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Author : Michael Balls,William Moy Stratton Russell,Rex Leonard Burch
Publisher : Unknown
Page : 0 pages
File Size : 46,6 Mb
Release : 2009
Category : Alternative toxicity testing
ISBN : 095017002X
Author : William Moy Stratton Russell,Rex Leonard Burch
Publisher : Hyperion Books
Page : 256 pages
File Size : 55,6 Mb
Release : 1992
Category : Nature
ISBN : CUB:U183070482379
Author : Edward N. Eadie
Publisher : Springer Science & Business Media
Page : 139 pages
File Size : 41,5 Mb
Release : 2012-08-31
Category : Medical
ISBN : 9783642305764
This book examines the contents, influence, and potential of a personal selection of modern books published over the last fifty years that have been relevant to improving welfare. The works selected comprise three earlier classics that mainly deal with animal experimentation and intensive farming, as well as five that concentrate on specific subject areas, namely history, science, applied ethics, politics and law, that are important to protecting the welfare of animals against suffering inflicted by humans. The books are arranged in the order of their publication date, and for each one a few related works are also mentioned or discussed. This collection provides a broad understanding of animal protection issues, and provides the necessary basis for an informed and comprehensive approach to improving the welfare of animals. The books selected have been influential and they have the potential to improve animal welfare in the future.
Author : Anonim
Publisher : Academic Press
Page : 352 pages
File Size : 50,5 Mb
Release : 2018-10-20
Category : Medical
ISBN : 9780128136980
The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Author : Mageshwaran Lakshmanan,Deepak Gopal Shewade,Gerard Marshall Raj
Publisher : Springer Nature
Page : 900 pages
File Size : 55,7 Mb
Release : 2022-11-15
Category : Medical
ISBN : 9789811953439
This volume is designed to impart the fundamental concepts in experimental pharmacology, research methodology and biostatistics. Through this book, the readers will learn about different methods involved in drug discovery, experimental animals and their care, equipments and the various bioassays used in experimental pharmacology. This book contains special sections on various drug screening methods involved in the evaluation of different body systems. Certain sections provide the healthcare professionals with the knowledge necessary to interpret clinical research articles, design clinical studies, and learn essential concepts in biostatistics in an expedient and concise manner. Basic principles and applications of simple analytical methods employed in drug analysis are well written under one section. It focuses on the basic and advanced laboratory techniques and also on computer simulated data, written extensively under the Biostatistics section. The methods used for drug analysis have been described in adequate detail with cross-references for further studies and comprehension. Overall, the book is designed systematically with four broad sections with extensive subdivisions for easy tracking, interpretation, and understanding.
Author : Kathryn Bayne,Patricia V. Turner
Publisher : Academic Press
Page : 336 pages
File Size : 41,5 Mb
Release : 2013-09-02
Category : Science
ISBN : 9780123851048
Laboratory Animal Welfare provides a comprehensive, up-to-date look into the new science of animal welfare within laboratory research. Animals specifically considered include rodents, cats and dogs, nonhuman primates, agricultural animals, avian animals and aquatic animals. The book examines the impact of experiment design and environment on animal welfare, as well as emergency situations and euthanasia practices. Readers will benefit from a review of regulations and policy guidelines concerning lab animal use, as well as information on assessing animal welfare. With discussions of the history and ethics of animals in research, and a debate on contemporary and international issues, this book is a go-to resource for laboratory animal welfare.
Author : Oliver Kayser,Heribert Warzecha
Publisher : John Wiley & Sons
Page : 677 pages
File Size : 47,7 Mb
Release : 2012-03-27
Category : Science
ISBN : 9783527651252
This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also the use of biopharmaceuticals in diagnostics and vaccinations. With a foreword by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at MIT and member of the National Academy of Engineering and the National Academy of Sciences.
