The Use Of Resealed Erythrocytes As Carriers And Bioreactors

Author : Mauro Magnani,John R. DeLoach
Publisher : Springer Science & Business Media
Page : 342 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461530305

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The Use of Resealed Erythrocytes as Carriers and Bioreactors by Mauro Magnani,John R. DeLoach Pdf

Until recently the only biomedical use of erythrocytes was in transfusion medicine to restore a normal oxygen delivery. The development of a technology that permits one to open and reseal erythrocytes has dramatically changed this perspective. Currently, a number of teams have shown that engineered erythrocytes can behave as circulating bioreactors for the degradation of toxic metabolites or the inactivation of xenobiotics, as drug delivery systems, as carriers of antigens of vaccinal interest, and in many others biomedical applications. The technology of opening and resealing the erythrocytes has also been used successfully to investigate several basic aspects of erythrocyte metabolism, survival, pathology, etc. Thus, researchers in this field have an extraordinary opportunity to specifically modify the erythrocytes by the introduction of enzymes that generate new metabolic abilities, antibodies that inactivate single metabolic steps, or metabolites that can influence oxygen delivery and/or other cell properties. Furthermore, the pharmacokinetics of any drug can be potentially manipulated by using the erythrocytes as a delivery system. This book, The Use of Resealed Erythrocytes, is based on the fourth meeting of the "International Society for the Use of Resealed Erythrocytes as Carriers and Bioreactors" (I. S. U. R. E. ), held in Urbino, Italy, in 1991, and examines the most recent applications and developments of this technology.

Author : John R. DeLoach
Publisher : Pergamon Press
Page : 200 pages
File Size : 49,7 Mb
Release : 1994-01-01
Category : Medical
ISBN : 0080424961

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Carrier and Bioreactor Red Blood Cells for Drug Delivery and Targeting by John R. DeLoach Pdf

A collection of research papers on erythrocyte encapsulation. It covers immunotargeting using erythrocyte carriers and should be useful to those exploring ways to improve drug delivery. It also covers biochemical studies on the erythrocyte and is relevant to studies of circulating bioreactors.

Author : Ralph Green,John R. DeLoach
Publisher : Pergamon
Page : 252 pages
File Size : 50,7 Mb
Release : 1991-01-01
Category : Medical
ISBN : 0080411568

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Resealed Erythrocytes as Carriers and Bioreactors by Ralph Green,John R. DeLoach Pdf

Author : Mauro Magnani
Publisher : Springer Science & Business Media
Page : 168 pages
File Size : 55,6 Mb
Release : 2003-01-31
Category : Science
ISBN : 0306476916

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Erythrocyte Engineering for Drug Delivery and Targeting by Mauro Magnani Pdf

The International Symposia on Plant Lipids, the 15th of which was held in Okazaki, Japan, in May 12-17, 2002, is held every two years and is the only international meeting in this field. The contributions from the symposium collected in this book represent the most up-to-date research results on plant lipids, including their structure, analysis, biosynthesis, regulation, physiological function, environmental aspects, and biotechnology, obtained world-wide during 2000-2002

Author : Ulrich Sprandel,James L. Way
Publisher : Springer Science & Business Media
Page : 149 pages
File Size : 45,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489900449

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Erythrocytes as Drug Carriers in Medicine by Ulrich Sprandel,James L. Way Pdf

The sixth meeting on the use of resealed annealed red blood cells was held in Irsee, Germany by the International Society for the Use of Resealed Erythrocytes (ISURE) on July 25-28, 1996. Although earlier meetings focused on the technology toward develop ment of methods and standardization for efficient, consistent encapsulation, most of the present studies now are directed toward the application use of these carrier blood cells. Basic studies now have been directed toward exploration of commercial applications. In deed, clinical trials were initiated to evaluate the dose-response curves employing L asparagenase in human patients. Also, studies have shown the use of thrombolytic agent in erythrocyte carriers with the use of human red blood cells to provide a new conceptual ap proach in thrombolytic therapy to prevent thrombosis in individuals with higher risk fac tors. For example, with the use of carrier red blood cells, the thrombolytic agents will have a greater potential of acting on clot formation without systemic activation and thus lower the risk of hemorrhage, which is always prevalent in the thrombolytic therapy.

