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Turmeric and Curcumin for Neurodegenerative Diseases

Magisetty Obulesu

Author : Magisetty Obulesu
Publisher : Academic Press
Page : 188 pages
File Size : 49,7 Mb
Release : 2021-01-26
Category : Medical
ISBN : 9780128224496

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Turmeric and Curcumin for Neurodegenerative Diseases by Magisetty Obulesu Pdf

Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer’s Disease, Parkinson’s, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference. Summarizes the therapeutic efficacy of turmeric and curcumin for neurodegenerative diseases Includes effects on Alzheimer’s, Parkinson’s and liver diseases Focuses on different types of drug delivery systems and their challenges Examines novel nanotechnological therapeutics and biomaterial design strategies

Curcumin and Neurodegenerative Diseases

Mahendra Rai,Chistiane M. Feitosa

Author : Mahendra Rai,Chistiane M. Feitosa
Publisher : Springer
Page : 0 pages
File Size : 43,7 Mb
Release : 2024-03-09
Category : Medical
ISBN : 9819977304

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Curcumin and Neurodegenerative Diseases by Mahendra Rai,Chistiane M. Feitosa Pdf

This book explores the potential benefits of turmeric, and specifically curcumin, in the treatment and prevention of neurodegenerative diseases. The book covers various aspects of turmeric, including its traditional use in Ayurveda and Chinese medicine, secondary metabolites, curcuminoids, and sesquiterpenoids found in turmeric, as well as the use of nano curcumin in neurodegenerative diseases. It discusses the different ways in which turmeric can be used to treat neurodegenerative diseases, including as a therapy for brain diseases, curcumin-induced neuroprotection in cerebral ischemia, and neural stem cell therapy in combination with curcumin. It also discusses the role of nano curcumin in neurodegenerative diseases, including its potential use in the treatment of Alzheimer's disease. The book provides the scientific evidence behind the use of turmeric and its compounds in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Overall, this book is an invaluable resource for researchers and healthcare professionals interested in exploring the potential benefits of turmeric and curcumin in the treatment and prevention of neurodegenerative diseases.

Curcumin for Neurological and Psychiatric Disorders

Tahira Farooqui,Akhlaq A. Farooqui

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : Academic Press
Page : 544 pages
File Size : 47,7 Mb
Release : 2019-03-16
Category : Medical
ISBN : 9780128154625

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Curcumin for Neurological and Psychiatric Disorders by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases. The book's editors discuss the neurochemical and pharmacological properties of curcumin, followed by the effect of curcumin in neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases. The book also offers a perspective on future studies on the treatment of neurological disorders. The beneficial effects of curcumin have been observed both in cultured cells and in animal models, thus paving the way for ongoing present and future human clinical trials. Curcumin produces antioxidant and anti-inflammatory effects not only by blocking oxidative stress and neuroinflammation in neurotraumatic and neurodegenerative diseases, but also by restoring cellular homeostasis and rebalancing redox equilibrium. Identifies molecular mechanisms of curcumin effects in neurological diseases Includes effects on neurotraumatic, neurodegenerative and psychiatric diseases Covers the antioxidant, anti-inflammatory and immunomodulatory effects of curcumin Examines curcumin’s potential in developing new therapeutic drugs

Therapeutic Potentials of Curcumin for Alzheimer Disease

Akhlaq A Farooqui

Author : Akhlaq A Farooqui
Publisher : Springer
Page : 402 pages
File Size : 51,5 Mb
Release : 2016-03-05
Category : Medical
ISBN : 9783319158891

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Therapeutic Potentials of Curcumin for Alzheimer Disease by Akhlaq A Farooqui Pdf

This is the first book on the market that explores the importance of curcumin for the treatment of neurological disorders. It has been estimated that 35.6 million people globally had dementia in 2010 and the prevalence of dementia has been predicted to double every 20 years. Thus, 115.4 million people may be living with dementia in 2050. Alzheimer’s disease (AD) is the leading cause of dementia and is present in 60%–70% of people with dementia. Unless new discoveries are made in the prevention or treatment of AD, the number of cases in the US alone is estimated to increase threefold, to 13.2 million by the year 2050. Thus, it is important to focus on delaying and treating the onset of AD by curcumin may be an important step for controlling AD. Regular consumption of healthy diet containing curcumin enriched foods, moderate exercise, and regular sleep may produce beneficial effects not only on motor and cognitive functions, but also on memory deficits that occur to some extent during normal aging and to a large extent in AD. Delaying the onset and progression of AD and improving its symptoms by few years with regular consumption of curcumin may relieve some of the burden on health care systems. In service of this goal, this volume gives readers a comprehensive and cutting edge description of the importance of curcumin for the treatment of AD in cell culture and animal models in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. It can be used as supplement text for a range of neuroscience and nutrition courses. Clinicians, neuroscientists, neurologists and pharmacologists will find this book useful for understanding molecular aspects of AD treatment by curcumin.

