Transcriptomics In Health And Disease

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Transcriptomics in Health and Disease

Geraldo A. Passos
Transcriptomics in Health and Disease Book PDF

Author : Geraldo A. Passos
Publisher : Springer Nature
Page : 473 pages
File Size : 42,6 Mb
Release : 2022-03-07
Category : Science
ISBN : 9783030878214

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Transcriptomics in Health and Disease by Geraldo A. Passos Pdf

The study of transcriptomics is key to understanding complex diseases. This new edition will build on the foundation of the first edition while incorporating the progress that has been made in the field of transcriptomics in the past six years, including bioinformatics for data analysis. Written by leading experts, chapters address new subjects such as methodological advances in large-scale sequencing, the sequencing of single-cells, and spatial transcriptomics. The new edition will address how transcriptomics may be used in combination with genetic strategies to identify causative genes in monogenic and complex genetic diseases. Coverage will also explore transcriptomics in challenging groups of diseases, such as cancer, inflammation, bacterial infection, and autoimmune diseases. The updated volume will be useful for geneticists, genome biologists, biomedical researchers, molecular biologists, bioinformaticians, and students, among others.

Evolution of Translational Omics

Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Evolution of Translational Omics Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 41,5 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185

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Evolution of Translational Omics by Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials Pdf

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Nutrigenomics and Proteomics in Health and Disease

Martin Kussmann,Patrick J. Stover
Nutrigenomics and Proteomics in Health and Disease Book PDF

Author : Martin Kussmann,Patrick J. Stover
Publisher : John Wiley & Sons
Page : 350 pages
File Size : 50,6 Mb
Release : 2017-05-08
Category : Technology & Engineering
ISBN : 9781119098836

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Nutrigenomics and Proteomics in Health and Disease by Martin Kussmann,Patrick J. Stover Pdf

Now in a revised second edition, Nutrigenomics and Proteomics in Health and Disease brings together the very latest science based upon nutrigenomics and proteomics in food and health. Coverage includes many important nutraceuticals and their impact on gene interaction and health. Authored by an international team of multidisciplinary researchers, this book acquaints food and nutrition professionals with these new fields of nutrition research and conveys the state of the science to date. Thoroughly updated to reflect the most current developments in the field, the second edition includes six new chapters covering gut health and the personal microbiome; gut microbe-derived bioactive metabolites; proteomics and peptidomics in nutrition; gene selection for nutrigenomic studies; gene-nutrient network analysis, and nutrigenomics to nutritional systems biology. An additional five chapters have also been significantly remodelled. The new text includes a rethinking of in vitro and in vivo models with regard to their translatability into human phenotypes, and normative science methods and approaches have been complemented by more comprehensive systems biology-based investigations, deploying a multitude of omic platforms in an integrated fashion. Innovative tools and methods for statistical treatment and biological network analysis are also now included.

Integration of Omics Approaches and Systems Biology for Clinical Applications

Antonia Vlahou,Fulvio Magni,Harald Mischak,Jerome Zoidakis
Integration of Omics Approaches and Systems Biology for Clinical Applications Book PDF

Author : Antonia Vlahou,Fulvio Magni,Harald Mischak,Jerome Zoidakis
Publisher : John Wiley & Sons
Page : 386 pages
File Size : 42,7 Mb
Release : 2018-02-21
Category : Science
ISBN : 9781119181149

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Integration of Omics Approaches and Systems Biology for Clinical Applications by Antonia Vlahou,Fulvio Magni,Harald Mischak,Jerome Zoidakis Pdf

Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed. Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting. Describes a range of state of the art omics analytical platforms Covers all aspects of the systems biology approach—from sample preparation to data integration and bioinformatics analysis Contains specific examples of omics methods applied in the investigation of human diseases (Chronic Kidney Disease, Bladder Cancer) Integration of omics Approaches and Systems Biology for Clinical Applications will appeal to a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, and bioinformaticians working on the different molecular platforms. It is also an excellent text for students interested in these fields.

Genetics of Animal Health and Disease in Livestock

Bianca Castiglioni
Genetics of Animal Health and Disease in Livestock Book PDF

Author : Bianca Castiglioni
Publisher : MDPI
Page : 188 pages
File Size : 54,6 Mb
Release : 2021-06-02
Category : Science
ISBN : 9783036508962

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Genetics of Animal Health and Disease in Livestock by Bianca Castiglioni Pdf

Wood surface attributes can be established by examining its several different physical or chemical properties. Differences in the wood surfaces occur between the manufacturing and post-treatment processes as well. Understanding how their unique anisotropic molecular organization, chemical linkages, branching, and other molecular features govern micro- and macroscale accessibility is essential for coating and complex modification processes. It is therefore important for scientific as well as practical reasons to qualify and quantify the effects of wood surface treatments and modifications. Challenges still exist to fully understanding the effect of the numerous applied chemicals and the wide range of treatment processes on wood surfaces.

