A Handbook Of Mouse Models Of Cardiovascular Disease

Author : Qingbo Xu
Publisher : John Wiley & Sons
Page : 402 pages
File Size : 52,9 Mb
Release : 2006-08-04
Category : Science
ISBN : 9780470028780

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A Handbook of Mouse Models of Cardiovascular Disease by Qingbo Xu Pdf

The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.

Author : Qingbo Xu
Publisher : Unknown
Page : 360 pages
File Size : 43,6 Mb
Release : 2006-10-28
Category : Science
ISBN : 0470028793

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A Handbook of Mouse Models of Cardiovascular Disease by Qingbo Xu Pdf

The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook will enable scientists to develop these models in their own laboratories. It contains detailed advice on the issues that investigators need to consider before starting their experiments. It then provides essential information about experimental procedures, specific instruments and technical knowledge and will prove an indispensable guide to all scientists planning to work with these mouse models. This book includes a brief introduction to each disease, followed by a detailed description of the methods and materials used to establish the relevant mouse model. Each chapter has been written by an expert familiar with that system, who provides helpful discussion of the problems that may be encountered and examples of applications of the model. Importantly, each technique is clearly illustrated on the accompanying CD, so that researchers can observe the operational procedures directly. With coverage of all the major mouse models of cardiovascular disease, this book may be used to obtain a broad overview of commonly used methods and, more importantly, as a comprehensive source of detailed information on the development and study of such models. It will prove essential reading to all those working on experimental animal models of cardiovascular disease, from students to independent investigators.

Author : Li Chen,Richard P. Shannon,You-Tang Shen
Publisher : Elsevier Inc. Chapters
Page : 1108 pages
File Size : 42,5 Mb
Release : 2013-05-29
Category : Medical
ISBN : 9780128071984

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Animal Models for the Study of Human Disease by Li Chen,Richard P. Shannon,You-Tang Shen Pdf

With advances in molecular and genomic research offering novel insights into cardiovascular diseases, many transgenic animal models have been recently developed and characterized. Currently, more than 90 percent of all laboratory animal experiments are conducted in mice and rats. Although there are many scientific advantages to using small animal models, it has been recently recognized that many exciting therapeutic targets identified in small animals are not validated in clinical trials in patients. Thus, suitable large animal models, particularly under conscious state with appropriate direct measurements of cardiovascular function, are needed to serve as a better translational bridge between preclinical and clinical studies. In this chapter, we primarily focus on surgically instrumented large animal models of common cardiovascular disease studied in the conscious state. In addition, several important physiological factors that influence the characteristics of the models, as well as the importance of proper data interpretation, will also be discussed.

Author : Masataka Sata
Publisher : Unknown
Page : 296 pages
File Size : 52,9 Mb
Release : 2016
Category : Blood-vessels
ISBN : 4431558128

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Mouse Models of Vascular Diseases by Masataka Sata Pdf

This book is a methodological source on mice models of vascular diseases. Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce, each model is described in detail and numerous photographs are provided with links to videos. Genetically modified mice are a very powerful tool for studying the pathogenesis of various diseases, including immunological and oncological disorders, but they had always been thought to be too small to be used in the field of cardiovascular disease. Recently, however, various mice models of vascular diseases have been reported, and these will make a substantial contribution to basic research on cardiovascular and metabolic disorders.

Author : D.R. Gross
Publisher : Springer Science & Business Media
Page : 630 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400950061

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Animal Models in Cardiovascular Research by D.R. Gross Pdf

Author : Kiyotake Ishikawa
Publisher : Unknown
Page : 404 pages
File Size : 40,6 Mb
Release : 2018
Category : Cardiovascular system
ISBN : 1493985973

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Experimental Models of Cardiovascular Diseases by Kiyotake Ishikawa Pdf

Author : Hans Hedrich
Publisher : Academic Press
Page : 868 pages
File Size : 49,8 Mb
Release : 2012-06-14
Category : Science
ISBN : 9780123820099

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The Laboratory Mouse by Hans Hedrich Pdf

The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

Author : G. Casadesus
Publisher : IOS Press
Page : 352 pages
File Size : 47,6 Mb
Release : 2011-07-05
Category : Medical
ISBN : 9781607507338

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Handbook of Animal Models in Alzheimer’s Disease by G. Casadesus Pdf

Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals – including transgenic animals – has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.

Author : Barry L. Zaret,George A. Beller
Publisher : Elsevier Health Sciences
Page : 896 pages
File Size : 40,9 Mb
Release : 2010-05-24
Category : Medical
ISBN : 9780323085724

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Clinical Nuclear Cardiology: State of the Art and Future Directions E-Book by Barry L. Zaret,George A. Beller Pdf

Clinical Nuclear Cardiology—now in its fourth edition—covers the tremendous clinical growth in this field, focusing on new instrumentation and techniques. Drs. Barry L. Zaret and George A Beller address the latest developments in technology, radiopharmaceuticals, molecular imaging, and perfusion imaging. Thoroughly revised to include 20 new chapters—Digital/Fast SPECT, Imaging in Revascularized Patients, and more—this new edition provides state-of-the-art guidance on key areas and hot topics with stunning visuals. Online access to the fully searchable text at expertconsult.com includes highly illustrated case studies that let you see the problem using a variety of imaging modalities. In other words, this is an invaluable resource no clinician or researcher in nuclear cardiology should be without. Features an editorial and contributing team of worldwide leaders in nuclear cardiology to provide you with current and authoritative guidance. Includes a section focusing on acute coronary syndromes to provide you with practical management tools for these conditions. Presents a full-color design that allows color images to be integrated throughout the text. Includes access to the fully searchable contents of the book online at expertconsult.com, along with highly illustrated case studies that let you see the problem using a variety of imaging modalities. Features 20 new chapters including Cellular Mechanisms of Tracer Uptake and Clearance; Attenuation/Scatter Corrections: Clinical Aspects; Hybrid Imaging; Digital/Fast SPECT; Imaging in Revascularized Patients; and more. Focuses on perfusion imaging in a section dedicated to this hot topic so you get all the information you need to stay current.

