Valor S Trial

Author : Tanya Huff
Publisher : Jabberwocky Literary Agency, Inc.
Page : 537 pages
File Size : 42,8 Mb
Release : 2022-07-29
Category : Fiction
ISBN : 9781625675910

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Valor's Trial by Tanya Huff Pdf

Bestselling author Tanya Huff’s Confederation series of military science fiction returns with a novel where one woman’s discovery shakes the foundations of the intergalactic alliance itself... Gunnery Sergeant Torin Kerr has had enough of special treatment—and of gaping, skepticism, and whispers of Silsviss or Big Yellow as she passes. She’s glad to be back with her own Sh’quo Company, surrounded by familiar faces and enduring more razzing than awe. Of course, the company is going into battle again, facing death on all sides in a centuries-old war where every attempt at diplomacy fails, and she’s got a brand-new second lieutenant to train. Another glorious day in the Confederation Marine Corps. The battle goes disastrously wrong. And yet somehow Torin wakes up. The Others don’t take prisoners—or so the Confederation has always said. But the dark tunnels and mysterious mechanisms of the warren around her certainly seem like a prison. And there’s more going on than simple confinement. One after another, Torin’s most cherished beliefs are shaken to the core. She’s always been a survivor. But time is running out. If she has to question everything to escape, answers had better start coming fast...

Author : Tanya Huff
Publisher : Unknown
Page : 389 pages
File Size : 46,9 Mb
Release : 2008
Category : Life on other planets
ISBN : 1436241170

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Valor's Trial by Tanya Huff Pdf

Gunnery Sergeant Torin Kerr is a Confederation Marine's marine. She's survived more deadly encounters--and kept more of her officers and enlistees alive--than anyone in the Corps. Unexpectedly pulled from battle, Torin finds herself in an underground POW camp that shouldn't exist, where her fellow marine prisoners seem to have lost all will to escape. Now, Torin must fight her way not only out of the prison but also past the growing compulsion to sit down and give up--not realizing that her escape could mean the end of the war ...

Author : David L. Slaughter II
Publisher : Xlibris Corporation
Page : 248 pages
File Size : 48,7 Mb
Release : 2012-05-08
Category : Poetry
ISBN : 9781469198651

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Eye Soar's Trials... Tribulations... & Blessed Treasures by David L. Slaughter II Pdf

Having been inspired by dreams, ideas, entertainment, history, fiction and non-fiction, and so much more in life, Eye Soars Trials... Tribulations... & Blessed Treasures is a culmination of poems that have been written over a number of years by David L. Slaughter II. As such, you will find poems that deal with military and war (whether on the broad spectrum or from an individual perspective), political stances, love of family, faith in God, dreams, fears and anxieties, as well as lighthearted poems that still possess a message in their own right. Of course, not all the poems contained within are based on what has inspired David, but also to inspire others to overcome their own demons, problems, self-esteem issues, concerns, etc. with the hope that the reader, whether reading those that have inspired or to inspire will gain a perspective for themselves to relate to. If we find relation in our own lives by the words of another, we also find we learn and grow.

Author : Steven Piantadosi,Curtis L. Meinert
Publisher : Springer Nature
Page : 2573 pages
File Size : 42,9 Mb
Release : 2022-07-19
Category : Medical
ISBN : 9783319526362

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Principles and Practice of Clinical Trials by Steven Piantadosi,Curtis L. Meinert Pdf

This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.

Author : Avery McIntosh,Oleksandr Sverdlov
Publisher : CRC Press
Page : 490 pages
File Size : 51,5 Mb
Release : 2024-05-23
Category : Mathematics
ISBN : 9781003855965

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Development of Gene Therapies by Avery McIntosh,Oleksandr Sverdlov Pdf

Cell and gene therapies have become the third major drug modality in pharmaceutical medicine of the 21st century after low molecular weight and antibody drugs. The gene therapy (GTx) field is rapidly advancing, and yet there are still fundamental scientific questions that remain to be answered. Development of GTx products poses unique challenges and opportunities for drug developers. However, there is lack of a systematic exposition of the GTx product development and the pivotal role of the biostatistician in this process. Development of Gene Therapies: Strategic, Scientific, and Regulatory, and Access Considerations attempts to summarize the current state-of-the-art strategic, scientific, statistical, and regulatory aspects of GTx development. Intended to provide an exposition to the GTx new product development through peer-reviewed papers written by subject matter experts in this emerging field, this book will be useful for researchers in gene therapy drug development, biostatisticians, regulators, patient advocates, graduate students, and the finance and business development community . Key Features: A collection of papers covering a wide spectrum of topics in gene therapies (GTx), written by leading subject matter experts An exposition of the core principles of GTx product development, emerging business models, industry standards, best practices, and regulatory pathways An exposition of statistical and innovative modeling tools for design and analysis of clinical trials of GTx Insights into commercial models, access hurdles, and health economics of gene therapies Case studies of successful GTx approvals from core team members that developed the first two FDA-approved AAV gene therapies: Luxturna and Zolgensma A discussion of potential benefits and hurdles to be overcome for GTx in coming years from a multi-stakeholder perspective

