Alternative Radionuclide Production With A Cyclotron

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Alternative Radionuclide Production with a Cyclotron

IAEA
Alternative Radionuclide Production with a Cyclotron Book PDF

Author : IAEA
Publisher : International Atomic Energy Agency
Page : 102 pages
File Size : 46,8 Mb
Release : 2021-10-01
Category : Medical
ISBN : 9789201032218

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Alternative Radionuclide Production with a Cyclotron by IAEA Pdf

Cyclotrons are currently used for the preparation of a wide variety of radionuclides that have applications in single photon emission computed tomography (SPECT) and positron emission tomography (PET). Consequently, there is high demand from IAEA Member States for support in the area of radiopharmaceutical production using cyclotron produced radioisotopes. This publication describes the potential radionuclide production routes using cyclotrons in different energy ranges and provides methods for the development of targets and provides details of the chemistry for the separation of radionuclides from target materials. The readership of this publication includes scientists, operators interested in putting this technology into practice, technologists already working with cyclotrons who wish to enhance the utility of existing machines, and managers in the process of setting up radionuclide facilities in their countries. Students working towards higher level degrees in related fields may also benefit from this publication.

Cyclotron Produced Radionuclides

International Atomic Energy Agency
Cyclotron Produced Radionuclides Book PDF

Author : International Atomic Energy Agency
Publisher : Unknown
Page : 266 pages
File Size : 46,6 Mb
Release : 2009
Category : Business & Economics
ISBN : 9201069081

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Cyclotron Produced Radionuclides by International Atomic Energy Agency Pdf

Application of radioisotopes has shown significant growth in the past decade, and a major factor contributing towards this growth is the availability of a large number of cyclotrons dedicated to the production of radioisotopes for medical applications. Although there are many articles in journals on cyclotrons and their use for radioisotope production, there is no single source of information for beginners on radioisotope production using cyclotrons. This publication attempts to address this deficiency. Its contains chapters on accelerator technology, theoretical considerations of nuclear reactions, the technology behind targetry, techniques on preparation of targets, irradiation of targets under high beam currents, target processing and target recovery.

An Introduction to the Physics of Nuclear Medicine

Laura Harkness-Brennan
An Introduction to the Physics of Nuclear Medicine Book PDF

Author : Laura Harkness-Brennan
Publisher : Morgan & Claypool Publishers
Page : 95 pages
File Size : 41,7 Mb
Release : 2018-06-27
Category : Science
ISBN : 9781643270340

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An Introduction to the Physics of Nuclear Medicine by Laura Harkness-Brennan Pdf

The complexity and vulnerability of the human body has driven the development of a diverse range of diagnostic and therapeutic techniques in modern medicine. The Nuclear Medicine procedures of Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT) and Radionuclide Therapy are well-established in clinical practice and are founded upon the principles of radiation physics. This book will offer an insight into the physics of nuclear medicine by explaining the principles of radioactivity, how radionuclides are produced and administered as radiopharmaceuticals to the body and how radiation can be detected and used to produce images for diagnosis. The treatment of diseases such as thyroid cancer, hyperthyroidism and lymphoma by radionuclide therapy will also be explored.

Cyclotron Based Production of Technetium-99m

International Atomic Energy Agency
Cyclotron Based Production of Technetium 99m Book PDF

Author : International Atomic Energy Agency
Publisher : Unknown
Page : 0 pages
File Size : 46,8 Mb
Release : 2017
Category : Technology & Engineering
ISBN : 9201029160

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Cyclotron Based Production of Technetium-99m by International Atomic Energy Agency Pdf

This publication presents a comprehensive overview of the technologies involved in the production of cyclotron based 99mTc. These would include techniques relevant to preparation of targets, irradiation of targets under high beam currents, target processing, target recovery and quality control of the final product. The publication provides broad information, well supported with references, on improved production routes and improved separation and purification of cyclotron based 99mTc. These approaches achieve high specific activity and chemical purity of 99mTc suitable for labelling molecules of medical interest and also enable spare capacity to be available at medical cyclotron centres. The readership of this publication is scientists interested in translating this technology to practice, technologists already working with cyclotrons wanting to enhance the utility of the existing machines and managers who are in the process of setting up facilities in their countries. Students working towards higher level degrees in related fields may also benefit from this publication.

Cyclotron Produced Radionuclides

Anonim
Cyclotron Produced Radionuclides Book PDF

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 41,8 Mb
Release : 2008
Category : Business & Economics
ISBN : 9201002084

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Cyclotron Produced Radionuclides by Anonim Pdf

This book provides a comprehensive treatment of cyclotrons, with a special emphasis on production of radionuclides. Individual sections are devoted to accelerator technology, theoretical aspects of nuclear reactions, the technology behind targetry, techniques for preparation of targets, irradiation of targets under high beam currents, target processing and target recovery. This book will appeal to scientists and technologists interested in translating cyclotron technology into practice, as well as postgraduate students in this field.

