Vascular Effects Of Hydrogen Sulfide

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Vascular Effects of Hydrogen Sulfide

Jerzy Bełtowski
Vascular Effects of Hydrogen Sulfide Book PDF

Author : Jerzy Bełtowski
Publisher : Springer Nature
Page : 223 pages
File Size : 55,5 Mb
Release : 2019-05-30
Category : Science
ISBN : 9781493995288

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Vascular Effects of Hydrogen Sulfide by Jerzy Bełtowski Pdf

This book explores techniques for exploring hydrogen sulfide (H2S) and its effects on the vascular system through numerous experimental animal models and vascular preparations. Alterations of vascular H2S generation/signaling may be involved in the pathogenesis of systemic and pulmonary arterial hypertension, ischemic heart disease, ischemic stroke, preeclampsia, and erectile dysfunction, and H2S also serves as an attractive target for pharmacotherapy of cardiovascular diseases, as well as possible effects on cancer, wound healing, and diabetic retinopathy, among other pathologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vascular Effects of Hydrogen Sulfide: Methods and Protocols is an ideal aid for scientists working to extend our knowledge in this valuable and wide-ranging field of study.

Advances in Hydrogen Sulfide Biology

Yi-Chun Zhu
Advances in Hydrogen Sulfide Biology Book PDF

Author : Yi-Chun Zhu
Publisher : Springer Nature
Page : 242 pages
File Size : 47,8 Mb
Release : 2021-07-24
Category : Medical
ISBN : 9789811609916

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Advances in Hydrogen Sulfide Biology by Yi-Chun Zhu Pdf

Hydrogen sulfide (H2S) has emerged as an important gas signalling molecule in a series of organs/tissues, on the diseases of which it plays protective roles, such as proangiogenic effects in ischemic tissues, antiapoptotic effects in the cardiomyocytes, regularization of fatal arrhythmia in myocardial infarction, amelioration of inflammation in autoimmune diseases, modification of neuronal transmission, increase in sodium excretion from the kidney, and amelioration of insulin resistance, etc. This book focuses on the effect of hydrogen sulfide in cardiovascular system, immune system, nervous system, kidney, as well as on the metabolism of glucose and lipids and regulation of ion channels and so on. This book also provides the advances in the understanding of endogenous H2S metabolism and H2S protein targets, as well as H2S donors. It will benefit researchers in both academics and industry working on the underlying mechanism of H2S field and the future of translational medicine of H2S.

Hydrogen Sulfide

C.-H. Selene J. Chou
Hydrogen Sulfide Book PDF

Author : C.-H. Selene J. Chou
Publisher : Unknown
Page : 44 pages
File Size : 44,8 Mb
Release : 2003
Category : Health risk assessment
ISBN : OSU:32435072064496

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Hydrogen Sulfide by C.-H. Selene J. Chou Pdf

Sudden death among sewage workers is the most familiar form of hydrogen sulphide poisoning. This colorless, flammable gas has a characteristic odor of rotten eggs. It is produced naturally and as a result of human activity. Natural sources include nonspecific and anaerobic bacterial reduction of sulphates and sulphur-containing organic compounds. Hydrogen sulphide is found naturally in crude petroleum, natural gas, volcanic gases, and hot springs. It is also found in ground water. It is released from stagnant or polluted waters and manure or coal pits. In the industry, it is used as an intermediate in the manufacture of sulphuric acid and inorganic sulphides and as an agricultural disinfectant.--Publisher's description.

Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

Philip K. Moore,Matt Whiteman
Chemistry Biochemistry and Pharmacology of Hydrogen Sulfide Book PDF

Author : Philip K. Moore,Matt Whiteman
Publisher : Springer
Page : 395 pages
File Size : 43,6 Mb
Release : 2015-07-10
Category : Medical
ISBN : 9783319181448

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Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide by Philip K. Moore,Matt Whiteman Pdf

This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.

Hydrogen Sulfide in Redox Biology

Anonim
Hydrogen Sulfide in Redox Biology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 344 pages
File Size : 40,7 Mb
Release : 2015-02-25
Category : Science
ISBN : 9780128016237

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Hydrogen Sulfide in Redox Biology by Anonim Pdf

These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant. Continues the legacy of this premier serial with quality chapters on hydrogen sulfide research authored by leaders in the field Covers conventional and new hydrogen sulfide detection methods Covers the pharmacological activity of hydrogen sulfide donors Contains chapters on important topics on hydrogen sulfide modulation of cell signaling and transcriptional pathways, and the the role of hydrogen sulfide in the cardiovascular and nervous systems and in inflammation

Review of Submarine Escape Action Levels for Selected Chemicals

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Submarine Escape Action Levels
Review of Submarine Escape Action Levels for Selected Chemicals Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Submarine Escape Action Levels
Publisher : National Academies Press
Page : 310 pages
File Size : 43,7 Mb
Release : 2002-02-04
Category : Nature
ISBN : 9780309182683

