G Protein Coupled Receptor Dimers

Author : Katharine Herrick-Davis,Graeme Milligan,Giuseppe Di Giovanni
Publisher : Springer
Page : 501 pages
File Size : 54,8 Mb
Release : 2017-08-31
Category : Medical
ISBN : 9783319601748

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G-Protein-Coupled Receptor Dimers by Katharine Herrick-Davis,Graeme Milligan,Giuseppe Di Giovanni Pdf

G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses. They dimerize (form a pair of macromolecules) with a wide variety of other receptors. The proposed book will provide a comprehensive overview of GPCR dimers, starting with a historical perspective and including, basic information about the different dimers, how they synthesize, their signaling properties, and the many diverse physiological processes in which they are involved. In addition to presenting information about healthy GPCR dimer activity, the book will also include a section on their pathology and therapeutic potentials.

Author : Lakshmi A. Devi
Publisher : Springer Science & Business Media
Page : 412 pages
File Size : 49,6 Mb
Release : 2008-03-01
Category : Medical
ISBN : 9781592599196

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The G Protein-Coupled Receptors Handbook by Lakshmi A. Devi Pdf

A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.

Author : Denis J. Dupré,Terence E. Hébert,Ralf Jockers
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 44,7 Mb
Release : 2012-11-19
Category : Medical
ISBN : 9789400747654

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GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity by Denis J. Dupré,Terence E. Hébert,Ralf Jockers Pdf

Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.

Author : Kjell Fuxe,Luigi F. Agnati
Publisher : Springer Science & Business Media
Page : 577 pages
File Size : 52,5 Mb
Release : 2013-03-13
Category : Computers
ISBN : 9781468454154

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Receptor-Receptor Interactions by Kjell Fuxe,Luigi F. Agnati Pdf

Author : Francisco Ciruela,Rafael Luján
Publisher : Nova Publishers
Page : 328 pages
File Size : 41,5 Mb
Release : 2008
Category : Science
ISBN : 1600219152

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Molecular Aspects of G Protein-coupled Receptors by Francisco Ciruela,Rafael Luján Pdf

In the recent years, studies based on two-hybrid screens, proteomic, biochemical and cell biology approaches, have shown that intracellular domains of G protein-coupled receptors (GPCR) or heptaspanning membrane receptors (HSMRs) interact with intracellular proteins. These interactions are the basis of a protein network associated to these receptors which includes scaffolding proteins containing one or several PDZ (post-synaptic density-95, discs large, zona occludens-1) domains, signalling proteins and proteins of the cytoskeleton. The present book is focused on the emerging evidence for interactions of G protein-coupled receptors with scaffolding, cytoskeletal and signalling proteins that will play a role in the targeting, anchoring and functioning of these receptors in the plasma membrane, thus contributing to cell development and plasticity.

Author : KJELL FUXE,Dasiel O. Borroto-Escuela
Publisher : Humana
Page : 0 pages
File Size : 47,5 Mb
Release : 2018-08-02
Category : Medical
ISBN : 1493985752

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Receptor-Receptor Interactions in the Central Nervous System by KJELL FUXE,Dasiel O. Borroto-Escuela Pdf

This volume covers methodologies, ranging from the molecular level to the network level, used to study receptor-receptor interactions in heteroreceptor complexes inside the central nervous system. The chapters in this book cover topics such as biochemical binding techniques; receptor autoradiography; superfused synaptosome techniques; RTK-GPCR interaction; fluorescence and bioluminiscence energy transfer methods, Co-IP cytometry-based FRET; and novel bioinformatic approaches to understand membrane heteroreceptor complexes and the global panorama of their receptor-receptor interactions. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Receptor-Receptor Interactions in the Central Nervous System is a valuable resource for any scientist or researcher interested in this field of study.

Author : Didier Rognan
Publisher : John Wiley & Sons
Page : 300 pages
File Size : 50,7 Mb
Release : 2006-03-10
Category : Medical
ISBN : 3527312846

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Ligand Design for G Protein-coupled Receptors, Volume 30 by Didier Rognan Pdf

1. G protein-coupled receptors in the human genome -- 2. Why G protein-coupled receptors databases are needed -- 3. A novel drug screening assay for G protein-coupled receptors -- 4. Importance of GPCR dimerization for function : the case of the class C GPCRs -- 5. Molecular mechanisms of GPCR activation -- 6. Allosteric properties and regulation of G protein-coupled receptors -- 7. Chemogenomics approaches to ligand design -- 8. Strategies for the design of pGPCR-targeted libraries -- 9. Ligand-based rational design : virtual screening -- 10. 3-D structure of G protein-coupled receptors --11. 7TM models in structure-based drug design -- 12. Receptor-based rational design : virtual screening.

