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Author : Sigrun Lange,Marcel I. Ramirez
Publisher : Frontiers Media SA
Page : 91 pages
File Size : 40,6 Mb
Release : 2021-03-09
Category : Science
ISBN : 9782889665808
Author : Felicity N.E. Gavins,Karen Y. Stokes
Publisher : Academic Press
Page : 252 pages
File Size : 42,6 Mb
Release : 2015-10-31
Category : Medical
ISBN : 9780128013250
Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease. Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature. This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease. Covers a wide spectrum of organisms and provides analysis of pathogens and current therapeutic strategies in the context of their vasculature Provides detailed perspectives on key components contributing to vascular pathogens from leaders in the field Interfaces between both vascular biology and microbiology by encompassing information on how pathogens affect both macro and microvasculature Includes coverage of the clinical aspects of sepsis and current therapeutic strategies and anti-sepsis drugs
Author : Ru-Rong Ji,Jianguo Cheng,Jasmine Ji
Publisher : Springer Nature
Page : 365 pages
File Size : 54,7 Mb
Release : 2023-05-05
Category : Medical
ISBN : 9783031292316
As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
Author : M. Donald McGavin
Publisher : Mosby
Page : 0 pages
File Size : 47,8 Mb
Release : 2007
Category : Medical
ISBN : 0323028705
The 4th edition of this textbook, now in full color, presents both general pathology and special pathology in one comprehensive resource. Coverage includes a brief review of basic principles related to anatomy, structure and function, followed by congenital and functional abnormalities and discussions of viral, bacterial, and parasitic infections and neoplasia. Logically organized chapters discuss normal functions of the body system, followed by pathologic conditions found in domestic and companion animals. While focusing primarily on diseases in North America, the text also includes pathologic conditions found in other parts of the world, as well as those being brought into this country, such as West Nile virus, through the importation of cattle, sheep, and other animals. Contributors are recognized in their area of expertise and are well known in research and education. Now in full color throughout with vivid new illustrations that clarify difficult concepts. Includes six new chapters covering general pathology that discuss topics such as cellular and tissue responses to injury, vascular disorders, inflammation, and tumor biology. All chapters emphasize mechanisms of disease (organ, tissue, cell, and molecular injury). Features sequential presentations of disease processes (portal of entry * target cells * cellular injury * visual appearance of injury * resolution of injury * clinical outcomes). Emphasizes portals of entry for microbes and injurious agents. Focuses on defense mechanisms against microbes and injurious agents.
Author : Vinod Krishnan,Ze'ev Davidovitch
Publisher : John Wiley & Sons
Page : 530 pages
File Size : 51,7 Mb
Release : 2012-01-30
Category : Medical
ISBN : 9781444335972
Integrated Clinical Orthodontics provides an important new resource on the clinical interactions between the practice of orthodontics and other areas of clinical dentistry and medicine. Having at its heart the paradigm of patient-centred care, the book not only integrates the knowledge, skills, and experience of all the disciplines of dentistry and medicine, but also eases the work of orthodontists in arriving at an accurate diagnosis and a comprehensive treatment plan. Presented in a highly visual and practical format, Integrated Clinical Orthodontics uses clinical case presentations to illustrate the rationale and application of the integrated approach to a variety of clinical scenarios. Integrated Clinical Orthodontics covers areas of complexity in clinical orthodontics, specifically the role of the orthodontist as a member of a multidisciplinary team. The book outlines and details the management of congenital orofacial deformities, sleep disorders, esthetic smile creation and temporomandibular joint problems, and additionally and importantly includes specific protocols for effective communication with experts in other specialties.