Cyclotron Produced Radionuclides

Anonim
Cyclotron Produced Radionuclides Book PDF

Author : Anonim
Publisher : Technical Reports Series
Page : 0 pages
File Size : 44,7 Mb
Release : 2009
Category : Cyclotrons
ISBN : 9201031092

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Cyclotron Produced Radionuclides by Anonim Pdf

Cyclotrons are used for preparation of a wide variety of radionuclides that find application in single photon emission computed tomography (SPECT) as well as in positron emission tomography (PET). This publication gives comprehensive guidelines for the planning and decision making processes and design and implementation of a cyclotron based radionuclide production facility. It will enable Member States to plan such facilities in a cost effective manner.

Radiation Safety of Accelerator Based Radioisotope Production Facilities

IAEA
Radiation Safety of Accelerator Based Radioisotope Production Facilities Book PDF

Author : IAEA
Publisher : International Atomic Energy Agency
Page : 102 pages
File Size : 49,5 Mb
Release : 2020-08-18
Category : Technology & Engineering
ISBN : 9789201057228

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Radiation Safety of Accelerator Based Radioisotope Production Facilities by IAEA Pdf

Radioisotopes are used worldwide in a range of medical, industrial, research and academic applications. A large proportion of these radioisotopes are produced in particle accelerators, and the number of institutions that operate linear accelerators or cyclotrons and manufacture and distribute radiopharmaceuticals, for example, is significant and increasing. The production of radioisotopes using particle accelerators poses significant radiation hazards to workers, members of the public, and the environment when accelerators are operated without adequate radiation safety measures. This Safety Guide provides practical guidance for implementing radiation protection and safety measures in such facilities involved in the production and use of radioisotopes.

Cyclotron Produced Radionuclides

International Atomic Energy Agency
Cyclotron Produced Radionuclides Book PDF

Author : International Atomic Energy Agency
Publisher : Unknown
Page : 0 pages
File Size : 51,6 Mb
Release : 2012
Category : Technology & Engineering
ISBN : 9201173105

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Cyclotron Produced Radionuclides by International Atomic Energy Agency Pdf

This publication provides practical information for planning and operating a fluorodeoxyglucose (FDG) production facility, including design and implementation of the laboratories, facility layout, equipment, personnel, and quality assessment of FDG. Information useful for assessing the resource requirements, planning and aspects necessary for compliance with the applicable national regulatory requirements for manufacturing of radio-pharmaceuticals is also included.

Handbook of Radiopharmaceuticals

Michael R. Kilbourn,Peter J. H. Scott
Handbook of Radiopharmaceuticals Book PDF

Author : Michael R. Kilbourn,Peter J. H. Scott
Publisher : John Wiley & Sons
Page : 768 pages
File Size : 55,5 Mb
Release : 2021-04-12
Category : Science
ISBN : 9781119500544

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Handbook of Radiopharmaceuticals by Michael R. Kilbourn,Peter J. H. Scott Pdf

The thoroughly updated new edition of the authoritative reference in Radiopharmaceutical Sciences The second edition of Handbook of Radiopharmaceuticals is a comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provide readers with an immersive examination of radiochemistry, nuclear medicine, molecular imaging, and more. Since the first edition of the Handbook was published, Nuclear Medicine and Radiopharmaceutical Sciences have undergone major changes. New radiopharmaceuticals for diagnosis and therapy have been approved by the FDA, the number of clinical PET and SPECT scans have increased significantly, and advances in Artificial Intelligence have dramatically improved research techniques. This fully revised edition reflects the current state of the field and features substantially updated and expanded content. New chapters cover topics including current Good Manufacturing Practice (cGMP), regulatory oversight, novel approaches to quality control—ensuring that readers are informed of the exciting developments of recent years. This important resource: Features extensive new and revised content throughout Covers key areas of application for diagnosis and therapy in oncology, neurology, and cardiology Emphasizes the multidisciplinary nature of Radiopharmaceutical Sciences Discusses how drug companies are using modern radiopharmaceutical imaging techniques to support drug discovery Examines current and emerging applications of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Edited by recognized experts in radiochemistry and PET imaging, Handbook of Radiopharmaceuticals: Radiochemistry and Applications, 2 nd Edition is an indispensable reference for post-doctoral fellows, research scientists, and professionals in the pharmaceutical industry, and for academics, graduate students, and newcomers in the field of radiopharmaceuticals.

