A Tale Of Two Viruses

Author : Neeraja Sankaran
Publisher : University of Pittsburgh Press
Page : 394 pages
File Size : 43,6 Mb
Release : 2021-03-30
Category : Science
ISBN : 9780822987710

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A Tale of Two Viruses by Neeraja Sankaran Pdf

In 1965, French microbiologist André Lwoff was awarded the Nobel Prize in Physiology or Medicine for his work on lysogeny—one of the two types of viral life cycles—which resolved a contentious debate among scientists about the nature of viruses. A Tale of Two Viruses is the first study of medical virology to compare the history of two groups of medically important viruses—bacteriophages, which infect bacteria, and sarcoma agents, which cause cancer—and the importance of Lwoff’s discovery to our modern understanding of what a virus is. Although these two groups of viruses may at first glance appear to have little in common, they share uniquely parallel histories. The lysogenic cycle, unlike the lytic, enables viruses to replicate in the host cell without destroying it and to remain dormant in a cell’s genetic material indefinitely, or until induced by UV radiation. But until Lwoff’s discovery of the mechanism of lysogeny, microbiologist Félix d’Herelle and pathologist Peyton Rous, who themselves first discovered and argued for the viral identity of bacteriophages and certain types of cancer, respectively, faced opposition from contemporary researchers who would not accept their findings. By following the research trajectories of the two virus groups, Sankaran takes a novel approach to the history of the development of the field of medical virology, considering both the flux in scientific concepts over time and the broader scientific landscapes or styles that shaped those ideas and practices.

Author : Gina Kolata
Publisher : Farrar, Straus and Giroux
Page : 378 pages
File Size : 44,9 Mb
Release : 2011-04-01
Category : Social Science
ISBN : 9781429979351

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Flu by Gina Kolata Pdf

Veteran journalist Gina Kolata's Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It presents a fascinating look at true story of the world's deadliest disease. In 1918, the Great Flu Epidemic felled the young and healthy virtually overnight. An estimated forty million people died as the epidemic raged. Children were left orphaned and families were devastated. As many American soldiers were killed by the 1918 flu as were killed in battle during World War I. And no area of the globe was safe. Eskimos living in remote outposts in the frozen tundra were sickened and killed by the flu in such numbers that entire villages were wiped out. Scientists have recently rediscovered shards of the flu virus frozen in Alaska and preserved in scraps of tissue in a government warehouse. Gina Kolata, an acclaimed reporter for The New York Times, unravels the mystery of this lethal virus with the high drama of a great adventure story. Delving into the history of the flu and previous epidemics, detailing the science and the latest understanding of this mortal disease, Kolata addresses the prospects for a great epidemic recurring, and, most important, what can be done to prevent it.

Author : Seth Mnookin
Publisher : Simon and Schuster
Page : 466 pages
File Size : 43,7 Mb
Release : 2012-01-03
Category : Health & Fitness
ISBN : 9781439158654

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The Panic Virus by Seth Mnookin Pdf

A searing account of how vaccine opponents have used the media to spread their message of panic, despite no scientific evidence to support them.

Author : Volker Thiel
Publisher : Unknown
Page : 0 pages
File Size : 50,6 Mb
Release : 2020-01-28
Category : Science
ISBN : 191253035X

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Coronaviruses by Volker Thiel Pdf

Paperback. ISBN 978-1-912530-35-9. In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. Essential reading for all coronavirologists as well as scientists working on other viruses of the respiratory and/or gastrointestinal tract.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 431 pages
File Size : 54,7 Mb
Release : 2005-04-09
Category : Medical
ISBN : 9780309095044

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The Threat of Pandemic Influenza by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Public health officials and organizations around the world remain on high alert because of increasing concerns about the prospect of an influenza pandemic, which many experts believe to be inevitable. Moreover, recent problems with the availability and strain-specificity of vaccine for annual flu epidemics in some countries and the rise of pandemic strains of avian flu in disparate geographic regions have alarmed experts about the world's ability to prevent or contain a human pandemic. The workshop summary, The Threat of Pandemic Influenza: Are We Ready? addresses these urgent concerns. The report describes what steps the United States and other countries have taken thus far to prepare for the next outbreak of "killer flu." It also looks at gaps in readiness, including hospitals' inability to absorb a surge of patients and many nations' incapacity to monitor and detect flu outbreaks. The report points to the need for international agreements to share flu vaccine and antiviral stockpiles to ensure that the 88 percent of nations that cannot manufacture or stockpile these products have access to them. It chronicles the toll of the H5N1 strain of avian flu currently circulating among poultry in many parts of Asia, which now accounts for the culling of millions of birds and the death of at least 50 persons. And it compares the costs of preparations with the costs of illness and death that could arise during an outbreak.

