The Neuroscience Of Cocaine

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The Neuroscience of Cocaine

Victor R. Preedy
The Neuroscience of Cocaine Book PDF

Author : Victor R. Preedy
Publisher : Academic Press
Page : 774 pages
File Size : 46,7 Mb
Release : 2017-05-23
Category : Psychology
ISBN : 9780128037928

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The Neuroscience of Cocaine by Victor R. Preedy Pdf

The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms. Cocaine is one of the most highly abused illicit drugs worldwide and is frequently associated with other forms of drug addiction and misuse, but researchers are still struggling to understand cocaine’s neuropharmacological profile and the mechanisms of its effects and manifestations at the cognitive level. Cessation of cocaine use can lead to numerous adverse withdrawal conditions, from the cellular and molecular level to the behavioral level of the individual user. Written by worldwide experts in cocaine addiction, this book assists neuroscientists and other addiction researchers in unraveling the many complex facets of cocaine use and abuse. Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Illustrated in full color Provides unique full coverage of all aspects of cocaine and its related pathology Provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms

The Neurobiology of Cocaine Addiction

Herman Joseph,Regina Quattrochi
The Neurobiology of Cocaine Addiction Book PDF

Author : Herman Joseph,Regina Quattrochi
Publisher : Routledge
Page : 156 pages
File Size : 48,8 Mb
Release : 2014-03-18
Category : Psychology
ISBN : 9781317826781

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The Neurobiology of Cocaine Addiction by Herman Joseph,Regina Quattrochi Pdf

With the use of crack on the rise in American cities, there is more need than ever to understand the biological, environmental, and social factors behind cocaine addiction, as well as the pharmacological properties of cocaine that make it such an addictive drug. The Neurobiology of Cocaine Addiction helps clinicians and researchers analyze research findings and their relevance to the clinical treatment of cocaine dependency. To do this, it looks at the whole spectrum of cocaine use, from trends in cocaine-involved deaths, hospital emergencies, arrests, and treatment admissions to the specific impact the drug has on brain function. The book reports on important findings from positron emission tomography (PET) and a “binge” pattern cocaine administration mode. This will enable you to improve your understanding of how cocaine alters the pleasure/reward system of the brain and creates new instinctual needs that displace the inherent instinctual needs of hunger and sex. By reading The Neurobiology of Cocaine Addiction, you will sharpen your knowledge of the basic actions of cocaine, the factors related to daily cocaine use, the neurobiological basis of addictive diseases, and drug-induced alterations in normal physiology. You will also learn about: the coexistence of cocaine and heroin addiction cocaine’s disruption of the endogenous opioid system QEEG and how it can play a potentially useful role in drug development and planning hypotheses of sensitization in the pathophysiology of cocaine dependence factors that predict daily cocaine use among patients in a methadone maintenance program abnormalities in brain function that persist for up to six months after last cocaine use patterns of cocaine use the importance of prospective data analysis and the limitations of a self-selective study group Clinicians, researchers, psychiatrists, and other professionals in chemical dependency and narcotics rehabilitation will turn the last page of The Neurobiology of Cocaine Addiction with a better understanding of cocaine’s addictive qualities and the characteristics of the individuals who become addicted to it. You will see what headway has been made in research at some of the nation’s top laboratories, but you will also see what remains to be done. Hopefully, you will find where you can make a contribution either at the practical level, the research level, or both.

