Viral Transformation And Endogenous Viruses

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Viral Transformation and Endogenous Viruses

Albert Kaplan
Viral Transformation and Endogenous Viruses Book PDF

Author : Albert Kaplan
Publisher : Elsevier
Page : 186 pages
File Size : 53,9 Mb
Release : 2012-12-02
Category : Medical
ISBN : 9780323160537

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Viral Transformation and Endogenous Viruses by Albert Kaplan Pdf

Viral Transformation and Endogenous Viruses is a collection of papers presented at the symposium on ""Viral Transformation and Endogenous Viruses"" held at Vanderbilt University on April 1-2, 1974. Contributors discuss the viral function(s) responsible for the transformation of the cells that are infected with oncogenic viruses, emphasizing the type of changes that characterize transformed cells and the regulatory mechanisms that are altered after malignant transformations. This volume is organized into 10 chapters and begins with an overview of DNA-containing tumor viruses, particularly Simian Virus 40 (SV40) and its mutants with DNA deletions, insertions, and duplications. The integration and transcription of adenovirus DNA is considered, along with the characteristics of temperature-sensitive mutants of these viruses. The reader is then introduced to the chemistry and biology of RNA-containing tumor viruses, which are useful reagents to study neoplastic transformation both in vivo and in vitro. A major aspect of these viruses concerns the analysis of their genome at the chemical and genetic levels. The last part of the book is devoted to biochemical and genetic analyses of endogenous viruses isolated from avian cells. This book is a valuable resource for scientists and investigators in fields such as pathology, molecular virology, molecular biology, microbiology, oncology, and biochemistry.

Human Retroviruses

Bryan Cullen
Human Retroviruses Book PDF

Author : Bryan Cullen
Publisher : Oxford University Press
Page : 220 pages
File Size : 45,9 Mb
Release : 1993
Category : Gene Expression Regulation.
ISBN : 0199633827

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Human Retroviruses by Bryan Cullen Pdf

The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.

Retrovirus Genes in Lymphocyte Function and Growth

E. Wecker,I. Horak
Retrovirus Genes in Lymphocyte Function and Growth Book PDF

Author : E. Wecker,I. Horak
Publisher : Springer Science & Business Media
Page : 151 pages
File Size : 50,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642683695

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Retrovirus Genes in Lymphocyte Function and Growth by E. Wecker,I. Horak Pdf

All but one* of the following articles represent comprehensive reports on a workshop held between 7 and 9 May 1981 at the Institute of Virology and Immunobiology, University of Wfuzburg, Federal Republic of Germany. The title of the workshop was "The Involvement of Endogenous Retroviruses inN ormalFunction and Pathological Growth of Lymphocytes." Rather than collecting and printing manuscripts of the individual communications, the organizers asked selected parti cipants to write, after the workshop, concise articles each compris ing several contributions and discussions on major topics. In so doing, we hope to present to a larger audience a synopsis of the various information and views exchanged at the meeting. Such a procedure seemed the more appropriate as the workshop was intended to bring together specialists from two rather diverse fields: RNA-tumor virology and immunobiology. While this created some initial problems of terminology, it was quite effective in making representatives of one field more aware of the significance and the contributions ofthe other. It also great ly contributed to realization of the complexity of the problems involved in virus-induced leukemogenesis.

Viruses: Essential Agents of Life

Günther Witzany
Viruses Essential Agents of Life Book PDF

Author : Günther Witzany
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 55,9 Mb
Release : 2012-11-13
Category : Science
ISBN : 9789400748996

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Viruses: Essential Agents of Life by Günther Witzany Pdf

A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.

The Nature and Organization of Retroviral Genes in Animal Cells

David R. Strayer,D.H. Gillespie
The Nature and Organization of Retroviral Genes in Animal Cells Book PDF

Author : David R. Strayer,D.H. Gillespie
Publisher : Springer Science & Business Media
Page : 207 pages
File Size : 40,7 Mb
Release : 2013-03-07
Category : Medical
ISBN : 9783709185711

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The Nature and Organization of Retroviral Genes in Animal Cells by David R. Strayer,D.H. Gillespie Pdf

l RNA tumor viruses have become increasingly utilized in studies of cellular transformation and gene regulation. The genes of retroviruses exist in two forms; as extrachromosomal, RNA-containing, infectious particles and as DNA pro 2 viruses stably associated with cell genes. Components from the extracellular form can be collected in large quantity and purified for the preparation of molec ular probes. These probes can be used to dissect the sequence of events required for the establishment and expression of the integrated form. Furthermore the 2 genomes of retroviruses originated from normal cell genes, genes called virogenes • The nucleic acid and protein probes isolated from these viruses are therefore useful for studying the nature and expression of this normal cell gene and in elucidating the physiological role of its products. RNA tumor viruses perhaps offer us one of the most complete sets of biochemical reagents and biological responses for examining gene regulation in vertebrates and for studying the consequences of aberrant gene regulation on cell growth in tissue culture and in animals. Further more, there is an increasing conviction that virogenes play an important role in normal development and/or differentiation (RISSER, STOCKERT and OLD, 1978). Consequently, there is a growing feeling that DNA proviruses are altered viro genes and are capable of interfering with normal development or differentiation, causing reprogrammed growth or the incapacity to specialize.

