Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 44,5 Mb
Release : 2023
Category : Electronic
ISBN : 1668714779
MACK'S CRIMINAL LAW TRIAL BOOK.
Anonim
Trials
Trials Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Trials book. This book definitely worth reading, it is an incredibly well-written.
Cluster Randomised Trials
Richard J. Hayes,Lawrence H. Moulton
Author : Richard J. Hayes,Lawrence H. Moulton
Publisher : CRC Press
Page : 466 pages
File Size : 52,8 Mb
Release : 2017-07-06
Category : Mathematics
ISBN : 9781315353234
Cluster Randomised Trials by Richard J. Hayes,Lawrence H. Moulton Pdf
Cluster Randomised Trials, Second Edition discusses the design, conduct, and analysis of trials that randomise groups of individuals to different treatments. It explores the advantages of cluster randomisation, with special attention given to evaluating the effects of interventions against infectious diseases. Avoiding unnecessary mathematical detail, the book covers basic concepts underlying the use of cluster randomisation, such as direct, indirect, and total effects. In the time since the publication of the first edition, the use of cluster randomised trials (CRTs) has increased substantially, which is reflected in the updates to this edition. There are greatly expanded sections on randomisation, sample size estimation, and alternative designs, including new material on stepped wedge designs. There is a new section on handling ordinal outcome data, and an appendix with descriptions and/or generating code of the example data sets. Although the book mainly focuses on medical and public health applications, it shows that the rigorous evidence of intervention effects provided by CRTs has the potential to inform public policy in a wide range of other areas. The book encourages readers to apply the methods to their own trials, reproduce the analyses presented, and explore alternative approaches.
The Prevention and Treatment of Missing Data in Clinical Trials
National Research Council,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Panel on Handling Missing Data in Clinical Trials
Author : National Research Council,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Panel on Handling Missing Data in Clinical Trials
Publisher : National Academies Press
Page : 163 pages
File Size : 46,9 Mb
Release : 2010-12-21
Category : Medical
ISBN : 9780309186513
The Prevention and Treatment of Missing Data in Clinical Trials by National Research Council,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Panel on Handling Missing Data in Clinical Trials Pdf
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
The Princess Trials
Cordelia K. Castel
Author : Cordelia K. Castel
Publisher : Unknown
Page : 504 pages
File Size : 41,8 Mb
Release : 2020-05-02
Category : Electronic
ISBN : 9798642502532
The Princess Trials by Cordelia K. Castel Pdf
Thirty young women. A handsome prince. A battle to the death Water is scarce. Deserts have taken over the land. Nuclear war has devastated humanity. Humans live in walled super cities to keep out the irradiated. The land that was formerly known as America is divided into kingdoms ruled by royal elites.Born into the lowest Echelon of the Kingdom of Phangloria, sixteen-year-old Zea Calico faces a life of hunger, thirst, and toil. The only way out of this drudgery is revolution, and Zea is desperate to help the cause. When the palace calls for candidates to compete to marry Prince Kevon, Zea joins the Princess Trials to search the palace for weaknesses. The trials should be a fairytale of sumptuous meals, ballgowns, and romance, but one misplaced word causes Zea to attract the Prince's attention. When Zea uncovers the man beneath Prince Kevon's public facade, she is at risk of falling in love and losing sight of her mission. But the televised beauty pageant turns deadly, and Zea must fight for survival.Perfect for fans of The Hunger Games and The Selection, this exciting tale of courage, intrigue, and betrayal will have you turning pages.