The Neurobiology of Cocaine

Ronald P. Hammer, Jr.
The Neurobiology of Cocaine Book PDF

Author : Ronald P. Hammer, Jr.
Publisher : CRC Press
Page : 286 pages
File Size : 44,6 Mb
Release : 1995-07-17
Category : Science
ISBN : 0849383110

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The Neurobiology of Cocaine by Ronald P. Hammer, Jr. Pdf

Representing the latest data from active research groups, The Neurobiology of Cocaine is designed to educate students and inform experts in a rapidly changing field. This volume presents current research regarding the mechanisms of cocaine's action in the brain. Recent developments of cellular, molecular, and brain imaging methods provide new evidence that chemical and molecular substrates underlie cocaine reinforcement, dependence, and withdrawal. This book explores the biological bases of such effects, describing the brain circuits affected by cocaine, neuroendocrine and neurophysiological actions of cocaine, neurochemistry and pharmacology of cocaine, and cocaine effects on signal transduction, gene expression, and protein phosphorylation. This up-to-date text also describes the recently cloned class of neurotransporters affected by cocaine and characterizes their interaction with the drug. These reports focus on the effects of chronic exposure and subsequent withdrawal, which are differentiated from acute cocaine actions. Thus, they provide information on brain mechanisms likely active during long-term use and abuse in humans. Such commonalities are illustrated by a discussion of cocaine action in the human brain as visualized by positron emission tomography. This volume is a must for anyone interested in the mechanisms underlying cocaine abuse.

Never Enough

Judith Grisel
Never Enough Book PDF

Author : Judith Grisel
Publisher : Anchor
Page : 258 pages
File Size : 52,7 Mb
Release : 2020-01-14
Category : Psychology
ISBN : 9780525434900

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Never Enough by Judith Grisel Pdf

A NEW YORK TIMES BESTSELLER From a renowned behavioral neuroscientist and recovering addict, a rare page-turning work of science that draws on personal insights to reveal how drugs work, the dangerous hold they can take on the brain, and the surprising way to combat today's epidemic of addiction. Judith Grisel was a daily drug user and college dropout when she began to consider that her addiction might have a cure, one that she herself could perhaps discover by studying the brain. Now, after twenty-five years as a neuroscientist, she shares what she and other scientists have learned about addiction, enriched by captivating glimpses of her personal journey. In Never Enough, Grisel reveals the unfortunate bottom line of all regular drug use: there is no such thing as a free lunch. All drugs act on the brain in a way that diminishes their enjoyable effects and creates unpleasant ones with repeated use. Yet they have their appeal, and Grisel draws on anecdotes both comic and tragic from her own days of using as she limns the science behind the love of various drugs, from marijuana to alcohol, opiates to psychedelics, speed to spice. With more than one in five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide, and Grisel delves with compassion into the science of this scourge. She points to what is different about the brains of addicts even before they first pick up a drink or drug, highlights the changes that take place in the brain and behavior as a result of chronic using, and shares the surprising hidden gifts of personality that addiction can expose. She describes what drove her to addiction, what helped her recover, and her belief that a “cure” for addiction will not be found in our individual brains but in the way we interact with our communities. Set apart by its color, candor, and bell-clear writing, Never Enough is a revelatory look at the roles drugs play in all of our lives and offers crucial new insight into how we can solve the epidemic of abuse.

Behavioral Neuroscience of Drug Addiction

David W. Self,Julie K. Staley Gottschalk
Behavioral Neuroscience of Drug Addiction Book PDF

Author : David W. Self,Julie K. Staley Gottschalk
Publisher : Springer Science & Business Media
Page : 392 pages
File Size : 53,9 Mb
Release : 2009-12-18
Category : Medical
ISBN : 9783642030017

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Behavioral Neuroscience of Drug Addiction by David W. Self,Julie K. Staley Gottschalk Pdf

Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain’s natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug exposure. Behaviorally, these neural aberrations manifest as exaggerated, altered or dysfunctional expr- sion of learned behavioral responses related to the pursuit of drug rewards, or to environmental factors that precipitate craving and relapse during periods of drug withdrawal. Current research efforts are aimed at understanding the associative and causal relationships between these neurobiological and behavioral events, such that treatment options will ultimately employ therapeutic amelioration of neural de?cits and restoration of normal brain processing to promote efforts to abstain from further drug use. The Behavioral Neuroscience of Drug Addiction, part of the Springer series on Current Topics in Behavioral Neurosciences, contains scholarly reviews by noted experts on multiple topics from both basic and clinical neuroscience ?elds.

