5 Ht2c Receptors In The Pathophysiology Of Cns Disease

Author : Giuseppe Di Giovanni,Ennio Esposito,Vincenzo Di Matteo
Publisher : Springer Science & Business Media
Page : 556 pages
File Size : 52,8 Mb
Release : 2010-11-30
Category : Medical
ISBN : 9781607619413

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5-HT2C Receptors in the Pathophysiology of CNS Disease by Giuseppe Di Giovanni,Ennio Esposito,Vincenzo Di Matteo Pdf

Part of Springer’s “The Receptors,” series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors’ therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy.

Author : Anonim
Publisher : Unknown
Page : 572 pages
File Size : 44,9 Mb
Release : 2011-04-11
Category : Electronic
ISBN : 1607619423

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5-Ht2c Receptors in the Pathophysiology of CNS Disease by Anonim Pdf

Author : Bruno P. Guiard,Giuseppe Di Giovanni
Publisher : Springer
Page : 446 pages
File Size : 41,7 Mb
Release : 2018-02-14
Category : Medical
ISBN : 9783319704746

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5-HT2A Receptors in the Central Nervous System by Bruno P. Guiard,Giuseppe Di Giovanni Pdf

5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets. ​

Author : Amitabha Chattopadhyay
Publisher : CRC Press
Page : 230 pages
File Size : 40,9 Mb
Release : 2007-05-17
Category : Medical
ISBN : 9781420005752

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Serotonin Receptors in Neurobiology by Amitabha Chattopadhyay Pdf

A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from l

Author : Abel Lajtha
Publisher : Springer
Page : 516 pages
File Size : 40,5 Mb
Release : 1982-12-01
Category : Science
ISBN : 0306409720

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Experimental Neurochemistry by Abel Lajtha Pdf

The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.

Author : Robin A.J. Lester
Publisher : Springer
Page : 468 pages
File Size : 46,7 Mb
Release : 2014-11-11
Category : Medical
ISBN : 9781493911677

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Nicotinic Receptors by Robin A.J. Lester Pdf

A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.

Author : Katharine Herrick-Davis,Graeme Milligan,Giuseppe Di Giovanni
Publisher : Springer
Page : 501 pages
File Size : 44,8 Mb
Release : 2017-08-31
Category : Medical
ISBN : 9783319601748

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G-Protein-Coupled Receptor Dimers by Katharine Herrick-Davis,Graeme Milligan,Giuseppe Di Giovanni Pdf

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 42,6 Mb
Release : 19??
Category : Electronic
ISBN : 1461464382

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Encyclopedia of Signaling Molecules by Anonim Pdf

Author : Kjell Fuxe,Luigi F. Agnati
Publisher : Springer Science & Business Media
Page : 577 pages
File Size : 45,5 Mb
Release : 2013-03-13
Category : Computers
ISBN : 9781468454154

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Receptor-Receptor Interactions by Kjell Fuxe,Luigi F. Agnati Pdf

Author : Anonim
Publisher : Academic Press
Page : 1042 pages
File Size : 40,8 Mb
Release : 2020-01-23
Category : Medical
ISBN : 9780444641267

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Handbook of the Behavioral Neurobiology of Serotonin by Anonim Pdf

Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood. Features two new sections on serotonin systems interactions and serotonin in neurological disorders Focuses on ionotropic and metabotropic 5-HT receptor involvement in behavior Maps receptors and receptor signaling pathways to neurochemical and behavioral outcomes Covers the interactions between serotonin, melatonin and kynurenine pathways

Author : Anonim
Publisher : Elsevier
Page : 484 pages
File Size : 40,5 Mb
Release : 2021-03-26
Category : Science
ISBN : 9780444642592

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5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part B by Anonim Pdf

The Progress in Brain Research series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Covers all key aspects of current research on 5-HT interaction with other neurotransmitters Provides extensively referenced chapters, thus giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists

Author : Anonim
Publisher : Elsevier
Page : 334 pages
File Size : 45,5 Mb
Release : 2021-02-02
Category : Science
ISBN : 9780128245682

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5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance Part A by Anonim Pdf

5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance, Part B, Volume 260 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Serotonin-noradrenalin interactions, Electrophysiological and neurochemical evidence for an interaction of serotonin on noradrenergic neurons, Serotonin and cannabinoid system, 5-HT/CB interaction in the CNS in health and disease, Serotonin2A receptors and Cannabinoids, CB1/5-HT/GABA in food intake, A close interaction between serotonergic system and BDNF in the mechanism of action of antidepressant, 5-HT/ Ach, Interaction of 5-HT2A/2C ligands and nicotine, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Brain Research series Includes the latest information on the 5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance, Part B

Author : Rona R. Ramsay,Giuseppe Di Giovanni
Publisher : Frontiers Media SA
Page : 206 pages
File Size : 47,8 Mb
Release : 2017-03-24
Category : Electronic book
ISBN : 9782889451234

