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This title examines the history of biotechnology when it was new, especially when synonymous with recombinant DNA technology. It focuses on the academic community in the San Francisco Bay Area where recombinant DNA technology was developed and adopted as the first major commercial technology for genetic engineering at Stanford in the 1970s. The book argues that biotechnology was initially a hybrid creation of academic and commercial institutions held together by the assumption of a positive relationship between private ownership and the public interest.
With a Foreword writer Sydney Brenner (Nobel laureate in Physiology or Medicine, 2002) This biography details the life of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's life from birth, in 1926, to the present, with special emphasis on his enormous scientific contributions, including being the first to develop technology that led to gene cloning science. In 1980, Berg received a Nobel Prize in chemistry for this work. In addition to his contributions in the research laboratory, Berg orchestrated and oversaw a historic meeting at Asilomar, California that centered on a threatening controversy surrounding the perception by some of the harmful potential of recombinant DNA technology. This meeting did much to forestall this controversy and to put in place the regulation of recombinant DNA work, thus putting fears to rest. The recombinant DNA controversy was a historic outcome of the discovery of gene cloning. Notably, it represented a paramount example of scientific foresight and due diligence by the scientific community, rather than by regulatory entities in the United States and many other countries. The ultimate acceptance of gene/DNA cloning led to a new era of modern biology that thrives to the present. This book is aimed primarily at scientists and those in training. The book strives to simply provide information for the general reader, but is not specifically tailored for a general reading audience. While many books cover the recombinant DNA controversy, none have satisfactorily addressed this historic period and are often contradictory about the many who's, where's, and why's involved. Additionally, the great majority of these were written by non-scientists. This biography of Paul Berg provides access to numerous archived letters and documents at Stanford University not previously addressed, and to the chronology of events as recalled and documented by him, as well as other key personalities, many of whom were interviewed. Contents:Part I:Growing Up in BrooklynThe Essential Paul BergCollege — and World War IIWestern Reserve UniversityCopenhagenPart II:Washington University, St. LouisDiscovering Transfer RNAStanford University — and Its Refurbished Department of BiochemistryTranscription and Translation: New DirectionsPart III:Making Recombinant DNA — The First Faltering StepsMaking Recombinant DNA — A Major BreakthroughEcoRI Restriction Endonuclease — A Major Breakthrough“Coincidence is the Word We Use When We Can't See the Levers and Pulleys”Yet Another Stanford ContributionPart IV:An Historic Meeting in HawaiiThe Recombinant DNA ControversyA Momentous Gordon Research ConferenceMaking Recombinant Molecules with Frog DNAThe Controversy Heats UpAsilomar IIThe Dissenters: A Different Point of ViewThe AftermathLegislative and Revisionist Challenges to Recombinant DNAAsilomar II — Lessons LearnedPart V:The Nobel Prize in ChemistryCommercializing the TechnologyLife Goes onThe “Retirement” YearsPublic Policy Issues — and Other InterestsPersonal Challenges Readership: Researchers, graduate students, undergraduates in life sciences, medicine and chemistry and interested lay public. Keywords:Recombinant DNA;Paul Berg;Stanford University;Errol Friedberg;DNA;tRNA;Asilomar Meeting Western Reserve University;Stanley Cohen Gene Cloning;Nobel PrizeReviews: “This is a great and very readable story of a renowned biochemist moving outside his comfort zone to provide needed leadership at a time of national turmoil. Friedberg takes us from Berg's beginnings in Brooklyn in an immigrant Yiddish-speaking family to his receipt of the Nobel Prize. He also describes Berg's guidance of a process of public acceptance of a revolutionary scientific advance — Recombinant DNA technology — that appeared to be hazardous because it was so innovative. The book reads easily, with enough technical discussion to be informative without being too demanding. It also includes an insightful investigation of the mystery of who actually deserves credit for making the technology a reality, which will fascinate other scientists and anyone who cares about the history of science and technology.” David Baltimore Nobel Laureate “Friedberg's book is a valuable addition to the literature on the scientific development of recombinant DNA technology, particularly the interactions among the numerous scientists involved who jockeyed for priority. It also details the life and times of one of the most outstanding biochemists this country has ever produced. ” DNA Repair
Institute of Medicine,Committee on Technological Innovation in Medicine
Author : Institute of Medicine,Committee on Technological Innovation in Medicine Publisher : National Academies Press Page : 254 pages File Size : 43,6 Mb Release : 1995-01-01 Category : Medical ISBN : 9780309176682
Sources of Medical Technology by Institute of Medicine,Committee on Technological Innovation in Medicine Pdf
Evidence suggests that medical innovation is becoming increasingly dependent on interdisciplinary research and on the crossing of institutional boundaries. This volume focuses on the conditions governing the supply of new medical technologies and suggest that the boundaries between disciplines, institutions, and the private and public sectors have been redrawn and reshaped. Individual essays explore the nature, organization, and management of interdisciplinary R&D in medicine; the introduction into clinical practice of the laser, endoscopic innovations, cochlear implantation, cardiovascular imaging technologies, and synthetic insulin; the division of innovating labor in biotechnology; the government- industry-university interface; perspectives on industrial R&D management; and the growing intertwining of the public and proprietary in medical technology.
