Targeted Radionuclide Therapy

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
Page : 564 pages
File Size : 45,9 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9781451153262

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Targeted Radionuclide Therapy by Tod W. Speer Pdf

Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine
Publisher : National Academies Press
Page : 173 pages
File Size : 46,8 Mb
Release : 2007-09-11
Category : Medical
ISBN : 9780309134156

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Advancing Nuclear Medicine Through Innovation by National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Nuclear and Radiation Studies Board,Committee on State of the Science of Nuclear Medicine Pdf

Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.

Author : Franklin C.L. Wong
Publisher : Springer Nature
Page : 271 pages
File Size : 54,9 Mb
Release : 2020-12-08
Category : Medical
ISBN : 9783030562670

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Locoregional Radionuclide Cancer Therapy by Franklin C.L. Wong Pdf

This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach. Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed. This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.

Author : Michael J. Welch,Carol S. Redvanly
Publisher : John Wiley & Sons
Page : 872 pages
File Size : 53,6 Mb
Release : 2003-01-17
Category : Medical
ISBN : 0471495603

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Handbook of Radiopharmaceuticals by Michael J. Welch,Carol S. Redvanly Pdf

A comprehensive, authoritative and up-to-date reference for the newcomer to radiopharmaceuticals and those already in the field. Radiopharmaceuticals are used to detect and characterise disease processes, or normal biological function, in living cells, animals or humans. Used as tracer molecules, they map the distribution, uptake and metabolism of the molecule in clinical studies, basic research or applied research. The area of radiopharmaceuticals is expanding rapidly. The number of PET centers in the world is increasing at 20% per year, and many drug companies are utilising PET and other forms of radiopharmaceutical imaging to evaluate products. * Readers will find coverage on a number of important topics such as radionuclide production, PET and drug development, and regulations * Explains how to use radiopharmaceuticals for the diagnosis and therapy of cancer and other diseases * The editors and a majority of the contributors are from the United States

Author : Torgny Stigbrand,Jorgen Carlsson,Gregory P. Adams
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 51,8 Mb
Release : 2008-09-01
Category : Medical
ISBN : 9781402086960

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Targeted Radionuclide Tumor Therapy by Torgny Stigbrand,Jorgen Carlsson,Gregory P. Adams Pdf

The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.

Author : Cumali Aktolun,Stanley J. Goldsmith
Publisher : Springer Science & Business Media
Page : 443 pages
File Size : 52,7 Mb
Release : 2012-08-31
Category : Medical
ISBN : 9781461440215

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Nuclear Medicine Therapy by Cumali Aktolun,Stanley J. Goldsmith Pdf

Nuclear Medicine Therapy presents the state of the art in targeted radionuclide therapy, both in clinical practice and contemporary clinical investigation and trials. With contributions from an internationally-distinguished group of physicians and scientists, the book is devoted entirely to the use of nuclear medicine techniques and technology for therapy of malignant and benign diseases. Individual chapters cover the scientific principles and clinical applications of radionuclide therapy and the state of clinical trials of agents currently under investigation in the therapy of tumors involving virtually every organ system. Due to overlapping interest in techniques, indications, and clinical use, the development of radionuclide therapy attracts considerable input from other medical specialists whose collaboration is essential, including radiation and medical oncologists, hematologists, diagnostic radiologists, hepatologists, endocrinologists, and rheumatologists. And because radionuclide therapy is a rapidly evolving field of nuclear medicine, it is the aim of this volume to appeal to all specialists involved in targeted radionuclide therapy and to contribute to the standardization of the practice globally.

Author : Gang Huang
Publisher : Springer
Page : 346 pages
File Size : 52,5 Mb
Release : 2019-06-11
Category : Medical
ISBN : 9789811374586

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Nuclear Medicine in Oncology by Gang Huang Pdf

This book introduces molecular imaging and Target Therapy in various cancers. The first part is the subjects and primary focused on the basics of nuclear physics, radiation dosimetry, nuclear medicine equipment and small animal imaging equipment. The second part is about the radiopharmaceutical and commonly used clinical radiopharmaceuticals, including positron emission imaging agent, single photon emission imaging agent, and radionuclide therapy agents as well as their radioactive preparation, quality control, and a brief clinical application were included. Also, this part introduces a number of new imaging agents which were potential value of clinical applications. In the third part, the clinical application of the conventional imaging agent 18F-FDG in different tumors and neurodegenerative diseases and 18F-Dopa imaging in the nervous system are discussed. Besides the clinical applications of 99mTc labeled radiopharmaceuticals in parathyroid disease, coronary heart disease, myocardial infarction, sentinel lymph node, metastatic bone tumors, liver and gallbladder disease in children are introduced. Finally, the applications of radionuclide 131I on treatments of Graves' disease and differentiated thyroid cancer and metastases are investigated respectively. This book is a useful reference for professionals engaged in nuclear medicine and clinical research, including clinical nuclear medicine physicians, nuclear medicine engineers and nuclear medicine pharmacists.

Author : Richard P. Baum
Publisher : Springer
Page : 951 pages
File Size : 50,8 Mb
Release : 2014-08-16
Category : Medical
ISBN : 9783540367192

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Therapeutic Nuclear Medicine by Richard P. Baum Pdf

The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. This up-to-date, comprehensive book, written by world-renowned experts, discusses the basic principles of radionuclide therapy, explores in detail the available treatments, explains the regulatory requirements, and examines likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the role of the therapeutic nuclear physician in coordinating a diverse multidisciplinary team, which is central to the safe provision of treatment.