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Structure-Based Drug Design for Diagnosis and Treatment of Neurological Diseases by Rona R. Ramsay,Giuseppe Di Giovanni Pdf

European Cooperation in Science and Technology (COST) supports the collaboration of nationally-funded science and technology research through the creation of networks. COST is the longest-running European framework enhancing cooperation among researchers, engineers and scholars across Europe. The COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” is a good example of the advances possible through interdisciplinary collaboration on difficult problems. COST Action CM1103 brought together 28 research groups from 18 countries to collaborate for four years on multi-target drug design for complex neuropathologies. The interdisciplinary expertise of the members is spans the range from computational enzymology to human studies, providing outstanding opportunities for the interdisciplinary development of trainees, and is reflected in the articles in this e-book. This Research Topic covers progress in multi-target drug design for the complex neuropathologies of the monoamine system that are apparent, for example, in Alzheimer’s disease. After a mini-review to introduce the topic of multi-target drug design, the other articles review the Research topic from their own perspective, two from computational approaches, three from medicinal chemistry, two from molecular pharmacology, and two from studies in whole brain. This multi-faceted approach describes new compounds, new methodology, and advances in the basic science of understanding the brain. This Ebook is based upon work from COST Action (CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain"), supported by COST (European Cooperation in Science and Technology). COST (European Cooperation in Science and Technology) is a pan-European intergovernmental framework. Its mission is to enable break-through scientific and technological developments leading to new concepts and products and thereby contribute to strengthening Europe’s research and innovation capacities. It allows researchers, engineers and scholars to jointly develop their own ideas and take new initiatives across all fields of science and technology, while promoting multi- and interdisciplinary approaches. COST aims at fostering a better integration of less research intensive countries to the knowledge hubs of the European Research Area. The COST Association, an International not-for-profit Association under Belgian Law, integrates all management, governing and administrative functions necessary for the operation of the framework. The COST Association has currently 36 Member Countries. www.cost.eu

Author : Matthew Macaluso,Sheldon H. Preskorn,Richard C. Shelton
Publisher : Springer Nature
Page : 457 pages
File Size : 53,5 Mb
Release : 2023-03-16
Category : Medical
ISBN : 9783031210549

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Drug Development in Psychiatry by Matthew Macaluso,Sheldon H. Preskorn,Richard C. Shelton Pdf

The book reviews clinical trial methodology as it pertains to drug development in psychiatry. The reader will understand the process of drug development in psychiatry from discovery through marketing with the help of clinically relevant examples. The reader will appreciate the history of drug development in psychiatry dating back to the era of serendipitous discovery and culminating in an era of new and highly focused targets. Readers will understand how drug development in psychiatry has changed and adapted with the discovery of novel mechanism of action drugs. Novel drugs and disease targets have changed the way developers and regulatory agencies think about clinical trial methodology. The book elucidates how biomarkers, genetics and advances in neuroscience and neuroimaging have influenced drug development approaches, which will ultimately change the practice of psychiatry. The book will be broken down into the following sections: a. Prior to the 1960s - Drug discovery by chance observation b. The last 50 years – refined targeting of CNS drugs without the discovery of mechanistically new drugs c. The future – the discovery and development of mechanistically new drugs. The examination of new targets, genetics and biomarkers.

Author : Laurival Antonio De Luca Jr.,Jose Vanderlei Menani,Alan Kim Johnson
Publisher : CRC Press
Page : 340 pages
File Size : 49,6 Mb
Release : 2013-10-01
Category : Science
ISBN : 9781466506930

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Neurobiology of Body Fluid Homeostasis by Laurival Antonio De Luca Jr.,Jose Vanderlei Menani,Alan Kim Johnson Pdf

A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration was held at Araraquara, São Paulo, Brazil in 2011. This meeting was convened as an official satellite of a joint gathering of the International Society for Autonomic Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, Rio de Janeiro. Broad international participation at this event generated stimulating discussion among the invited speakers, leading to the publication of Neurobiology of Body Fluid Homeostasis: Transduction and Integration. Drawn from the proceedings and filled with rich examples of integrative neurobiology and regulatory physiology, this volume: Provides updated research using human and animal models for the control of bodily fluids, thirst, and salt appetite Explores neural and endocrine control of body fluid balance, arterial pressure, thermoregulation, and ingestive behavior Discusses recent developments in molecular genetics, cell biology, and behavioral plasticity Reviews key aspects of brain serotonin and steroid and peptide control of fluid consumption and arterial pressure The book highlights research conducted by leading scientists on signal transduction and sensory afferent mechanisms, molecular genetics, perinatal and adult long-term influences on regulation, central neural integrative circuitry, and autonomic/neuroendocrine effector systems. The findings discussed by the learned contributors are relevant for a basic understanding of disorders such as heat injury, hypertension, and excess salt intake. A unique reference on the neurobiology of body fluid homeostasis, this volume is certain to fuel additional research and stimulate further debate on the topic.