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Review of Submarine Escape Action Levels for Selected Chemicals by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Submarine Escape Action Levels Pdf

On-board fires can occur on submarines after events such as collision or explosion. These fires expose crew members to toxic concentrations of combustion products such as ammonia, carbon monoxide, hydrogen chloride, and hydrogen sulfide. Exposure to these substances at high concentrations may cause toxic effects to the respiratory and central nervous system; leading possible to death. T protect crew members on disabled submarines, scientists at the U.S. Navy Health Research Center's Toxicology Detachment have proposed two exposure levels, called submarine escape action level (SEAL) 1 and SEAL 2, for each substance. SEAL 1 is the maximum concentration of a gas in a disabled submarine below which healthy submariners can be exposed for up to 10 days without encountering irreversible health effects while SEAL 2 the maximum concentration of a gas in below which healthy submariners can be exposed for up to 24 hours without experiencing irreversible health effects. SEAL 1 and SEAL 2 will not impair the functions of the respiratory system and central nervous system to the extent of impairing the ability of crew members in a disabled submarine to escape, be rescued, or perform specific tasks. Hoping to better protect the safety of submariners, the chief of the Bureau of Medicine and Surgery requested that the National Research Council (NRC) review the available toxicologic and epidemiologic data on eight gases that are likely to be produced in a disabled submarine and to evaluate independently the scientific validity of the Navy's proposed SEALs for those gases. The NRC assigned the task to the Committee on Toxicology's (COT's) Subcommittee on Submarine Escape Action Levels. The specific task of the subcommittee was to review the toxicologic, epidemiologic, and related data on ammonia, carbon monoxide, chlorine, hydrogen chloride, hydrogen cyanide, hydrogen sulfide, nitrogen dioxide, and sulfur dioxide in order to validate the Navy's proposed SEALs. The subcommittee also considered the implications of exposures at hyperbaric conditions and potential interactions between the eight gases. Review of Submarine Escape Action Levels for Selected Chemicals presents the subcommittee's findings after evaluation human data from experimental, occupational, and epidemiologic studies; data from accident reports; and experimental-animal data. The evaluations focused primarily on high-concentration inhalation exposure studies. The subcommittee's recommended SEALs are based solely on scientific data relevant to health effects. The report includes the recommendations for each gas as determined by the subcommittee as well as the Navy's original instructions for these substances.

The Endothelium

Michel Félétou
The Endothelium Book PDF

Author : Michel Félétou
Publisher : Morgan & Claypool Publishers
Page : 309 pages
File Size : 51,5 Mb
Release : 2011
Category : Science
ISBN : 9781615041237

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The Endothelium by Michel Félétou Pdf

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

The Arterial Chemoreceptors

Yoshiaki Hayashida,Constancio Gonzalez,Hisatake Kondo
The Arterial Chemoreceptors Book PDF

Author : Yoshiaki Hayashida,Constancio Gonzalez,Hisatake Kondo
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 40,9 Mb
Release : 2006-04-24
Category : Medical
ISBN : 9780387313115

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The Arterial Chemoreceptors by Yoshiaki Hayashida,Constancio Gonzalez,Hisatake Kondo Pdf

This book represents an updated review of the physiology of the carotid body chemoreceptors. It contains results in the topics at the frontiers of future developments in O2-sensing in chemoreceptor cells. Additionally, this volume provides data from studies carried out in other O2-sensing tissues including pulmonary vasculature and erythropoietin producing cells. It is a prime source of information and a guideline for arterial chemoreception researchers.

Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants
Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants
Publisher : National Academies Press
Page : 190 pages
File Size : 51,6 Mb
Release : 2009-10-21
Category : Nature
ISBN : 9780309143790

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Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Committee on Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants Pdf

U.S. Navy personnel who work on submarines are in an enclosed and isolated environment for days or weeks at a time when at sea. Unlike a typical work environment, they are potentially exposed to air contaminants 24 hours a day. To protect workers from potential adverse health effects due to those conditions, the U.S. Navy has established exposure guidance levels for a number of contaminants. The Navy asked a subcommittee of the National Research Council (NRC) to review, and develop when necessary, exposure guidance levels for specific contaminants. This volume, the third in a series, recommends 1-hour and 24-hour emergency exposure guidance levels (EEGLs) and 90-day continuous exposure guidance levels (CEGLs) for acetaldehyde, hydrogen chloride, hydrogen fluoride, hydrogen sulfide, and propylene glycol dinitrate.

Redox Biochemistry

Ruma Banerjee
Redox Biochemistry Book PDF

Author : Ruma Banerjee
Publisher : John Wiley & Sons
Page : 350 pages
File Size : 50,5 Mb
Release : 2007-12-04
Category : Science
ISBN : 0470177322

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Redox Biochemistry by Ruma Banerjee Pdf

This is the premier, single-source reference on redox biochemistry, a rapidly emerging field. This reference presents the basic principles and includes detailed chapters focusing on various aspects of five primary areas of redox biochemistry: antioxidant molecules and redox cofactors; antioxidant enzymes; redox regulation of physiological processes; pathological processes related to redox; and specialized methods. This is a go-to resource for professionals in pharmaceuticals, medicine, immunology, nutrition, and environmental fields and an excellent text for upper-level students.

