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Author : Jorge Manzanares,Maria S. Garcia-Gutierrez,Francisco Navarrete Rueda,Piotr Gałecki
Publisher : Frontiers Media SA
Page : 205 pages
File Size : 42,5 Mb
Release : 2021-09-14
Category : Medical
ISBN : 9782889713011
Author : Judith Pratt,Jeremy Hall
Publisher : Springer
Page : 437 pages
File Size : 50,6 Mb
Release : 2019-01-05
Category : Medical
ISBN : 9783319996424
This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.
Author : Michael S. Ritsner
Publisher : Springer Science & Business Media
Page : 233 pages
File Size : 43,8 Mb
Release : 2009-04-24
Category : Medical
ISBN : 9789048122981
Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.
Author : Michael Berk,Marion Leboyer,Iris E. Sommer
Publisher : Springer Nature
Page : 438 pages
File Size : 44,8 Mb
Release : 2021-08-14
Category : Medical
ISBN : 9783030712297
This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.
Author : Bernhard Baune
Publisher : Academic Press
Page : 604 pages
File Size : 50,9 Mb
Release : 2019-10-16
Category : Medical
ISBN : 9780128131770
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
Author : Willem Bruin
Publisher : Unknown
Page : 0 pages
File Size : 42,6 Mb
Release : 2024
Category : Electronic
ISBN : OCLC:1427502267
"Diagnosis in psychiatry relies on the subjective assessment of symptoms, both reported by patients and observed by clinicians. This purely symptom-based classification has its limitations. Patients with the same diagnosis express different symptoms, and there is considerable overlap in symptoms across different mental disorders, leading to the possibility of over- or misdiagnosis. Moreover, these diagnoses tell us little about the individual patient, as treatment guidelines tend to follow a one-size-fits-all approach that may not be effective for every patient, resulting in delayed or ineffective treatment for some. To address these issues, there has been a shift towards more objective approaches to diagnosis and personalized treatment in psychiatry . An important means to this end is the search for objective biomarkers , which are measurable characteristics that indicate normal (neuro)biological processes or responses to therapeutic intervention. These biomarkers could help clinicians make more evidence-based decisions that are tailored to individual patients, potentially leading to more efficient and effective psychiatric care. The aim of this thesis was to investigate whether machine learning techniques could be used to find generalizable biomarkers for various psychiatric disorders. We used neuroimaging data to develop diagnostic biomarkers for OCD, (trans)diagnostic biomarkers for anxiety disorders in juveniles, and biomarkers predictive for ECT treatment outcome in patients with depression. This thesis showed that machine learning techniques can be applied to predict diagnosis and treatment outcome with variable success. Future studies should carefully consider sources of heterogeneity to facilitate the development of more accurate and clinically relevant biomarkers, ultimately improving psychiatric care."--
Author : Patrick D. McGorry,Ian B. Hickie
Publisher : Cambridge University Press
Page : 301 pages
File Size : 44,7 Mb
Release : 2019-08-29
Category : Medical
ISBN : 9781108718844
Clinical staging is a solution to transform psychiatric diagnosis and improve mental health outcomes.
Author : Rodrigo Machado-Vieira,Jair Soares
Publisher : Academic Press
Page : 529 pages
File Size : 46,8 Mb
Release : 2022-01-16
Category : Medical
ISBN : 9780128213995
Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes), prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development. Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder. Describes strategies for the biomarker discovery of relevant proteins differentially expressed in Bipolar Disorder Presents techniques and main findings in transcriptome research related to CNS synaptic function Provides an overview on current behavioral strategies and their validity in drug development in Bipolar Disorder Discusses current genetic findings, integrating tests for treatments leading to personalized treatments
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 128 pages
File Size : 42,5 Mb
Release : 2008-01-08
Category : Medical
ISBN : 9780309178280
Biomarkers, or biological markers, are quantitative measurements that offer researchers and clinicians valuable insight into diagnosis, treatment and prognosis for many disorders and diseases. A major goal in neuroscience medical research is establishing biomarkers for disorders of the nervous system. Given the promising potential and necessity for neuroscience biomarkers, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened a public workshop and released the workshop summary entitled Neuroscience Biomarkers and Biosignatures: Converging Technologies, Emerging Partnerships. The workshop brought together experts from multiple areas to discuss the most promising and practical arenas in neuroscience in which biomarkers will have the greatest impact. The main objective of the workshop was to identify and discuss biomarker targets that are not currently being aggressively pursued but that could have the greatest near-term impact on the rate at which new treatments are brought forward for psychiatric and neurological disorders.
