, prenatal ultrasound, diagnostic testing, and more. Contains a chapter on fetal treatment of genetic disorders. Consolidates today’s available information and experience in this important area into one convenient resource.
This book is a comprehensive and easily accessible reference for physicians caring for pregnant women with diabetes. Covering patients with type 1, type 2, and gestational diabetes, this handbook offers guidance on the different methods of treatment necessary for each population. Chapters cover the entire scope of patient care, including: diagnosis, patient education, dietary recommendations, medications, management during labor, potential fetal complications, and postpartum management. Obstetricians, gynecologists, primary care physicians, and residents will use this text to quickly answer any question they have on diabetes and pregnancy.
Chromosome Abnormalities and Genetic Counseling by R.J. MKinlay Gardner,Grant R Sutherland,Lisa G. Shaffer Pdf
Advances in cytogenetics continue to crop up in wonderful ways, and we know exponentially more about chromosomes now than mere decades ago. Likewise, the necessary skills in offering genetic counseling continue to evolve. This new edition of Chromosome Abnormalities in Genetic Counseling offers a practical, up-to-date guide for the genetic counselor to marshal cytogenetic data and analysis clearly and effectively to families.
The Maternal Experience explores the powerful and dynamic nature of maternal ambivalence and disrupts the conventional narrative of the mother’s lived experience by arguing that encounters with feelings of hatred are both universal and have the capacity to stimulate and enrich her maternal love. The book draws on the author’s personal mothering experiences, those of other women, and examples from film to inspire new introspection about the everyday maternal experience. Lowy takes a psychosocial approach to weave thinking from selected psychoanalytic and contemporary accounts together with personal stories to explore how maternal ambivalence operates, and how mothering is sourced in psychic struggles between loving and hating feelings in an atmosphere that is rife with social and personal expectations and prohibitions. By reworking the experience of maternal ambivalence, the book secures an understanding of the mother’s feelings of hatred as a catalyst for her love and allows these maligned and taboo emotions to be named and reframed into acceptable and transformative feelings. Brought alive by examples from film and first-hand experience, this book is fascinating reading for academics and students of psychology, maternal and women’s studies, and sociology, as well as practitioners in the fields of psychology, social work, medicine and counselling.
Since the late nineteenth century, medicine has sought to foster the birth of healthy children by attending to the bodies of pregnant women, through what we have come to call prenatal care. Women, and not their unborn children, were the initial focus of that medical attention, but prenatal diagnosis in its present form, which couples scrutiny of the fetus with the option to terminate pregnancy, came into being in the early 1970s. Tangled Diagnoses examines the multiple consequences of the widespread diffusion of this medical innovation. Prenatal testing, Ilana Löwy argues, has become mainly a risk-management technology—the goal of which is to prevent inborn impairments, ideally through the development of efficient therapies but in practice mainly through the prevention of the birth of children with such impairments. Using scholarship, interviews, and direct observation in France and Brazil of two groups of professionals who play an especially important role in the production of knowledge about fetal development—fetopathologists and clinical geneticists—to expose the real-life dilemmas prenatal testing creates, this book will be of interest to anyone concerned with the sociopolitical conditions of biomedical innovation, the politics of women’s bodies, disability, and the ethics of modern medicine.