Unraveling The Complexities Of Metastasis

Author : Ammad Ahmad Farooqi,Muhammad Zahid Qureshi,Uteuliyev Yerzhan Sabitaliyevi
Publisher : Academic Press
Page : 342 pages
File Size : 46,7 Mb
Release : 2022-05-14
Category : Science
ISBN : 9780128217900

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Unraveling the Complexities of Metastasis by Ammad Ahmad Farooqi,Muhammad Zahid Qureshi,Uteuliyev Yerzhan Sabitaliyevi Pdf

Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis. Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and newcomers in the field of cancer metastasis

Author : John Oloche Onuh,Yashwant V. Pathak
Publisher : CRC Press
Page : 645 pages
File Size : 55,5 Mb
Release : 2024-02-27
Category : Medical
ISBN : 9781000935875

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Plant Food Phytochemicals and Bioactive Compounds in Nutrition and Health by John Oloche Onuh,Yashwant V. Pathak Pdf

Phytochemicals are receiving increasing attention due to their observed nutritional and health-promoting effects in numerous food applications. As plant secondary metabolites with bioactive properties, they may provide desirable health benefits beyond basic nutrition to reduce chronic disease conditions. Their importance in nutrition and health cannot be overstated as it has generated so much interest and studies focused on elucidating their roles has produced so many outstanding results. Plant phytochemicals are readily used in alternative medicine in South East Asia especially, in China and India and they are becoming widely acceptable worldwide. However, very little is still known about the phytochemicals despite these intense research efforts because of their diverse biological and chemical nature. In this newest addition to the series, Nutraceuticals: Basic Research and Clinical Applications, Plant Food Phytochemicals and Bioactive Compounds in Nutrition and Health provides a comprehensive review of the current state of knowledge in the field of bioactive plant phytochemical compounds, their food sources, bioactivities, bioavailability, extraction, production, and applications. Experts in the field discuss various bioactivities of the notable and promising plant phytochemicals of significance in nutrition and health, e.g., lowering of CVD, hypertension, cholesterol, diabetes, obesity, inflammation, cancer, oxidative stress, neurodegenerative diseases and a host of other chronic disease conditions. Key Features: Describes the various nutritional and bioactive significances of notable and promising plant phytochemicals of significance in nutritional and medical research and their food and/or plant sources Includes various approaches for the quantification, extraction and production of the notable and promising phytochemical compounds in nutrition and health Examines the challenges and promises of plant phytochemical as ingredients for the development of functional foods and nutraceuticals as well as their use in alternative medicine Discusses regulatory issues regarding plant phytochemicals, especially as it pertains to their health claims and use

Author : Leonard Weiss
Publisher : Unknown
Page : 456 pages
File Size : 50,6 Mb
Release : 1985
Category : Medical
ISBN : UOM:39015009548473

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Principles of Metastasis by Leonard Weiss Pdf

Author : Steven A. Stacker,Marc G. Achen
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 49,7 Mb
Release : 2009-09-30
Category : Medical
ISBN : 9789048122479

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Lymphangiogenesis in Cancer Metastasis by Steven A. Stacker,Marc G. Achen Pdf

Lymphangiogenesis and Cancer Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells. The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi’s sarcoma, and approaches for imaging lymphatics in cancer. The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer. The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis. Key Features: Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process Provides a comprehensive summary of current research in this ground breaking area Provides a book which links progress in basic tumor and developmental biology with current and future oncology practise Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area.

Author : Zheng Wang,Yanfeng Liu,Hangcheng Fu,Yonglong Zhang
Publisher : Frontiers Media SA
Page : 132 pages
File Size : 41,6 Mb
Release : 2024-02-22
Category : Medical
ISBN : 9782832545065

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Novel molecular mechanisms and clinical strategies in solid tumor recurrence and metastasis: from bench to bedside by Zheng Wang,Yanfeng Liu,Hangcheng Fu,Yonglong Zhang Pdf

Recurrence and metastasis of malignancy is a multistep process that involves the escape of tumor cells from the primary location, systemic translocation in the body, and adaptation to the foreign microenvironment of distant sites. The spread of cancer cells is mediated by the interaction between tumor cells (seeds) and the microenvironment of the host organ (soil). Emerging evidence has revealed several stages of the invasion-metastasis cascade, including epithelial-mesenchymal transition, angiogenesis, and immune surveillance escape. Moreover, host organs could develop premetastatic niches and be more vulnerable to cancer cell colonization, adaptation and growth.

Author : Anonim
Publisher : Academic Press
Page : 390 pages
File Size : 45,5 Mb
Release : 2016-09-03
Category : Medical
ISBN : 9780128041581

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Molecular and Cellular Basis of Metastasis: Road to Therapy by Anonim Pdf

Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis. Presents groundbreaking information on the molecular and cellular basis of metastasis Provides information on cancer research Outstanding and original reviews Suitable for both researchers and students

Author : wim ceelen
Publisher : Springer Science & Business Media
Page : 535 pages
File Size : 55,6 Mb
Release : 2007-03-06
Category : Medical
ISBN : 9780387489933

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Peritoneal Carcinomatosis: A Multidisciplinary Approach by wim ceelen Pdf

This is the first volume to provide a multidisciplinary approach to peritoneal carcinomatosis encompassing molecular mechanisms, histopathology, regional and systemic cytotoxic therapy, and surgical options. Illustrations aid the reader throughout in the many facets of this disease. The book will be of particular interest for medical, surgical and gynecological oncologists faced with the complexities of decision making in patients suffering from PC.

