Understanding Multiple Myeloma

Author : Morie A. Gertz,S. Vincent Rajkumar
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 49,5 Mb
Release : 2013-10-01
Category : Medical
ISBN : 9781461485209

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Multiple Myeloma by Morie A. Gertz,S. Vincent Rajkumar Pdf

This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 54,6 Mb
Release : 2024-05-22
Category : Electronic
ISBN : 9781284149821

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by Anonim Pdf

Author : Thomas Moehler,Hartmut Goldschmidt
Publisher : Springer Science & Business Media
Page : 349 pages
File Size : 52,6 Mb
Release : 2011-04-21
Category : Medical
ISBN : 9783540857723

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Multiple Myeloma by Thomas Moehler,Hartmut Goldschmidt Pdf

Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.

Author : Hillard M. Lazarus,Mary J. Laughlin
Publisher : Springer Science & Business Media
Page : 881 pages
File Size : 53,7 Mb
Release : 2010-03-02
Category : Medical
ISBN : 9781597454780

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Allogeneic Stem Cell Transplantation by Hillard M. Lazarus,Mary J. Laughlin Pdf

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Author : Meletios A. Dimopoulos,Thierry Facon,Evangelos Terpos
Publisher : Springer
Page : 245 pages
File Size : 48,7 Mb
Release : 2018-02-16
Category : Medical
ISBN : 9783319255866

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Multiple Myeloma and Other Plasma Cell Neoplasms by Meletios A. Dimopoulos,Thierry Facon,Evangelos Terpos Pdf

This book is a comprehensive source of up-to-date information on plasma cell neoplasms. Key features include the provision of new criteria for the diagnosis of symptomatic multiple myeloma requiring treatment and the description of novel therapies for myeloma and other plasma cell neoplasms that have only very recently been licensed by the U.S. Food and Drug Administration. Examples include lenalidomide as first-line therapy, panobinostat in combination with bortezomib plus dexamethasone for relapsed/refractory myeloma, ibrutinib for Waldenström’s macroglobulinemia, and new therapeutic regimens for systemic amyloidosis and POEMS syndrome. Information is also provided on drug combinations that have shown encouraging results and are very near to approval. Other important aspects covered in the book are the role of different imaging modalities in workup and the significance of newly acquired data relating to prognosis and minimal residual disease. Readers will find Multiple Myeloma and Other Plasma Cell Neoplasms to be a rich source of knowledge that will be invaluable in improving patient management.

Author : Mohamad Mohty,Jean-Luc Harousseau
Publisher : Springer
Page : 90 pages
File Size : 49,5 Mb
Release : 2015-07-14
Category : Medical
ISBN : 9783319182186

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Handbook of Multiple Myeloma by Mohamad Mohty,Jean-Luc Harousseau Pdf

This handbook is an in-depth and comprehensive guide to the pathophysiology, diagnosis, staging, treatment and management of patients with multiple myeloma. The Handbook was commissioned to address an unmet need for a book of this kind in the myeloma field and to provide busy healthcare professionals with an informative and educational review of the current and emerging treatment recommendations for multiple myeloma. Myeloma is a type of bone marrow cancer arising from plasma cells and is the second most common form of bone marrow cancer, but represents just 1% of all cancers. The causes of myeloma are not fully understood but it is thought to be caused by an interaction of both genetic and environmental factors. This Handbook discusses these issues as well the latest developments in the field and will be an invaluable source of topical information for all healthcare professionals with an interest in multiple myeloma.

Author : Silvia CW Ling,Steven Trieu
Publisher : Springer Nature
Page : 154 pages
File Size : 46,7 Mb
Release : 2021-07-23
Category : Medical
ISBN : 9783030734404

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Resistance to Targeted Therapies in Multiple Myeloma by Silvia CW Ling,Steven Trieu Pdf

Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.

Author : CancerBACUP.
Publisher : Unknown
Page : 44 pages
File Size : 54,7 Mb
Release : 1998
Category : Multiple myeloma
ISBN : 1901276112

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Understanding Myeloma by CancerBACUP. Pdf

Written for people who have been diagnosed with myeloma (also known as multiple myeloma or myelomatosis), this booklet discusses the causes and symptoms, the tests used for diagnosis, treatments - chemotherapy, steroid therapy and radiotherapy - relief of symptoms, and rehabilitation and recovery.

