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In the 1800s, opium and cocaine could be easily obtained to treat a range of ailments. Drug dependency, when it occurred, was considered a matter of personal vice. Near the end of the century, attitudes shifted and access to drugs became more restricted. Dan Malleck reveals how different forces converged in the early 1900s to influence lawmakers and set the course for the drug laws that exist today. As this book shows, social concerns about drug addiction had less to do with the long pipe and shadowy den than with lobbying by medical professionals, concern about the morality and future of the nation, and a burgeoning pharmaceutical industry.
In the 1800s, opium and cocaine could be easily obtained to treat a range of ailments. Drug dependency, when it occurred, was considered a matter of personal vice. Near the end of the century, attitudes shifted and access to drugs became more restricted. Dan Malleck reveals how different forces converged in the early 1900s to influence lawmakers and set the course for the drug laws that exist today. As this book shows, social concerns about drug addiction had less to do with the long pipe and shadowy den than with lobbying by medical professionals, concern about the morality and future of the nation, and a burgeoning pharmaceutical industry.
Drugs, Alcohol and Addiction in the Long Nineteenth Century by Daniel Malleck Pdf
This collection captures key themes and issues in the broad history of addiction and vice in the Anglo-American world. Focusing on the long nineteenth-century, the volumes consider how scientific, social, and cultural experiences with drugs, alcohol, addiction, gambling, and prostitution varied around the world. What might be considered vice, or addiction could be interpreted in various ways, through various lenses, and such activities were interpreted differently depending upon the observer: the medical practitioner; the evangelical missionary; the thrill seeking bon-vivant, and the concerned government commissioner, to name but a few. For example, opium addiction in middle class households resulting from medical treatment was judged much differently than Chinese opium smoking by those in poverty or poor living conditions in North American work camps on the west coast, or on the streets of East London. This collection will assemble key documents representing both the official and general view of these various activities, providing readers with a cross section of interpretations and a solid grounding in the material that shaped policy change, cultural interpretation, and social action.
Argues that doctors are deliberately misinformed by profit-seeking pharmaceutical companies that casually withhold information about drug efficacy and side effects, explaining the process of pharmaceutical data manipulation and its global consequences. By the best-selling author of Bad Science.
Pleasure and Panic by Dan Malleck,Cheryl Krasnick Warsh Pdf
Booze, dope, smokes, and weed. Mind-altering, mood-changing substances have been part of human society for millennia. Pleasure and Panic reveals how attitudes toward drug and alcohol consumption have always been deeply embedded in cultural fears and social, political, and economic disparities. Contributors to this collection explore how drugs and alcohol intersect with diverse histories, including gender, medicine, popular culture, and business. Pleasure and Panic brings a dispassionate voice to current debates about liberalizing drug and alcohol laws and challenges existing ideas about how to deal with the so-called problems of drug and alcohol use.
This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal.
Author : Konstantin V. Balakin Publisher : John Wiley & Sons Page : 584 pages File Size : 50,9 Mb Release : 2009-11-19 Category : Medical ISBN : 9780470567616
Pharmaceutical Data Mining by Konstantin V. Balakin Pdf
Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery—including chemogenomics, toxicogenomics, and individual drug response prediction. The five main sections of this volume cover: A general overview of the discipline, from its foundations to contemporary industrial applications Chemoinformatics-based applications Bioinformatics-based applications Data mining methods in clinical development Data mining algorithms, technologies, and software tools, with emphasis on advanced algorithms and software that are currently used in the industry or represent promising approaches In one concentrated reference, Pharmaceutical Data Mining reveals the role and possibilities of these sophisticated techniques in contemporary drug discovery and development. It is ideal for graduate-level courses covering pharmaceutical science, computational chemistry, and bioinformatics. In addition, it provides insight to pharmaceutical scientists, principal investigators, principal scientists, research directors, and all scientists working in the field of drug discovery and development and associated industries.
Genes are important modifiers of the human response to drugs, hormones, and toxins. In this second edition of 'Pharmacogenetics', Weber brings together laboratory methods and epidemiologic studies in defining the role of heredity in human drug response.
Author : Ming Hu,Xiaoling Li Publisher : John Wiley & Sons Page : 932 pages File Size : 45,5 Mb Release : 2024-01-18 Category : Medical ISBN : 9781119660651
Oral Bioavailability and Drug Delivery by Ming Hu,Xiaoling Li Pdf
ORAL BIOAVAILABILITY AND DRUG DELIVERY Improve the performance and viability of newly-developed and approved drugs with this crucial guide Bioavailability is the parameter which measures the rate and extent to which a drug reaches a user’s circulatory system depending on the method of administration. For example, intravenous administration produces a bioavailability of 100%, since the drugs are injected directly into the circulatory system; in the case of oral administration, however, bioavailability can vary widely based on factors which, if not properly understood, can result in a failure in drug development, adverse effects, and other complications. The mechanics of oral bioavailability are therefore critical aspects of drug development. Oral Bioavailability and Drug Delivery provides a comprehensive coverage of this subject as well as its drug development applications. Beginning with basic terminology and fundamental concepts, it provides a thorough understanding of the challenges and barriers to oral bioavailability as well as the possibilities for improving this parameter. The resulting book is an indispensable tool for drug development research. Oral Bioavailability and Drug Delivery readers will also find: Discussion questions in many chapters to facilitate comprehension Detailed discussion of topics including dissolution, absorption, metabolism, and more Real-world examples of methods in actions throughout Oral Bioavailability and Drug Delivery is ideal for pharmaceutical and biotechnology scientists working in drug discovery and development; researchers in chemistry, biology, pharmacology, immunology, neuroscience, and other related fields; and graduate courses in drug development and delivery.
Post-genomic Approaches in Drug and Vaccine Development by Kishore R. Sakharkar,Meena K. Sakharkar,Ramesh Chandra Pdf
Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. T
Atkinson's Principles of Clinical Pharmacology by Shiew-Mei Huang,Juan J.L. Lertora,Paolo Vicini,Arthur J. Atkinson Jr. Pdf
Atkinson’s Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. Presents the essential knowledge for effective practice of clinical pharmacology Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology Offers an extensive regulatory section that addresses US and international issues and guidelines Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on "Phase 0" studies (microdosing) and PBPK
Author : Sean Ekins,Jinghai J. Xu Publisher : John Wiley & Sons Page : 442 pages File Size : 43,8 Mb Release : 2009-01-28 Category : Medical ISBN : 9780470431801
Drug Efficacy, Safety, and Biologics Discovery by Sean Ekins,Jinghai J. Xu Pdf
Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.
