Therapeutic Protein Targets For Drug Discovery And Clinical Evaluation Bio Crystallography And Drug Design

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Therapeutic Protein Targets for Drug Discovery and Clinical Evaluation: Bio-Crystallography and Drug Design

D. Velmurugan,Atanu Bhattacharjee,D. Gayathri
Therapeutic Protein Targets for Drug Discovery and Clinical Evaluation Bio Crystallography and Drug Design Book PDF

Author : D. Velmurugan,Atanu Bhattacharjee,D. Gayathri
Publisher : World Scientific Publishing Company
Page : 0 pages
File Size : 44,7 Mb
Release : 2022-09-30
Category : Science
ISBN : 9811254788

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Therapeutic Protein Targets for Drug Discovery and Clinical Evaluation: Bio-Crystallography and Drug Design by D. Velmurugan,Atanu Bhattacharjee,D. Gayathri Pdf

The book reviews the recent research advances and their outcomes in the areas of structural biology, bioinformatics, phytochemistry and drug discovery. Chapters in the book cover multidisciplinary research to understand the molecular mechanisms involved in protein-protein/ligand interactions. It employs an integrative approach to identify the therapeutic targets for HIV, and cancer, pathogen and viral infection pathways and the identification of their potential drug candidates. The book also provides examples of computational molecular dynamics simulations to understand the conformational changes in the molecules. Some chapters are focused on exploring potent bioactive compounds from natural sources.This book can serve as a single source that covers several interdisciplinary research fields which will be beneficial to Researchers and students in postgraduate studies.

Multifaceted Roles of Crystallography in Modern Drug Discovery

Giovanna Scapin,Disha Patel,Eddy Arnold
Multifaceted Roles of Crystallography in Modern Drug Discovery Book PDF

Author : Giovanna Scapin,Disha Patel,Eddy Arnold
Publisher : Springer
Page : 240 pages
File Size : 45,5 Mb
Release : 2015-02-27
Category : Science
ISBN : 9789401797191

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Multifaceted Roles of Crystallography in Modern Drug Discovery by Giovanna Scapin,Disha Patel,Eddy Arnold Pdf

The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design.

Therapeutic Protein Targets For Drug Discovery And Clinical Evaluation: Bio-crystallography And Drug Design

D Velmurugan,Atanu Bhattacharjee,D Gayathri
Therapeutic Protein Targets For Drug Discovery And Clinical Evaluation Bio crystallography And Drug Design Book PDF

Author : D Velmurugan,Atanu Bhattacharjee,D Gayathri
Publisher : World Scientific
Page : 403 pages
File Size : 45,9 Mb
Release : 2022-10-04
Category : Science
ISBN : 9789811254802

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Therapeutic Protein Targets For Drug Discovery And Clinical Evaluation: Bio-crystallography And Drug Design by D Velmurugan,Atanu Bhattacharjee,D Gayathri Pdf

The book reviews the recent research advances and their outcomes in the areas of structural biology, bioinformatics, phytochemistry and drug discovery. Chapters in the book cover multidisciplinary research to understand the molecular mechanisms involved in protein-protein/ligand interactions. It employs an integrative approach to identify the therapeutic targets for HIV, and cancer, pathogen and viral infection pathways and the identification of their potential drug candidates. The book also provides examples of computational molecular dynamics simulations to understand the conformational changes in the molecules. Some chapters are focused on exploring potent bioactive compounds from natural sources.This book can serve as a single source that covers several interdisciplinary research fields which will be beneficial to Researchers and students in postgraduate studies.

Chirality in Drug Design and Development

Indra K. Reddy,Reza Mehvar
Chirality in Drug Design and Development Book PDF

Author : Indra K. Reddy,Reza Mehvar
Publisher : CRC Press
Page : 406 pages
File Size : 42,5 Mb
Release : 2004-03-15
Category : Science
ISBN : 9780824751098

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Chirality in Drug Design and Development by Indra K. Reddy,Reza Mehvar Pdf

Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Structural Biology in Drug Discovery

Jean-Paul Renaud
Structural Biology in Drug Discovery Book PDF

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
Page : 1367 pages
File Size : 43,9 Mb
Release : 2020-01-09
Category : Medical
ISBN : 9781118900505