Cellular Endocrinology in Health and Disease

Alfredo Ulloa-Aguirre,Ya-Xiong Tao
Cellular Endocrinology in Health and Disease Book PDF

Author : Alfredo Ulloa-Aguirre,Ya-Xiong Tao
Publisher : Academic Press
Page : 488 pages
File Size : 55,5 Mb
Release : 2021-02-02
Category : Science
ISBN : 9780128198025

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Cellular Endocrinology in Health and Disease by Alfredo Ulloa-Aguirre,Ya-Xiong Tao Pdf

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field

Medical and Health Genomics

Dhavendra Kumar,Stylianos Antonarakis
Medical and Health Genomics Book PDF

Author : Dhavendra Kumar,Stylianos Antonarakis
Publisher : Academic Press
Page : 358 pages
File Size : 49,9 Mb
Release : 2016-06-04
Category : Science
ISBN : 9780127999227

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Medical and Health Genomics by Dhavendra Kumar,Stylianos Antonarakis Pdf

Medical and Health Genomics provides concise and evidence-based technical and practical information on the applied and translational aspects of genome sciences and the technologies related to non-clinical medicine and public health. Coverage is based on evolving paradigms of genomic medicine—in particular, the relation to public and population health genomics now being rapidly incorporated in health management and administration, with further implications for clinical population and disease management. Provides extensive coverage of the emergent field of health genomics and its huge relevance to healthcare management Presents user-friendly language accompanied by explanatory diagrams, figures, and many references for further study Covers the applied, but non-clinical, sciences across disease discovery, genetic analysis, genetic screening, and prevention and management Details the impact of clinical genomics across a diverse array of public and community health issues, and within a variety of global healthcare systems

Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods

Debasis Bagchi,Anand Swaroop,Manashi Bagchi
Genomics Proteomics and Metabolomics in Nutraceuticals and Functional Foods Book PDF

Author : Debasis Bagchi,Anand Swaroop,Manashi Bagchi
Publisher : John Wiley & Sons
Page : 685 pages
File Size : 44,6 Mb
Release : 2015-10-12
Category : Technology & Engineering
ISBN : 9781118930427

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Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods by Debasis Bagchi,Anand Swaroop,Manashi Bagchi Pdf

Functional foods and nutraceuticals have received considerable interest in the past decade largely due to increasing consumer awareness of the health benefits associated with food. Diet in human health is no longer a matter of simple nutrition: consumers are more proactive and increasingly interested in the health benefits of functional foods and their role in the prevention of illness and chronic conditions. This, combined with an aging population that focuses not only on longevity but also quality of life, has created a market for functional foods and nutraceuticals. A fully updated and revised second edition, Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods reflects the recent upsurge in "omics" technologies and features 48 chapters that cover topics including genomics, proteomics, metabolomics, epigenetics, peptidomics, nutrigenomics and human health, transcriptomics, nutriethics and nanotechnology. This cutting-edge volume, written by a panel of experts from around the globe reviews the latest developments in the field with an emphasis on the application of these novel technologies to functional foods and nutraceuticals.

Transcriptome Analysis

Miroslav Blumenberg
Transcriptome Analysis Book PDF

Author : Miroslav Blumenberg
Publisher : BoD – Books on Demand
Page : 110 pages
File Size : 46,9 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9781789843279

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Transcriptome Analysis by Miroslav Blumenberg Pdf

Transcriptome analysis is the study of the transcriptome, of the complete set of RNA transcripts that are produced under specific circumstances, using high-throughput methods. Transcription profiling, which follows total changes in the behavior of a cell, is used throughout diverse areas of biomedical research, including diagnosis of disease, biomarker discovery, risk assessment of new drugs or environmental chemicals, etc. Transcriptome analysis is most commonly used to compare specific pairs of samples, for example, tumor tissue versus its healthy counterpart. In this volume, Dr. Pyo Hong discusses the role of long RNA sequences in transcriptome analysis, Dr. Shinichi describes the next-generation single-cell sequencing technology developed by his team, Dr. Prasanta presents transcriptome analysis applied to rice under various environmental factors, Dr. Xiangyuan addresses the reproductive systems of flowering plants and Dr. Sadovsky compares codon usage in conifers.

