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Volume Ii Novel Molecular Mechanisms And Innovative Therapeutic Approaches For Age Associated Diseases Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Volume Ii Novel Molecular Mechanisms And Innovative Therapeutic Approaches For Age Associated Diseases book. This book definitely worth reading, it is an incredibly well-written.
Author : Leming Sun,Zhen Fan,Zhe-Sheng Chen
Publisher : Frontiers Media SA
Page : 120 pages
File Size : 52,6 Mb
Release : 2023-01-09
Category : Science
ISBN : 9782832511213
Author : Leming Sun,Zhe-Sheng Chen,Zhen Fan
Publisher : Frontiers Media SA
Page : 370 pages
File Size : 51,7 Mb
Release : 2022-06-03
Category : Science
ISBN : 9782889763252
Author : Vladimir Titorenko
Publisher : MDPI
Page : 322 pages
File Size : 43,9 Mb
Release : 2019-08-19
Category : Science
ISBN : 9783039213559
Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.
Author : Javier Egea,Carmen Gomez-Guerrero,Águeda González Rodríguez,Juan Antonio Moreno
Publisher : Frontiers Media SA
Page : 257 pages
File Size : 54,5 Mb
Release : 2020-01-02
Category : Electronic
ISBN : 9782889633166
Author : Taihao Quan
Publisher : CRC Press
Page : 0 pages
File Size : 42,9 Mb
Release : 2016
Category : Older people
ISBN : 1498704646
Chapter 5: CCN Family Proteins in Skin Connective Tissue Aging
Author : Paul C. Guest
Publisher : Unknown
Page : 128 pages
File Size : 45,8 Mb
Release : 2021
Category : Drug targeting
ISBN : 3030550362
Aging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in 'omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry. This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from 'omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America, Uruguay and Vietnam, this is a timely follow up to Guest's previous book Reviews on New Drug Targets in Age-Related Disorders.
Author : Anonim
Publisher : Academic Press
Page : 1656 pages
File Size : 53,5 Mb
Release : 2019-11-20
Category : Medical
ISBN : 9780128160763
Encyclopedia of Biomedical Gerontology, Three Volume Set presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years
Author : Victoria Campos-Peña,Oscar Rosas-Carrasco,Karla Guadalupe Carvajal,Rocío Martínez De Pablos
Publisher : Frontiers Media SA
Page : 213 pages
File Size : 41,5 Mb
Release : 2022-01-24
Category : Science
ISBN : 9782889741496
Author : Alexandrina Ferreira Mendes,Maria Teresa Cruz,Oreste Gualillo
Publisher : Frontiers Media SA
Page : 255 pages
File Size : 49,6 Mb
Release : 2019-02-20
Category : Electronic
ISBN : 9782889457298
Chronic diseases are increasingly recognized as involving low grade inflammation, that is, a self-perpetuating tissue response to stress caused by exogenous or endogenous triggers, that progressively evokes danger-associated molecular pattern release, ultimately driving tissue damage and loss of function. This response is frequently unapparent clinically, thus the designation "low grade". This eBook comprises nineteen reviews and original articles that provide the most updated knowledge on the causes and roles of this inflammatory response in a variety of diseases and conditions. The editorial that precedes these articles not only summarizes each one, but provides a broader interpretation of the role of inflammation in health and a variety of disease conditions, the underlying mechanisms and the targets more promising for therapy. Finally, it also highlights the most relevant and emerging research topics that are already shaping future directions for the development of more fine-tuned and innovative therapies.
Author : Rameshwar Nath Chaurasia,Sunny Ohia,Debasis Bagchi
Publisher : Elsevier
Page : 732 pages
File Size : 48,8 Mb
Release : 2024-06-14
Category : Medical
ISBN : 9780323957366
According to World Health Organization (WHO) one billion people worldwide are affected by one of the thousands of neurological disorders, including epilepsy, Alzheimer disease, strokes, and headaches. Neurological disorders also include brain injuries, neuroinfections, multiple sclerosis and Parkinson disease. A Review on Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics covers the major topics related to neurological disorders, current challenges in diagnosis and intervention. This book is organized into four distinct sections, starting with an introduction, providing a general overview of the epidemiology of neurological disorders, pathogenesis and management. The second section presents the aspects of brain diseases due to infection of bacteria, parasite, fungus and viruses. The third section discusses neurodegenerative disorders due to comorbid factors like diabetes, hypertension, hyperlipidemia and post traumatic brain injuries. The last section covers prevention through application of bioactive compounds and neuroprotective agents. Epidemiology of neurological disorders and pathogenesis. Explores neuroinflammation, ligand-receptors binding, and neurodegeneration. Discusses aging and associated disorders in the onset of neurological disorders. Neuropharmacology and the protective role of bioactive compounds in neuroprotection.
Author : United States. Congress. Senate. Office of Management and Budget. Executive Office of the President
Publisher : Unknown
Page : 1780 pages
File Size : 53,6 Mb
Release : 2016
Category : Economic assistance, Domestic
ISBN : 0160936357
Identifies and describes specific government assistance opportunities such as loans, grants, counseling, and procurement contracts available under many agencies and programs.
Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 802 pages
File Size : 47,5 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9780128027875
As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease Explains the practice of “molecular medicine and the translational aspects of molecular pathology Teaches from the perspective of “integrative systems biology Enhanced digital version included with purchase
Author : Naofumi Shiomi
Publisher : BoD – Books on Demand
Page : 128 pages
File Size : 51,8 Mb
Release : 2016-08-31
Category : Medical
ISBN : 9789535125686
Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.
Author : John Michels
Publisher : Unknown
Page : 882 pages
File Size : 48,7 Mb
Release : 2006
Category : Science
ISBN : MINN:31951P00972595F
Author : Anatoli I. Yashin,S. Michal Jazwinski
Publisher : Unknown
Page : 0 pages
File Size : 44,6 Mb
Release : 2015
Category : Medical
ISBN : 3318027294
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