Author : Michael B. A. Oldstone
Publisher : Oxford University Press, USA
Page : 513 pages
File Size : 53,8 Mb
Release : 2020
Category : Medical
ISBN : 9780190056780

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Viruses, Plagues, and History by Michael B. A. Oldstone Pdf

"Here, my previous edition of Viruses, Plagues, & History is updated to reflect both progress and disappointment since that publication. This edition describes newcomers to the range of human infections, specifically, plagues that play important roles in this 21st century. The first is Middle East Respiratory Syndrome (MERS), an infection related to Sudden Acute Respiratory Syndrome (SARS). SARS was the first new-found plague of this century. Zika virus, which is similar to yellow fever virus in being transmitted by mosquitos, is another of the recent scourges. Zika appearing for the first time in the Americas is associated with birth defects and a paralytic condition in adults. Lastly, illness due to hepatitis viruses were observed prominently during the second World War initially associated with blood transfusions and vaccine inoculations. Since then, hepatitis virus infections have afflicted millions of individuals, in some leading to an acute fulminating liver disease or more often to a life-long persistent infection. A subset of those infected has developed liver cancer. However, in a triumph of medical treatments for infectious diseases, pharmaceuticals have been developed whose use virtually eliminates such maladies. For example, Hepatitis C virus infection has been eliminated from almost all (>97%) of its victims. This incredible result was the by-product of basic research in virology as well as cell and molecular biology during which intelligent drugs were designed to block events in the hepatitis virus life-cycle"--

Author : Matt Ridley,Alina Chan
Publisher : HarperCollins
Page : 448 pages
File Size : 54,7 Mb
Release : 2022-06-28
Category : Medical
ISBN : 9780063273603

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Viral by Matt Ridley,Alina Chan Pdf

"Chan and Ridley write with an urgency...that inspires gripping depictions of what viruses are, how infectious-disease laboratories work and wonderfully lucid descriptions of bats. . . . They powerfully recount how dangerous pathogens can both leak from a lab and emerge in nature." (New York Times Book Review) Understanding how Covid-19 started is crucial for the future of humankind. Viral is the most incisive and authoritative book about the search for the source of the virus. A new virus descended on the human species in 2019 wreaking unprecedented havoc. Finding out where it came from and how it first jumped into people is an urgent priority, but early expectations that this would prove an easy question to answer have been dashed. Nearly two years into the pandemic, the crucial mystery of the origin of SARS-CoV-2 is not only unresolved but has deepened. In this uniquely insightful book, a scientist and a writer join forces to try to get to the bottom of how a virus whose closest relations live in bats in subtropical southern China somehow managed to begin spreading among people more than 1,500 kilometres away in the city of Wuhan. They grapple with the baffling fact that the virus left none of the expected traces that such outbreaks usually create: no infected market animals or wildlife, no chains of early cases in travellers to the city, no smouldering epidemic in a rural area, no rapid adaptation of the virus to its new host—human beings. To try to solve this pressing mystery, Viral delves deep into the events of 2019 leading up to 2021, the details of what went on in animal markets and virology laboratories, the records and data hidden from sight within archived Chinese theses and websites, and the clues that can be coaxed from the very text of the virus’s own genetic code. The result is a gripping detective story that takes the reader deeper and deeper into a metaphorical cave of mystery. One by one the authors explore promising tunnels only to show that they are blind alleys, until, miles beneath the surface, they find themselves tantalisingly close to a shaft that leads to the light.