Modern Trends in Human Leukemia IV

R. Neth,R. C. Gallo,T. Graf,K. Mannweiler,K. Winkler
Modern Trends in Human Leukemia IV Book PDF

Author : R. Neth,R. C. Gallo,T. Graf,K. Mannweiler,K. Winkler
Publisher : Springer Science & Business Media
Page : 574 pages
File Size : 45,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642679841

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Modern Trends in Human Leukemia IV by R. Neth,R. C. Gallo,T. Graf,K. Mannweiler,K. Winkler Pdf

Organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie. Wilsede, June 21-23, 1982

Discovering Retroviruses

Anna Marie Skalka
Discovering Retroviruses Book PDF

Author : Anna Marie Skalka
Publisher : Harvard University Press
Page : 192 pages
File Size : 49,5 Mb
Release : 2018-10-22
Category : Science
ISBN : 9780674988750

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Discovering Retroviruses by Anna Marie Skalka Pdf

Eight percent of our DNA contains retroviruses that are millions of years old. Anna Marie Skalka explains how our evolving knowledge of these particles has advanced genetic engineering, gene delivery systems, and precision medicine. Retroviruses cause disease but also hold clues to prevention and treatment possibilities that are anything but retro.

International Symposium: Retroviruses and Human Pathology

Robert C. Gallo,Dominique Stehelin,Oliviero E. Varnier
International Symposium Retroviruses and Human Pathology Book PDF

Author : Robert C. Gallo,Dominique Stehelin,Oliviero E. Varnier
Publisher : Springer Science & Business Media
Page : 551 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461250081

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International Symposium: Retroviruses and Human Pathology by Robert C. Gallo,Dominique Stehelin,Oliviero E. Varnier Pdf

For decades retroviruses have been riding the crest of a wave of experimental research directed toward the identification of an infectious agent of human neoplastic diseases. In the early 1970s, several scientists successfully demonstrated the presence of retroviruses in numerous animal species and proved their etiological role in some related diseases. Corresponding findings in humans were somewhat discouraging. Although financial support for this line· of research declined, a few dedicated retrovirologists survived and continued to collect more biological information and technological expertise that opened a new approach to the search for a human retrovirus. The rewards came with the discovery that the genes responsible for neoplastic transformation (oncogenes) are of cellular origin and can be shuttled about by retroviruses, and with the identification of a new family of Human T-cell Lymphotrophic retroViruses (HTLV) from patients with diseases ranging from leukemia to the acquired immunodeficiency syndrome (AIDS). An understanding of the role and significance of retroviruses in human pathology requires basic knowledge of the major animal systems studied. With this perspective in mind, we present here a survey that includes general overviews, minireviews on each animal system studied with selected experimental reports and, finally, a stimulating review of the field of human retrovirology by many of the pioneer scientists who created it. We are especially grateful to Profs. C. A. Romanzi and G. C. Schito for promoting the organization of the Symposium. On behalf of the Sym posium Committee, we thank E. Soeri, L. Casarino, G. P. Gesu, M.

Retroviruses and Insights into Cancer

Jaquelin Dudley
Retroviruses and Insights into Cancer Book PDF

Author : Jaquelin Dudley
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 40,7 Mb
Release : 2010-10-22
Category : Medical
ISBN : 9780387095813

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Retroviruses and Insights into Cancer by Jaquelin Dudley Pdf

This book will contain a series of review articles that focus on retroviral models of human and animal cancers. Each article will be written by an expert in the field of retrovirology. The reviews will summarize current work on a particular retrovirus, with particular emphasis on the relevance of this research to human disease.

Retroviruses 1

P.K. Vogt,H. Koprowski
Retroviruses 1 Book PDF

Author : P.K. Vogt,H. Koprowski
Publisher : Springer Science & Business Media
Page : 150 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642689437

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Retroviruses 1 by P.K. Vogt,H. Koprowski Pdf

1. 1 Scope of the Review This review was intended initially as a reference source for those interested in the origins and fITst descriptions ofthe defective avian sarcoma viruses. Quite a few of these viruses have been characterized in the past few years and their varied nomenclature according to source, discoverer, date of isolation or biological properties could result in some con fusion among those attempting to follow the literature. Information will be included on the molecular biology of the sarcoma viruses, rather more of which is available than when the review was fITst conceived, although in this respect the review will inevitably be out of date by the time of publication. If any bias of content is introduced, this will be towards a more detailed coverage of the author's own area of interest, the gene products of the defective sarcoma viruses. Rous sarcoma virus (RSV) serves as the model for much of this work and will frequently be referred to for comparative purposes, as will the mammalian defective transforming viruses. Recent reviews provide more complete coverage of these topics (l-4a). This review is complemented by a discussion ofthe avian acute leukaemia viruses, which appears elsewhere in this volume [5]. As will be seen, concentrating primarily on the defective sarcoma viruses and comparing them to RSV can be justified in terms of their biochemical properties as well as their similar biology.