The Sunbearer Trials
Aiden Thomas
Author : Aiden Thomas
Publisher : Feiwel & Friends
Page : 380 pages
File Size : 45,9 Mb
Release : 2022-09-06
Category : Young Adult Fiction
ISBN : 9781250822147
The Sunbearer Trials by Aiden Thomas Pdf
Welcome to The Sunbearer Trials, where teen semidioses compete in a series of challenges with the highest of stakes, in this electric new Mexican-inspired fantasy from Aiden Thomas, the New York Times bestselling author of Cemetery Boys. “Only the most powerful and honorable semidioses get chosen. I’m just a Jade. I’m not a real hero.” As each new decade begins, the Sun’s power must be replenished so that Sol can keep traveling along the sky and keep the chaotic Obsidian gods at bay. Sol selects ten of the most worthy semidioses to compete in the Sunbearer Trials. The winner carries light and life to all the temples of Reino del Sol, but the loser has the greatest honor of all—they will be sacrificed to Sol, their body melted down to refuel the Sun Stones, protecting the world for another ten years. Teo, a seventeen-year-old Jade semidiós and the trans son of the goddess of birds, isn't worried about the Trials . . . at least, not for himself. His best friend, Niya is a Gold semidiós and a shoo-in for the Trials, and while he trusts her abilities, the odds of becoming the sacrifice is one-in-ten. But then, for the first time in over a century, the impossible happens. Sol chooses not one, but two Jade competitors. Teo, and Xio, the thirteen-year-old child of the god of bad luck. Now they must compete in five trials against Gold opponents who are more powerful and better trained. Worst of all, Teo’s annoyingly handsome ex-best friend and famous semidiós Hero, Aurelio is favored to win. Teo is determined to get himself and his friends through the trials unscathed—for fame, glory, and their own survival.
Behavioral Clinical Trials for Chronic Diseases
Lynda H. Powell,Kenneth E. Freedland,Peter G. Kaufmann
Author : Lynda H. Powell,Kenneth E. Freedland,Peter G. Kaufmann
Publisher : Springer Nature
Page : 324 pages
File Size : 54,6 Mb
Release : 2021-10-13
Category : Psychology
ISBN : 9783030393304
Behavioral Clinical Trials for Chronic Diseases by Lynda H. Powell,Kenneth E. Freedland,Peter G. Kaufmann Pdf
This is the first comprehensive guide to the design of behavioral randomized clinical trials (RCT) for chronic diseases. It includes the scientific foundations for behavioral trial methods, problems that have been encountered in past behavioral trials, advances in design that have evolved, and promising trends and opportunities for the future. The value of this book lies in its potential to foster an ability to “speak the language of medicine” through the conduct of high-quality behavioral clinical trials that match the rigor commonly seen in double-blind drug trials. It is relevant for testing any treatment aimed at improving a behavioral, social, psychosocial, environmental, or policy-level risk factor for a chronic disease including, for example, obesity, sedentary behavior, adherence to treatment, psychosocial stress, food deserts, and fragmented care. Outcomes of interest are those that are of clinical significance in the treatment of chronic diseases, including standard risk factors such as cholesterol, blood pressure, and glucose, and clinical outcomes such as hospitalizations, functional limitations, excess morbidity, quality of life, and mortality. This link between behavior and chronic disease requires innovative clinical trial methods not only from the behavioral sciences but also from medicine, epidemiology, and biostatistics. This integration does not exist in any current book, or in any training program, in either the behavioral sciences or medicine.
