Translational Research Methods For Major Depressive Disorder

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Translational Research Methods for Major Depressive Disorder

Yong-Ku Kim,Meysam Amidfar
Translational Research Methods for Major Depressive Disorder Book PDF

Author : Yong-Ku Kim,Meysam Amidfar
Publisher : Humana
Page : 519 pages
File Size : 42,8 Mb
Release : 2022-02-13
Category : Medical
ISBN : 1071620827

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Translational Research Methods for Major Depressive Disorder by Yong-Ku Kim,Meysam Amidfar Pdf

This volume explores the latest techniques used to study brain function and pathophysiology of major depressive disorder (MDD), and includes suggestions of new therapeutic approaches for the treatment of MDD. The chapters into this book are organized into five parts. Part One discusses advanced approaches to studying well-established pathophysiological mechanisms. Part Two details behavioral research methods for MDD. Part Three looks at the cellular and molecular research methods for major depression, and Part Four describes the latest developments in non-invasive neuroimaging. Part Five focuses on the pharmacological and non-pharmacological interactions, including antidepressant agents and their properties, such as sexual side effects and neuroimaging biomarkers. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Translational Research Methods for Major Depressive Disorders is a valuable resource for researchers and scientists interested in learning more about this important and developing field.

Understanding Depression

Carmine Pariante
Understanding Depression Book PDF

Author : Carmine Pariante
Publisher : Oxford University Press
Page : 404 pages
File Size : 49,9 Mb
Release : 2009-07-02
Category : Medical
ISBN : 9780199533077

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Understanding Depression by Carmine Pariante Pdf

Depression is a major cause of morbidity and a significant public health problem. This book brings together world leaders in research on depression to discuss both classical and innovative ideas for understanding this devastating disorder. It includes cutting edge research from neurobiology, psychology, genetics, and evolutionary biology.

Translational Research Methods for Alcohol Use Disorders

Melissa A. Cyders
Translational Research Methods for Alcohol Use Disorders Book PDF

Author : Melissa A. Cyders
Publisher : Springer Nature
Page : 205 pages
File Size : 48,9 Mb
Release : 2023-06-06
Category : Medical
ISBN : 9781071632673

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Translational Research Methods for Alcohol Use Disorders by Melissa A. Cyders Pdf

This volume covers the latest translational research methods used to study Alcohol Use Disorders (AUD). The chapters in this book highlight cross-species complementary approaches and discusses ways that this translational work will further advance scientific progress in this field. In the Neuromethods series style, chapter include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Translational Research Methods for Alcohol Use Disorders is a valuable resource for all students and researchers interested in expanding their knowledge of AUD.

Understanding Depression

Anonim
Understanding Depression Book PDF

Author : Anonim
Publisher : Unknown
Page : 385 pages
File Size : 54,5 Mb
Release : 2009
Category : Depression, Mental
ISBN : 0191768855

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Understanding Depression by Anonim Pdf

Depression is a major cause of morbidity throughout the world. Given that between 8 and 12% of the population (in most countries) will suffer from depression at some point in their lives, it is clearly a significant public health problem. As our knowledge of this illness has expanded in recent years, it has become clear that depression can no longer be viewed as a simple disorder of the brain. It has to be seen as a series of behavioural and biological changes that span mind, brain, genes, and body--indeed, affecting both psychological and physical health. This book brings together world leaders in research on depression to discuss, for the first time, in an interdisciplinary setting, both classical and innovative ideas to understand this devastating disorder. It presents neurobiological, psyschological, genetic, and evolutionary models with a particular emphasis on the mechanisms linking the brain to the endocrine and the immune systems, and therefore, linking depression to physical health. Opening with a powerful, personal account of depression that conveys something of the all-consuming, debilitating nature of this illness, the book then presents cutting-edge research from those at the frontier of work in this area.