Author : Ruth F. Craven,Constance Hirnle,Christine Henshaw
Publisher : Lippincott Williams & Wilkins
Page : 3906 pages
File Size : 45,9 Mb
Release : 2019-12-26
Category : Medical
ISBN : 9781975120436
Providing a big-picture approach to nursing practice, Fundamentals of Nursing: Concepts and Competencies for Practice, 9th Edition instills the foundational knowledge and clinical skills to help your students think critically and achieve positive outcomes throughout the nursing curriculum and in today’s fast-paced clinical settings. This revision immerses students in a proven nursing framework that clarifies key capabilities — from promoting health, to differentiating between normal function and dysfunction, to the use of scientific rationales and the approved nursing process — and includes new Unfolding Patient Stories and Critical Thinking Using QSEN Competencies. NCLEX®-style review questions online and within the book further equip students for the challenges ahead.
Author : Christine Henshaw,Renee Rassilyer
Publisher : Lippincott Williams & Wilkins
Page : 3828 pages
File Size : 54,5 Mb
Release : 2023-12-15
Category : Medical
ISBN : 9781975205720
Instilling a foundation for success from the classroom to the clinical setting. Craven & Hirnle’s Fundamentals of Nursing: Concepts and Competencies for Practice, 10th Edition, fosters the strong critical thinking, clinical judgment, clear communication, and sound clinical skills students need to succeed throughout the nursing curriculum and to meet the challenges practicing nurses confront each day. Drawing on the latest clinical evidence, this immersive text trains students to think and act like nurses, immersing them in a proven nursing process framework that clarifies key capabilities, from promoting health to identifying dysfunction to the use of scientific rationales and the nursing process.
Author : Julia Rogers
Publisher : Elsevier Health Sciences
Page : 1738 pages
File Size : 48,5 Mb
Release : 2022-08-03
Category : Medical
ISBN : 9780323789899
NEW! More than 50 new or revised illustrations visually reinforce pathophysiology concepts. NEW! Emerging Science boxes highlight the most current research and clinical developments.
Author : Helmut Popper
Publisher : Springer
Page : 699 pages
File Size : 48,5 Mb
Release : 2016-12-22
Category : Medical
ISBN : 9783662504918
This well-illustrated textbook covers the full range of lung and pleural diseases from the pathologic standpoint. Both diseases of adults and pediatric lung diseases are presented. The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. Genetics and molecular biology are also discussed whenever necessary for a full understanding. The author is an internationally recognized expert who runs courses on lung and pleural pathology attended by participants from all over the world. In compiling this book, he has drawn on more than 30 years’ experience in the field.
Author : Waliza Ansar,Shyamasree Ghosh
Publisher : Springer
Page : 301 pages
File Size : 40,8 Mb
Release : 2016-03-23
Category : Medical
ISBN : 9788132226802
This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.
Author : Jerome O. Nriagu,Eric P. Skaar
Publisher : MIT Press
Page : 501 pages
File Size : 44,8 Mb
Release : 2024-06-11
Category : Medical
ISBN : 9780262552486
Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang
Author : Virginia S. Cowen
Publisher : F.A. Davis
Page : 529 pages
File Size : 50,5 Mb
Release : 2015-05-08
Category : Medical
ISBN : 9780803645080
Develop the knowledge you need to evaluate a client based on how diseases and disorders affect the systems of the body and the critical-thinking skills to apply that knowledge in practice.