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Structural Biology in Drug Discovery by Jean-Paul Renaud Pdf

With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Haematococcus

Rathinam Raja,Shanmugam Hemaiswarya,Mathiyazhagan Narayanan,Sabariswaran Kandasamy,K.R. Jayappriyan
Haematococcus Book PDF

Author : Rathinam Raja,Shanmugam Hemaiswarya,Mathiyazhagan Narayanan,Sabariswaran Kandasamy,K.R. Jayappriyan
Publisher : Springer Nature
Page : 357 pages
File Size : 50,6 Mb
Release : 2023-08-02
Category : Science
ISBN : 9789819929016

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Haematococcus by Rathinam Raja,Shanmugam Hemaiswarya,Mathiyazhagan Narayanan,Sabariswaran Kandasamy,K.R. Jayappriyan Pdf

This book offers a comprehensive analysis of microalgal cultivation methods and optimization of astaxanthin production for various applications, including clinical uses, algae polymers, proteins and pigments, food applications and packaging, algae forming, cosmetics, and more. Microalgae are unicellular living forms and are the primary producers that play a major role in the ecosystem. Commercially, while many documents are available, some recent fields are yet to be explored. The book comprises 19 chapters contributed by experts and reviews the recent developments in the cultivation, harvest, and genetic engineering of H. pluvialis-derived astaxanthin. It also discusses their bottlenecks and challenges in commercial-scale production, as well as current and prospective global market. Current research supports the exploration of new topics and practical applications of microalgae and their products, which will also benefit academia. The book will be an important resource for researchers and industry, providing comprehensive knowledge on broad topics. Flow charts, updated methods, and colour images are included to help the readers' understanding.

Structure-Based Drug Design

Pandi Veerapandian
Structure Based Drug Design Book PDF

Author : Pandi Veerapandian
Publisher : Routledge
Page : 665 pages
File Size : 49,6 Mb
Release : 2018-03-29
Category : Medical
ISBN : 9781351413060

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Structure-Based Drug Design by Pandi Veerapandian Pdf

Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!

Protein Crystallography in Drug Discovery, Volume 20

Robert E. Babine,Sherin S. Abdel-Meguid
Protein Crystallography in Drug Discovery Volume 20 Book PDF

Author : Robert E. Babine,Sherin S. Abdel-Meguid
Publisher : John Wiley & Sons
Page : 284 pages
File Size : 52,8 Mb
Release : 2004-02-13
Category : Medical
ISBN : 3527306781

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Protein Crystallography in Drug Discovery, Volume 20 by Robert E. Babine,Sherin S. Abdel-Meguid Pdf

The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included. A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.

Fragment-Based Drug Discovery

Steven Howard,Chris Abell
Fragment Based Drug Discovery Book PDF

Author : Steven Howard,Chris Abell
Publisher : Royal Society of Chemistry
Page : 314 pages
File Size : 42,9 Mb
Release : 2015-07-03
Category : Medical
ISBN : 9781849739085

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Fragment-Based Drug Discovery by Steven Howard,Chris Abell Pdf

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design

Sanjeev Kumar Singh
Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design Book PDF

Author : Sanjeev Kumar Singh
Publisher : Springer Nature
Page : 334 pages
File Size : 51,9 Mb
Release : 2021-02-02
Category : Science
ISBN : 9789811589362

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Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design by Sanjeev Kumar Singh Pdf

This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic methods and highlights the applications of Molecular Dynamics Simulation in the drug discovery process. It also explores the application of quantum mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing, the book provides illustrative descriptions of major challenges associated with computer-aided drug discovery for the development of therapeutic drugs. Given its scope, it offers a valuable asset for life sciences researchers, medicinal chemists and bioinformaticians looking for the latest information on computer-aided methodologies for drug development, together with their applications in drug discovery.

Targeted Protein Degradation

Angela M. Cacace,Christopher M. Hickey,Miklós Békés
Targeted Protein Degradation Book PDF

Author : Angela M. Cacace,Christopher M. Hickey,Miklós Békés
Publisher : Humana
Page : 351 pages
File Size : 45,7 Mb
Release : 2021-08-26
Category : Science
ISBN : 1071616641

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Targeted Protein Degradation by Angela M. Cacace,Christopher M. Hickey,Miklós Békés Pdf

This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.