Small Clinical Trials
Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Small-Number-Participant Clinical Research Trials
Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Small-Number-Participant Clinical Research Trials
Publisher : National Academies Press
Page : 222 pages
File Size : 43,9 Mb
Release : 2001-01-01
Category : Medical
ISBN : 0309171148
Small Clinical Trials by Institute of Medicine,Board on Health Sciences Policy,Committee on Strategies for Small-Number-Participant Clinical Research Trials Pdf
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Clinical Trials
Tom Brody
Author : Tom Brody
Publisher : Academic Press
Page : 897 pages
File Size : 55,7 Mb
Release : 2016-02-19
Category : Medical
ISBN : 9780128042588
Clinical Trials by Tom Brody Pdf
Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials. Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and more Extensively covers the "study schema" and related features of study design Incorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trials Includes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers
T.R.I.A.L.S.: A Journey From Anxiety to Peace
Chase Turner
Author : Chase Turner
Publisher : Ben Giselbach
Page : 204 pages
File Size : 47,6 Mb
Release : 2021-07-20
Category : Religion
ISBN : 195295505X
T.R.I.A.L.S.: A Journey From Anxiety to Peace by Chase Turner Pdf
If I told you the power of leaving anxiety behind and having positive, joy-filled days was as easy as reading this short book, would you believe me? No worries, I wouldn't either. However, I hope you will join me on a journey to see if you can convince yourself anxiety is a choice that we all have the power to choose to endure or let go. So many areas in our lives cause us anxiety, stress, worry, depression, etc. When we consider all the trigger points for these challenges we face, we must find the root or the core of what brings all these negative feelings and emotions. One of the underlying struggles we all deal with is the desire to be normal. We never want others to look at us and think we aren't "normal," or better put, "like them" (from our own perspective). When we look at the world around us, don't we find the biggest group of people who seem to be similar, and then we try to be like them because they are the "normal" ones? It feels silly just saying those words, but so many live by them. Do we really want to be like everyone else? The T.R.I.A.L.S. method has helped me in my journey to help others reduce stress in their lives. I have developed this acronym hoping to help us all find practical ways to overcome stressful situations and anxiety. T = Transparency R = Responsibility I = Intentionality A = Appreciation L = Limits S = Simplify At the end of each section, we will look at practical ways to implement these principles to reduce your current stress levels. There will also be a section of discussion questions at the end of each chapter to use for personal growth or group studies. Understanding T.R.I.A.L.S. has the potential to bring a tremendous amount of joy to your life. I encourage you to have an open mind and be optimistic about the possibility of reducing your stress and eliminating anxiety from your daily routine. The power to choose lies within you!
Fundamentals of Clinical Trials
Lawrence M. Friedman,Curt Furberg,David L. DeMets
Author : Lawrence M. Friedman,Curt Furberg,David L. DeMets
Publisher : Springer Science & Business Media
Page : 384 pages
File Size : 42,5 Mb
Release : 1998
Category : Clinical trials
ISBN : 0387985867
Fundamentals of Clinical Trials by Lawrence M. Friedman,Curt Furberg,David L. DeMets Pdf
This classic reference, now updated with the newest applications and results, addresses the fundamentals of such trials based on sound scientific methodology, statistical principles, and years of accumulated experience by the three authors.
The Essential Guide to N-of-1 Trials in Health
Jane Nikles,Geoffrey Mitchell
Author : Jane Nikles,Geoffrey Mitchell
Publisher : Springer
Page : 245 pages
File Size : 53,9 Mb
Release : 2015-10-05
Category : Medical
ISBN : 9789401772006
The Essential Guide to N-of-1 Trials in Health by Jane Nikles,Geoffrey Mitchell Pdf
N-of-1 trials, a type of individualized randomized controlled trial, are relevant to almost every discipline in medicine and psychology. They can tell the clinician with precision whether a treatment works in that individual, which distinguishes from the information available from most other trial designs. They have the potential to revolutionize the way clinical medicine is practiced. Whether you are a busy clinician, a researcher or a student, this book provides everything you need to know about N-of-1 trials. Written and edited by some of the world’s leading experts on N-of-1 trials, the book presents state of the art knowledge about N-of-1 trials, with chapters on ethics, statistics, health economics, design, analysis and reporting, and more. Full of examples and well illustrated, it is a comprehensive compendium of issues surrounding the design, conduct, interpretation and implementation of N-of-1 trials in a health system.