Author : Javier G. Nevarez
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 49,5 Mb
Release : 2021-09-21
Category : Medical
ISBN : 9781119233862
Blackwell's Five-Minute Veterinary Consult: Reptile and Amphibian bietet einen umfassenden Überblick über die Behandlung der häufigsten Krankheiten und Beschwerden bei Reptilien und Amphibien. Das Buch ist auf den schnellen und einfachen Zugang zu Informationen ausgelegt und ist ein unverzichtbares Nachschlagewerk für Tierärzte, die sich mit der Versorgung von Schildkröten, Eidechsen, Schlangen, Krokodilen und Amphibien befassen. Dieses Werk enthält Empfehlungen von führenden internationalen Persönlichkeiten auf dem Gebiet der Reptilien- und Amphibienpflege, verpackt in einem perfekten klinischen Handbuch. Die Angaben zu Diagnose und Behandlung sind logisch und schrittweise aufgebaut. Außerdem steht den Lesern eine begleitende Website zur Verfügung, auf der sie Anamnese- und Untersuchungsformulare zum Ausdrucken finden, Bilder, auf denen Techniken für die Venenpunktionen und intravenöse Katheterisierung bei verschiedenen Amphibien- und Reptiliengruppen dargestellt sind, sowie Bilder mit Methoden für die Geschlechtsbestimmung bei Reptilien. Das ideale Praxishandbuch für Tierärzte und Studierende der Tiermedizin, die verständliche und zuverlässige Informationen über Reptilien und Amphibien suchen, insbesondere mit den folgenden Themen: * Behandlung von häufigen Krankheiten und Beschwerden bei Schildkröten, insbesondere Erkrankungen der oberen Atemwege, Kloakenvorfall, Ohrenabszessen und Panzerfäule * Behandlung von häufigen Krankheiten bei Eidechsen, insbesondere Hypovitaminose A, ernährungsbedingtem sekundärem Hyperparathyreoidismus, Kryptosporidiose, Abszessen und Pilzinfektionen * Behandlung von Krankheiten bei Schlangen, insbesondere Dysecdysis, Erkrankungen der unteren Atemwege, Einschlusskörperkrankheit, Stomatitis und Paramyxovirus * Umfassende Betrachtung der Behandlung von Krankheiten bei Krokodilen, insbesondere West-Nil-Virus, Chlamydiose, Trauma, Abszessen und Gicht Blackwell's Five-Minute Veterinary Consult: Reptile and Amphibian ist ein unverzichtbares Nachschlagewerk für Tierärzte, Studierende der Tiermedizin, Assistenzärzte und Praktikanten, die ein größeres Verständnis von Schildkröten, Eidechsen, Schlangen, Krokodilen und Amphibien entwickeln und die Versorgung verbessern möchten.
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 51,8 Mb
Release : 1994
Category : Electronic
ISBN : OCLC:78842116
Author : Charles Dudley Mills,Laurel L Lenz,Klaus Ley
Publisher : Frontiers Media SA
Page : 281 pages
File Size : 55,8 Mb
Release : 2015-03-23
Category : Immunologic diseases
ISBN : 9782889194995
Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a precursor of polyamines and collagen for repair). The dual Arginine metabolic capacity of macrophages provided a functional explanation for their ability to kill or repair. Macrophages predominantly producing NO are called M1 and those producing Ornithine are called M2. M1 and M2 – dominant responses occur in lower vertebrates, and in T cell deficient vertebrates being directly driven by Damage and Pathogen Associated Molecular Patterns (DAMP and PAMP). Thus, M1 and M2 are Innate responses that protect the host without Adaptive Immunity. In turn, M1/M2 is supplanting previous models in which T cells were necessary to “activate” or “alternatively activate” macrophages (the Th1/Th2 paradigm). M1 and M2 macrophages were named such because of the additional key findings that these macrophages stimulate Th1 and Th2 – like responses, respectively. So, in addition to their unique ability to kill or repair, macrophages also govern Adaptive Immunity. All of the foregoing would be less important if M1 or M2 – dominant responses were not observed in disease. But, they are. The best example to date is the predominance of M2 macrophages in human tumors where they act like wound repair macrophages and actively promote growth. More generally, humans have become M2 – dominant because sanitation, antibiotics and vaccines have lessened M1 responses. And, M2 dominance seems the cause of ever - increasing allergies in developed countries. Obesity represents a new and different circumstance. Surfeit energy (e.g., lipoproteins) causes monocytes to become M1 dominant in the vessel walls causing plaques. Because M1 or M2 dominant responses are clearly causative in many modern diseases, there is great potential in developing the means to selectively stimulate (or inhibit) either M1 or M2 responses to kill or repair, or to stimulate Th1 or Th2 responses, depending on the circumstance. The contributions here are meant to describe diseases of M1 or M2 dominance, and promising new methodologies to modulate the fungible metabolic machinery of macrophages for better health.