Isotopes for Medicine and the Life Sciences

Institute of Medicine,Committee on Biomedical Isotopes
Isotopes for Medicine and the Life Sciences Book PDF

Author : Institute of Medicine,Committee on Biomedical Isotopes
Publisher : National Academies Press
Page : 144 pages
File Size : 55,9 Mb
Release : 1995-01-27
Category : Medical
ISBN : 9780309176699

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Isotopes for Medicine and the Life Sciences by Institute of Medicine,Committee on Biomedical Isotopes Pdf

Radioactive isotopes and enriched stable isotopes are used widely in medicine, agriculture, industry, and science, where their application allows us to perform many tasks more accurately, more simply, less expensively, and more quickly than would otherwise be possible. Indeed, in many casesâ€"for example, biological tracersâ€"there is no alternative. In a stellar example of "technology transfer" that began before the term was popular, the Department of Energy (DOE) and its predecessors has supported the development and application of isotopes and their transfer to the private sector. The DOE is now at an important crossroads: Isotope production has suffered as support for DOE's laboratories has declined. In response to a DOE request, this book is an intensive examination of isotope production and availability, including the education and training of those who will be needed to sustain the flow of radioactive and stable materials from their sources to the laboratories and medical care facilities in which they are used. Chapters include an examination of enriched stable isotopes; reactor and accelerator-produced radionuclides; partnerships among industries, national laboratories, and universities; and national isotope policy.

Handbook of Radiopharmaceuticals

Michael J. Welch,Carol S. Redvanly
Handbook of Radiopharmaceuticals Book PDF

Author : Michael J. Welch,Carol S. Redvanly
Publisher : John Wiley & Sons
Page : 872 pages
File Size : 52,6 Mb
Release : 2003-01-17
Category : Medical
ISBN : 0471495603

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Handbook of Radiopharmaceuticals by Michael J. Welch,Carol S. Redvanly Pdf

A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States

Production and Quality Control of Fluorine-18 Labelled Radiopharmaceuticals

International Atomic Energy Agency
Production and Quality Control of Fluorine 18 Labelled Radiopharmaceuticals Book PDF

Author : International Atomic Energy Agency
Publisher : Unknown
Page : 0 pages
File Size : 45,5 Mb
Release : 2021-10-19
Category : Cyclotrons
ISBN : 9201227213

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Production and Quality Control of Fluorine-18 Labelled Radiopharmaceuticals by International Atomic Energy Agency Pdf

Since their clinical use initiation in the 1970's, Fluorine-18 (F-18) radiopharmaceuticals continue to play an important role in nuclear medicine. It is therefore essential to make available broad information on practical production routes and optimal quality control for F- 18 tracers, to achieve the best possible products in high quantity and quality for clinical applications while fulfilling all regulatory requirements. This publication describes the chemical and biological properties of F-18 radiopharmaceuticals. This includes aspects relating to F-18 target production and radiofluorination methods, with focus on the applied techniques. The publication presents a disease oriented approach, describing F-18 radiopharmaceuticals, ranging from the physiological/biological aspects to dedicated radiopharmaceutical development approaches and provides readers with clear guidelines and methods for the production of F-18 radiopharmaceuticals.

Targeted Radionuclide Therapy

Tod W. Speer
Targeted Radionuclide Therapy Book PDF

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
Page : 564 pages
File Size : 54,7 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9781451153262

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Targeted Radionuclide Therapy by Tod W. Speer Pdf

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Radionuclides Production

Frank Helus
Radionuclides Production Book PDF

Author : Frank Helus
Publisher : CRC Press
Page : 232 pages
File Size : 44,8 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000013177

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Radionuclides Production by Frank Helus Pdf

First Published in 1983, this book offers a full, comprehensive guide into the production of radioactive nuclides. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Radiology, and other practitioners in their respective fields.

Status of Accelerator Driven Systems Research and Technology Development

International Atomic Energy Agency
Status of Accelerator Driven Systems Research and Technology Development Book PDF

Author : International Atomic Energy Agency
Publisher : IAEA Tecdoc
Page : 0 pages
File Size : 47,9 Mb
Release : 2015
Category : Science
ISBN : 9201053150

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Status of Accelerator Driven Systems Research and Technology Development by International Atomic Energy Agency Pdf

One of the greatest challenges for nuclear energy is how to properly manage the highly radioactive waste generated during irradiation in nuclear reactors. Accelerator Driven Systems (ADSs) may offer new prospects and advantages for the transmutation of such high level nuclear waste. ADS or accelerator driven transmutation of waste (ATW) consists of a high power proton accelerator, a heavy metal spallation target that produces neutrons when bombarded by the high power beam, and a sub-critical core that is neutronically coupled to the spallation target. This publication provides a comprehensive state of the art of the ADS technology by representing the different ADS concepts proposed worldwide in the last 15 years, as well as the related R&D activities and demonstration initiatives carried out at national international level.