Examines the history and current status of genetic research of recombinant DNA and discusses the controversy regarding the benefits and dangers of gentic engineering.
Author : Henry R. Bourne Publisher : University of California Press Page : 0 pages File Size : 51,9 Mb Release : 2011 Category : Genetics ISBN : 0983463921
"In less than a decade, scientists at the University of California San Francisco (UCSF) learned how to clone DNA, founded the company that created the field of biotechnology, identified the first cancer genes, and made the heretical discovery that a protein by itself can transmit an infectious disease. The discoveries of Herbert Boyer, Michael Bishop, Harold Varmus, and Stanley Prusiner show that real innovators require freedom and time to tackle hard problems in their own way."--P. [4] of cover.
Manipulation and Expression of Recombinant DNA by Sue Carson,Dominique Robertson Pdf
This manual is an indispensable tool for introducing advanced undergraduates and beginning graduate students to the techniques of recombinant DNA technology, or gene cloning and expression. The techniques used in basic research and biotechnology laboratories are covered in detail. Students gain hands-on experience from start to finish in subcloning a gene into an expression vector, through purification of the recombinant protein.The second edition has been completely re-written, with new laboratory exercises and all new illustrations and text, designed for a typical 15-week semester, rather than a 4-week intensive course. The “project approach to experiments was maintained: students still follow a cloning project through to completion, culminating in the purification of recombinant protein. It takes advantage of the enhanced green fluorescent protein—students can actually visualize positive clones following IPTG induction. *Cover basic concepts and techniques used in molecular biology research labs*Student-tested labs proven successful in a real classroom laboratories*Exercises simulate a cloning project that would be performed in a real research lab*"Project" approach to experiments gives students an overview of the entire process*Prep-list appendix contains necessary recipes and catalog numbers, providing staff with detailed instructions
Recombinant DNA: Science, Ethics, and Politics emerged from papers presented at a conference, Ethical and Methodological Dimensions of Scientific Research: Recombinant DNA, A Case Study, held at the University of Georgia, April 15-16, 1977. Starting with an introduction to the methods and uses of recombinant DNA technology, the remaining contributions made by researchers at the symposium are organized into four parts. The first part contains papers on the development and utilization of recombinant DNA technology; genetic engineering in agriculture; and the dangers of unrestricted research. The second part focuses on the ethical aspects of recombinant DNA research. It includes studies such as ethical prerequisites for examining biological research; the limitations of broad moral policies; and ethical theories underlying the recombinant DNA controversy. The third part examines the legal aspects of recombinant DNA research and examines the issue of whether such research should be regulated. The papers in the fourth part consider directors for future research.
Issues in Biotechnology and Medical Technology Research and Application: 2013 Edition by Anonim Pdf
Issues in Biotechnology and Medical Technology Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Biotechnology. The editors have built Issues in Biotechnology and Medical Technology Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biotechnology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biotechnology and Medical Technology Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Final Environmental Impact Statement on NIH Guidelines for Research Involving Recombinant DNA Molecules: Appendices by National Institutes of Health (U.S.) Pdf
Cells—Advances in Research and Application: 2012 Edition by Anonim Pdf
Cells—Advances in Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cells. The editors have built Cells—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cells—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