Omics in Clinical Practice

Yu Liu
Omics in Clinical Practice Book PDF

Author : Yu Liu
Publisher : CRC Press
Page : 456 pages
File Size : 46,8 Mb
Release : 2014-06-20
Category : Science
ISBN : 9781482262438

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Omics in Clinical Practice by Yu Liu Pdf

This title includes a number of Open Access chapters.This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation t

Bioinformatics for Biomedical Science and Clinical Applications

K-H Liang
Bioinformatics for Biomedical Science and Clinical Applications Book PDF

Author : K-H Liang
Publisher : Elsevier
Page : 170 pages
File Size : 41,7 Mb
Release : 2013-07-31
Category : Science
ISBN : 9781908818232

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Bioinformatics for Biomedical Science and Clinical Applications by K-H Liang Pdf

Contemporary biomedical and clinical research is undergoing constant development thanks to the rapid advancement of various high throughput technologies at the DNA, RNA and protein levels. These technologies can generate vast amounts of raw data, making bioinformatics methodologies essential in their use for basic biomedical and clinical applications.Bioinformatics for biomedical science and clinical applications demonstrates what these cutting-edge technologies can do and examines how to design an appropriate study, including how to deal with data and address specific clinical questions. The first two chapters consider Bioinformatics and analysis of the human genome. The subsequent three chapters cover the introduction of Transcriptomics, Proteomics and Systems biomedical science. The remaining chapters move on to critical developments, clinical information and conclude with domain knowledge and adaptivity. A coherent presentation of concepts, methodologies and practical tools that systematically lead to significant discoveries in the biomedical and clinical area Real examples of cutting edge discoveries The introduction of study types and technologies for all the DNA, RNA and protein levels

Nutritional Genomics

Regina Brigelius-Flohé,Hans-Georg Joost
Nutritional Genomics Book PDF

Author : Regina Brigelius-Flohé,Hans-Georg Joost
Publisher : John Wiley & Sons
Page : 470 pages
File Size : 49,5 Mb
Release : 2006-08-21
Category : Science
ISBN : 9783527607754

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Nutritional Genomics by Regina Brigelius-Flohé,Hans-Georg Joost Pdf

Nutritional genomics paves the way for novel applications in medicine and human nutrition, and this volume presents the latest data on how genetic variation is associated with dietary response and how nutrients influence gene expression. In so doing, it brings together the various disciplines involved in this field of research, making this essential reading for nutritionists, biochemists and molecular biologists.

Regulation of Inflammatory Signaling in Health and Disease

Dakang Xu
Regulation of Inflammatory Signaling in Health and Disease Book PDF

Author : Dakang Xu
Publisher : Springer
Page : 0 pages
File Size : 49,5 Mb
Release : 2018-12-14
Category : Medical
ISBN : 9811355436

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Regulation of Inflammatory Signaling in Health and Disease by Dakang Xu Pdf

This book discusses recent research in innate immunity, which has revealed a large number of receptors that sense the presence of microorganisms or cellular damage in tissues. In complex tissues, many of these sensing events occur simultaneously. Thus, the downstream signaling pathways need to be integrated so that an appropriate cellular inflammatory response can be initiated. In addition, the inflammasome defines the molecular and cellular processes of inflammation in response to microbial infection. Previous data suggested that regulation of inflammasomes is mediated by microbes, but inflammasomes also have antimicrobial functions. Increasing evidence in mouse models, together with human data, strongly implicates an involvement of the inflammasome and uncontrolled inflammation in the initiation and progression of diseases with a high impact on public health. The book reviews novel aspects of functional genomics, epigenomics, transcriptomics, post-translat ional modifications, microbiome and immunometabolism in order to understand inflammatory signaling and responses, covering recent findings on the mechanisms underlying the regulation of inflammatory responses to pathogens, dysregulation of these responses in inflammatory disease, and the use of such mechanisms to boost or subdue the inflammatory response. Bridging the gaps in understanding between the fields of human and mouse immunology, it provides valuable insights into inflammatory-mediated disease and immune defense. Such innovative perspectives in both basic and clinical research promote the translation of knowledge to the clinic.

Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 802 pages
File Size : 54,5 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9780128027875

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Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase

Toward Precision Medicine

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Toward Precision Medicine Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publisher : National Academies Press
Page : 142 pages
File Size : 43,9 Mb
Release : 2012-01-16
Category : Medical
ISBN : 9780309222228

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Toward Precision Medicine by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease Pdf

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.