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Author : P. M. Wallis,Brian R. Hammond
Publisher : Calgary : University of Calgary Press
Page : 316 pages
File Size : 55,5 Mb
Release : 1988
Category : Medical
ISBN : CORNELL:31924051111114
Author : Anonim
Publisher : Academic Press
Page : 296 pages
File Size : 47,5 Mb
Release : 2020-03-17
Category : Medical
ISBN : 9780128204757
Giardia and Giardiasis Volume 107-Part B, in the Advances in Parasitology series, is dedicated to aspects of cytoskeletal structure of this parasite with an emphasis on insights of new components and their function in trophozoites. Further, microtubule function and its critical involvement in motility, attachment, mitosis and cell division as well as in transitions between developmental stages are reviewed. Also a comprehensive revision in the progress of tools to explore and understand the functional biology of Giardia, its coding and non-coding genes, features and cellular and molecular biology is contained in this volume. Additionally, an exciting perspective on the interactions between Giardia and intestinal epithelial cell by reviewing transcriptomic and proteomic investigations is included along with a state-of-the art of the understanding pathophysiology of giardiasis and of how Giardia can cause post-infectious and extra-intestinal complications. A complete review of current knowledge including commonly prescribed drugs, causes of therapeutic fails, drug resistance mechanisms, strategies for the discovery of new agents for alternative drug therapies is covered. Informs and updates on all the latest developments in the field of parasitology Includes medical studies of parasites of major influence Features reviews of more traditional areas, such as zoology, taxonomy and life history which help to shape current thinking and applications
Author : Alfonso J. Rodriguez-Morales
Publisher : BoD – Books on Demand
Page : 178 pages
File Size : 46,8 Mb
Release : 2017-12-13
Category : Medical
ISBN : 9789535136538
Giardiasis is still a significant infectious and parasitic disease, caused by the protozoan Giardia intestinalis. There are estimates of more than 200 million cases of giardiasis occurred in the world annually. The advance in research in giardiasis during the last century and particularly during the last decade is considerable. Nevertheless, many challenges still are ahead in order to reach a higher control of this disease. This book tried to update the significant epidemiological and clinical research in many aspects with a multinational perspective. This book with 9 chapters has been organized in 3 major sections: 1. "Overview, Epidemiology and Clinical Aspects," 2. "Biological and Diagnostic Aspects," and 3. "Treatment, Prevention and Public Health."
Author : Guadalupe Ortega-Pierres
Publisher : Academic Press
Page : 268 pages
File Size : 46,9 Mb
Release : 2019-10-14
Category : Medical
ISBN : 9780128177211
Giardia and Giardiasis, Volume 106 in Advances in Parasitology series includes in the first part aspects of molecular and cellular biology of Giardia and the role of particular molecules or molecular groups in essential functions and/or trafficking in the parasite. These approaches are with the aim to explore how this parasite adapts to an ever-changing environment both within and outside of the host animal. Subsequently a comprehensive description of virulence factors secreted by Giardia, are reviewed on their cytotoxic mechanisms and roles in the pathophysiology of giardiasis, and also a description on the potential of these secreted molecules as targets for drugs is included. In the context of the immuno-pathogenesis of giardiasis a review on the data and information on innate and adaptive immunity to Giardia, is included as well as a discussion on how improved knowledge of immunity is advancing our understanding of the pathogenesis and clinical outcomes of giardiasis. The final part of this volume includes a review of the epidemiology of giardiasis in a veterinary context using molecular tools together with a discussion of the current status of the species and assemblages of Giardia, and issues surrounding the assignment of host specificity and the zoonotic potential using current molecular markers. Informs and updates on all the latest developments in the field of parasitology Includes medical studies of parasites of major influence Features reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications
Author : Stanley L. Erlandsen,Ernest A. Meyer
Publisher : Springer Science & Business Media
Page : 417 pages
File Size : 41,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489905949
The intestinal protozoan Giardia was first described over 300 years ago in 1681 by Leeuwenhoek, from his own stools. In his description of Giardia, he noted the size, movement, and morphology of the organism, and associated its presence with the diarrheic nature of his stools and his dietary habits. This truly remarkable account contains the first description of Giardia in morphologic, pathogenic, and epidemiologic terms. Our knowledge of the organisms in the genus Giardia has advanced tremendously in the past two decades. With the advent of new tech nologies, including techniques in electron microscopy, biochemistry, immunochemistry, tissue culture, and physiology, a tidal wave of information has appeared on the organization and function of this parasitic protozoan and its interaction with its host. The purpose of this book is to celebrate the tricentennial discovery of Giardia by Leeuwenhoek by presenting the above-mentioned advances in our knowledge of Giardia and giardiasis. In the first section of this book, the dominant theme is the biology of the organism and the correlation of structure-function relationships.