Computer Applications in Pharmaceutical Research and Development

Sean Ekins
Computer Applications in Pharmaceutical Research and Development Book PDF

Author : Sean Ekins
Publisher : John Wiley & Sons
Page : 840 pages
File Size : 41,9 Mb
Release : 2006-07-11
Category : Medical
ISBN : 9780470037225

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Computer Applications in Pharmaceutical Research and Development by Sean Ekins Pdf

A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a holistic and integrative approach to the use of computers in all phases of drug discovery, development, and marketing. It explains how applications are used at various stages, including bioinformatics, data mining, predicting human response to drugs, and high-throughput screening. By providing a comprehensive view, the book offers readers a unique framework and systems perspective from which they can devise strategies to thoroughly exploit the use of computers in their organizations during all phases of the discovery and development process. Chapters are organized into the following sections: * Computers in pharmaceutical research and development: a general overview * Understanding diseases: mining complex systems for knowledge * Scientific information handling and enhancing productivity * Computers in drug discovery * Computers in preclinical development * Computers in development decision making, economics, and market analysis * Computers in clinical development * Future applications and future development Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent structure and approach throughout the book. Figures are used extensively to illustrate complex concepts and multifaceted processes. References are provided in each chapter to enable readers to continue investigating a particular topic in depth. Finally, tables of software resources are provided in many of the chapters. This is essential reading for IT professionals and scientists in the pharmaceutical industry as well as researchers involved in informatics and ADMET, drug discovery, and technology development. The book's cross-functional, all-phases approach provides a unique opportunity for a holistic analysis and assessment of computer applications in pharmaceutics.

Inhibitors of Protein–Protein Interactions

Ali Tavassoli
Inhibitors of Protein Protein Interactions Book PDF

Author : Ali Tavassoli
Publisher : Royal Society of Chemistry
Page : 357 pages
File Size : 46,9 Mb
Release : 2020-12-07
Category : Science
ISBN : 9781788015691

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Inhibitors of Protein–Protein Interactions by Ali Tavassoli Pdf

Protein-protein interactions (PPI) are at the heart of the majority of cellular processes, and are frequently dysregulated or usurped in disease. Given this central role, the inhibition of PPIs has been of significant interest as a means of treating a wide variety of diseases. However, there are inherent challenges in developing molecules capable of disrupting the relatively featureless and large interfacial areas involved. Despite this, there have been a number of successes in this field in recent years using both traditional drug discovery approaches and innovative, interdisciplinary strategies using novel chemical scaffolds. This book comprehensively covers the various aspects of PPI inhibition, encompassing small molecules, peptidomimetics, cyclic peptides, stapled peptides and macrocycles. Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.

Quantitative Proteomics by Mass Spectrometry

Salvatore Sechi
Quantitative Proteomics by Mass Spectrometry Book PDF

Author : Salvatore Sechi
Publisher : Methods in Molecular Biology
Page : 322 pages
File Size : 41,5 Mb
Release : 2018-04-15
Category : Science
ISBN : 1493980661

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Quantitative Proteomics by Mass Spectrometry by Salvatore Sechi Pdf

This volume describes prominent methodologies developed by laboratories that have been leading the field of quantitative proteomics by mass spectrometry. The procedures for performing the experiments are described in an easy-to-understand manner with many technical details that usually are not reported in typical research articles. This second edition of Quantitative Proteomics by Mass Spectrometry provides a broad perspective of the methodologies used for quantifying proteins and post-translational modifications in different types of biomedical specimens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Quantitative Proteomics by Mass Spectrometry, Second Edition is a valuable resource to help researchers understand and learn about the latest tools used in the study of quantitative proteomics by mass spectrometry.

Human Herpesviruses

Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Human Herpesviruses Book PDF

Author : Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publisher : Cambridge University Press
Page : 1325 pages
File Size : 52,7 Mb
Release : 2007-08-16
Category : Medical
ISBN : 9781139461641

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Human Herpesviruses by Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi Pdf

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.