The Physiological Genomics Of The Critically Ill Mouse

Author : Can Ince
Publisher : Springer Science & Business Media
Page : 555 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461504832

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The Physiological Genomics of the Critically Ill Mouse by Can Ince Pdf

The physiological genomics of the cardiovascular system studies the relationship between gene and physiological (dys)function. It is a rapidly developing area of research and distinguishes itself from other areas of molecular medicine by its highly integrative nature. In this multi disciplinarian area of the physiological sciences, there is interaction between gene structure and physiological cardiovascular function as well as interactions between the different organs and their physiological compartments. The mouse has played a central role in the study of genomics due to the detailed knowledge of the mouse genome and the wide availability of genetically modified mice. In the past, the mouse had mainly been used in the area of immunology and molecular biology, and physiological interest in the mouse was scarce. As more insight has come into the structural genomics of the mouse, however, it has become increasingly important to understand the relation between gene and physiological function. With this in mind we have been organizing the Amsterdam Mouse Symposia to bring together different disciplines interested in the molecular basis of cardiovascular function (see J. of Clinical and Exp. Pharmacology and rd Physiology (2002) 29:A69-AI02 for the proceedings of the 3 Amsterdam Mouse Symposium and Basic Research in Cardiology (2000) 95:492-535 for nd the proceedings of the 2 symposium).

Author : Paul Flecknell
Publisher : Academic Press
Page : 350 pages
File Size : 51,8 Mb
Release : 2015-09-21
Category : Science
ISBN : 9780128005781

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Laboratory Animal Anaesthesia by Paul Flecknell Pdf

Laboratory Animal Anaesthesia, Fourth Edition provides a basic guide to anaesthesia for a very diverse audience needing content, with straight-forward, structured style of writing. Updated with effects of anaesthetics in different laboratory species, including sources of dose rates will be incorporated into tabular material. New information on pain assessment and pain management will be covered, and an increased emphasis on rats and mice for anaesthesia and perioperative care. With newly revised, full color illustrations to facilitate best learning, Laboratory animal Anesthesia, Fourth Edition provides procedures, key points and invaluable advice from a well-known and respected veterinary anesthetist and scientist with over 30 years of experience in the field. Written by a veterinary anesthetist and scientist with over 30 years' experience in the field, and who is actively engaged in research in this area Focuses on procedures involving rats and mice used in research Provides those with limited experience of anesthesia with the information they need to carry our procedures effectively, safely, and humanely, as well as those with more experience to continue a career with laboratory animal model research Includes rapid, easily accessed information using tabulated summaries

Author : Edward D. Frohlich,Richard Noel Re
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 46,7 Mb
Release : 2006
Category : Cardiology
ISBN : 0387278257

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The Local Cardiac Renin-Angiotensin Aldosterone System by Edward D. Frohlich,Richard Noel Re Pdf

Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system.Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest.Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION.Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

Author : Toshio Nishikimi
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 49,6 Mb
Release : 2005-04-28
Category : Medical
ISBN : 0387254048

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Adrenomedullin in Cardiovascular Disease by Toshio Nishikimi Pdf

Adrenomedullin was discovered in 1993 in an extract of human pheochromocytoma while monitoring cAMP levels in rat platelets. Adrenomedullin has attracted considerable interest among cardiologists due to its impact on the cardiovascular system which includes a decrease in blood pressure in vivo; an impact on vascular smooth muscle cells; increases cAMP levels; indirectly reduces blood pressure and has a role in the pathogenesis of arteriosclerosis. Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology, pathophysiology of cardiovascular disease and clinical applications of adrenomedullin to cardiovascular disease. Toshio Nishikimi, MD, PhD, is an Associate Professor in the Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.

Author : Nico Westerhof,Nikos Stergiopulos,Mark I.M. Noble
Publisher : Springer Science & Business Media
Page : 182 pages
File Size : 44,8 Mb
Release : 2006-01-12
Category : Medical
ISBN : 9780387233468

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Snapshots of Hemodynamics by Nico Westerhof,Nikos Stergiopulos,Mark I.M. Noble Pdf

Hemodynamics makes it possible to characterize in a quantitative way, the function of the heart and arterial system, thereby producing information about what genetic and molecular processes are of importance for cardiovascular function. Snapshots of Hemodynamics: An Aid for Clinical Research and Graduate Education by Nico Westerhof, Nikos Stergiopulos and Mark I. M. Noble is a quick reference guide designed to help basic and clinical researchers as well as graduate students to understand hemodynamics. The layout of the book provides short and independent chapters that provide teaching diagrams as well as clear descriptions of the essentials of basic and applied principles of hemodynamics. References are provided at the end of each chapter for further reading and reference.