Author : Ynes R. Ortega
Publisher : Springer Science & Business Media
Page : 301 pages
File Size : 45,6 Mb
Release : 2006-11-22
Category : Technology & Engineering
ISBN : 9780387311975
This book examines the two major parasite groups that are transmitted via water or foods: the single-celled protozoa, and the helminths: cestodes (tapeworms), nematodes (round worms), and trematodes (flukes). Each chapter covers the biology, mechanisms of pathogenesis, epidemiology, treatment, and inactivation of these parasites. This important new text offers a better understanding of the biology and control of parasitic infections necessary to reduce or eliminate future outbreaks in the U.S. and elsewhere.
Author : Alfonso J. Rodriguez-Morales
Publisher : Unknown
Page : 508 pages
File Size : 51,7 Mb
Release : 2016-11-30
Category : Electronic
ISBN : 9789535127895
Author : Hugo D. Lujan,Staffan Svärd
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 44,6 Mb
Release : 2011-06-30
Category : Medical
ISBN : 9783709101988
Giardia is a relatively simple eukaryotic microbe, causing acute and chronic diarrhea which has been used as a model to understand complex biological processes occurring in eukaryotic cells. Further, due to its parasitic lifestyle, Giardia is an excellent system for the study of the mechanisms of adaptation and cell differentiation from the perspectives of molecular and cell biology. This book presents a comprehensive review of the current state of knowledge regarding all aspects of Giardia’s biology, including epidemiology, cell and molecular biology, genetics, pathogenesis, diagnostics, and clinical treatment. It was written by internationally renowned authors, the leading researchers in the field including several chapters with techniques and resources available for the study of this microorganism. Questions that need to be addressed to fully understand the molecular mechanisms of the parasite as well as the cause of its pathology are presented. Furthermore, Giardia’s biology is compared with that of other parasites in relation to their complexity. This volume is an indispensable resource for researchers working with this parasite. It is a “must” for libraries and the bookshelves of everyone interested in the biology of parasites and early-branching eukaryotes.
Author : Anonim
Publisher : Elsevier
Page : 434 pages
File Size : 41,6 Mb
Release : 2004-12-09
Category : Medical
ISBN : 9780080490397
The Advances in Parasitology series contains in-depth reviews on current topics of interest in contemporary parasitology. It includes medical studies on parasites of major influence, such as trypanosomiasis and scabies, and more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Series has the second highest ISI impact factor in the parasitology group! (4.818 in 2002) Contributors are international experts in the field
Author : Anjan Debnath,James H. McKerrow
Publisher : Frontiers Media SA
Page : 179 pages
File Size : 42,8 Mb
Release : 2017-08-25
Category : Electronic book
ISBN : 9782889452484
One of the top four contributors to the global burden of disease is diarrheal infections. Intestinal parasites are major causes of morbidity and mortality associated with diarrheal diseases in both the developed and developing world. Amebiasis is responsible for 50 million cases of invasive disease and 70,000 deaths annually in the world. Giardiasis has an estimated worldwide prevalence of 280 million cases annually. In developed countries, Giardia lamblia infects about 2% of adults and 6-8% of children. The prevalence of G. lamblia infection is generally higher in developing countries, ranging from 3% to 90%. Furthermore, giardial infections contribute substantially to the 2.5 million annual deaths from diarrheal disease. In Asia, Africa, and Latin America, about 500,000 new giardiasis cases are reported each year. Cryptosporidium accounts for 20% and 9% of diarrheal episodes in children in developing and developed countries, respectively. Infection with Cryptosporidium can be chronic and especially debilitating in immunosuppressed individuals and malnourished children. A recent study to measure disease burden, based on disability-adjusted life years (DALYs), found that cryptosporidiosis and amebiasis produce about 10.6 million DALYs. This exceeds the DALYs of any helminth infection currently being targeted by the World Health Organization for preventive chemotherapy. Because of its link with poverty, Giardia and Cryptosporidium were included in the WHO Neglected Diseases Initiative in 2004. E. histolytica, G. lamblia, and C. parvum have been listed by the National Institutes of Health (NIH) as category B priority biodefense pathogens due to low infectious dose and potential for dissemination through compromised food and water supplies in the United States. Despite the prevalence of amebiasis, giardiasis, and cryptosporidiosis there are no vaccines or prophylactic drugs. The first-line drugs for invasive amebiasis and giardiasis chemotherapy are nitroimidazoles, with the prototype, metronidazole, being the most common drug used worldwide. Metronidazole has been shown to be both mutagenic in a microbiological system and carcinogenic to rodents, and frequently causes gastrointestinal side effects. In spite of the efficacy of nitroimidazole drugs, treatment failures in giardiasis occur in up to 20% of cases. Clinical resistance of G. lamblia to metronidazole is proven and cross resistance is a concern with all commonly used antigiardial drugs. Nitazoxanide, the only FDA-approved drug for the treatment of cryptosporidiosis, is effective in the treatment of immunocompetent patients and partially effective for immunosuppressed patients. Therefore, it is critical to search for more effective drugs to treat amebiasis, giardiasis, and cryptosporidiosis. This Research Topic for Frontiers in Microbiology will explore the recent progress in drug development for parasitic diarrheal diseases. This includes an understanding of drug resistance mechanisms. We would also welcome submissions on the drug development for other diarrheal parasites. We hope that this research topic will include a comprehensive survey of various attempts by the parasitology research community to create effective drugs for these diseases.