Translational Neuroimaging

Robert A. McArthur
Translational Neuroimaging Book PDF

Author : Robert A. McArthur
Publisher : Academic Press
Page : 464 pages
File Size : 44,7 Mb
Release : 2012-10-05
Category : Medical
ISBN : 9780123869975

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Translational Neuroimaging by Robert A. McArthur Pdf

Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment combines the experience of academic, clinical and industrial neuroimagers in a unique collaborative approach to provide an integrated perspective of the use of small animal and human brain imaging in developing and validating translational models and biomarkers for the study and treatment of neuropsychiatric disorders. Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment examines the translational role of neuroimaging in model development from preclinical animal models, to human experimental medicine, and finally to clinical studies. The focus of this book is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This book covers methodical issues in human and animal neuroimaging translational research as well as detailed applied examples of the use of neuroimaging in neuropsychiatric disorders and the development of drugs for their treatment. Offering an accompanying website with illustrations and text available for further knowledge and presentations, Translational Neuroimaging: Tools for CNS Drug Discovery, Development and Treatment appeals to non-clinical and clinical neuroscientists working in and studying neuropsychiatric disorders and their treatment as well as providing the novice researcher or researcher outside of his/her expertise the opportunity to understand the background of translational research and the use of imaging in this field. Provides a background to translational research and the use of brain imaging in neuropsychiatric disorders Critical discussion of the potential and limitations of neuroimaging as a translational tool for identifying and validating biomarkers Identifies cross species neurosystems and common endpoints necessary to help accelerate CNS drug discovery and development for the treatment of neuropsychiatric disorders Features an accompanying website with additional images and text

Translational Research Models and Methods for Mother-Infant Interactions and Developmental Studies

Josephine Johns,Rina Eiden,Elizabeth M. Byrnes,John H. Gilmore,Sheryl Moy,Joan I. Morrell,Linda Mayes,Karen Grewen
Translational Research Models and Methods for Mother Infant Interactions and Developmental Studies Book PDF

Author : Josephine Johns,Rina Eiden,Elizabeth M. Byrnes,John H. Gilmore,Sheryl Moy,Joan I. Morrell,Linda Mayes,Karen Grewen
Publisher : Frontiers Media SA
Page : 360 pages
File Size : 47,5 Mb
Release : 2012-10-01
Category : Electronic
ISBN : 9782889190454

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Translational Research Models and Methods for Mother-Infant Interactions and Developmental Studies by Josephine Johns,Rina Eiden,Elizabeth M. Byrnes,John H. Gilmore,Sheryl Moy,Joan I. Morrell,Linda Mayes,Karen Grewen Pdf

The disruption of mother-infant interactions can have life-long detrimental consequences for offspring and mothers. This topic of Frontiers will focus on maternal-infant interactions including factors that may affect or alter infant or child development and maternal response capability in clinical and preclinical (animal) populations. Articles may highlight topics such as drug abuse, maternal neglect, altered reward systems, stress, biological and neural system development, child and infant behavioral development, genetics/epigenetics and intergenerational studies. Submissions can include research methods papers, reviews, original research articles, techniques and opinion articles that address the topics of interest. This Research Topic will highlight translational research including common measures and results found in both animal and human studies. Please contact one of the Editors for submission proposals or for additional information.

Neurobiology of Depression

Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate
Neurobiology of Depression Book PDF

Author : Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate
Publisher : Academic Press
Page : 471 pages
File Size : 41,7 Mb
Release : 2019-01-03
Category : Medical
ISBN : 9780128133347

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Neurobiology of Depression by Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate Pdf

Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Depression in Parents, Parenting, and Children

Institute of Medicine,National Research Council,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on Depression, Parenting Practices, and the Healthy Development of Children
Depression in Parents Parenting and Children Book PDF

Author : Institute of Medicine,National Research Council,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on Depression, Parenting Practices, and the Healthy Development of Children
Publisher : National Academies Press
Page : 488 pages
File Size : 47,8 Mb
Release : 2009-10-28
Category : Medical
ISBN : 9780309121781

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Depression in Parents, Parenting, and Children by Institute of Medicine,National Research Council,Division of Behavioral and Social Sciences and Education,Board on Children, Youth, and Families,Committee on Depression, Parenting Practices, and the Healthy Development of Children Pdf