Recent Advances in the Biology, Therapy and Management of Melanoma

Lester Davids
Recent Advances in the Biology Therapy and Management of Melanoma Book PDF

Author : Lester Davids
Publisher : BoD – Books on Demand
Page : 388 pages
File Size : 49,9 Mb
Release : 2013-02-13
Category : Medical
ISBN : 9789535109761

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Recent Advances in the Biology, Therapy and Management of Melanoma by Lester Davids Pdf

The book Recent Advances in the Biology, Therapy and Management of Melanoma brings up-to-date information regarding a number of aspects which culminate in illuminating potential targets in the fight against melanoma. This book is intended to be a reference book for both the scientific and clinical communities and brings complicated subject matter together in an easy, readable way. Undoubtedly fundamental scientific understanding has to then be translated to the clinic in order for us to make significant strides in eradicating melanoma. It is hoped that scientists, clinicians, students and residents find this book useful in their studies on melanoma and that it not only expands their perspectives and views on the field, but challenges them to forge ahead towards discovering the ultimate cure.

Viruses: More Friends Than Foes (Revised Edition)

Karin Moelling
Viruses More Friends Than Foes Revised Edition Book PDF

Author : Karin Moelling
Publisher : World Scientific
Page : 446 pages
File Size : 44,9 Mb
Release : 2020-08-26
Category : Science
ISBN : 9789811224768

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Viruses: More Friends Than Foes (Revised Edition) by Karin Moelling Pdf

Coronavirus, AIDS, and Ebola: Viruses are normally defined as pathogens. Most viruses are, however, not enemies or killers. Well-known virologist and cancer researcher Karin Moelling describes surprising insights about a completely new and unexpected world of viruses. Viruses are ubiquitous, in the oceans, our environment, in animals, plants, bacteria, in our body, even in our genomes. They influence our weather, can contribute to control obesity, and can surprisingly be applied against threatening multi-resistant bacteria. The success story of the viruses started more than 3.5 billion years ago in the dawn of life when even cells did not exist. They are the superpower of life. There are more viruses on earth than stars in the sky. Viruses are everywhere. Some of them are incredibly ancient. Many viruses are hundredfold smaller than bacteria, but others are tenfold bigger and they were discovered only recently — the giant viruses, even deep within the permafrost where they were reactivated after 30,000 years.The author talks about a completely new world of viruses, which are based on the most recent, in part her own research results. Could viruses have been our oldest ancestors? Have viruses even 'invented' social behavior, do they lead to geniuses such as Mozart or Einstein — or alternatively to cancer? They can help to cure cancer. In this book, the author made a clear distinction between what is fact and what is her vision. This book is written for a general audience and not just for the experts. Its aim is to stimulate thinking, and perhaps to attract more young scientists to enter this field of research.This revised edition is brought up to date by a new chapter on the SARS-CoV-2 pandemic. Related Link(s)

Virus Bioinformatics

Manja Marz,Bashar Ibrahim,Franziska Hufsky,David L. Robertson
Virus Bioinformatics Book PDF

Author : Manja Marz,Bashar Ibrahim,Franziska Hufsky,David L. Robertson
Publisher : MDPI
Page : 330 pages
File Size : 54,9 Mb
Release : 2020-02-21
Category : Science
ISBN : 9783039218820

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Virus Bioinformatics by Manja Marz,Bashar Ibrahim,Franziska Hufsky,David L. Robertson Pdf

Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.

Modern Trends in Human Leukemia V

R. Neth,R. C. Gallo,M. F. Greaves,M. A. S. Moore,K. Winkler
Modern Trends in Human Leukemia V Book PDF

Author : R. Neth,R. C. Gallo,M. F. Greaves,M. A. S. Moore,K. Winkler
Publisher : Springer Science & Business Media
Page : 539 pages
File Size : 40,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642687617

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Modern Trends in Human Leukemia V by R. Neth,R. C. Gallo,M. F. Greaves,M. A. S. Moore,K. Winkler Pdf

Organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie, Wilsede, June 21-23, 1982

Jaagsiekte Sheep Retrovirus and Lung Cancer

Hung Y. Fan
Jaagsiekte Sheep Retrovirus and Lung Cancer Book PDF

Author : Hung Y. Fan
Publisher : Springer Science & Business Media
Page : 254 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642556388

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Jaagsiekte Sheep Retrovirus and Lung Cancer by Hung Y. Fan Pdf

Retroviruses have been of great importance to biomedical science for the past half century. Initially, studies on oncogenic animal retroviruses provided important insights into molecular processes in carcinogenesis – most notably the existence and mechanisms of action of oncogenes and proto-oncogenes. Moreover, several human diseases are caused by retroviruses, including AIDS, adult T-cell leukemia and the neurological disease HAM/TSP. The topic of this volume is a relatively unknown animal retrovirus, jaagsiekte sheep retrovirus, the causative agent of transmissible lung cancer in sheep –ovine pulmonary adenocarcinoma. The disease was first documented in South Africa in the 1800s, it has a wide geographical distribution, and it is of economic importance in high endemic regions. However, until very recently the nature of the etiologic agent was unclear, and relatively few laboratories actively studied the disease.