Author : Vladimir P Torchilin
Publisher : World Scientific
Page : 756 pages
File Size : 55,5 Mb
Release : 2006-09-29
Category : Medical
ISBN : 9781908979971

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Nanoparticulates as Drug Carriers by Vladimir P Torchilin Pdf

Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, biomedical engineering, physiology, experimental and clinical medicine, and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting, as well as in more specialized topics of using nanoparticulate-mediated drug delivery approaches in the individual areas of clinical medicine. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Contents:Nanoparticle Flow: Implications for Drug Delivery (A T Florence)Polymer Micelles as Drug Carriers (E V Batrakova et al.)Lipoproteins as Pharmaceutical Carriers (S Liu et al.)Dendrimers as Nanoparticular Drug Carriers (S Svenson & D A Tomalia)Cells and Cell Ghosts as Drug Carriers (J M Lanao & M L Sayalero)Magnetic Nanoparticles as Drug Carriers (U O Häfeli & M Chastellain)Liposomal Drug Carriers in Cancer Therapy (A A Gabizon)Delivery of Nanoparticles to the Cardiovascular System (B-A Khaw)Nanoparticles for Targeting Lymphatics (W Phillips)Nanoparticular Carriers for Ocular Drug Delivery (A Sanchez & M J Alonso)and other papers Readership: Graduate students, academics in nanomedicine, clinicians, pharmacologists, pharmacists, bioengineers, researchers in biotechnology and diagnostic imaging. Keywords:Drug Delivery;Drug Targeting;Drug Carriers;Nanomedicine;Nanotechnology;Pharmaceutical Biotechnology;Experimental TherapyKey Features:Chapters are written by leading scientists such as Prof Gregoriadis, Prof Moghimi, Prof Kabanov, Prof Tomalia, Prof Couvreur, Prof Mueller, Prof Gabizon and Prof Kreuter

Author : Akhlesh K. Jain,Keerti Mishra
Publisher : Bentham Science Publishers
Page : 500 pages
File Size : 45,9 Mb
Release : 2022-12-09
Category : Medical
ISBN : 9789815049794

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Nanoparticles and Nanocarriers Based Pharmaceutical Formulations by Akhlesh K. Jain,Keerti Mishra Pdf

Nanomedicine is a rapidly expanding field because of its benefits over conventional drug delivery technology, as it offers site-specific and target-oriented delivery of therapeutic agents. Nanoparticles and Nanocarriers Based Pharmaceutical Preparations presents a structured summary of recent advances and discoveries in nanomedicine and nanocarrier-based drug delivery. The book covers several key topics in a very simple and easy to understand language. Readers will be familiarized with many types of nanocarriers that have been developed over the past decade, the pharmaceutical formulations composed of organic and inorganic materials as well as their clinical benefits. Chapters are written with the help of authoritative sources of knowledge with the goal of building a foundational understanding of novel drug delivery systems. Since the subject matter is interdisciplinary, it will be of interest to students, teachers and researchers in a broad range of fields, including pharmaceutical sciences, nanotechnology, biomedical engineering and material sciences.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1628 pages
File Size : 49,8 Mb
Release : 1993
Category : Medicine
ISBN : UOM:39015074107676

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Current Catalog by National Library of Medicine (U.S.) Pdf

First multi-year cumulation covers six years: 1965-70.

Author : George G. Guilbault,Marco Mascini
Publisher : Springer Science & Business Media
Page : 578 pages
File Size : 53,9 Mb
Release : 2012-12-06
Category : Technology & Engineering
ISBN : 9789401119320

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Uses of Immobilized Biological Compounds by George G. Guilbault,Marco Mascini Pdf

In Uses of Immobilized Biological Compounds the reader will find a comprehensive survey of the field written by acknowledged experts who met in Brixen, Italy, between May 9 and 14, 1993 for a NATO Advanced Research Workshop devoted to the topic. The resulting volume presents a critical review of the latest results in the area and sets guidelines for future research. The 53 reports presented here cover: (A) General Aspects of Immobilizing Biological Compounds; (B) Medical, Clinical and Pharmaceutical Applications; (C) Electrochemical Biosensors; (E) Defense Applications; (F) Immunosensors and Receptors; (G) Food, Environmental, Clinical and Analytical Applications; and (H) Biotechnology and Marketing. In short, all aspects of the area are presented, in a compact format which will appeal to undergraduates, technicians, and professional scientists in the food, clinical, environmental, pharmaceutical and industrial fields.