Author : Dennis V. P. Cokkinos,C. Pantos,Gerd Heusch,H. Taegtmeyer
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 44,6 Mb
Release : 2006-03-08
Category : Medical
ISBN : 9780387286587

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Myocardial Ischemia by Dennis V. P. Cokkinos,C. Pantos,Gerd Heusch,H. Taegtmeyer Pdf

Effective new treatments of heart disease are based on a refined understanding of cellular function and the heart's response to environmental stresses. Not surprisingly therefore, the field of experimental cardiology has experienced a phase of rapid expo nential growth during the last decade. The acquisition of new knowledge has been so fast that textbooks of cardiology or textbooks of cardiovascular physiology are often hard-pressed to keep up with the most important conceptual advances. Witness the explosive increase in knowledge about signaling pathways of cardiac growth, transcrip tional regulation of cardiac metabolism, hormonal signaling, and the complex responses of the heart to ischemia, reperfusion, or ischemic preconditioning. This book is meant to bridge the gap between original literature and textbook reviews. It brings together inves tigators of various backgrounds who share their expertise in the biology of myocardial ischemia. Each chapter is a self-contained mini-review, but it will soon become apparent to the reader that there is also a common thread: Molecular and cellular cardiology has never been more exciting than now, but ever more exciting times are yet to come. The Editors ACKNOWLEDGEMENTS - Publication of this book was generously supported by Sanofi-Aventis Hellas. - Eikon creative team provided the technical assistance in preparing the manuscripts. - We thank Dr. Bernard Swynghedauw for all his scientific support.

Author : P. Michael Conn
Publisher : Springer Science & Business Media
Page : 756 pages
File Size : 55,6 Mb
Release : 2008-03-07
Category : Medical
ISBN : 9781597452854

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Sourcebook of Models for Biomedical Research by P. Michael Conn Pdf

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Author : Michael R. Pinsky,Didier Payen
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 45,9 Mb
Release : 2005-08-11
Category : Medical
ISBN : 9783540269007

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Functional Hemodynamic Monitoring by Michael R. Pinsky,Didier Payen Pdf

This is the newest volume in the softcover series "Update in Intensive Care Medicine". It takes a novel, practical approach to analyzing hemodynamic monitoring, focusing on the patient and outcomes based on disease, treatment options and relevance of monitoring to direct patient care. It will rapidly become a classic in the approach to patient monitoring and management during critical illness.

Author : Arthur James Wells
Publisher : Unknown
Page : 1382 pages
File Size : 51,7 Mb
Release : 2004
Category : Bibliography, National
ISBN : UOM:39015057956560

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The British National Bibliography by Arthur James Wells Pdf

Author : Richard Polin,Steven H. Abman,David H. Rowitch,William Benitz
Publisher : Elsevier Health Sciences
Page : 2555 pages
File Size : 54,6 Mb
Release : 2021-07-29
Category : Medical
ISBN : 9780323712859

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Fetal and Neonatal Physiology by Richard Polin,Steven H. Abman,David H. Rowitch,William Benitz Pdf

Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today’s busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice. It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Contains new chapters on Pathophysiology of Genetic Neonatal Disease, Genetic Variants and Neonatal Disease, and Developmental Biology of Lung Stem Cells, as well as significantly revised chapters on Cellular Mechanisms of Neonatal Brain Injury, Neuroprotective Therapeutic Hypothermia, Enteric Nervous System Development and Gastrointestinal Motility, and Physiology of Twin-Twin Transfusion. Features 1,000 full-color diagrams, graphs and anatomic illustrations, 170+ chapters, and more than 350 global contributors. Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout. Provides summary boxes at the end of each chapter and extensive cross-referencing between chapters for quick reference and review. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 41,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Anonim
Publisher : Unknown
Page : 1206 pages
File Size : 40,5 Mb
Release : 2006
Category : American literature
ISBN : UOM:39015066180392

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American Book Publishing Record by Anonim Pdf

Author : Webb
Publisher : Oxford University Press
Page : 1961 pages
File Size : 48,9 Mb
Release : 2020-01-10
Category : Medical
ISBN : 9780198855439

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Oxford Textbook of Critical Care by Webb Pdf

Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 49,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Norbert Voelkel,Sharon Rounds
Publisher : John Wiley & Sons
Page : 532 pages
File Size : 55,9 Mb
Release : 2009-08-25
Category : Medical
ISBN : 0470747501

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The Pulmonary Endothelium by Norbert Voelkel,Sharon Rounds Pdf

The Pulmonary Endothelium is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals – specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.