Author : Anonim
Publisher : Academic Press
Page : 350 pages
File Size : 41,9 Mb
Release : 2020-01-16
Category : Science
ISBN : 9780128179307

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Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors by Anonim Pdf

Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scienti?c importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine ß-synthase, and Oligomerization of Porphobilinogen Synthase. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field of molecular biology

Author : Jacqueline M. Matthews
Publisher : Springer Science & Business Media
Page : 170 pages
File Size : 50,6 Mb
Release : 2012-09-04
Category : Medical
ISBN : 9781461432296

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Protein Dimerization and Oligomerization in Biology by Jacqueline M. Matthews Pdf

This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.

Author : Kenneth H. Lundstrom,Mark L. Chiu
Publisher : CRC Press
Page : 376 pages
File Size : 41,6 Mb
Release : 2005-07-11
Category : Medical
ISBN : 9781420028218

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G Protein-Coupled Receptors in Drug Discovery by Kenneth H. Lundstrom,Mark L. Chiu Pdf

The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development. Using disease-oriented methods to cover everything from screening to expression and crystallization, G Protein-Coupled Receptors in Drug Discovery describes the physiological roles of GPCRs

Author : Marta Filizola
Publisher : Springer Science & Business Media
Page : 228 pages
File Size : 45,7 Mb
Release : 2013-10-25
Category : Science
ISBN : 9789400774230

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G Protein-Coupled Receptors - Modeling and Simulation by Marta Filizola Pdf

G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors. Luckily, there has been a steady increase of high-resolution crystal structures of these receptors since 2007, and this information, integrated with dynamic inferences from computational and experimental methods, holds great potential for the discovery of new, improved drugs. This book, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the second part of the book. The third part reports recent progress in rational ligand discovery and mathematical modeling, whereas the fourth part provides an overview of bioinformatics tools and resources that are available for GPCRs.

Author : Jesús Giraldo,Jean-Philippe Pin
Publisher : Royal Society of Chemistry
Page : 522 pages
File Size : 53,5 Mb
Release : 2011
Category : Medical
ISBN : 9781849731836

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G Protein-coupled Receptors by Jesús Giraldo,Jean-Philippe Pin Pdf

G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. The book lies between the fields of chemical biology, molecular pharmacology, and medicinal chemistry.

Author : Anonim
Publisher : Elsevier
Page : 194 pages
File Size : 54,7 Mb
Release : 2023-01-25
Category : Science
ISBN : 9780323994354

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G Protein-Coupled Receptors - Part B by Anonim Pdf

G Protein-Coupled Receptors, Part B, Volume 195 represents the largest class of cell H103 surface proteins that have intricate involvement in nearly every physiological process in our body. Approximately one third of the clinically prescribed medicines target GPCRs and the quest to improve the exiting GPCR-targeting therapeutics continues. Sections in this volume include Adhesion G protein-coupled receptors: Structure and functions, Molecular and cellular mechanisms underlying brain region-specific cannabinoid receptor modulation by estradiol across the rodent estrus cycle, Probing the orphan receptors: Tools and directions, Asymmetric activation of Class C GPCRs, Common and selective signal transduction mechanisms of GPCRs, and much more. Covers a broad range of topics related to GPCR activation and signaling Provides several receptor systems, with an emphasis on emerging paradigms Includes different processes and model systems, with a focus on GPCRs

Author : Peter J. Woolf
Publisher : Unknown
Page : 420 pages
File Size : 44,9 Mb
Release : 2002
Category : Electronic
ISBN : UOM:39015054296200

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Computational Analysis of G-protein Coupled Receptor Screening, Dimerization, and Desensitization by Peter J. Woolf Pdf

Author : Sandra Siehler,Graeme Milligan
Publisher : Cambridge University Press
Page : 447 pages
File Size : 42,7 Mb
Release : 2010-09-30
Category : Medical
ISBN : 9781139491747

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G Protein-Coupled Receptors by Sandra Siehler,Graeme Milligan Pdf

Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.