Author : Kimberly Coates
Publisher : Enslow Publishing, LLC
Page : 232 pages
File Size : 48,8 Mb
Release : 2019-07-15
Category : Young Adult Nonfiction
ISBN : 9781978503847
Animal testing is a controversial issue, with some arguing it is essential to medical advancement and others stating it is cruel and unnecessary. In this book, articles from a variety of viewpoints and individuals, including scientists, government and legal professionals, media outlets, and ordinary citizens, highlight key areas of contention over animal testing. Questions at the end of each article encourage readers to think critically about what they have read and to form their own opinions on this important issue.
Author : Hajime Kojima,Troy Seidle,Horst Spielmann
Publisher : Springer
Page : 130 pages
File Size : 51,7 Mb
Release : 2018-12-27
Category : Medical
ISBN : 9789811324475
This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
Author : Anonim
Publisher : Unknown
Page : 380 pages
File Size : 54,8 Mb
Release : 2009
Category : Biological models
ISBN : UCLA:L0090618208
Author : David E. Newton
Publisher : Bloomsbury Publishing USA
Page : 341 pages
File Size : 48,5 Mb
Release : 2013-05-09
Category : Political Science
ISBN : 9781610693189
Reviewing the topic from antiquity to the present day, this book examines the debate over the use of animals in research in a fair and balanced way. The debate over the use of nonhuman animals in experimental research has gone on for centuries, and it continues as vigorously today as it ever has. In fact, in the last decade, the controversy has intensified, making animal testing a topic at the highest level of debate of any socioscientific issue in the United States. This book presents all sides of the issue so that readers can come to their own conclusions as to the morality and validity of animal experimentation, and provides biographies of individuals and descriptions of organizations that have been involved in the debate over the centuries. Additionally, it documents the historical shift in thinking that made animal experimentation commonplace between the time of the ancient Greeks and the 19th century, to the mindset of some who argue for an end to the practice and alternative ways of conducting medical experimentation to benefit human health.
Author : Heather A.E. Benson,Michael S. Roberts,Vania Rodrigues Leite-Silva,Kenneth Walters
Publisher : CRC Press
Page : 479 pages
File Size : 45,5 Mb
Release : 2019-04-05
Category : Medical
ISBN : 9781482235401
Cosmetics are the most widely applied products to the skin and include creams, lotions, gels and sprays. Their formulation, design and manufacturing ranges from large cosmetic houses to small private companies. This book covers the current science in the formulations of cosmetics applied to the skin. It includes basic formulation, skin science, advanced formulation, and cosmetic product development, including both descriptive and mechanistic content with an emphasis on practical aspects. Key Features: Covers cosmetic products/formulation from theory to practice Includes case studies to illustrate real-life formulation development and problem solving Offers a practical, user-friendly approach, relying on the work of recognized experts in the field Provides insights into the future directions in cosmetic product development Presents basic formulation, skin science, advanced formulation and cosmetic product development
Author : Anonim
Publisher : Unknown
Page : 70 pages
File Size : 46,8 Mb
Release : 1996
Category : Animal welfare
ISBN : UOM:39015038856442
Author : Erika Jensen-Jarolim
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 42,6 Mb
Release : 2013-12-09
Category : Science
ISBN : 9783709115596
This new volume provides a concise overview of the most basic and exciting chapters of comparative medicine with regards to physiology and function in healthy individuals. The book includes core concepts in anatomy and physiology in human and animal models, which are key to understanding comparative medicine and to making contributions to research in this area. While writing this book, the authors were in constant interdisciplinary dialogue. They aim to contribute to improvements in quality of life for human and animal patients.
Author : Uwe Marx,Volker Sandig
Publisher : John Wiley & Sons
Page : 318 pages
File Size : 54,8 Mb
Release : 2007-02-27
Category : Science
ISBN : 9783527609567
Here, expert scientists from industry and academia share their knowledge on the assembly of functional human tissues in vitro and how to design drug screenings predictive of human exposure. In so doing, they combine the latest technological developments with strategic outlooks, such as novel cell and tissue systems for drug screening and testing, as well as emerging in vitro culture technologies. Equally importantly, the book does not shy away from regulatory acceptance and ethical issues.