Author : American Association for Cancer Research
Publisher : CTI Meeting Technology
Page : 128 pages
File Size : 42,8 Mb
Release : 2018-04-10
Category : Electronic
ISBN : 9781370247707

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AACR 2018 Proceedings: Abstracts 3028-5930 by American Association for Cancer Research Pdf

Author : Dr. Spineanu Eugenia
Publisher : Dr. Spineanu Eugenia
Page : 108 pages
File Size : 51,6 Mb
Release : 2024-03-03
Category : Medical
ISBN : 8210379456XXX

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Neuro-Oncology Unveiled: A Comprehensive Guide to Brain Cancer by Dr. Spineanu Eugenia Pdf

Neuro-Oncology Unveiled: A Comprehensive Guide to Brain Cancer offers readers an unparalleled deep dive into the intricate world of brain tumors. This treatise, meticulously crafted by experts in the fields of oncology and biochemistry, serves as an essential resource for both medical professionals and those personally affected by a brain cancer diagnosis. From the historical evolution of our understanding of brain tumors to the latest advancements in treatment, this book covers it all. Delve into the cellular anatomy of the brain, explore the biochemical pathways that can lead to cancer, and understand the genetic and epigenetic factors that play a role in tumorigenesis. With detailed chapters on diagnostic techniques, ranging from advanced neurological assessments to cutting-edge imaging, readers will gain insights into the tools that are shaping the future of brain cancer diagnosis and treatment. But this treatise goes beyond the scientific. It delves into the holistic aspects of brain cancer care, discussing the role of nutrition, mind-body practices, and alternative therapies. It also addresses the emotional and psychological challenges faced by patients and their families, offering guidance on navigating the healthcare system, understanding insurance nuances, and seeking support. With a special focus on pediatric brain tumors, metastatic brain tumors, and the ethical implications of genetic testing and editing, this book ensures a holistic understanding of brain cancer from multiple perspectives. Whether you're a healthcare professional seeking a comprehensive resource, a patient looking for guidance, or a caregiver hoping to better support a loved one, Neuro-Oncology Unveiled is an invaluable companion on your journey through the complexities of brain cancer.

Author : Fred Hollande,Delphine Merino
Publisher : MDPI
Page : 314 pages
File Size : 40,7 Mb
Release : 2021-01-21
Category : Science
ISBN : 9783039288533

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Metastatic Progression and Tumour Heterogeneity by Fred Hollande,Delphine Merino Pdf

Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.

Author : American Association for Cancer Research (AACR)
Publisher : CTI Meeting Technology
Page : 128 pages
File Size : 51,7 Mb
Release : 2016-03-28
Category : Medical
ISBN : 8210379456XXX

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AACR 2016: Abstracts 1-2696 by American Association for Cancer Research (AACR) Pdf

The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 1-2696 presented on April 17-18, 2016, at the AACR Annual Meeting.

Author : Sybille Mazurek,Maria Shoshan
Publisher : Springer
Page : 374 pages
File Size : 55,6 Mb
Release : 2015-01-19
Category : Medical
ISBN : 9783709118245

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Tumor Cell Metabolism by Sybille Mazurek,Maria Shoshan Pdf

The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagnostic development, as well as for clinicians and oncologists.

Author : Mariano Bizzarri
Publisher : Springer Nature
Page : 261 pages
File Size : 48,9 Mb
Release : 2024-01-08
Category : Science
ISBN : 9781071635773

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Systems Biology by Mariano Bizzarri Pdf

This second edition volume expands on the previous edition with discussions of the latest advancements and methods used by scientists to study systems biology. The chapters in this book are organized into four parts. Part One looks at models in systems biology and parameters identification such as short peptide analysis, metastasis models, and metabolomics. Part Two covers computational methods in the study of organisms, and cancer non-linear dynamics. Part Three discusses critical transition states across Waddington’s like landscapes such as understanding cell differentiation through single-cell approaches and modeling mammary organogenesis from biological first principles. Part Four talks about specific fields of investigation including inborn errors of metabolism, system biology approach in epithelial-mesenchymal transition, and an approach to understanding how COVID-19 spreads in the population. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Systems Biology, Second Edition is a valuable tool for any researcher looking to learn more about this important and developing field.

Author : Yahwardiah Siregar
Publisher : Inst za onkologiju i radiol
Page : 497 pages
File Size : 42,9 Mb
Release : 2013-01-24
Category : Medical
ISBN : 9789535108580

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Oncogene and Cancer by Yahwardiah Siregar Pdf

This book describes a course of cancer growth starting from normal cells to cancerous form and the genomic instability, the cancer treatment as well as its prevention in form of the invention of a vaccine. Some diseases are also discussed in detail, such as breast cancer, leucaemia, cervical cancer, and glioma. Understanding cancer through its molecular mechanism is needed to reduce the cancer incidence. How to treat cancer more effectively and the problems like drug resistance and metastasis are very clearly illustrated in this publication as well as some research result that could be used to treat the cancer patients in the very near future. The book was divided into six main sections: 1. HER2 Carcinogenesis: Etiology, Treatment and Prevention; 2. DNA Repair Mechanism and Cancer; 3. New Approach to Cancer Mechanism; 4. New Role of Oncogenes and Tumor Suppressor Genes; 5. Non Coding RNA and Micro RNA in Tumorigenesis; 6. Oncogenes for Transcription Factors

Author : Francesco Pezzella,Mahvash Tavassoli,David Kerr
Publisher : Oxford University Press
Page : 505 pages
File Size : 49,6 Mb
Release : 2019-05-02
Category : Medical
ISBN : 9780198779452

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Oxford Textbook of Cancer Biology by Francesco Pezzella,Mahvash Tavassoli,David Kerr Pdf

The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.