Author : Khalid Ahmed Al-Anazi
Publisher : Unknown
Page : 236 pages
File Size : 48,6 Mb
Release : 2019-02
Category : Neoplasms. Tumors. Oncology. Including cancer and carcinogens
ISBN : 9781789852172

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Update on Multiple Myeloma by Khalid Ahmed Al-Anazi Pdf

This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries.

Author : Z.-H. Liui,J.C. He
Publisher : Karger Medical and Scientific Publishers
Page : 277 pages
File Size : 51,6 Mb
Release : 2014-05-16
Category : Medical
ISBN : 9783318026511

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Podocytopathy by Z.-H. Liui,J.C. He Pdf

The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.

Author : Klaus Podar,Kenneth C. Anderson
Publisher : Bentham Science Publishers
Page : 217 pages
File Size : 52,8 Mb
Release : 2012-01-03
Category : Medical
ISBN : 9781608052974

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Multiple Myeloma - A New Era of Treatment Strategies by Klaus Podar,Kenneth C. Anderson Pdf

"Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced"

Author : Neil S. Harris, MD,William E. Winter
Publisher : Demos Medical Publishing
Page : 163 pages
File Size : 53,9 Mb
Release : 2012-03-23
Category : Medical
ISBN : 9781933864754

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Multiple Myeloma and Related Serum Protein Disorders by Neil S. Harris, MD,William E. Winter Pdf

A practical guide to the clinical use of serum and urine electrophoresis and also includes coverage of immunofixation electrophoresis. These techniques are essential in the accurate identification of monoclonal gammopathies and the diagnosis of multiple myeloma and related disorders. Interpretation is often challenging even for the experienced practitioner. Throughout the book the emphasis is on indications and practical aspects of interpreting test results. Particular attention is paid to differentiating false negative and false positive test results. The text provides clear, practical discussions extensively supported by representative images to guide the reader to accurate identification of specimens.

Author : Eric P. Cohen
Publisher : Oxford University Press, USA
Page : 382 pages
File Size : 44,8 Mb
Release : 2010-11-11
Category : Medical
ISBN : 9780199580194

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Cancer and the Kidney by Eric P. Cohen Pdf

Cancer and the Kidney covers the challenging overlap area of nephrology and oncology, both in terms of kidney problems in cancer patients, and cancer that affects kidney patients, including assessment of kidney function, to paraneoplastic disorders, acquired cysts and native kidney cancers, and all points inbetween.

Author : James R. Berenson
Publisher : Springer Science & Business Media
Page : 523 pages
File Size : 53,9 Mb
Release : 2004-05-14
Category : Medical
ISBN : 9781592598175

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Biology and Management of Multiple Myeloma by James R. Berenson Pdf

Expert physicians and clinical researchers summarize and explain all the recent advances in the biology and treatment of bone marrow-based malignancy. On the biological side, the authors show the characteristics of the malignant cell and describe the significant roles played by oncogenic changes, chromosomal anomalies, Kaposi's sarcoma herpes virus, and cytokines. New epidemiological findings and prognostic factors are also analyzed. On the clinical side, the authors provide a comprehensive review of conventional treatment regimens, as well as a discussion of newer experimental approaches involving immunologic targeting, inhibitors of drug resistance, and antitumor agents.

Author : Elena Zamagni
Publisher : Springer Nature
Page : 213 pages
File Size : 52,8 Mb
Release : 2021-01-11
Category : Medical
ISBN : 9783030636623

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Management of Bone Disease and Kidney Failure in Multiple Myeloma by Elena Zamagni Pdf

This pocket guide provides a concise yet comprehensive overview of the two most prominent clinical features of multiple myeloma (MM), bone disease and renal failure. The first half of the text reviews critical aspects of bone disease in MM, including pathophysiology, the use of imaging modalities and drugs in treatment, and the role of orthopedic surgery. The latter half of the book reviews major components of kidney disease in MM, from pathophysiology to treatment. Written by experts in the field, Management of Bone Disease and Kidney Failure in Multiple Myeloma: A Pocket Guide is a valuable resource for clinicians and practitioners who manage patients afflicted with multiple myeloma.