Toxins And Cancer Therapy

Author : Adam E. Snook
Publisher : MDPI
Page : 104 pages
File Size : 51,9 Mb
Release : 2021-03-02
Category : Science
ISBN : 9783036501901

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Toxins and Cancer Therapy by Adam E. Snook Pdf

Cancer has been a patient-specific and difficult-to-treat disease for decades, resulting in more deaths since 1900 than all other diseases except cardiovascular diseases. As societies around the world continue to shift towards an aging population, the social and economic burden created by cancer will only rise in the coming decades, necessitating continued improvement in our cancer therapies. Remarkably, in the late 1800s, bone surgeon William Coley serendipitously discovered that bacteria could be administered to patients as an effective (and sometimes toxic) form of cancer therapy known as "Coley's Toxins". His discoveries unknowingly led to two fields of cancer therapy that have been in development for decades and are now leading to significant improvements in therapy for cancer patients: immune-based and toxin-based therapies for cancer. Articles included here discuss the discoveries that emerged from Coley's Toxins that enable us to harness the immune system and microbial toxins to combat cancers, as oncology shifts from a field dominated by chemotherapy for most of the 20th century to biologic therapies that will dominate the 21st century.

Author : Adam E. Snook
Publisher : Unknown
Page : 104 pages
File Size : 46,8 Mb
Release : 2021
Category : Electronic
ISBN : 3036501916

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Toxins and Cancer Therapy by Adam E. Snook Pdf

Cancer has been a patient-specific and difficult-to-treat disease for decades, resulting in more deaths since 1900 than all other diseases except cardiovascular diseases. As societies around the world continue to shift towards an aging population, the social and economic burden created by cancer will only rise in the coming decades, necessitating continued improvement in our cancer therapies. Remarkably, in the late 1800s, bone surgeon William Coley serendipitously discovered that bacteria could be administered to patients as an effective (and sometimes toxic) form of cancer therapy known as "Coley's Toxins". His discoveries unknowingly led to two fields of cancer therapy that have been in development for decades and are now leading to significant improvements in therapy for cancer patients: immune-based and toxin-based therapies for cancer. Articles included here discuss the discoveries that emerged from Coley's Toxins that enable us to harness the immune system and microbial toxins to combat cancers, as oncology shifts from a field dominated by chemotherapy for most of the 20th century to biologic therapies that will dominate the 21st century.

Author : Per-Ulf Tunn
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 50,7 Mb
Release : 2008-12-28
Category : Medical
ISBN : 9783540779605

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Treatment of Bone and Soft Tissue Sarcomas by Per-Ulf Tunn Pdf

Bone and soft tissue sarcomas represent only about 2% of all malignancies; however, their treatment – with the goal of curing the patient while preserving the functionality of the affected body part – can, unlike other malignancies, only be successful with therapy concepts devised by interdisciplinary teams. This volume provides an extensive up-to-date overview of the specific diagnostics and current treatment standards of these rare entities, presenting the various limb-sparing modalities for patients with bone and soft tissue sarcomas with special regard to innovative reconstructive options. The evaluation of quality of life based on validated scores and the individual methods of coping with the illness through creative artistic projects are also acknowledged and integrated in the whole concept.

Author : Ralph W. Moss
Publisher : Unknown
Page : 532 pages
File Size : 47,9 Mb
Release : 1992
Category : Health & Fitness
ISBN : 1881025063

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Cancer Therapy by Ralph W. Moss Pdf

This thorough guide is a must-read for cancer patients and their families seeking treatment options.

Author : Hang Fai (Henry) Kwok
Publisher : MDPI
Page : 178 pages
File Size : 52,9 Mb
Release : 2019-10-01
Category : Science
ISBN : 9783039211890

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Venom and Toxin as Targeted Therapy by Hang Fai (Henry) Kwok Pdf

Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers.

