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Interactivity is the catchword for a wide range of innovative solutions that concept designers and engineers are developing in every area of technology and culture. For the authors interaction is more than a technological or aesthetic concept, it is a new means to ally humans and technology in a dynamic and reciprocal form of “living in technology”. This publication gathers together scientists and contributors from diverse fields of activity, providing a fascinating, up-to-date survey of the technological and conceptual equipment of experts engaged in aesthetic disciplines and product design. The editor, Professor Gerhard M. Buurman, is Head of Interactiondesign at the University of Art, Media and Design (HGKZ) in Zurich.
Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer by Kosuke Ohsawa Pdf
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments because the supply of TB1 from natural sources was limited. Unique 2,2’,6,6’-tetrasubstituted diphenyl ether moiety of TB1 was synthesized from a depsidone skeleton by chemoselective reduction of lactone. In the process of elongating side wings, efficient formylation utilizing dichloromethyl methyl ether–silver trifluoromethanesulfonate was developed for the sterically hindered aromatic compound. NMR titration experiments and paramagnetic relaxation enhancement observation of PAC3 homodimer were performed with synthesized TB1 and its molecular probe, respectively. The results of the above NMR studies and additional in silico docking studies suggested that TB1 promotes the dissociation to monomeric PAC3 after interaction with PAC3 homodimer. The rare mechanism shown in this book indicates a potential novel drug target in the interfaces of PPIs with no cavity or groove.
Protein-Protein Interactions by Weibo Cai,Hao Hong Pdf
Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.
Peer Interaction and Second Language Learning by Masatoshi Sato,Susan Ballinger Pdf
This volume represents the first collection of empirical studies focusing on peer interaction for L2 learning. These studies aim to unveil the impact of mediating variables such as task type, mode of interaction, and social relationships on learners’ interactional behaviors and language development in this unique and pedagogically powerful learning context. To examine these issues, contributors employed quantitative, qualitative, and mixed-methods designs as well as cognitive, social, and sociocognitive theoretical frameworks. The majority of the studies are classroom based and were conducted in a rich array of settings covering five continents and encompassing a wide range of learner L1s and target languages. These settings include second and foreign language classrooms from primary to university level, content-based programs, online contexts, and after-school programs. To span the divide between research and practice, each study includes a section suggesting pedagogical implications.
Nuclear Structure Physics by Amritanshu Shukla,Suresh Kumar Patra Pdf
Nuclear structure Physics connects to some of our fundamental questions about the creation of universe and its basic constituents. At the same time, precise knowledge on the subject has lead to develop many important tools of human kind such as proton therapy, radioactive dating etc. This book contains chapters on some of the crucial and trending research topics in nuclear structure, including the nuclei lying on the extremes of spin, isospin and mass. A better theoretical understanding of these topics is important beyond the confines of the nuclear structure community. Additionally, the book will showcase the applicability and success of the different nuclear effective interaction parameters near the drip line, where hints for level reordering have already been seen, and where one can test the isospin-dependence of the interaction. The book offers comprehensive coverage of the most essential topics, including: • Nuclear Structure of Nuclei at or Near Drip-Lines • Synthesis challenges and properties of Superheavy nuclei • Nuclear Structure and Nuclear models - Ab-initio calculations, cluster models, Shell-model/DSM, RMF, Skyrme • Shell Closure, Magicity and other novel features of nuclei at extremes • Structure of Toroidal, Bubble Nuclei, halo and other exotic nuclei These topics are not only very interesting from theoretical nuclear physics perspective but are also quite complimentary for ongoing nuclear physics experimental program worldwide. It is hoped that the book chapters written by experienced and well known researchers/experts will be helpful for the master students, graduate students and researchers and serve as a standard & uptodate research reference book on the topics covered.
