The Use Of Human Cells For The Evaluation Of Risk From Physical And Chemical Agents

Author : Amleto Castellani
Publisher : Springer Science & Business Media
Page : 794 pages
File Size : 45,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475711172

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The Use of Human Cells for the Evaluation of Risk from Physical and Chemical Agents by Amleto Castellani Pdf

In this volume are collected 30 papers, 9 round table discus sions and 11 communications presented at the ASI Course on "The use of human cells for the evaluation of risk from physical and chemical agents", sponsored by NATO and organized by ENEA. The aim of the Course was to present different scientific ap proaches and technical advices in order to get dose-effect relation ships which are the basis for risk evaluation. The scientific back ground which is behind this approach was extensively discussed. Emphasis has been given to the use of human cells or human data in order to attempt to have a correct and realistic evaluation of the damage in humans. There are many criticisms on the use of animal data for human risk evaluation because of differences between species and between strains within the same species: differences in metabolism, activa tion processes and DNA repair ability makes uncertain the extrapola tion of animal data to humans. Also data obtained using specific strains or highly inbred strains in order to reduce the variance are not applicable due to the heterogeneity of the human population connected with individual responses. In this respect only the use of human cells enable us to detect the individual variability and to identify sensitive subpopu lations that would be at greater risk. My appreciation to Pieranita and Alberto Castellani for the as sistance during the meeting and to Giuseppe Biondi for his help in some of the editorial work.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Possible Effects of Electromagnetic Fields on Biologic Systems
Publisher : National Academies Press
Page : 379 pages
File Size : 53,6 Mb
Release : 1997-03-18
Category : Science
ISBN : 9780309054478

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Possible Health Effects of Exposure to Residential Electric and Magnetic Fields by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Possible Effects of Electromagnetic Fields on Biologic Systems Pdf

Can the electric and magnetic fields (EMF) to which people are routinely exposed cause health effects? This volume assesses the data and draws conclusions about the consequences of human exposure to EMF. The committee examines what is known about three kinds of health effects associated with EMF: cancer, primarily childhood leukemia; reproduction and development; and neurobiological effects. This book provides a detailed discussion of hazard identification, dose-response assessment, exposure assessment, and risk characterization for each. Possible Health Effects of Exposure to Residential Electric and Magnetic Fields also discusses the tools available to measure exposure, common types of exposures, and what is known about the effects of exposure. The committee looks at correlations between EMF exposure and carcinogenesis, mutagenesis, neurobehavioral effects, reproductive and developmental effects, effects on melatonin and other neurochemicals, and effects on bone healing and stimulated cell growth.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
Publisher : National Academies Press
Page : 300 pages
File Size : 52,6 Mb
Release : 2007-11-19
Category : Science
ISBN : 9780309178891

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology Pdf

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1442 pages
File Size : 48,6 Mb
Release : 1983
Category : Medicine
ISBN : UOM:39015074107650

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Current Catalog by National Library of Medicine (U.S.) Pdf

First multi-year cumulation covers six years: 1965-70.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1456 pages
File Size : 40,7 Mb
Release : 1983
Category : Medicine
ISBN : MINN:31951D00170007S

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : Anonim
Publisher : Unknown
Page : 506 pages
File Size : 41,9 Mb
Release : 1984
Category : Power resources
ISBN : MINN:30000010508723

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Energy Research Abstracts by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 388 pages
File Size : 41,7 Mb
Release : 1993
Category : Environmental health
ISBN : MINN:30000007296084

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Environmental Health Perspectives by Anonim Pdf

Author : Scientific Group on Methodologies for the Safety Evaluation of Chemicals,International Council of Scientific Unions. Scientific Committee on Problems of the Environment
Publisher : Chichester [West Sussex] ; New York : Wiley
Page : 720 pages
File Size : 44,7 Mb
Release : 1985
Category : Science
ISBN : UOM:39015056470647

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Methods for Estimating Risk of Chemical Injury by Scientific Group on Methodologies for the Safety Evaluation of Chemicals,International Council of Scientific Unions. Scientific Committee on Problems of the Environment Pdf

This book provides a review and evaluation of existing methods for estimation and quantification of risks associated with chemical exposure. Dealing first with the assessment of probable damage to the human organism, the book discusses the basic mechanisms of mutagenesis and carcinogenesis, the validity of long-term whole-animal studies as predictors of human response and the use of epidemiology, statistics and mathematical modelling in developing quantitative risk estimation. The same approach is adopted for non-human biota and ecosystems, including a state-of-the-art assessment of work in single-species tests, multispecies tests and ecotoxicological modelling. Where suitable methods are not available, inadequacies are identified and suggestions made for the improvement and development of more appropriate procedures to fill them.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Board on Chemical Sciences and Technology,Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decisions
Publisher : National Academies Press
Page : 280 pages
File Size : 41,5 Mb
Release : 2014-10-29
Category : Science
ISBN : 9780309310161

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A Framework to Guide Selection of Chemical Alternatives by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Board on Chemical Sciences and Technology,Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decisions Pdf

Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. A Framework to Guide Selection of Chemical Alternatives develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.

Author : National Institutes of Health (U.S.)
Publisher : Unknown
Page : 484 pages
File Size : 55,9 Mb
Release : 1984
Category : Biochemistry
ISBN : UOM:39015028208893

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Scientific Directory and Annual Bibliography by National Institutes of Health (U.S.) Pdf

Each issue lists papers published during the preceding year.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 46,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Anonim
Publisher : Unknown
Page : 378 pages
File Size : 45,5 Mb
Release : 1984
Category : Cancer
ISBN : UCLA:31158012486782

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Indian Journal of Cancer by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 280 pages
File Size : 46,7 Mb
Release : 1984
Category : Cancer
ISBN : IOWA:31858012408443

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National Cancer Institute Monograph by Anonim Pdf

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Commission on Life Sciences,Committee on Risk Assessment of Hazardous Air Pollutants
Publisher : National Academies Press
Page : 668 pages
File Size : 43,6 Mb
Release : 1994-01-01
Category : Science
ISBN : 9780309048941

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Science and Judgment in Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Commission on Life Sciences,Committee on Risk Assessment of Hazardous Air Pollutants Pdf

The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.

Author : Anonim
Publisher : Unknown
Page : 164 pages
File Size : 53,8 Mb
Release : 1984
Category : United States
ISBN : UOM:39015058392823

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American Book Publishing Record by Anonim Pdf