Author : Koji Kawakami,Bharat B. Aggarwal,Raj K. Puri
Publisher : CRC Press
Page : 242 pages
File Size : 55,6 Mb
Release : 2004-11-15
Category : Medical
ISBN : 9780203303160

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Cytotoxins and Immunotoxins for Cancer Therapy by Koji Kawakami,Bharat B. Aggarwal,Raj K. Puri Pdf

Recent advances in cytotoxins and immunotoxins are accelerating our understanding of cancer and leading to more effective therapeutic treatments. Although a large number of articles have been published on these cytotoxins and immunotoxins, this important information has yet to be compiled into one comprehensive resource. For the first time,

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 51,8 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : Tanya Harter Pierce
Publisher : Thoughtworks Publishing
Page : 482 pages
File Size : 46,5 Mb
Release : 2020-01-02
Category : Electronic
ISBN : 0972886702

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Outsmart Your Cancer by Tanya Harter Pierce Pdf

THIRD EDITION - UPDATED AND EXPANDED "Outsmart Your Cancer" is an in-depth alternative treatment guide that could save your life. It explodes the myths about alternative cancer treatments and presents more than twenty approaches that are non-toxic along with dozens of real-life cases from people who used these approaches to completely recover from a variety of cancers, many of which were in late stages. In this updated and expanded Third Edition, all the resources have been updated and new key information has broadened the scope of the book-including new sections on the Ketogenic diet for cancer, on using the natural plant compound "Paw Paw" to obliterate multidrug-resistant cancer cells, and on how you might be able to cure your dog or cat with cancer. Plus, critical information is presented on what men and women need to know about hormone-blocking drugs, the real truth about DCIS breast cancer (Is it really cancer?), what a man's PSA count really means, and whether he is better or worse off if he takes a testosterone-blocking drug, as well as how to evaluate conventional claims of efficacy for toxic treatments such as chemotherapy and radiation. Highly esteemed doctors and scientists are quoted regarding the scientific basis behind each approach and extra information has been included regarding the amazing liquid formula called "Protocel" with new recent Protocel recovery cases added. This book completely demystifies cancer and makes it clear why non-toxic approaches are often more effective at bringing about complete cures than toxic ones. There are two very different worlds of cancer treatment today - conventional and alternative - and it can be difficult to understand what one's best treatment options might be and why. This book will help you make a much more fully informed treatment decision!

Author : Haya Lorberboum-Galski,Philip Lazarovici
Publisher : CRC Press
Page : 448 pages
File Size : 43,9 Mb
Release : 2002-05-30
Category : Medical
ISBN : 9781134454549

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Chimeric Toxins by Haya Lorberboum-Galski,Philip Lazarovici Pdf

Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as binding to specific surface receptors, internalizati

Author : Arthur E. Frankel
Publisher : Springer Science & Business Media
Page : 550 pages
File Size : 49,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461310839

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Immunotoxins by Arthur E. Frankel Pdf

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Author : Anonim
Publisher : Academic Press
Page : 258 pages
File Size : 43,8 Mb
Release : 2022-06-30
Category : Medical
ISBN : 9780323900881

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Strategies to Mitigate the Toxicity of Cancer Therapeutics by Anonim Pdf

Strategies to Mitigate the Toxicity of Cancer Therapeutics, Volume 155 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters, each of which is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Cancer Research series Includes the latest information on Strategies to Mitigate the Toxicity of Cancer Therapeutics

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 41,9 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

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How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Rama Shanker Verma,Benjamin Bonavida
Publisher : Unknown
Page : 128 pages
File Size : 40,5 Mb
Release : 2015
Category : Electronic
ISBN : 331917276X

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Resistance to Immunotoxins in Cancer Therapy by Rama Shanker Verma,Benjamin Bonavida Pdf

This volume is a guide to understanding resistance against targeted therapeutic approaches for cancer using immunotoxins. It contains a detailed review of the history and development of targeted therapy. As well, it includes an in-depth description of the molecular and cellular mechanisms involved in cancer resistance and several novel methods to overcome resistance. Each chapter discusses different aspects of resistance and covers all the factors that may contribute to resistance in cancer cells. Finally, this volume highlights the recent findings and advances associated with tackling cancer resistance.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 54,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Robert K. Oldham,Robert O. Dillman
Publisher : Springer Science & Business Media
Page : 743 pages
File Size : 47,5 Mb
Release : 2009-08-29
Category : Medical
ISBN : 9789048122899

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Principles of Cancer Biotherapy by Robert K. Oldham,Robert O. Dillman Pdf

At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.