Author : M. G. Ortega-Pierres,S. Cacciò,R. Fayer,T. Mank,H. Smith
Publisher : CABI
Page : 520 pages
File Size : 45,9 Mb
Release : 2009-01-01
Category : Medical
ISBN : 9781845934446
Giardia and Cryptosporidium are both parasites of considerable global interest due to the gastrointestinal problems the organisms can cause in humans as well as domestic and wild animals. This book presents a comprehensive overview of recent research. Chapters discuss topics from taxonomy, nomenclature and evolution to molecular epidemiology, advances in diagnostics and zoonotic, human and animal health issues.
Author : Anonim
Publisher : ScholarlyEditions
Page : 431 pages
File Size : 41,6 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781464993640
Antigens—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Antigens. The editors have built Antigens—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antigens in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antigens—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Anonim
Publisher : ScholarlyEditions
Page : 169 pages
File Size : 42,7 Mb
Release : 2012-01-09
Category : Science
ISBN : 9781464925573
Phosphorus Compounds: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Phosphorus Compounds. The editors have built Phosphorus Compounds: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phosphorus Compounds in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phosphorus Compounds: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Barbara E. Olson,Merle Edwin Olson,P. M. Wallis
Publisher : Wallingford, England : CABI Publishing
Page : 360 pages
File Size : 41,9 Mb
Release : 2002
Category : Medical
ISBN : UOM:39015056487534
This book covers all aspects of research into Giardia as an organism and giardiasis the disease. It includes chapters on biochemistry, biology, detection and diagnosis, host-parasite relationships, immunoprophylaxis and immunotherapy, legislation and policy, therapeutics and new drug targets, water treatment and zoonotic transmission and epidemiology. It deals with Giardia in companion animals, in farm animals, and as a public health problem. Based on papers presented at the 2000 Giardia in the Rockies conference, held in Alberta, Canada, it contains contributions from leading international experts.
Author : Alyaa Farid,Azza El Amir
Publisher : Anchor Academic Publishing
Page : 89 pages
File Size : 51,7 Mb
Release : 2015-12-07
Category : Medical
ISBN : 9783954894673
Giardia duodenalis (synonyms G. lamblia or G. intestinalis), the only species belonging to the genus Giardia found in humans, is a pathogenic protozoan with a worldwide distribution having a more relevant prevalence in warm climate and in children. G. duodinalis is a water-borne flagellated parasite that causes giardiasis in humans. In addition, giardiasis affects domestic and wild mammals “e.g., cats, dogs, cattle, deer, and beavers” (Thompson, 2000). Host-to-host transference of Giardia cysts takes place via the fecal-oral route. This allows the protozoan to infect the next generation of hosts through a diverse range of mechanisms: person to person, animal to human or by contact with contaminated water and food. Outbreaks commonly occur in areas with inadequate water treatment, especially developing countries, where infection rates can be higher than 50% of the total population. It is well documented that in developing countries, infections are associated with poor sanitary conditions, poor water quality and overcrowding. Giardia is one of the leading protozoan causes of gastrointestinal illness worldwide and has joined the ranks of the WHO Neglected Diseases Initiative. Giardiasis constitutes an important public health problem in Egyptian children. Contamination of the Nile River with fecal materials including viruses and pathogenic protozoa still represents an environmental health hazard in Egypt, especially in rural areas. The clinical features of giardiasis range from acute or chronic diarrhea, abdominal pain, nausea, flatulence, vomiting, weight loss, to absence of symptoms and signs. In the diagnosis of Giardia, stool examination is the traditional, safest and easiest method. Microscopy of Giardia cysts and trophozoites is more straightforward, and there is little risk of confusion with other parasites. Moreover, only “ghost” cysts with an empty appearance are sometimes not recognized as Giardia parasites. However, the sensitivity of microscopy is quite low due to the intermittent excretion of Giardia cysts, the microscopical examination of a single stool specimen has a low sensitivity and may therefore miss up to 50% of Giardia infections. And thus, it is recommended that at least three samples be examined in order to rule out giardiasis which is time consuming and delay the diagnosis.