Principles of Radiation Interaction in Matter and Detection by Claude Leroy,Pier-Giorgio Rancoita Pdf
This book, like the first and second editions, addresses the fundamental principles of interaction between radiation and matter and the principles of particle detection and detectors in a wide scope of fields, from low to high energy, including space physics and medical environment. It provides abundant information about the processes of electromagnetic and hadronic energy deposition in matter, detecting systems, performance of detectors and their optimization.The third edition includes additional material covering, for instance: mechanisms of energy loss like the inverse Compton scattering, corrections due to the Landau?Pomeranchuk?Migdal effect, an extended relativistic treatment of nucleus?nucleus screened Coulomb scattering, and transport of charged particles inside the heliosphere. Furthermore, the displacement damage (NIEL) in semiconductors has been revisited to account for recent experimental data and more comprehensive comparisons with results previously obtained.This book will be of great use to graduate students and final-year undergraduates as a reference and supplement for courses in particle, astroparticle, space physics and instrumentation. A part of the book is directed toward courses in medical physics. The book can also be used by researchers in experimental particle physics at low, medium, and high energy who are dealing with instrumentation.
Research Methods in Social Relations by Geoffrey Maruyama,Carey S. Ryan Pdf
Research Methods in Social Relations, 8th Edition, features a series of updates and revisions in its comprehensive introduction to current research methods in the social and behavioural sciences. Offers comprehensive coverage of a wide variety of traditional and topical research methods Addresses many newer research approaches such as propensity score matching, mixed methods designs, and confirmatory factor analysis Written to be accessible to a range of social and behavioural science disciplines, including public health, political science, sociology, and psychology Includes new chapters that engage readers in critical thinking about the processes involved in building sustainable partnerships in field and community settings The Companion website includes an array of resources for Instructors, including Test Banks, Power Point lecture slides, discussion questions and exercises This new edition is the much-anticipated follow-up to 2001’s seventh edition by Hoyle, Harris and Judd
Applying Maths in the Chemical and Biomolecular Sciences by Godfrey Beddard Pdf
Godfrey Beddard is Professor of Chemical Physics in the School of Chemistry, University of Leeds, where his research interests encompass femtosecond spectroscopy, electron and energy transfer, and protein folding and unfolding. 1. Numbers, Basic Functions, and Algorithms 2. Complex Numbers 3. Differentiation 4. Integration 5. Vectors 6. Matrices and Determinants 7. Matrices in Quantum Mechanics 8. Summations, Series, and Expansion of Functions 9. Fourier Series and Transforms 10. Differential Equations 11. Numerical Methods 12. Monte-carlo Methods 13. Statistics and Data Analysis
Human Development and Interaction in the Age of Ubiquitous Technology by Rahman, Hakikur Pdf
The human condition is affected by numerous factors in modern society. In modern times, technology is so integrated into culture that it has become necessary to perform even daily functions. Human Development and Interaction in the Age of Ubiquitous Technology is an authoritative reference source for the latest scholarly research on the widespread integration of technological innovations around the globe and examines how human-computer interaction affects various aspects of people’s lives. Featuring emergent research from theoretical perspectives and case studies, this book is ideally designed for professionals, students, practitioners, and academicians.
Shock wave research covers important inderdisciplinary areas which range from basic topics on gasdynamics, combustion and detonation, physico-chemistry of high temperature gases, plasma physics, astro and geophysics, materials science, astronautics and space technology to medical and industrial applications. This book includes 202 papers presented at the 18th the International Symposium on Shock Waves which describe the research frontier of shock wave phenopmena and 14 plenary lectures which show the state of the art of various fields of shock wave research. This proceedings is a unique collection of most important and updated shock wave research.
Discotic Liquid Crystals by Olga Viktorovna Kruglova Pdf
Deals with the dependency between structure and dynamics and its influence on charge transfer properties of self-assembling discotic liquid crystalline materials. This title provides an overview of liquid crystals in general and discotic liquid crystals in particular. It discusses a theory of neutron scattering.
