Alzheimer S Disease Epidemiology Neuropathology Neurochemistry And Clinics

Author : Konrad Maurer,Peter Riederer,Helmut Beckmann
Publisher : Springer Science & Business Media
Page : 475 pages
File Size : 49,9 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9783709133965

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Alzheimer’s Disease. Epidemiology, Neuropathology, Neurochemistry, and Clinics by Konrad Maurer,Peter Riederer,Helmut Beckmann Pdf

The book Alzheimer's Disease - Epidemiology, Neuropathology, Neurochemistry, and Clinics is derived from an International Symposium on the occasion of the 125th Anniversary of the Birth of Alois Alzheimer (14.6.1864-19.12.1915). Over the past decade, as the elderly have become the fastest-growing segment of the population in industrialized countries, Alzheimer's disease has emerged as one of the major mental health problems. The contributors to this book represent internationally recognized authorities in the field of dementia and present new information about epidemiology, neuropathology, neurochemistry, and clinics in Alzheimer's disease. This book is a rich and valuable up-to-date resource for psychiatrists, neurologists, scientists working in the fields of neuropathology, neurochemistry and molecular genetics, behavioral scientists, family physicians and all who share an interest in understanding and treating the older individual with Alzheimer's disease/dementia.

Author : Colin J. Barrow,David H. Small
Publisher : Springer Science & Business Media
Page : 298 pages
File Size : 48,6 Mb
Release : 2006-12-22
Category : Medical
ISBN : 9781846284403

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Abeta Peptide and Alzheimer's Disease by Colin J. Barrow,David H. Small Pdf

Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer’s Disease (AD). This book summarizes current knowledge of the Abeta peptide and its role in AD. Written by specialists in this fast moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta.

Author : Hanna Falk Erhag,Ulrika Lagerlöf Nilsson,Therese Rydberg Sterner,Ingmar Skoog
Publisher : Springer Nature
Page : 254 pages
File Size : 47,5 Mb
Release : 2022-01-10
Category : Social Science
ISBN : 9783030780630

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A Multidisciplinary Approach to Capability in Age and Ageing by Hanna Falk Erhag,Ulrika Lagerlöf Nilsson,Therese Rydberg Sterner,Ingmar Skoog Pdf

This open access book provides insight on how to interpret capability in ageing – one’s individual ability to perform actions in order to reach goals one has reason to value – from a multidisciplinary approach. With for the first time in history there being more people in the world aged 60 years and over than there are children below the age of 5, the book describes this demographic trends as well as the large global challenges and important societal implications this will have such as a worldwide increase in the number of persons affected with dementia, and in the ratio of retired persons to those still in the labor market. Through contributions from many different research areas, it discussed how capability depends on interactions between the individual (e.g. health, genetics, personality, intellectual capacity), environment (e.g. family, friends, home, work place), and society (e.g. political decisions, ageism, historical period). The final chapter summarizes the differences and similarities in these contributions. As such this book provides an interesting read for students, teachers and researchers at different levels and from different fields interested in capability and multidisciplinary research.

Author : T. Hori,Robert W. Ridge,Walter Tulecke,Peter Del Tredici,Jocelyne Tremouillaux-Guiller,Hiroshi Tobe
Publisher : Springer Science & Business Media
Page : 422 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9784431684169

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Ginkgo Biloba A Global Treasure by T. Hori,Robert W. Ridge,Walter Tulecke,Peter Del Tredici,Jocelyne Tremouillaux-Guiller,Hiroshi Tobe Pdf

Interest in this unique plant has grown dramatically over the last 10 years, and this book provides an overview and recent findings concerning cell biology, biochemistry, development, morphology, phylogeny, paleobotany, as well as possible applications in chemistry and medicine. It also covers environmental aspects and the relationship between G. biloba and humans. Thus it will be of wide interest to botanists, horticulturists and scientists working on this attractive and useful plant, and aims to both stimulate further study and contribute to the development of new fields in Ginkgo research.