Methods of Behavior Analysis in Neuroscience

Jerry J. Buccafusco
Methods of Behavior Analysis in Neuroscience Book PDF

Author : Jerry J. Buccafusco
Publisher : CRC Press
Page : 341 pages
File Size : 54,5 Mb
Release : 2000-08-29
Category : Medical
ISBN : 9781420041811

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Methods of Behavior Analysis in Neuroscience by Jerry J. Buccafusco Pdf

Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Neuroscience of Alcohol

Victor R. Preedy
Neuroscience of Alcohol Book PDF

Author : Victor R. Preedy
Publisher : Academic Press
Page : 736 pages
File Size : 52,6 Mb
Release : 2019-03-19
Category : Medical
ISBN : 9780128131268

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Neuroscience of Alcohol by Victor R. Preedy Pdf

Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function Discusses alcohol use as a component of dual-use and poly addictions Outlines numerous screening and treatment strategies for alcohol misuse Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects

The Science of Addiction: From Neurobiology to Treatment

Carlton K. Erickson
The Science of Addiction From Neurobiology to Treatment Book PDF

Author : Carlton K. Erickson
Publisher : W. W. Norton & Company
Page : 303 pages
File Size : 43,5 Mb
Release : 2007-02-17
Category : Medical
ISBN : 9780393704631

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The Science of Addiction: From Neurobiology to Treatment by Carlton K. Erickson Pdf

Runner-up winner of the Hamilton Book Author Award, this book is a comprehensive overview of the neurobiology behind addictions. Neuroscience is clarifying the causes of compulsive alcohol and drug use––while also shedding light on what addiction is, what it is not, and how it can best be treated––in exciting and innovative ways. Current neurobiological research complements and enhances the approaches to addiction traditionally taken in social work and psychology. However, this important research is generally not presented in a forthright, jargon-free way that clearly illustrates its relevance to addiction professionals. The Science of Addiction presents a comprehensive overview of the roles that brain function and genetics play in addiction. It explains in an easy-to-understand way changes in the terminology and characterization of addiction that are emerging based upon new neurobiological research. The author goes on to describe the neuroanatomy and function of brain reward sites, and the genetics of alcohol and other drug dependence. Chapters on the basic pharmacology of stimulants and depressants, alcohol, and other drugs illustrate the specific and unique ways in which the brain and the central nervous system interact with, and are affected by, each of these substances Erickson discusses current and emerging treatments for chemical dependence, and how neuroscience helps us understand the way they work. The intent is to encourage an understanding of the body-mind connection. The busy clinical practitioner will find the chapter on how to read and interpret new research findings on the neurobiological basis of addiction useful and illuminating. This book will help the almost 21.6 million Americans, and millions more worldwide, who abuse or are dependent on drugs by teaching their caregivers (or them) about the latest addiction science research. It is also intended to help addiction professionals understand the foundations and applications of neuroscience, so that they will be able to better empathize with their patients and apply the science to principles of treatment.

Cocaine and Methamphetamine Dependence

Thomas R. Kosten
Cocaine and Methamphetamine Dependence Book PDF

Author : Thomas R. Kosten
Publisher : American Psychiatric Pub
Page : 236 pages
File Size : 45,8 Mb
Release : 2012
Category : Medical
ISBN : 9781585624072

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Cocaine and Methamphetamine Dependence by Thomas R. Kosten Pdf

This volume provides a summary of the most current information about stimulant dependence and its treatment. In addition, it sheds light on how the epidemiology of cocaine, amphetamine and methamphetamine abuse and dependence have substantial differences in geographic distribution, and how treatments are evolving to help these complex patients benefit from emerging pharmacological and behavioral therapies. Also, the editors provide literature that discusses, among many topics: the recent shift to more humane responses within the criminal justice system that is useful in obtaining treatment for the estimated 1.6 million cocaine and half-million methamphetamine users who abuse these drugs each day in the U.S., and also key treatment considerations, such as HIV comorbidity and polydrug abuse.