Author : Dennis Meredith
Publisher : Glyphus LLC
Page : 392 pages
File Size : 40,5 Mb
Release : 2013-02
Category : Fiction
ISBN : 9780981884851

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The Rainbow Virus Young Adult Edition by Dennis Meredith Pdf

It's the weirdest bioterrorism attack ever! A frightening epidemic of unknown viruses is turning people red, yellow, blue, chartreuse, emerald, pumpkin, fuschia. . . . An eccentric, brilliant biologist vanishes from a local biotech company. Is he the culprit? An unlikely team pursues the mystery: disgraced FBI agent Bobby Loudon and obsessive CDC disease detective Kathleen Shinohara. They race to find the bioterrorist, but they are thwarted by a shadowy, deadly network called the faction. Who is this group and what is their goal? Will Loudon's and Shinohara's worst fear be realized¿that the colorful infections are prelude to an unstoppable virus that the bioterrorist will unleash to devastate the world? The Rainbow Virus is a breakneck science fiction adventure based on the looming potential of new biowarfare technology to pose a global terrorist threat. It's also a witty commentary on the peculiar human tendency to judge people by their skin color. Author and veteran science writer Dennis Meredith has crafted this riveting tale drawing on his decades of experience working at leading research universities such as Caltech, MIT, Cornell and Duke. For more information on Dennis Meredith's novels, go to www.DennisMeredith.com.

Author : Dorothy H. Crawford
Publisher : Oxford University Press
Page : 177 pages
File Size : 55,6 Mb
Release : 2018
Category : Medical virology
ISBN : 9780198811718

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Viruses by Dorothy H. Crawford Pdf

Viruses are big news. From pandemics such as HIV, swine flu, and SARS, we are constantly being bombarded with information about new lethal infections. In this Very Short Introduction, Dorothy Crawford demonstrates from their discovery and the unravelling of their intricate structures, how clever these entities really are.

Author : Richard Preston
Publisher : Anchor
Page : 450 pages
File Size : 45,8 Mb
Release : 1995
Category : Health & Fitness
ISBN : 9780385479561

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The Hot Zone by Richard Preston Pdf

The virus kills nine out of ten of its victims. Its effects are so quick and so gruesome that even biohazard experts are terrified. It is airborne, it is extremely contagious, and it is about to burn through the suburbs of Washington, D.C. Is there any way to stop it? This doomsday scenario confronted a biohazard SWAT team struggling in secret to stop the outbreak of an exotic "hot" virus at an Army research facility outside Washington. "The Hot Zone" tells the dramatic story of their dangerous race against time, along with an alarming account of how previously unknown viruses that have lived undetected in the rain forest for eons are now entering human populations. From the airlocked confines of a biosafety level 4 military lab, to an airliner over Kenya carrying a passenger dissolving into a human virus bomb, to a deserted jungle cave alive with deadly virus, THE HOT ZONE is a non-fiction thriller like no other. "The Andromeda Strain" was fiction--- "this is real!"

Author : Carl Zimmer
Publisher : University of Chicago Press
Page : 133 pages
File Size : 53,6 Mb
Release : 2015-10-06
Category : Science
ISBN : 9780226320267

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A Planet of Viruses by Carl Zimmer Pdf

For years, scientists have been warning us that a pandemic was all but inevitable. Now it's here, and the rest of us have a lot to learn. Fortunately, science writer Carl Zimmer is here to guide us. In this compact volume, he tells the story of how the smallest living things known to science can bring an entire planet of people to a halt--and what we can learn from how we've defeated them in the past. Planet of Viruses covers such threats as Ebola, MERS, and chikungunya virus; tells about recent scientific discoveries, such as a hundred-million-year-old virus that infected the common ancestor of armadillos, elephants, and humans; and shares new findings that show why climate change may lead to even deadlier outbreaks. Zimmer’s lucid explanations and fascinating stories demonstrate how deeply humans and viruses are intertwined. Viruses helped give rise to the first life-forms, are responsible for many of our most devastating diseases, and will continue to control our fate for centuries. Thoroughly readable, and, for all its honesty about the threats, as reassuring as it is frightening, A Planet of Viruses is a fascinating tour of a world we all need to better understand.

Author : Frank Fenner,Adrian J. Gibbs
Publisher : S. Karger AG (Switzerland)
Page : 360 pages
File Size : 44,5 Mb
Release : 1988
Category : Medical
ISBN : MINN:31951D00005672H

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Portraits of Viruses by Frank Fenner,Adrian J. Gibbs Pdf

Author : Mark Honigsbaum
Publisher : W H Allen
Page : 0 pages
File Size : 48,6 Mb
Release : 2020
Category : Health & Fitness
ISBN : 0753558289

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The Pandemic Century by Mark Honigsbaum Pdf