Author : P. Michael Conn
Publisher : Elsevier
Page : 1075 pages
File Size : 53,9 Mb
Release : 2011-04-28
Category : Medical
ISBN : 0080460062

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Handbook of Models for Human Aging by P. Michael Conn Pdf

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Author : George C. Kagadis,Nancy L. Ford,Dimitrios N. Karnabatidis,George K. Loudos
Publisher : CRC Press
Page : 602 pages
File Size : 53,8 Mb
Release : 2018-09-03
Category : Medical
ISBN : 9781315362793

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Handbook of Small Animal Imaging by George C. Kagadis,Nancy L. Ford,Dimitrios N. Karnabatidis,George K. Loudos Pdf

The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.

Author : Paul A. Iaizzo
Publisher : Springer Science & Business Media
Page : 460 pages
File Size : 43,6 Mb
Release : 2007-11-08
Category : Medical
ISBN : 9781592598359

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Handbook of Cardiac Anatomy, Physiology, and Devices by Paul A. Iaizzo Pdf

the Lillehei Heart Institute in their funding of illustrator Martin Finally, I would like to thank my family and friends for their Finch, who prepared several of the original figures; Gary support of my career and their assistance over the years. Without Williams for his computer expertise and assistance with such encouragement, I would not have even dreamed of taking on numerous figures; William Gallagher and Charles Soule, who such an ambitious project. Specifically, I would like to thank my made sure the laboratory kept running smoothly while many of wife Marge, my three daughters, Maria, Jenna, and Hanna, my us were busy writing or editing; Dick Bianco for his support of morn Irene, and siblings, Mike, Chris, Mark, and Susan, for always our lab and this book project; the Chairman of the Department being there for me. On a personal note, some of my motivation for of Surgery, Dr. David Dunn, for his support and encouragement; working on this project comes from the memory of my father and the Biomedical Engineering Institute at the University of Anthony, who succumbed to sudden cardiac death at too early an Minnesota, headed by Dr. Jeffrey McCullough, who supported age, and from the positive encouragement of my uncle Tom Halicki, this project by funding the Cardiovascular Physiology Interest who is doing well seven years after a heart transplant. Group (most of whose members contributed chapters). Paul A. laizzo, PhD Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V Blood Pressure, Heart Tones, and Diagnoses Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix George Bojanov . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Author : Nicolas Musi,Peter Hornsby
Publisher : Academic Press
Page : 469 pages
File Size : 55,9 Mb
Release : 2021-01-19
Category : Education
ISBN : 9780128162835

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Handbook of the Biology of Aging by Nicolas Musi,Peter Hornsby Pdf

Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more. Assists researchers in keeping abreast of research and clinical findings outside their subdiscipline Helps medical, behavioral and social gerontologists understand what basic scientists and clinicians are discovering Includes new chapters on genetics, evolutionary biology, bone aging, and epigenetic control Examines the diverse research being conducted in the study of the biology of aging

Author : Robert Krams,Magnus Bäck
Publisher : Oxford University Press
Page : 280 pages
File Size : 42,9 Mb
Release : 2017-02-17
Category : Medical
ISBN : 9780191074080

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The ESC Textbook of Vascular Biology by Robert Krams,Magnus Bäck Pdf

Atherosclerosis is the most significant cause of cardiovascular disease worldwide. Vascular biology is the key to understanding how atherosclerosis arises and operates. The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and reasearch. The textbook covers molecular findings and novel targets within the speciality while also providing the basics of vascular biology and disease pathophysiology. It also covers the major changes in the diagnosis, prevention and treatment of atherosclerosis that have occurred in recent years, developments and recent breakthroughs in the field are specifically highlighted. The official publication of the ESC Working Group on Arthrosclerosis and Vascular Biology, this print edition comes with access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. The textbook particularly appeals to vascular biologists, cardiologists, and other practising clinicians.

Author : Colin R Martin,Vinood B. Patel,Victor R Preedy
Publisher : Elsevier
Page : 708 pages
File Size : 48,6 Mb
Release : 2022-11-29
Category : Medical
ISBN : 9780323898867

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Handbook of Animal Models in Neurological Disorders by Colin R Martin,Vinood B. Patel,Victor R Preedy Pdf

Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction. Summarizes animal models for a variety of neurological conditions Contains chapter abstracts, key facts, a dictionary and a summary Covers both neurodegenerative diseases and other neurological conditions Compares and contrasts different models and experimental systems Includes sections on Alzheimer’s, Parkinson’s, brain injury, migraine, multiple sclerosis, and more