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Tracer Kinetics in Biomedical Research by Claudio Cobelli,David Foster,Gianna Toffolo Pdf
1. Introduction. 2. Fundamentals of Tracer Kinetics. 3. The Noncompartmental Model of Multipool Systems. 4. The Compartmental Model. 5. Identifiability of the Tracer Model. 6. Using the Tracer Model to Estimate Kinetic Parameters. 7. Compartmental Versus Noncompartmental Kinetic Parameters. 8. Parameter Estimation: Some Fundamentals of Regression Analysis. 9. Parameter Estimation in Noncompartmental Models. 10. Parameter Estimation in Compartmental Models. 11. Precursor-Product Models. Appendices. Index.
Author : Robert R. Wolfe,David L. Chinkes Publisher : John Wiley & Sons Page : 494 pages File Size : 43,6 Mb Release : 2004-10-18 Category : Medical ISBN : 0471462098
Isotope Tracers in Metabolic Research by Robert R. Wolfe,David L. Chinkes Pdf
In the past few years, the number of applications of tracers for in vivo biomedical studies has greatly increased. New analytical tools at the genetic and protein levels have spurred this growth, opening the door for a deeper understanding of metabolic events. This in turn promises to yield significant advances in the understanding and treatment of human disease. Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches. This new Second Edition includes: All-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis A completely updated categorized list of over 750 references Major advances in the development of mass isotopomer and positional isotopomer techniques, noninvasive isotope techniques for studying metabolic pathways, hyphenated techniques, and new tracer techniques The latest developments in quantification of DNA synthesis and mass spectrometry spurred by genome sequencing and proteomics New coverage of mathematical modeling Expanded coverage of microdialysis probes, laboratory procedures, and regulatory issues related to human studies In this complete guide to performing tracer studies, the authors systematically cover tracer selection, modeling considerations, sample derivitization, mass spectrometry analysis, and data interpretation. Problems and discussion questions highlight key points in each chapter. Isotope Tracers in Metabolic Research, Second Edition offers students and researchers a comprehensive, practical resource for utilizing the latest tracer methodologies.
Tracer Methods for in Vivo Kinetics by Reginald Shipley Pdf
Tracer Methods for In Vivo Kinetics: Theory and Applications summarizes and evaluates the variety of working formulas in applying tracer methods for kinetic studies in vivo. This book discusses the basic concepts, derives the important equations, and evaluates each working formula to ensure its proper application within the set of experimental conditions available. Organized into 12 chapters, this book starts with an overview of tracers such as radioactive atoms. This text then discusses the errors inherent in treating a two-pool system as though it were one pool. Other chapters describe how, from curves of tracer content of the labeled pool or of the secondary pool, a definitive evaluation is made of rate constants and rate of interflow and outflow in the two-pool open system. This book discusses as well the limited usefulness of a curve of specific gravity when information is limited to such a curve obtained from the secondary pool. This book is intended for mathematicians, biomedical scientists, and graduate students.
Tracer Kinetics and Physiologic Modeling by R.M. Lambrecht,Aldo Rescigno Pdf
These lectures were prepared by the authors for Seminars to be held on June 6, 1983, in St.Louis, Missouri, under the spon sorship of the Radiopharmaceutical Science Council of the So ciety of Nuclear Medicine . All manuscript? were refereed . Tracer kinetics and the modeling of physiological and bio chemical processes in vivo are the focus of a contemporary di rection in biochemical research. Recent advances in instrumen tation (especially positron emission tomography and digital autoradiography) and parallel developments in the production of short-lived radionuclides and rapid synthetic chemistry to pre pare tracers that probe metabolism, flow, receptor-ligand kinetics, etc., are responsible for new scientific frontiers. These developments, coupled with biomathematics and computer science, make it possible to quantitatively evaluate tracer kinetic models in animals and man. (The choice of animal models in radiotracer design and tracer kinetics is the subject of a book edited by R.M.Lambrecht and W.C.Eckleman in press at Sprin ger Verlag.) Tracer kinetics and physiological modeling is truly multi disciplinary, as evidenced by the intellectual diversity and international representation observable in the list of contri butors . The lectures outline and attempt to show the transition from the theoretical description to the practical application of modeling for understanding normal and pathological processes .
Information Processing in Medical Imaging by Jerry L. Prince,Dzung L. Pham,Kyle J. Myers Pdf
This book constitutes the refeered proceedings of the 21st International Conference on Information Processing in Medical Imaging, IPMI 2009, held in Williamsburg, VA, USA, in July 2009 The 26 revised full papers and 33 revised poster papers presented were carefully reviewed and selected from 150 submissions. The papers are organized in topical sections on diffusion imaging, PET imaging, image registration, functional networks, space curves, tractography, microscopy, exploratory analyses, features and detection, image guided surgery, shape analysis, motion, and segmentation and validation.
Quantification of Contrast Kinetics in Clinical Imaging by Massimo Mischi,Simona Turco,Osama I. Soliman,Folkert J. ten Cate,Hessel Wijkstra,Ivo Schoots Pdf
This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.
Introduction to Modeling in Physiology and Medicine by Claudio Cobelli,Ewart Carson Pdf
This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine Extensive case studies and engineering applications from BME, plus end-of-chapter exercises
National Institutes of Health (U.S.). Division of Research Grants
Author : National Institutes of Health (U.S.). Division of Research Grants Publisher : Unknown Page : 1224 pages File Size : 49,8 Mb Release : 1975 Category : Medicine ISBN : UOM:39015072175246
Radiocarbon After Four Decades by Ervin Taylor,Austin Long,Renee S. Kra Pdf
Radiocarbon After Four Decades: An Interdisciplinary Perspective commemorates the 40th anniversary of radiocarbon dating. The volume presents discussions of every aspect of this dating technique, as well as chronicles of its development and views of future advancements and applications. All of the 64 authors played major roles in establishment, development or application of this revolutionary scientific tool. The 35 chapters provide a solid foundation in the essential topics of radiocarbon dating: Historical Perspectives; The Natural Carbon Cycle; Instrumentation and Sample Preparation; Hydrology; Old World Archaeology; New World Archaeology; Earth Sciences; and Biomedical Applications.
Biomedical Information Technology by David Dagan Feng Pdf
The enormous growth in the field of biotechnology necessitates the utilization of information technology for the management, flow and organization of data. The field continues to evolve with the development of new applications to fit the needs of the biomedicine. From molecular imaging to healthcare knowledge management, the storage, access and analysis of data contributes significantly to biomedical research and practice. All biomedical professionals can benefit from a greater understanding of how data can be efficiently managed and utilized through data compression, modelling, processing, registration, visualization, communication, and large-scale biological computing. In addition Biomedical Information Technology contains practical integrated clinical applications for disease detection, diagnosis, surgery, therapy, and biomedical knowledge discovery, including the latest advances in the field, such as ubiquitous M-Health systems and molecular imaging applications. The world's most recognized authorities give their "best practices" ready for implementation Provides professionals with the most up to date and mission critical tools to evaluate the latest advances in the field and current integrated clinical applications Gives new staff the technological fundamentals and updates experienced professionals with the latest practical integrated clinical applications
National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine
Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine Publisher : National Academies Press Page : 173 pages File Size : 40,6 Mb Release : 2007-09-11 Category : Medical ISBN : 9780309134156
Advancing Nuclear Medicine Through Innovation by National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine Pdf
Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.