The Benefits of Natural Products for Neurodegenerative Diseases

M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin

Author : M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin
Publisher : Springer
Page : 496 pages
File Size : 42,7 Mb
Release : 2016-09-20
Category : Medical
ISBN : 9783319283838

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The Benefits of Natural Products for Neurodegenerative Diseases by M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin Pdf

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Curcumin

Daniel Loïc Pouliquen

Author : Daniel Loïc Pouliquen
Publisher : Nova Science Publishers
Page : 527 pages
File Size : 48,7 Mb
Release : 2014-07-26
Category : Turmeric
ISBN : 1633213307

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Curcumin by Daniel Loïc Pouliquen Pdf

Examples of plant-derived pharmaceuticals that have become the focus of continuous and exponential research and development interest have, to date, been somewhat scarce. After a long period, the last two decades have been characterized by a 100-fold increase in the number of scientific articles published annually that are of relevance to the use of curcumin in biomedicine. Today, the already-wide spectrum of potential clinical applications of this natural drug and its synthetic derivatives continues to grow, including chemoprevention and the treatment of cancers, inflammatory and immune diseases, diabetes, bacterial and viral infections, parasitosis, and cardiovascular and neurodegenerative diseases. Over the last two decades, numerous findings have confirmed the safety of curcumin, both in preclinical and clinical studies. Its physicochemical properties, low bioavailability and rapid metabolism have, however, somewhat limited its potential therapeutic applications. To overcome these limitations, the last few years have seen an impressive development of research on analogs, prodrugs and nanostructured systems, a number of which are already demonstrating improved properties compared with the parent structure. In parallel, new administration routes have been explored, and additional pharmacological properties have been documented, leading in particular to promising prospects for pain management.

Curcumin

Daniel Loïc Pouliquen

Author : Daniel Loïc Pouliquen
Publisher : Unknown
Page : 548 pages
File Size : 49,8 Mb
Release : 2014-01-01
Category : Medical
ISBN : 1633213196

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Curcumin by Daniel Loïc Pouliquen Pdf

Examples of plant-derived pharmaceuticals that have become the focus of continuous and exponential research and development interest have, to date, been somewhat scarce. After a long period, the last two decades have been characterized by a 100-fold increase in the number of scientific articles published annually that are of relevance to the use of curcumin in biomedicine. Today, the already-wide spectrum of potential clinical applications of this natural drug and its synthetic derivatives continues to grow, including chemoprevention and the treatment of cancers, inflammatory and immune diseases, diabetes, bacterial and viral infections, parasitosis, and cardiovascular and neurodegenerative diseases. Over the last two decades, numerous findings have confirmed the safety of curcumin, both in preclinical and clinical studies. Its physicochemical properties, low bioavailability and rapid metabolism have, however, somewhat limited its potential therapeutic applications. To overcome these limitations, the last few years have seen an impressive development of research on analogs, prodrugs and nanostructured systems, a number of which are already demonstrating improved properties compared with the parent structure. In parallel, new administration routes have been explored, and additional pharmacological properties have been documented, leading in particular to promising prospects for pain management.

The Chemistry and Bioactive Components of Turmeric

Sreeraj Gopi,Sabu Thomas,Ajaikumar B Kunnumakkara,Bharat B Aggarwal,Augustine Amalraj

Author : Sreeraj Gopi,Sabu Thomas,Ajaikumar B Kunnumakkara,Bharat B Aggarwal,Augustine Amalraj
Publisher : Royal Society of Chemistry
Page : 405 pages
File Size : 53,8 Mb
Release : 2020-10-15
Category : Technology & Engineering
ISBN : 9781839160592

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The Chemistry and Bioactive Components of Turmeric by Sreeraj Gopi,Sabu Thomas,Ajaikumar B Kunnumakkara,Bharat B Aggarwal,Augustine Amalraj Pdf

