The Role Of Nitric Oxide In Type 2 Diabetes

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The Role of Nitric Oxide in Type 2 Diabetes

Asghar Ghasemi,Khosrow Kashfi,Zahra Bahadoran
The Role of Nitric Oxide in Type 2 Diabetes Book PDF

Author : Asghar Ghasemi,Khosrow Kashfi,Zahra Bahadoran
Publisher : Bentham Science Publishers
Page : 386 pages
File Size : 46,5 Mb
Release : 2022-12-01
Category : Medical
ISBN : 9789815079821

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The Role of Nitric Oxide in Type 2 Diabetes by Asghar Ghasemi,Khosrow Kashfi,Zahra Bahadoran Pdf

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by impaired glucose metabolism and pancreatic β-cell dysfunction. No effective treatments are available for T2D, although there have been many developments in the therapeutic arena. Nitric oxide (NO) is an endocrine agent with multiple and important biological roles in most mammalian tissues. NO has emerged as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in T2D. Several of the pharmaceuticals used in T2D affect the NO system and perhaps even more so by the drugs we use to treat diabetic cardiovascular complications. Experimental works in animal models of T2D show promising results with interventions aimed to increase NO signaling. However, translation into human studies has so far been less successful, but more large-scale prolonged studies are clearly needed to understand its role. This book is a collection of reviews that deal with the role of nitric oxide in type 2 diabetes, providing a unique overview of NO signaling, and pointing out key areas for more detailed research. The book includes contributions about the pathophysiology of T2D, a brief history of discovery and timeline of NO research, a comprehensive overview of impaired NO metabolism in T2D, precursors of NO (i.e., L-arginine, L-citrulline, nitrate, nitrites, and NO donors), NO and T2D from genetic points of view, NO and diabetic wound healing, NO and osteoporosis, NO and hyperuricemia, NO and Alzheimer’s Disease, therapeutic applications of NO and NO donors in T2D. The compilation is of great value to anyone interested in the biochemistry of NO and its relationship to diabetes.

Diabetes and Hypertension

Samy I. McFarlane,George L. Bakris
Diabetes and Hypertension Book PDF

Author : Samy I. McFarlane,George L. Bakris
Publisher : Springer Science & Business Media
Page : 196 pages
File Size : 42,6 Mb
Release : 2012-10-19
Category : Medical
ISBN : 9781603273572

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Diabetes and Hypertension by Samy I. McFarlane,George L. Bakris Pdf

Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.

Type 2 Diabetes

Claire J. Stocker
Type 2 Diabetes Book PDF

Author : Claire J. Stocker
Publisher : Humana
Page : 0 pages
File Size : 50,5 Mb
Release : 2019-10-05
Category : Science
ISBN : 1493998803

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Type 2 Diabetes by Claire J. Stocker Pdf

This second edition volume expands on the previous editions with updates on the commonly used techniques and analysis used by clinicians and scientists to study diabetes. The chapters in this book cover topics such as nutritional models of type 2 diabetes mellitus; the isolation and purification of rodent pancreatic islets of Langerhans; nitric oxide and redox state measurements in pancreatic beta cells; and primary adipocytes as a model for insulin sensitivity. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Type 2 Diabetes: Methods and Protocols, Second Edition is a valuable resource for all researchers who are interested in learning more about this important and evolving field.

Endothelial Dysfunction

Helena Lenasi
Endothelial Dysfunction Book PDF

Author : Helena Lenasi
Publisher : BoD – Books on Demand
Page : 432 pages
File Size : 43,9 Mb
Release : 2018-10-24
Category : Medical
ISBN : 9781789842531

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Endothelial Dysfunction by Helena Lenasi Pdf

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Diabetes and Cardiovascular Disease

Michael T. Johnstone,Aristidis Veves
Diabetes and Cardiovascular Disease Book PDF

Author : Michael T. Johnstone,Aristidis Veves
Publisher : Springer Science & Business Media
Page : 645 pages
File Size : 52,9 Mb
Release : 2007-10-28
Category : Medical
ISBN : 9781592599080

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Diabetes and Cardiovascular Disease by Michael T. Johnstone,Aristidis Veves Pdf

The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.