A Financial Times Best Book of the Year The most timely and informative history book you will read this year, tracing a century of pandemics, with a new chapter on COVID-19. Ever since the 1918 Spanish influenza pandemic, scientists have dreamed of preventing catastrophic outbreaks of infectious disease. Yet, despite a century of medical progress, viral and bacterial disasters continue to take us by surprise, inciting panic and dominating news cycles. From the Spanish flu and the 1924 outbreak of pneumonic plague in Los Angeles, to the 1930 'parrot fever' pandemic and the more recent SARS, Ebola, Zika and - now - COVID-19 epidemics, the last 100 years have been marked by a succession of unanticipated pandemic alarms. In The Pandemic Century, Mark Honigsbaum chronicles 100 years of history in 10 outbreaks. Bringing us right up-to-date with a new chapter on COVID-19, this fast-paced, critically-acclaimed book combines science history, medical sociology and thrilling front-line reportage to deliver the story of our times. As we meet dedicated disease detectives, obstructive public health officials, and gifted scientists often blinded by their own expertise, we come face-to-face with the brilliance and medical hubris shaping both the frontier of science - and the future of humanity's survival.

Author : Rebecca Skloot
Publisher : Crown
Page : 386 pages
File Size : 42,7 Mb
Release : 2010-02-02
Category : Science
ISBN : 9780307589385

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The Immortal Life of Henrietta Lacks by Rebecca Skloot Pdf

#1 NEW YORK TIMES BESTSELLER • “The story of modern medicine and bioethics—and, indeed, race relations—is refracted beautifully, and movingly.”—Entertainment Weekly NOW A MAJOR MOTION PICTURE FROM HBO® STARRING OPRAH WINFREY AND ROSE BYRNE • ONE OF THE “MOST INFLUENTIAL” (CNN), “DEFINING” (LITHUB), AND “BEST” (THE PHILADELPHIA INQUIRER) BOOKS OF THE DECADE • ONE OF ESSENCE’S 50 MOST IMPACTFUL BLACK BOOKS OF THE PAST 50 YEARS • WINNER OF THE CHICAGO TRIBUNE HEARTLAND PRIZE FOR NONFICTION NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The New York Times Book Review • Entertainment Weekly • O: The Oprah Magazine • NPR • Financial Times • New York • Independent (U.K.) • Times (U.K.) • Publishers Weekly • Library Journal • Kirkus Reviews • Booklist • Globe and Mail Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than sixty years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions. Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave. Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of. Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah. Deborah was consumed with questions: Had scientists cloned her mother? Had they killed her to harvest her cells? And if her mother was so important to medicine, why couldn’t her children afford health insurance? Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 397 pages
File Size : 46,6 Mb
Release : 2016-10-21
Category : Medical
ISBN : 9780309377591

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Global Health Impacts of Vector-Borne Diseases by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Global Health,Forum on Microbial Threats Pdf

Pathogens transmitted among humans, animals, or plants by insects and arthropod vectors have been responsible for significant morbidity and mortality throughout recorded history. Such vector-borne diseases â€" including malaria, dengue, yellow fever, and plague â€" together accounted for more human disease and death in the 17th through early 20th centuries than all other causes combined. Over the past three decades, previously controlled vector-borne diseases have resurged or reemerged in new geographic locations, and several newly identified pathogens and vectors have triggered disease outbreaks in plants and animals, including humans. Domestic and international capabilities to detect, identify, and effectively respond to vector-borne diseases are limited. Few vaccines have been developed against vector-borne pathogens. At the same time, drug resistance has developed in vector-borne pathogens while their vectors are increasingly resistant to insecticide controls. Furthermore, the ranks of scientists trained to conduct research in key fields including medical entomology, vector ecology, and tropical medicine have dwindled, threatening prospects for addressing vector-borne diseases now and in the future. In June 2007, as these circumstances became alarmingly apparent, the Forum on Microbial Threats hosted a workshop to explore the dynamic relationships among host, pathogen(s), vector(s), and ecosystems that characterize vector-borne diseases. Revisiting this topic in September 2014, the Forum organized a workshop to examine trends and patterns in the incidence and prevalence of vector-borne diseases in an increasingly interconnected and ecologically disturbed world, as well as recent developments to meet these dynamic threats. Participants examined the emergence and global movement of vector-borne diseases, research priorities for understanding their biology and ecology, and global preparedness for and progress toward their prevention, control, and mitigation. This report summarizes the presentations and discussions from the workshop.