Depression is a widespread condition affecting approximately 7.5 million parents in the U.S. each year and may be putting at least 15 million children at risk for adverse health outcomes. Based on evidentiary studies, major depression in either parent can interfere with parenting quality and increase the risk of children developing mental, behavioral and social problems. Depression in Parents, Parenting, and Children highlights disparities in the prevalence, identification, treatment, and prevention of parental depression among different sociodemographic populations. It also outlines strategies for effective intervention and identifies the need for a more interdisciplinary approach that takes biological, psychological, behavioral, interpersonal, and social contexts into consideration. A major challenge to the effective management of parental depression is developing a treatment and prevention strategy that can be introduced within a two-generation framework, conducive for parents and their children. Thus far, both the federal and state response to the problem has been fragmented, poorly funded, and lacking proper oversight. This study examines options for widespread implementation of best practices as well as strategies that can be effective in diverse service settings for diverse populations of children and their families. The delivery of adequate screening and successful detection and treatment of a depressive illness and prevention of its effects on parenting and the health of children is a formidable challenge to modern health care systems. This study offers seven solid recommendations designed to increase awareness about and remove barriers to care for both the depressed adult and prevention of effects in the child. The report will be of particular interest to federal health officers, mental and behavioral health providers in diverse parts of health care delivery systems, health policy staff, state legislators, and the general public.

Treatment-Resistant Depression

Anonim
Treatment Resistant Depression Book PDF

Author : Anonim
Publisher : Elsevier
Page : 190 pages
File Size : 43,6 Mb
Release : 2023-07-05
Category : Science
ISBN : 9780323957793

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Treatment-Resistant Depression by Anonim Pdf

Progress in Brain Research, Volume 278, the latest release in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters on Treatment Resistant Depression overview in Adult, Treatment Resistant Depression in Children and Adolescents, Treatment Resistant Depression in Elderly, Headache and Treatment Resistant Depression, Insomnia and Treatment Resistant Depression, Tinnitus and Treatment Resistant Depression, Genetics of Antidepressant Response and Treatment Resistant Depression, Neuroinflammation via Gut-Microbiota-Brain Axis in Treatment Resistant Depression, Molecular Imaging findings for Treatment Resistant Depression, and more. Additional sections cover Functional MRI markers for Treatment Resistant Depression: Insights and Current Challenges, Medication Strategies for Treatment Resistant Depression, Brain Stimulation for Treatment Resistant Depression, Electroconvulsive Therapy for Treatment Resistant Depression, Next Generation Antidepressants with Novel Mechanisms for Treatment Resistant Depression, Psychological aspects and Psychotherapy for Treatment Resistant Depression, and Psychiatric Rehabilitation for Treatment Resistant Depression. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Brain Research serials Updated release includes the latest information on Treatment-Resistant Depression

Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease

Andrew J. Krentz,Christian Weyer,Marcus Hompesch
Translational Research Methods in Diabetes Obesity and Nonalcoholic Fatty Liver Disease Book PDF

Author : Andrew J. Krentz,Christian Weyer,Marcus Hompesch
Publisher : Springer
Page : 556 pages
File Size : 52,9 Mb
Release : 2019-04-02
Category : Medical
ISBN : 9783030117481

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Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease by Andrew J. Krentz,Christian Weyer,Marcus Hompesch Pdf

This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Personalized Psychiatry

Bernhard Baune
Personalized Psychiatry Book PDF

Author : Bernhard Baune
Publisher : Academic Press
Page : 604 pages
File Size : 48,6 Mb
Release : 2019-10-16
Category : Medical
ISBN : 9780128131770

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Personalized Psychiatry by Bernhard Baune Pdf

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Serotonin and the CNS

Berend Olivier
Serotonin and the CNS Book PDF

Author : Berend Olivier
Publisher : BoD – Books on Demand
Page : 198 pages
File Size : 49,8 Mb
Release : 2022-06-23
Category : Medical
ISBN : 9781839691997

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Serotonin and the CNS by Berend Olivier Pdf

Serotonin is an ancient neurotransmitter system involved in various systems and functions in the body and plays an important role in health and disease. The present volume illustrates the broadness of the involvement of serotonergic activity in many processes, focusing particularly on disorders of the brain, including depression, stress and fear, Alzheimer’s disease, aggression, sexual behavior, and neuro-immune disorders. Chapters illustrate techniques and methods used to study the complex role of the serotonergic system in all kinds of processes, present new hypotheses for several brain disorders like sleep and depression, and use mathematical modeling as a tool to advance knowledge of the extremely complex brain and body processes.

Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development

Andrew J. Krentz,Lutz Heinemann,Marcus Hompesch
Translational Research Methods for Diabetes Obesity and Cardiometabolic Drug Development Book PDF

Author : Andrew J. Krentz,Lutz Heinemann,Marcus Hompesch
Publisher : Springer
Page : 316 pages
File Size : 43,9 Mb
Release : 2014-11-29
Category : Medical
ISBN : 9781447149200

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Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development by Andrew J. Krentz,Lutz Heinemann,Marcus Hompesch Pdf

The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap. The development of new drugs for diabetes and obesity must be founded upon a sound appreciation of the pathophysiology of these common disorders. The dual defects of insulin resistance and impaired insulin secretion are fundamental to the pathogenesis and progression of obesity-associated type 2 diabetes. There is a need to explain how new drugs can counter insulin resistance and insulin deficiency to a broad range of professionals, from clinical scientists active in early (and later) phase drug development to specialist physicians and increasingly primary care doctors who must tailor drug regimens to the individual patient. Clinical research methods for measuring insulin action and insulin secretion have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. The purpose of the book is to aid the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans (with particular reference to new drugs) in phase 1 and 2 studies and aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes. The book will assume a working knowledge of human physiology relating to glucose metabolism and will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.

Heart Diseases—Advances in Research and Treatment: 2012 Edition

Anonim
Heart Diseases Advances in Research and Treatment 2012 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 831 pages
File Size : 42,8 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781464991448

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Heart Diseases—Advances in Research and Treatment: 2012 Edition by Anonim Pdf

Heart Diseases—Advances in Research and Treatment: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Heart Diseases. The editors have built Heart Diseases—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Heart Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Heart Diseases—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Translational Pain Research: Comparing preclinical studies and clinical pain management. Lost in translation?

Jianren Mao
Translational Pain Research Comparing preclinical studies and clinical pain management Lost in translation Book PDF

Author : Jianren Mao
Publisher : Nova Publishers
Page : 370 pages
File Size : 40,8 Mb
Release : 2006
Category : Pain
ISBN : 1600212050

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Translational Pain Research: Comparing preclinical studies and clinical pain management. Lost in translation? by Jianren Mao Pdf

Basic science and clinical pain research is particularly challenging for several reasons. First, pain is a subjective experience in response to nociception that follows actual or potential tissue damage. Since the ability to respond to this warning signal is essential for our survival, the nociceptive system that produces and transmits nociceptive signals is remarkably redundant and involves diffuse regions of the central nervous system. Second, unlike other sensory modalities, pain is a multi-dimensional experience including at least cognitive, affective, and sensory-discriminative components. Third, pain experiences can be influenced by psychological, socioeconomic, cultural, and genetic predispositions, making it exceedingly complicated to study pain and pain modulation. The topics covered in this volume are carefully selected and directly related to the daily practice of pain medicine. These topics include 1) central mechanisms of pain and pain modulation (Dickenson, Donovan-Rodriguez, Mattews) and clinical use of ion channel blockers (Chen); 2) spinal glutamatergic mechanisms (Guo, Dubner, Ren) and issues related to glutamate receptor antagonists in pain management (Mao); 3) basic science of opioid analgesics (Gintzler, Chakrabarti) and clinical opioid use (Smith, McCleane); 4) inflammatory cytokines (Samad) and clinical use of anti-inflammatory drugs (Fink, Brenner); 5) role of the sympathetic nervous system in pain mechanisms and its relation to clinical pain management (Sharma, Raja); 6) preclinical studies on tricyclic antidepressants (Gerner, Wang) and clinical use of antidepressants in pain management (Greenberg); 7) developing pain pathways and analgesic mechanisms during the developmental stage (Fitzgerald) and challenges of pediatric pain management (Lebel); 8) basic science mechanisms of serotonin agonists and their use in the clinical management of migraine headache (Biondi); 9) clinical research on gender differences in clinical pain and their implications for clinical pain management (Holdcroft); 10) current modalities of clinical cancer pain management (Popescu, Hord); and 11) preclinical and clinical information on alternative medicine (Chen).