Nitric Oxide

Louis J. Ignarro
Nitric Oxide Book PDF

Author : Louis J. Ignarro
Publisher : Academic Press
Page : 1017 pages
File Size : 44,8 Mb
Release : 2000-09-13
Category : Science
ISBN : 0080525032

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Nitric Oxide by Louis J. Ignarro Pdf

Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense

Type 2 Diabetes

Robert Fried,Richard M. Carlton
Type 2 Diabetes Book PDF

Author : Robert Fried,Richard M. Carlton
Publisher : CRC Press
Page : 800 pages
File Size : 42,7 Mb
Release : 2018-10-25
Category : Health & Fitness
ISBN : 9780429016769

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Type 2 Diabetes by Robert Fried,Richard M. Carlton Pdf

Approximately 29 million Americans are diagnosed with Type 2 diabetes annually. Of that number, only about 36 percent (10.44 million diabetes sufferers) achieve satisfactory medical outcomes and would need additional help—rarely available—to reliably control their glucose levels. Contrary to popular belief, although anti-diabetic medications can lower sugar levels, nevertheless they have a poor performance track record because inflammation in the blood vessels persists. This book details recent scientific findings that cardiovascular, kidney, vision, peripheral nervous system, and other body damage caused by chronic high levels of blood sugar (hyperglycemia) in Type 2 diabetes is actually due to excessive generation of unopposed free radicals and reactive oxygen species (ROS). These, in turn, cause chronic systemic inflammation and dysfunction of the endothelial lining of the arterial blood vessels, jeopardizing the formation of the protective molecule nitric oxide (NO), thus severely impairing the blood supply to every organ and tissue in the body. This book also catalogues the evidence that chronic hyperglycemia causes profound and often irreversible damage—even long before Type 2 diabetes has been diagnosed. In addition, because conventional prescription treatments are, unfortunately, often inadequate, the book details evidence-based complementary means of blood sugar control.

The Role of Nitric Oxide in Heart Failure

Bodh I. Jugdutt
The Role of Nitric Oxide in Heart Failure Book PDF

Author : Bodh I. Jugdutt
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 45,6 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9781402079603

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The Role of Nitric Oxide in Heart Failure by Bodh I. Jugdutt Pdf

Research on nitric oxide (NO) is a very hot topic since 1998, when three prominent researchers were recognized by Nobel prize awards. Addresses clinically pertinent issues related to nitric oxide in the pathophysiology and therapeutics of heart failure. Chapters written by basic scientists and clinicians to emphasize translation character of research in nitric oxide. An excellent reference source for researchers, practitioners and students.

Type 2 Diabetes

Barry J. Goldstein,Dirk Mueller-Wieland
Type 2 Diabetes Book PDF

Author : Barry J. Goldstein,Dirk Mueller-Wieland
Publisher : CRC Press
Page : 610 pages
File Size : 48,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9780849379581

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Type 2 Diabetes by Barry J. Goldstein,Dirk Mueller-Wieland Pdf

The incidence and prevalence of type 2 diabetes mellitus have increased dramatically in modernized and developing nations over the past few decades. Thoroughly revised and expanded, this Second Edition responds to the epidemic and supplies a current overview and guide to the management of diabetes in the modern healthcare environment. This Second E

Role of Oxidative Stress in Chronic Diseases

Isaias Dichi,José Wander Breganó,Andréa Name Colado Simão,Rubens Cecchini
Role of Oxidative Stress in Chronic Diseases Book PDF

Author : Isaias Dichi,José Wander Breganó,Andréa Name Colado Simão,Rubens Cecchini
Publisher : CRC Press
Page : 716 pages
File Size : 43,7 Mb
Release : 2014-03-14
Category : Medical
ISBN : 9781482216820