Author : Anonim
Publisher : Academic Press
Page : 976 pages
File Size : 51,5 Mb
Release : 2020-08-19
Category : Medical
ISBN : 9780128144565

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The Future of Pharmaceutical Product Development and Research by Anonim Pdf

The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals, and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries. Provides an overview of practical information for clinical trials Outlines how to ensure an environment that follows Good Manufacturing Practice (GMP) Examines recent developments and suggests future directions for drug production methods and techniques

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1536 pages
File Size : 40,5 Mb
Release : 1993
Category : Medicine
ISBN : MINN:31951D010928702

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : Ralph Green,John R. DeLoach
Publisher : Pergamon
Page : 272 pages
File Size : 42,7 Mb
Release : 1991
Category : Bioreactors
ISBN : 0080411568

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Resealed Erythrocytes as Carriers and Bioreactors by Ralph Green,John R. DeLoach Pdf

Author : Douglas J. Weiss,K. Jane Wardrop
Publisher : John Wiley & Sons
Page : 3278 pages
File Size : 42,8 Mb
Release : 2011-07-26
Category : Medical
ISBN : 9780470961834

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Schalm's Veterinary Hematology by Douglas J. Weiss,K. Jane Wardrop Pdf

The long-awaited Sixth Edition of Schalm’s Veterinary Hematology has been revised and reorganized to increase accessibility and cohesiveness of the text. Topics are grouped within established disciplines in hematology, and outlines are now included at the beginning of each chapter. The book features new sections on Hematotoxicity and Quality Control and Laboratory Techniques, and includes expanded sections on Laboratory Animal Hematology, Species Specific Hematology, and Hematologic Neoplasia. With in-depth coverage on all aspects of the field, this comprehensive reference is an essential purchase for veterinary clinical hematologists, internists, and students.

Author : Bharati, Shashi Lata,Chaurasia, Pankaj Kumar
Publisher : IGI Global
Page : 549 pages
File Size : 53,5 Mb
Release : 2018-05-11
Category : Medical
ISBN : 9781522552383

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Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology by Bharati, Shashi Lata,Chaurasia, Pankaj Kumar Pdf

Enzymes have interesting applications in our biological system and act as valuable biocatalysts. Their various functions allow enzymes to develop new drugs, detoxifications, and pharmaceutical chemistry. Research Advancements in Pharmaceutical, Nutritional, and Industrial Enzymology provides emerging research on biosynthesis, enzymatic treatments, and bioengineering of medicinal waste. While highlighting issues such as structural implications for drug development and food applications, this publication explores information on various applications of enzymes in pharmaceutical, nutritional, and industrial aspects. This book is a valuable resource for medical professionals, pharmacists, pharmaceutical companies, researchers, academics, and upper-level students seeking current information on developing scientific ideas for new drugs and other enzymatic advancements.

Author : Ulrich Dirnagl,K.M. Einhäupl,Arno Villringer
Publisher : Springer Science & Business Media
Page : 290 pages
File Size : 41,6 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781489924681

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Optical Imaging of Brain Function and Metabolism by Ulrich Dirnagl,K.M. Einhäupl,Arno Villringer Pdf

• . . . . At last the doctor will be freed from the tedious interpretation of screens and photographs. Instead, he will examine and scan through his patient directly. Wearing optical-shutter spectacles and aiming a pulsed laser torch, he will be able to peer at the beating heart, study the movement of a joint or the flexing of a muscle, press on suspect areas to see how the organs beneath respond, check that pills have been correctly swallowed or that an implant is savely in place, and so on. A patient wearing white cotton or nylon clothes that scatter but hardly absorb light, may not even have to undress . . . . •. David Jones, Nature (1990) 348:290 Optical imaging of the brain is a rapidly growing field of heterogenous techniques that has attracted considerable interest recently due to a number of theoretical advantages in comparison with other brain imaging modalities: it uses non ionizing radiation, offers high spatial and temporal resolution, and supplies new types of metabolic and functional information. From a practical standpoint it is important that bedside examinations seem feasible and that the implementations will be considerably less expensive compared with competing techniques. In October 1991, a symposium was held at the Eibsee near Garmisch, Germany to bring together the leading scientists in this new field.