Neurobiology of Addiction

George F. Koob,Michel Le Moal
Neurobiology of Addiction Book PDF

Author : George F. Koob,Michel Le Moal
Publisher : Elsevier
Page : 503 pages
File Size : 42,5 Mb
Release : 2005-11-11
Category : Psychology
ISBN : 9780080497372

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Neurobiology of Addiction by George F. Koob,Michel Le Moal Pdf

Neurobiology of Addiction is conceived as a current survey and synthesis of the most important findings in our understanding of the neurobiological mechanisms of addiction over the past 50 years. The book includes a scholarly introduction, thorough descriptions of animal models of addiction, and separate chapters on the neurobiological mechanisms of addiction for psychostimulants, opioids, alcohol, nicotine and cannabinoids. Key information is provided about the history, sources, and pharmacokinetics and psychopathology of addiction of each drug class, as well as the behavioral and neurobiological mechanism of action for each drug class at the molecular, cellular and neurocircuitry level of analysis. A chapter on neuroimaging and drug addiction provides a synthesis of exciting new data from neuroimaging in human addicts — a unique perspective unavailable from animal studies. The final chapters explore theories of addiction at the neurobiological and neuroadaptational level both from a historical and integrative perspective. The book incorporates diverse finding with an emphasis on integration and synthesis rather than discrepancies or differences in the literature. · Presents a unique perspective on addiction that emphasizes molecular, cellular and neurocircuitry changes in the transition to addiction · Synthesizes diverse findings on the neurobiology of addiction to provide a heuristic framework for future work · Features extensive documentation through numerous original figures and tables that that will be useful for understanding and teaching

Drugs and the Neuroscience of Behavior

Adam Prus
Drugs and the Neuroscience of Behavior Book PDF

Author : Adam Prus
Publisher : SAGE Publications
Page : 1278 pages
File Size : 40,5 Mb
Release : 2017-02-06
Category : Psychology
ISBN : 9781506338958

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Drugs and the Neuroscience of Behavior by Adam Prus Pdf

The up-to-date Second Edition presents an accessible introduction to the rapidly advancing field of psychopharmacology through an examination of how drug actions in the brain affect psychological processes. To help readers develop an appreciation of the development of drug treatments and neuroscience over time, the book provides historical background, covering major topics in psychopharmacology, including discussion on newer drugs and recent trends in drug use. Pedagogical features at the forefront of the latest scholarship of teaching and learning are integrated throughout the text to ensure readers are able to easily process and understand the material.

Cocaine Abuse

Stephen T. Higgins,Jonathan L. Katz
Cocaine Abuse Book PDF

Author : Stephen T. Higgins,Jonathan L. Katz
Publisher : Academic Press
Page : 471 pages
File Size : 55,8 Mb
Release : 1998-09-09
Category : Psychology
ISBN : 9780080529264

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Cocaine Abuse by Stephen T. Higgins,Jonathan L. Katz Pdf

Cocaine abuse remains a major public health problem and contributes to many of our most disturbing social problems, including the spread of infectious disease, crime, violence, and neonatal drug exposure. Cocaine abuse results from a complex interplay of behavioral, pharmacological, and neurobiological determinants. While a complete understanding of cocaine abuse is currently beyond us, significant progress has been made in preclinical research on fundamental determinants of this disorder. These advances are critically reviewed in the first section of this volume. Important advances also have been made in characterizing the clinical pharmacology of cocaine, and those advances have been extended to understanding individual vulnerability to cocaine abuse, development of effective treatments, and discussions of policy. Those advances are critically reviewed in the third section of this volume. Contributors to the book were selected because of their status as internationally recognized leaders in their respective areas of scientific expertise. Moreover, each is a proponent of the importance of a rigorous, interdisciplinary scientific approach to effectively addressing the problem of cocaine abuse. As such, this volume offers a coherent, empirically-based conceptual framework for addressing cocaine abuse that has continuity from the basic research laboratory through the clinical and policy arenas. Each of the specific chapters is sufficiently detailed, in-depth and current to be valuable to informed readers with specific interests while also offering a comprehensive overview for those who might be less informed or have broader interests in cocaine abuse. This blend of critical review within each chapter with an explicitly conceptual continuity that spans all of the chapters makes this volume a unique contribution to cocaine abuse in particular and substance abuse in general. Discusses cocaine abuse within the context of current principles of psychology, pharmacology, neuroscience, genetics and epidemiology Chapters are all authored by scientific experts First of its kind book on cocaine abuse to recognize behavioral/environmental determinants Coverage is comprehensive Informative for experts and generalists alike