Author : Carlos Mena,Sasanka Jayasuriya
Publisher : Lippincott Williams & Wilkins
Page : 400 pages
File Size : 51,9 Mb
Release : 2019-05-21
Category : Medical
ISBN : 9781496349422

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Peripheral Vascular Disease: A Clinical Approach by Carlos Mena,Sasanka Jayasuriya Pdf

Part of the new Clinical Approach series—which focuses on key topics in cardiology—this pragmatic, comprehensive guide is intended for residents, practitioners, advanced practice nurses, and physician assistants, and covers arterial, venous, and lymphatic diseases. Easy-to-read chapters are written by clinical experts in interventional cardiology, interventional radiology, vascular surgery, and podiatry, and begin with helpful quick-reference summaries.

Author : Jay J. H. Park,Edward J. Mills,J. Kyle Wathen
Publisher : Cambridge University Press
Page : 189 pages
File Size : 48,9 Mb
Release : 2023-03-31
Category : Medical
ISBN : 9781108934442

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Introduction to Adaptive Trial Designs and Master Protocols by Jay J. H. Park,Edward J. Mills,J. Kyle Wathen Pdf

This practical high-level guidebook offers an in-depth understanding of the newly emerging clinical trial designs in adaptive trial designs and master protocols. Both concise and readable without shying away from technical discussion, the book introduces the most innovative approaches in clinical trial research such as adaptive trial designs, master protocols, platform trial, basket trial, and umbrella trial designs. Featuring a revisionist history of clinical research before moving on to case-study based discussion and practical considerations from collective experience. The book enables readers to understand the strengths and limitations of these novel designs as well as their application to individual areas of research and clinical practice. Supplemented by real-world examples from the recent developments in medical research efficiency instigated by both personalized medicine and high-profile diseases like COVID-19 and cancer. The first book of its kind, it is the go-to resource for medical students and researchers working in clinical trial research.

Author : Eric Balch
Publisher : Sarcasca Chronicles
Page : 300 pages
File Size : 45,8 Mb
Release : 2022-02-10
Category : Fiction
ISBN : 1735549657

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Trial by Tournament by Eric Balch Pdf

Following their attack on Devil's Den, Pelagius and his friends nurse their wounds and mourn their losses. Marquis Babu is dead, but the cost was high - and an even more nefarious menace now waits in the wings... For, even as the friends now stand trial for murder at the castle of King Demonicus, power-hungry soulborn Alasdar has laid claim to Babu's lordship, and with the mysterious and sinister Green-Eyed Man, plans no less than treacherous, full-scale revolution. But when Babu's crimes are brought to light, the king proves merciful. When sentence is passed, with it comes the chance to redeem themselves: they will compete in the Grand Tourney - an epic gladiatorial event of valor, strength and honor, which brings together the strongest warriors of all the kingdoms the Sarcascan continent. Winning the tournament is their only hope of acquittal. Meanwhile, the threat to the kingdom of Diablos simmers and grows in Devil's Den... Trigger Warnings: Graphic Violence

Author : Takashi Sozu,Tomoyuki Sugimoto,Toshimitsu Hamasaki,Scott R. Evans
Publisher : Springer
Page : 95 pages
File Size : 43,9 Mb
Release : 2015-08-20
Category : Mathematics
ISBN : 9783319220055

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Sample Size Determination in Clinical Trials with Multiple Endpoints by Takashi Sozu,Tomoyuki Sugimoto,Toshimitsu Hamasaki,Scott R. Evans Pdf

This book integrates recent methodological developments for calculating the sample size and power in trials with more than one endpoint considered as multiple primary or co-primary, offering an important reference work for statisticians working in this area. The determination of sample size and the evaluation of power are fundamental and critical elements in the design of clinical trials. If the sample size is too small, important effects may go unnoticed; if the sample size is too large, it represents a waste of resources and unethically puts more participants at risk than necessary. Recently many clinical trials have been designed with more than one endpoint considered as multiple primary or co-primary, creating a need for new approaches to the design and analysis of these clinical trials. The book focuses on the evaluation of power and sample size determination when comparing the effects of two interventions in superiority clinical trials with multiple endpoints. Methods for sample size calculation in clinical trials where the alternative hypothesis is that there are effects on ALL endpoints are discussed in detail. The book also briefly examines trials designed with an alternative hypothesis of an effect on AT LEAST ONE endpoint with a prespecified non-ordering of endpoints.