Turmeric belongs to the family Zingiberaceae and is a yellow spice of high economic importance due to its medicinal value. Cultivated in tropical and sub-tropical regions around the world, it is used extensively as a colouring, flavouring and preserving agent. In recent years, several drugs derived from natural products have been developed and current drug research is actively investigating the possible therapeutic roles of many Ayurvedic medicines, most notable among those being examined is turmeric. The wide range of pharmacological activities attributed to turmeric come mainly from curcuminoids and two related compounds, demethoxycurcumin and bisdemethoxycurcumin. This comprehensive book brings together the research carried out on constituents obtained from turmeric and highlights their chemical and biological activities. Comprising 17 chapters, each written by experts in their respective field and curated by authorities, it will be invaluable to all those who are involved in the production, processing, marketing, and the use of turmeric. Appealing to researchers and professionals in natural products, nutraceuticals and food chemists, this book is exposing some of the myths and showing areas for possible future use.

Oxidative Stress and Neurodegenerative Disorders

G. Ali Qureshi,S. Hasan Parvez

Author : G. Ali Qureshi,S. Hasan Parvez
Publisher : Elsevier
Page : 794 pages
File Size : 45,6 Mb
Release : 2007-03-22
Category : Science
ISBN : 0080489494

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Oxidative Stress and Neurodegenerative Disorders by G. Ali Qureshi,S. Hasan Parvez Pdf

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Cerebral Ischemia

Ryszard M. Pluta

Author : Ryszard M. Pluta
Publisher : Unknown
Page : 224 pages
File Size : 49,8 Mb
Release : 2021
Category : Electronic
ISBN : OCLC:1291165922

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Cerebral Ischemia by Ryszard M. Pluta Pdf

Cerebral ischemia is one of the most common causes of dementia, which develops in more than half of patients after an ischemic episode. The main mechanism is thought to be pathological changes in the hippocampus, especially in the CA1 area, underlying episodic memory impairment, which is the earliest and most important clinical symptom of post-ischemic dementia. The 13 chapters of this book present a new picture of ischemic brain disease, synthesizing the latest data on disease mechanisms, care for patients with this disease, and potential therapeutic targets. The authors present the characteristics of cerebral ischemia from pregnancy and childhood through adolescence to adulthood. The first two chapters provide a snapshot of the anatomy of the cerebral cortex and the hippocampus, the most affected brain structures after cerebral ischemia. This is followed by nine chapters that present a comprehensive view of the pathological mechanisms of cerebral ischemia, and how a deep understanding of these pathomechanisms hold the key for the discovery and development of novel therapies to help patients affected by cerebral ischemia. Chapter 12 shares real-life experience and challenges of rehabilitating patients into the community after cerebral ischemia, and chapter 13 analyzes the social risk variations, including gender inequality, in the reintegration of post-ischemic stroke patients. Although primarily aimed at scientists and clinicians, the contents of the book will be of interest to all those who are interested in cerebral ischemia, including patients and their caregivers.

Levodopa-Induced Dyskinesia in Parkinson's Disease

Susan H. Fox,Jonathan M. Brotchie

Author : Susan H. Fox,Jonathan M. Brotchie
Publisher : Springer
Page : 0 pages
File Size : 55,8 Mb
Release : 2017-04-30
Category : Medical
ISBN : 1447172388

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Levodopa-Induced Dyskinesia in Parkinson's Disease by Susan H. Fox,Jonathan M. Brotchie Pdf

This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; on going RCTs in LID and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson’s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students.

Neuroprotective Effects of Phytochemicals in Neurological Disorders

Tahira Farooqui,Akhlaq A. Farooqui

Author : Tahira Farooqui,Akhlaq A. Farooqui
Publisher : John Wiley & Sons
Page : 648 pages
File Size : 47,6 Mb
Release : 2017-01-03
Category : Medical
ISBN : 9781119155171

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Neuroprotective Effects of Phytochemicals in Neurological Disorders by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.

Curcumin in Health and Disease

Beatrice E. Bachmeier

Author : Beatrice E. Bachmeier
Publisher : MDPI
Page : 274 pages
File Size : 52,7 Mb
Release : 2019-10-11
Category : Medical
ISBN : 9783039214495

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Curcumin in Health and Disease by Beatrice E. Bachmeier Pdf