Author : Yong-Ku Kim
Publisher : Springer Nature
Page : 641 pages
File Size : 50,7 Mb
Release : 2019-11-09
Category : Science
ISBN : 9789813297210
This book reviews key recent advances and new frontiers within psychiatric research and clinical practice. These advances either represent or are enabling paradigm shifts in the discipline and are influencing how we observe, derive and test hypotheses, and intervene. Progress in information technology is allowing the collection of scattered, fragmented data and the discovery of hidden meanings from stored data, and the impacts on psychiatry are fully explored. Detailed attention is also paid to the applications of artificial intelligence, machine learning, and data science technology in psychiatry and to their role in the development of new hypotheses, which in turn promise to lead to new discoveries and treatments. Emerging research methods for precision medicine are discussed, as are a variety of novel theoretical frameworks for research, such as theoretical psychiatry, the developmental approach to the definition of psychopathology, and the theory of constructed emotion. The concluding section considers novel interventions and treatment avenues, including psychobiotics, the use of neuromodulation to augment cognitive control of emotion, and the role of the telomere-telomerase system in psychopharmacological interventions.
Author : Yogesh Dwivedi
Publisher : CRC Press
Page : 485 pages
File Size : 52,6 Mb
Release : 2012-06-25
Category : Medical
ISBN : 9781439838815
With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
Author : Leanne M. Williams, Ph.D.,Laura M. Hack, M.D., Ph.D.
Publisher : American Psychiatric Pub
Page : 302 pages
File Size : 50,8 Mb
Release : 2021-10-15
Category : Medical
ISBN : 9781615371587
Precision psychiatry, as outlined in this groundbreaking book, presents a new path forward. By integrating findings from basic and clinical neuroscience, clinical practice, and population-level data, the field seeks to develop therapeutic approaches tailored for specific individuals with a specific constellation of health issues, characteristics, strengths, and symptoms.
Author : Paul C. Guest
Publisher : Springer
Page : 328 pages
File Size : 55,6 Mb
Release : 2019-02-12
Category : Science
ISBN : 9783030055424
This book includes a series of reviews on general aspects of biomarker use in the study of psychiatric and neurodegenerative diseases and the development of medications involved in their treatment. It describes the pros and cons of the various approaches and covers the successes and failures in this research field. It is only by a thorough understanding of the shortcomings that progress can be made. The overall goal is to facilitate the understanding and treatment of these disorders, by providing a viable mechanism of catching up with other areas of modern medicine, such as diabetes and heart disease. Finally, it is anticipated that the development and application of valid biomarker tests and the leveraging of novel drug targets will help the fields of psychiatry on neurodegenerative disorders move into the area of personalized medicine where the right patients can receive the right medication at the right time for the best possible outcome.
Author : Joel Paris
Publisher : Oxford University Press, USA
Page : 241 pages
File Size : 50,7 Mb
Release : 2020
Category : Medical
ISBN : 9780197504277
"This book, now revised in a section edition, examines the problem of over-diagnosis in psychiatry, focusing on problems with current diagnostic systems. It will show that diagnosis is not always a good guide to treatment selection, and that diagnoses have bee expanded in scope to justify currently popular methods of pharmacotherapy or psychotherapy. The most important categories that are over-diagnosed are bipolar disorders, major depression, attention-deficit hyperactivity disorder, and post-traumatic stress disorder. The boundary of pathology and normality remains unclear. This edition will also discuss dimensional systems that are transdiagnostic, and show how over-diagnosis is linked to the practice of aggressive psychopharmacology"--
Author : Dennis S. Charney,Pamela B. Sklar,Eric J. Nestler,Joseph D. Buxbaum
Publisher : Oxford University Press
Page : 1025 pages
File Size : 53,6 Mb
Release : 2018
Category : Medical
ISBN : 9780190681425
Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.