Author : James Henry Worman
Publisher : Unknown
Page : 610 pages
File Size : 54,9 Mb
Release : 1868
Category : German language
ISBN : UIUC:30112081466663

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A Complete Grammar of the German Language by James Henry Worman Pdf

Author : Thomas Bayly Howell
Publisher : Unknown
Page : 722 pages
File Size : 43,7 Mb
Release : 1816
Category : Electronic
ISBN : ONB:+Z173697007

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A Complete Collection of State Trials and Proceedings for High Treason and Other Crimes and Misdemeanors from the Earliest Period to the Year 1820. (etc.) by Thomas Bayly Howell Pdf

Author : Susan Halabi,Stefan Michiels
Publisher : CRC Press
Page : 626 pages
File Size : 50,5 Mb
Release : 2019-04-24
Category : Medical
ISBN : 9781351620970

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Textbook of Clinical Trials in Oncology by Susan Halabi,Stefan Michiels Pdf

There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others

Author : Francis Hargrave,Thomas Salmon,Sollom Emlyn
Publisher : Unknown
Page : 530 pages
File Size : 54,5 Mb
Release : 1781
Category : Crime
ISBN : UOM:35112101582502

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A Complete Collection of State-trials, and Proceedings for High-treason, and Other Crimes and Misdemeanours: 1494-5-1777. Appendix by Francis Hargrave,Thomas Salmon,Sollom Emlyn Pdf

Author : Jack L. Cronenwett,K. Wayne Johnston
Publisher : Elsevier Health Sciences
Page : 8124 pages
File Size : 44,6 Mb
Release : 2010-03-09
Category : Medical
ISBN : 9781455706327

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Rutherford's Vascular Surgery, 2-Volume Set by Jack L. Cronenwett,K. Wayne Johnston Pdf

Rutherford's Vascular Surgery - the most acclaimed comprehensive reference in its field - presents definitive, state-of-the-art guidance on every aspect of vascular health care, equipping you to make the best clinical decisions and optimize outcomes. Extensively revised by many new, international authors - led by Drs. Jack Cronenwett and K. Wayne Johnston - and now published in association with the Society for Vascular Surgery, this 7th Edition provides the authoritative answers that surgeons, interventionalists, and vascular medicine specialists need to provide effective care for vascular surgery patients. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you’re using or where you’re located. Get answers you can depend on. Now published in association with the Society for Vascular Surgery, Rutherford's delivers the world’s most trusted information on all major areas of vascular health care, written by international experts, with up-to-date bibliographies and annotated recommended references. Overcome any clinical challenge with in-depth sections on Fundamental Considerations, Patient Evaluation, Atherosclerotic Risk Factors, Perioperative Care, Bleeding and Clotting, Complications, Venous Disease, Lymphedema, Arteriovenous Anomalies, Hemodialysis Access, Miscellaneous Technique, Grafts and Devices, Cerebrovascular Disease, Lower Extremity Arterial Disease, Upper Extremity Arterial Disease, Arterial Aneurysms, Renal and Mesenteric Disease, and Trauma and Acute Limb Ischemia. Choose the best management option for each patient with discussions of operative, endovascular, and non-operative approaches for vascular conditions. Access the complete contents of Rutherford's Vascular Surgery online at www.expertconsult.com - with monthly updates from the Journal of Vascular Surgery and the European Journal of Vascular and Endovascular Surgery, plus videos of procedures, an image library, review questions, and more. Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more. View clinical and physical findings and operative techniques more vividly with a new full-color layout and more full-color images.

Author : Shahzad G. Raja
Publisher : Springer Nature
Page : 1089 pages
File Size : 50,5 Mb
Release : 2020-02-11
Category : Medical
ISBN : 9783030241742

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Cardiac Surgery by Shahzad G. Raja Pdf

This textbook provides a succinct overview of cardiac surgery, with key concepts being emphasized throughout. An abundance of illustrations, intra-operative photographs, tables as well as information boxes, aids the reader to visualise, grasp and retain difficult concepts. The inclusion of evidence-based approaches to the management of a range of cardiac surgical conditions equips the reader with an understanding of how to overcome a variety of potentially tough clinical challenges. Concise Cardiac Surgery: A Complete Guide comprehensively covers a range of techniques used in cardiac surgery. It is therefore, an ideal resource for the trainee and practising cardiac surgeon seeking a practically focused text detailing how to apply the latest techniques and evidence-based approaches in their day-to-day practice.