Chemistry of Biologically Potent Natural Products and Synthetic Compounds

Shahid Ul-Islam,Javid Ahmad Banday
Chemistry of Biologically Potent Natural Products and Synthetic Compounds Book PDF

Author : Shahid Ul-Islam,Javid Ahmad Banday
Publisher : John Wiley & Sons
Page : 434 pages
File Size : 43,5 Mb
Release : 2021-06-29
Category : Science
ISBN : 9781119640349

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Chemistry of Biologically Potent Natural Products and Synthetic Compounds by Shahid Ul-Islam,Javid Ahmad Banday Pdf

In view of their promising biological and pharmaceutical activities, natural product inspired and heterocyclic compounds have recently gained a reputation in the field of medicinal chemistry. Over the past decades, intensive research efforts have been ongoing to understand the synthesis, biochemistry and engineering involved in their preparation and action mechanisms. Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Chemistry of Biologically Potent Natural Products and Synthetic Compounds provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.

Cyclic Nucleotide Signaling

XiaoDong Cheng
Cyclic Nucleotide Signaling Book PDF

Author : XiaoDong Cheng
Publisher : CRC Press
Page : 288 pages
File Size : 50,7 Mb
Release : 2021-03-30
Category : Cellular signal transduction
ISBN : 0367658801

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Cyclic Nucleotide Signaling by XiaoDong Cheng Pdf

Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.

Calcific Aortic Valve Disease

Elena Aikawa
Calcific Aortic Valve Disease Book PDF

Author : Elena Aikawa
Publisher : BoD – Books on Demand
Page : 544 pages
File Size : 45,5 Mb
Release : 2013-06-12
Category : Medical
ISBN : 9789535111504

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Calcific Aortic Valve Disease by Elena Aikawa Pdf

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Gas Biology Research in Clinical Practice

Toshikazu Yoshikawa,Yuji Naito
Gas Biology Research in Clinical Practice Book PDF

Author : Toshikazu Yoshikawa,Yuji Naito
Publisher : Karger Medical and Scientific Publishers
Page : 155 pages
File Size : 42,5 Mb
Release : 2011
Category : Medical
ISBN : 9783805596640

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Gas Biology Research in Clinical Practice by Toshikazu Yoshikawa,Yuji Naito Pdf

An overview on the role of various gaseous molecules in health and disease The substantial biological importance of gaseous mediators in various physiological-pathological conditions has been realized only recently, but to date, the detailed mechanisms involved remain elusive. The publication at hand contains 16 overviews written by a panel of experts who summarize the current knowledge and provide fundamental insights into the roles of gaseous molecules in signal transduction in biological systems. The first part provides a comprehensive overview on gaseous mediators in health and disease. In the second part, the medical application of various molecules such as nitric oxide, carbon monoxide, hydrogen sulfide, hydrogen, acetone and phytoncide are discussed. Furthermore, articles on skin gas biology and Carbon-13 (13C), especially clinical applications of 13C-labeled substrate are included. This book provides valuable information not only for basic researchers in physiology and biochemistry, but also for gastroenterologists and clinicians who wish to learn more about the role of gaseous mediators.

Oxidative Stress and Vascular Disease

John F. Keaney Jr.
Oxidative Stress and Vascular Disease Book PDF

Author : John F. Keaney Jr.
Publisher : Springer Science & Business Media
Page : 404 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461546498

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Oxidative Stress and Vascular Disease by John F. Keaney Jr. Pdf

One of the major biomedical triumphs of the post-World War II era was the defmitive demonstration that hypercholesterolemia is a key causative factor in atherosclerosis; that hypercholesterolemia can be effectively treated; and that treatment significantly reduces not only coronary disease mortality but also all cause mortality. Treatment to lower plasma levels of cholesterol - primarily low density lipoprotein (LDL) cholesterol - is now accepted as best medical practice and both physicians and patients are being educated to take aggressive measures to lower LDL. We can confidently look forward to important decreases in the toll of coronary artery disease over the coming decades. However, there is still uncertainty as to the exact mechanisms by which elevated plasma cholesterol and LDL levels initiate and favor the progression of lesions. There is general consensus that one of the earliest responses to hypercholesterolemia is the adhesion of monocytes to aortic endothelial cells followed by their penetration into the subendothelial space, where they differentiate into macrophages. These cells, and also medial smooth muscle cells that have migrated into the subendothelial space, then become loaded with mUltiple, large droplets of cholesterol esters . . . the hallmark of the earliest visible atherosclerotic lesion, the so-called fatty streak. This lesion is the precursor of the more advanced lesions, both in animal models and in humans. Thus the centrality of hypercholesterolemia cannot be overstated. Still, the atherogenic process is complex and evolves over a long period of time.