Cocaine Addiction

Jerome J. Platt
Cocaine Addiction Book PDF

Author : Jerome J. Platt
Publisher : Harvard University Press
Page : 496 pages
File Size : 41,9 Mb
Release : 1997
Category : Medical
ISBN : 0674001788

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Cocaine Addiction by Jerome J. Platt Pdf

It inspired written testimonials from William McKinley, Thomas Edison, and Sarah Bernhardt; merited a medal from Pope Leo XIII; produced "exhilaration and lasting euphoria" in Sigmund Freud. Once the stimulant of choice of the enlightened and the elite, cocaine has become, a century later, a plague, ravaging the lives of millions. This book is the first to draw together all the facts about this pervasive drug--from its natural occurrence in a tea-like native South American plant to its devastating appearance as crack in the inner cities of the United States. Drawing on the latest work in medicine, psychiatry, neuroscience, pharmacology, epidemiology, social work, and sociology, the volume is a highly accessible reference on the history and use of cocaine, its physical and psychological effects, and the etiology and epidemiology of cocaine addiction. It also provides a critical evaluation of the pharmaceutical agents and psychosocial interventions that have been used to treat this addiction. Author Jerome J. Platt answers such basic questions as: What is cocaine? What forms does it come in? How is it administered? What does it do? What are the medical complications of cocaine addiction? What are the treatments, and how successful are they? Uniquely comprehensive, Cocaine Addiction makes all the latest information on this urgent subject readily available to medical professionals and practitioners, social workers and scholars, and anyone who cares to know more about this perennially troubling drug.

Pathways of Addiction

Institute of Medicine,Committee on Opportunities in Drug Abuse Research
Pathways of Addiction Book PDF

Author : Institute of Medicine,Committee on Opportunities in Drug Abuse Research
Publisher : National Academies Press
Page : 330 pages
File Size : 47,9 Mb
Release : 1996-11-01
Category : Medical
ISBN : 9780309055338

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Pathways of Addiction by Institute of Medicine,Committee on Opportunities in Drug Abuse Research Pdf

Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.

Dealing with Privilege

David Crawford
Dealing with Privilege Book PDF

Author : David Crawford
Publisher : Rowman & Littlefield
Page : 179 pages
File Size : 46,6 Mb
Release : 2019-06-25
Category : Social Science
ISBN : 9781498598170

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Dealing with Privilege by David Crawford Pdf

Dealing with Privilege: Cannabis, Cocaine, and the Economic Foundations of Suburban Drug Culture focuses on the careers of nine successfully retired drug dealers, offering a contrast to sociological, criminological, and other depictions of drug dealing as a realm of the desperate, dangerous, and poor. David Crawford tells the great untold story of drug dealing in America, where white, middle-class dealers are unlikely to suffer the enforcement of drug laws. Contrary to media portrayals, Crawford argues that suburban drug sales are not oriented around money making but friendship and fun. Using economic anthropology, classic sociology, and neuroscience to analyze the life trajectories of these dealers, Crawford touches on issues of crime, race, culture, aging, gender, privilege, illegal drugs, and the limits of conventional economics as a framework to understand economic behavior.