Transportation, Knowledge and Space in Urban and Regional Economics by Kakuya Matsushima,William P. Anderson Pdf
This collection of 16 original research chapters by international scholars addresses the complementary roles of transportation and knowledge and their spatial manifestations in modern urban and regional economies. The authors provide research from North America, Europe and Asia. While the studies employ sophisticated methods and theory, there is a strong element of practical applications and policy implications in each chapter as well. This book will be of interest to communities of research and practice in urban and regional economics and planning, regional science and economic geography, transportation research, planning and management and the knowledge economy.
COVID-19 and Existential Positive Psychology (PP2.0): The New Science of Self-Transcendence by Paul T. P. Wong,Claude-Hélène Mayer,Gökmen Arslan Pdf
In the era of COVID-19, many people have suffered high levels of stress and mental health problems. To cope with the widespread of suffering (physical, psychological, social, and economical) the positive psychology of personal happiness is no longer the sole approach to examine personal wellbeing. Other approaches such as Viktor Frankl’s theory of self-transcendence provide a promising framework for research and intervention on how to achieve resilience, wellbeing, and happiness through overcoming suffering and self-transcendence. The existential positive psychology of suffering complements the positive psychology of happiness, which is championed by Martin Seligman, as two equal halves of the circle of wellbeing and optimal mental health. This Research Topic aims to examine the different approaches to Positive Psychology and their influence on individual wellbeing during the COVID-19 era. One of the exciting development in the positive psychology of wellbeing is the mounting research on the adaptive benefits of negative emotions, such as shame, guilt, and anger, as well as the dialectical process of balancing negative and positive emotions. As an example, based on all the empirical research and Frankl’s self-transcendence model, Wong has developed the existential positive psychology of suffering (PP2.0) as the foundation for flourishing. Here are a few main tenets of PP2.0: (1) Life is suffering and a constant struggle throughout every stage of development, (2) The search for self-transcendence is a primary motive guided by the meaning mindset and mindful mindset. (3) Wellbeing cannot be sustainable without overcoming and transforming suffering. In this Research Topic we welcome diverse approaches discussing the following points: • The dialectic process of overcoming the challenges of every stage of development as necessary for personal growth and self-transcendence; • The role of self-transcendence in resilience, virtue, meaning, and happiness; • The upside of negative emotions; • The new science of resilience based on cultivating the resilient mindset and character; • How to make the best use of suffering to achieve out potentials & mental health.
Advanced Materials by Ivan A. Parinov,Shun-Hsyung Chang,Vijay K. Gupta Pdf
This book presents selected peer-reviewed contributions from the 2017 International Conference on “Physics and Mechanics of New Materials and Their Applications”, PHENMA 2017 (Jabalpur, India, 14–16 October, 2017), which is devoted to processing techniques, physics, mechanics, and applications of advanced materials. The book focuses on a wide spectrum of nanostructures, ferroelectric crystals, materials and composites as well as promising materials with special properties. It presents nanotechnology approaches, modern environmentally friendly piezoelectric and ferromagnetic techniques and physical and mechanical studies of the structural and physical–mechanical properties of materials. Various original mathematical and numerical methods are applied to the solution of different technological, mechanical and physical problems that are interesting from theoretical, modeling and experimental points of view. Further, the book highlights novel devices with high accuracy, longevity and extended capabilities to operate under wide temperature and pressure ranges and aggressive media, which show improved characteristics, thanks to the developed materials and composites, opening new possibilities for different physico-mechanical processes and phenomena.
Part I: Physical Chemistry. Part II: Solid State Physics by Arthur S. Wightman Pdf
The fourth volume of the Collected Works is devoted to Wigners contribution to physical chemistry, statistical mechanics and solid-state physics. One corner stone was his introduction of what is now called the Wigner function, while his paper on adiabatic perturbations foreshadowed later work on Berry phases. Although few in number, Wigners articles on solid-state physics laid the foundations for the modern theory of the electronic structure of metals.