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Role of Oxidative Stress in Chronic Diseases by Isaias Dichi,José Wander Breganó,Andréa Name Colado Simão,Rubens Cecchini Pdf

This book presents recent findings on the role of oxidative stress in chronic diseases. Understanding the mechanisms behind it enables readers to comprehend the rationale which underlies intervention in such conditions. The book places special emphasis on genetic polymorphism-an important issue related to this field of study. It covers the role of

Diabetes

Victor R Preedy
Diabetes Book PDF

Author : Victor R Preedy
Publisher : Academic Press
Page : 289 pages
File Size : 41,6 Mb
Release : 2013-10-29
Category : Medical
ISBN : 9780124055223

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Diabetes by Victor R Preedy Pdf

Diabetes: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide among diabetologists, endocrinologists, and nutritionists in understanding and treating diabetes. The book covers, in a single volume, the science of oxidative stress in diabetes and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, receptor-mediated responses and more. This approach recognizes that diseases are usually multifactorial and that oxidative stress is a single component of this.Pharmacological treatments for diabetes are commonly marked by unwanted side effects, leading to treatment efforts using naturally occurring substances. But a plant-based approach alone is not sufficient; understanding the processes inherent in the oxidative stress of diabetes is vital for clinical workers, dietitians, and nutritionists.This translational work provides that understanding. The book begins by covering the basic biology of oxidative stress from molecular biology to imaging in relation to diabetes. There are chapters on neuropathy, nephropathy, atherosclerosis, cardiomyopathy, and retinopathy. The book then moves on to antioxidants in foods, including plants, components of the diet, and their relevance to diabetes. Nutritionists will use the information related to mitochondrial oxidative stress in one disease and propose new diet-related strategies to prevent such conditions arising in another unrelated disease Dietitians will prescribe new foods or diets containing antioxidants for conditions that are refractory by conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams Nutritionists and dietitians will learn about cell signaling and will be able to suggest preventive or therapeutic strategies with antioxidant-rich foods to reduce damage done by diseases involving abnormal cell signaling

Type 2 Diabetes and Dementia

Velandai Srikanth,Zoe Arvanitakis
Type 2 Diabetes and Dementia Book PDF

Author : Velandai Srikanth,Zoe Arvanitakis
Publisher : Academic Press
Page : 320 pages
File Size : 54,8 Mb
Release : 2018-02-09
Category : Medical
ISBN : 9780128096949

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Type 2 Diabetes and Dementia by Velandai Srikanth,Zoe Arvanitakis Pdf

Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology. Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinology Includes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications

Index Medicus

Anonim
Index Medicus Book PDF

Author : Anonim
Publisher : Unknown
Page : 1972 pages
File Size : 43,9 Mb
Release : 2003
Category : Medicine
ISBN : MINN:31951P00880597M

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Index Medicus by Anonim Pdf

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Diabetic Neuropathy

Aristidis Veves,Rayaz A. Malik
Diabetic Neuropathy Book PDF

Author : Aristidis Veves,Rayaz A. Malik
Publisher : Springer Science & Business Media
Page : 520 pages
File Size : 53,5 Mb
Release : 2008-02-01
Category : Medical
ISBN : 9781597453110

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Diabetic Neuropathy by Aristidis Veves,Rayaz A. Malik Pdf

In this updated edition, leading medical specialists critically review for the general practitioner the latest techniques for the clinical management of diabetic neuropathy. The contributors focus on the practical aspects of diabetic neuropathy and describe in detail the treatments that are currently available or expected to become available in the near future. They also include concise discussions of the pathogenesis of diabetic neuropathy.

The Endothelium

Michel Félétou
The Endothelium Book PDF

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 43,8 Mb
Release : 2011
Category : Science
ISBN : 9781615041237

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The Endothelium by Michel Félétou Pdf

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References