The Blood Trials
N. E. Davenport
Author : N. E. Davenport
Publisher : HarperCollins
Page : 429 pages
File Size : 49,7 Mb
Release : 2022-04-05
Category : Fiction
ISBN : 9780063058507
The Blood Trials by N. E. Davenport Pdf
Blending fantasy and science fiction, N. E. Davenport’s fast-paced, action-packed debut kicks off a duology of loyalty and rebellion, in which a young Black woman must survive deadly trials in a racist and misogynistic society to become an elite warrior. It’s all about blood. The blood spilled between the Republic of Mareen and the armies of the Blood Emperor long ago. The blood gifts of Mareen’s deadliest enemies. The blood that runs through the elite War Houses of Mareen, the rulers of the Tribunal dedicated to keeping the republic alive. The blood of the former Legatus, Verne Amari, murdered. For his granddaughter, Ikenna, the only thing steady in her life was the man who had saved Mareen. The man who had trained her in secret, not just in martial skills, but in harnessing the blood gift that coursed through her. Who trained her to keep that a secret. But now there are too many secrets, and with her grandfather assassinated, Ikenna knows two things: that only someone on the Tribunal could have ordered his death, and that only a Praetorian Guard could have carried out that order. Bent on revenge as much as discovering the truth, Ikenna pledges herself to the Praetorian Trials—a brutal initiation that only a quarter of the aspirants survive. She subjects herself to the racism directed against her half-Khanaian heritage and the misogyny of a society that cherishes progeny over prodigy, all while hiding a power that—if found out—would subject her to execution…or worse. Ikenna is willing to risk it all because she needs to find out who murdered her grandfather…and then she needs to kill them. Mareen has been at peace for a long time… Ikenna joining the Praetorians is about to change all that. Magic and technology converge in the first part of this stunning debut duology, where loyalty to oneself—and one’s blood—is more important than anything.
The Poison Trials
Alisha Rankin
Author : Alisha Rankin
Publisher : University of Chicago Press
Page : 0 pages
File Size : 43,5 Mb
Release : 2021-01-01
Category : Science
ISBN : 022674485X
The Poison Trials by Alisha Rankin Pdf
In 1524, Pope Clement VII gave two condemned criminals to his physician to test a promising new antidote. After each convict ate a marzipan cake poisoned with deadly aconite, one of them received the antidote, and lived—the other died in agony. In sixteenth-century Europe, this and more than a dozen other accounts of poison trials were committed to writing. Alisha Rankin tells their little-known story. At a time when poison was widely feared, the urgent need for effective cures provoked intense excitement about new drugs. As doctors created, performed, and evaluated poison trials, they devoted careful attention to method, wrote detailed experimental reports, and engaged with the problem of using human subjects for fatal tests. In reconstructing this history, Rankin reveals how the antidote trials generated extensive engagement with “experimental thinking” long before the great experimental boom of the seventeenth century and investigates how competition with lower-class healers spurred on this trend. The Poison Trials sheds welcome and timely light on the intertwined nature of medical innovations, professional rivalries, and political power.
TRIAL OF SEXUAL OFFENCE CASES.
MICHELLE. FUERST
Author : MICHELLE. FUERST
Publisher : Unknown
Page : 128 pages
File Size : 50,9 Mb
Release : 2018
Category : Electronic
ISBN : 0779886305
TRIAL OF SEXUAL OFFENCE CASES. by MICHELLE. FUERST Pdf
The Condor Trials
Francesca Lessa
Author : Francesca Lessa
Publisher : Yale University Press
Page : 392 pages
File Size : 52,5 Mb
Release : 2022-05-31
Category : History
ISBN : 9780300265361
The Condor Trials by Francesca Lessa Pdf
Stories of transnational terror and justice illuminate the past and present of South America’s struggles for human rights. Through the voices of survivors, human rights activists, judicial actors, and experts, The Condor Trials unravels the secrets of transnational repression masterminded by South American dictators between 1969 and 1981. Under Operation Condor, the regimes of Argentina, Bolivia, Brazil, Chile, Paraguay, and Uruguay closely monitored hundreds of exiles and kidnapped, tortured, murdered, or forcibly returned them to their countries of origin. This cross-border network designed to silence opposition in exile transformed South America into a borderless zone of terror and impunity. Francesca Lessa shows how, gradually, transnational networks of activists materialized and effectively transcended national borders to achieve justice for the victims of these horrors. Based on extensive fieldwork, archival research, trial ethnography, and over 100 interviews, The Condor Trials explores South America’s past and present and sheds light on ongoing struggles for justice as its societies come to terms with the unparalleled atrocities of their not-so-distant pasts.