The plant-derived polyphenol curcumin has been used in promoting health and combating disease for thousands of years. Its therapeutic effects have been successfully utilized in Ayurvedic and Traditional Chinese Medicine in order to treat inflammatory diseases. Current results from modern biomolecular research reveal the modulatory effects of curcumin on a variety of signal transduction pathways associated with inflammation and cancer. In this context, curcumin’s antioxidant, anti-inflammatory, anti-tumorigenic, and even anti-metastatic activities are discussed. On the cellular level, the reduced activity of several transcription factors (such as NFkB or AP-1) and the suppression of inflammatory cytokines, matrix degrading enzymes, metastasis related genes and even microRNAs are reported. On functional levels, these molecular effects translate into reduced proliferative, invasive, and metastatic capacity, as well as induced tumor cell apoptosis. All these effects have been observed not only in vitro but also in animal models. In combination with anti-neoplastic drugs like Taxol, kinase inhibitors, and radiation therapy, curcumin potentiates the drugs’ therapeutic power and can protect against undesired side effects. Natural plant-derived compounds like curcumin have one significant advantage: They do not usually cause side effects. This feature qualifies curcumin for primary prevention in healthy persons with a predisposition to cancer, arteriosclerosis, or chronic inflammatory diseases. Nonetheless, curcumin is considered safe, although potential toxic effects stemming from high dosages, long-term intake, and pharmacological interactions with other compounds have yet to be assessed. This Special Issue examines in detail and updates current research on the molecular targets, protective effects, and modes of action of natural plant-derived compounds and their roles in the prevention and treatment of human diseases.

Neurotrophic Factors

Gary R. Lewin,Bruce D. Carter

Author : Gary R. Lewin,Bruce D. Carter
Publisher : Springer Science & Business Media
Page : 514 pages
File Size : 44,5 Mb
Release : 2014-03-25
Category : Medical
ISBN : 9783642451065

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Neurotrophic Factors by Gary R. Lewin,Bruce D. Carter Pdf

This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.

Nutraceuticals in Brain Health and Beyond

Dilip Ghosh

Author : Dilip Ghosh
Publisher : Academic Press
Page : 476 pages
File Size : 45,7 Mb
Release : 2020-11-12
Category : Health & Fitness
ISBN : 9780128206102

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Nutraceuticals in Brain Health and Beyond by Dilip Ghosh Pdf

Nutraceuticals in Brain Health and Beyond focuses on a variety of health disorders where intervention with nutritional supplements prove valuable, such as Alzheimer’s, Parkinson’s, autism, and attention-deficit disorder in children. In addition, Nutraceuticals in Brain Health and Beyond addresses "herb-nutra psychiatry" which is a field of research focused on developing a comprehensive, cohesive, and scientifically rigorous evidence base to shift conceptual thinking around the role of diet and nutrition in mental health. Intended for nutrition researchers, nutritionists, dieticians, regulatory bodies, health professionals, and students studying related fields, Nutraceuticals in Brain Health and Beyond will be a useful reference in understanding the links between nutrition and brain health. • Addresses nutritional psychiatry and cognitive health at all stages of the lifespan • Contains extensive coverage of vitamins, minerals, botanicals, and other nutrients • Offers novel insight into cognitive dysfunctions including depression and other neurodegenerative disorders • Explores the role of genomics and epigenetics, including discussion of the gut–brain axis

Turmeric And Curcumin For Neurodegenerative Diseases

Turmeric and Curcumin for Neurodegenerative Diseases by Magisetty Obulesu Pdf

Curcumin and Neurodegenerative Diseases by Mahendra Rai,Chistiane M. Feitosa Pdf

Curcumin for Neurological and Psychiatric Disorders by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Therapeutic Potentials of Curcumin for Alzheimer Disease by Akhlaq A Farooqui Pdf

The Benefits of Natural Products for Neurodegenerative Diseases by M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin Pdf

Curcumin by Daniel Loïc Pouliquen Pdf

Curcumin by Daniel Loïc Pouliquen Pdf

The Chemistry and Bioactive Components of Turmeric by Sreeraj Gopi,Sabu Thomas,Ajaikumar B Kunnumakkara,Bharat B Aggarwal,Augustine Amalraj Pdf

Oxidative Stress and Neurodegenerative Disorders by G. Ali Qureshi,S. Hasan Parvez Pdf

Cerebral Ischemia by Ryszard M. Pluta Pdf

Levodopa-Induced Dyskinesia in Parkinson's Disease by Susan H. Fox,Jonathan M. Brotchie Pdf

Neuroprotective Effects of Phytochemicals in Neurological Disorders by Tahira Farooqui,Akhlaq A. Farooqui Pdf

Curcumin in Health and Disease by Beatrice E. Bachmeier Pdf

Neurotrophic Factors by Gary R. Lewin,Bruce D. Carter Pdf

Nutraceuticals in Brain Health and Beyond by Dilip Ghosh Pdf

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