Author : F. F. (Russ) Knapp,Ashutosh Dash
Publisher : Springer
Page : 347 pages
File Size : 52,5 Mb
Release : 2016-01-20
Category : Medical
ISBN : 9788132226079

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Radiopharmaceuticals for Therapy by F. F. (Russ) Knapp,Ashutosh Dash Pdf

This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.

Author : Recep Bekiş,Berna Polack,Murat Fani Bozkurt
Publisher : Springer Nature
Page : 387 pages
File Size : 49,8 Mb
Release : 2022-08-01
Category : Medical
ISBN : 9783030972202

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Radionuclide Therapy by Recep Bekiş,Berna Polack,Murat Fani Bozkurt Pdf

The main purpose of this book is to create a reference for the indications, contraindications, patient selection, treatment practice, treatment side effect management, and follow-up of radionuclide treatments. Besides standard methods such as surgery, chemotherapy, radiotherapy, and hormone therapy, newly developed biological treatments, targeted treatments, personalized treatments, external beam radiotherapy, and targeted radionuclide treatments have begun to take their place in professional practice. Nuclear medicine, in addition to its role as a tracer of cancer, also assumes the role of treating with radioactive molecules directed to the cancer it traces. These traceable next-generation radionuclide treatments, whose efficacy and reliability have been proven and where diagnosis, treatment, and follow-up are carried out together, are increasingly included in oncology practice together with the new developed radiopharmaceuticals, ensuring a high rate of damage to cancer cells while protecting the surrounding normal tissues. Molecular cancer treatment will become more effective with individualized next-generation traceable radionuclide treatments, which will be shaped by genetic studies in the future. Radionuclide treatments for many cancer types and benign diseases are presented by experienced nuclear medicine experts in the light of their own experience and case studies, while systemic treatments in common cancer types and side effect management of these treatments are summarized by medical oncologists. This book will be of interest to nuclear medicine physicians as well as oncologists.

Author : Janet F. Eary,Winfried Brenner
Publisher : CRC Press
Page : 216 pages
File Size : 52,9 Mb
Release : 2007-03-30
Category : Medical
ISBN : 9781420016642

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Nuclear Medicine Therapy by Janet F. Eary,Winfried Brenner Pdf

One in three of the 30 million Americans who are hospitalized are diagnosed or treated with nuclear medicine techniques. This text provides a succinct overview and detailed set of procedures and considerations for patient therapy with unsealed radioactivity sources. Serving as a complete literature reference for therapy with radiopharmaceuticals c

Author : Sara Harsini,Abass Alavi,Nima Rezaei
Publisher : Springer Nature
Page : 532 pages
File Size : 50,9 Mb
Release : 2021-11-24
Category : Medical
ISBN : 9783030812614

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Nuclear Medicine and Immunology by Sara Harsini,Abass Alavi,Nima Rezaei Pdf

This book explores the close connection between immunology and nuclear medicine, which has led to radioimmunoimaging and radioimmunotherapy (RIT). Molecular imaging with positron emission tomography (PET) and single-photon emission computed tomography (SPECT) is increasingly being used to diagnose, characterize, and monitor disease activity in the context of inflammatory disorders of known and unknown etiology, such as sarcoidosis, atherosclerosis, vasculitis, inflammatory bowel disease, rheumatoid arthritis, and degenerative joint disease. The first chapters discuss the various radiopharmaceutical agents and radiolabeled preparations that have been employed in inflammation imaging. Of these, FDG-PET imaging has been shown to have the great value in the detection of inflammation and has become the centerpiece of several initiatives over the last several years. This very powerful technique will play an increasingly important role in the management of patients with inflammatory conditions in the future. The book also explores the growing role of nuclear medicine and molecular imaging in the diagnosis and treatment of cancer. The rapid pace of change has been fueled by advances in our understanding of tumor biology, on the one hand, and the development of specifically targeted medical therapies, diagnostic agents, and radiotherapies, on the other. Written by leading international experts in the field, this book is an invaluable tool for nuclear medicine physicians, radiologists, oncologists, and immunologists.

Author : Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 40,8 Mb
Release : 2012-08-28
Category : Medical
ISBN : 9783642256042

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Stereotactic Body Radiation Therapy by Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter Pdf

Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Author : Amen Sibtain,Andrew Morgan,Niall MacDougall
Publisher : Oxford University Press
Page : 305 pages
File Size : 49,6 Mb
Release : 2022-11-24
Category : Electronic
ISBN : 9780198862864

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Physics for Clinical Oncology by Amen Sibtain,Andrew Morgan,Niall MacDougall Pdf

Radiotherapy remains a major non-surgical treatment modality for malignant disease, and an understanding of how this treatment works is essential in ensuring optimum practice. Trainees in oncology learn about ionising radiation, but to understand it fully they must also understand the physics relevant to its use in therapy. This book is written specifically for the oncology and radiation team, supporting clinical oncologists in their understanding of the science which underpins radiotherapy. It begins with basic concepts and then explores the principles and practice of physics as it relates to radiotherapy, including discussion of specific types of therapy. Written by authors chosen for their expertise in in their respective fields, and aligned to the Royal College of Radiologists FRCR Curriculum in Oncology, this volume will provide an excellent source of information for trainee and practicing oncologists, and wider radiotherapy teams. This second edition has been fully updated to reflect advances in technology and the increased complexity in modern radiotherapy, including two new chapters on imaging and a new brachytherapy chapter.

Author : Keith F. Eckerman,Akira Endo
Publisher : Snmmi
Page : 684 pages
File Size : 52,5 Mb
Release : 2007
Category : Decay schemes (Radioactivity)
ISBN : 0932004806

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MIRD: Radionuclide Data and Decay Schemes by Keith F. Eckerman,Akira Endo Pdf