Author : Natasha J. Olby
Publisher : Elsevier Health Sciences
Page : 273 pages
File Size : 47,5 Mb
Release : 2014-11-12
Category : Medical
ISBN : 9780323326919

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Advances in Veterinary Neurology, An Issue of Veterinary Clinics of North America: Small Animal Practice, by Natasha J. Olby Pdf

This issue highlights the advances in neurological treatments for dogs and cats. Articles include: New Treatment Modalities for Brain Tumors in Dogs and Cats, Altered Mental Status in Dogs and Cats: Stupor and Coma, Steroid Use in Veterinary Neurology, Hereditary Ataxia and Paroxysmal Movement Disorders in Dogs and Cats, Paroxysmal Movement Disorders in Dogs and Cats, Cluster Seizures and Status Epilepticus, Aging in the canine and feline brain, Acute Spinal Cord Injury: Tetraparesis and Paraparesis, Meningoencephalitis of Unknown Etiology, and more!

Author : Rudi A.J.O. Dierckx,Andreas Otte,Erik F.J. de Vries,Aren van Waarde,Klaus L. Leenders
Publisher : Springer
Page : 1103 pages
File Size : 49,5 Mb
Release : 2014-06-02
Category : Medical
ISBN : 9783642543074

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PET and SPECT in Neurology by Rudi A.J.O. Dierckx,Andreas Otte,Erik F.J. de Vries,Aren van Waarde,Klaus L. Leenders Pdf

PET and SPECT in Neurology highlight the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable not only to neurologists and radiologists/nuclear medicine specialists but also to interested general practitioners and geriatricians. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.

Author : Jose L. Molinuevo,Jeffrey I. Cummings,Bruno Dubois,Philip Scheltens
Publisher : Elsevier Health Sciences
Page : 204 pages
File Size : 49,9 Mb
Release : 2013-05-28
Category : Medical
ISBN : 9781455772032

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Early Diagnosis and Intervention in Predementia Alzheimer's Disease, An Issue of Medical Clinics by Jose L. Molinuevo,Jeffrey I. Cummings,Bruno Dubois,Philip Scheltens Pdf

This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

Author : Zaven S Khachaturian,Teresa S. Radebaugh
Publisher : CRC Press
Page : 366 pages
File Size : 47,5 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9780429522505

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Alzheimer's Disease by Zaven S Khachaturian,Teresa S. Radebaugh Pdf

Published in 1996: Alzheimer's disease is characterized by memory disturbances and changes in personality and is associated with aging, although it can occur in people under 65. It is a progressive disease, painful to witness as the patient's health declines. Alzheimer's Disease: Cause(s), Diagnosis, and Care, with its complete and authoritative discussions, will help you understand all facets of this complex disease. This book addresses a broad spectrum of topics ranging from diagnosis, causes, treatment, epidemiology, genetics, risk factors, and care and management. Alzheimer's Disease: Cause(s), Diagnosis, and Care is intended for a diverse audience, including practitioners and students, family members, and everyone who is concerned about this disease.

Author : C. Exley
Publisher : Elsevier
Page : 453 pages
File Size : 50,9 Mb
Release : 2001-07-03
Category : Science
ISBN : 9780080525501

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Aluminium and Alzheimer's Disease by C. Exley Pdf

The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease. This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's.This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.

Author : D. Comar
Publisher : Springer Science & Business Media
Page : 355 pages
File Size : 55,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401104296

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PET for Drug Development and Evaluation by D. Comar Pdf

Can drug development and evaluation be improved by the use of positron emission tomography (PET)? PET is now well established and many PET centres participate in networks that warrant the quality of their research. PET allows one to follow the effect of a drug on a variety of patients' metabolic parameters. In addition, PET may be used to follow the fate in vivo of a compound, allowing visualisation of its binding to specific receptors and a direct study of the mechanism of drug action in normal and pathological situations. The book shows the fields in which PET offers new and unique information for the development of drugs (conception, toxicity, pharmacokinetics and metabolism, clinical research, and relations between clinical and biological effects) and evaluates fields in which PET may shorten the development time of drugs. Audience: Professionals in the pharmaceutical industry in all areas of drug discovery and pharmacology, pre-clinical testing, pharmacokinetics and metabolism, clinical evaluation, registration and regulatory affairs. Government health authority representatives who assess data and documentation on new drug development and radiopharmaceuticals. Academic experts concerned with any of these areas.

Author : Brad Bolon,Mark Butt
Publisher : John Wiley & Sons
Page : 661 pages
File Size : 44,8 Mb
Release : 2011-10-04
Category : Science
ISBN : 9780470227336

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Fundamental Neuropathology for Pathologists and Toxicologists by Brad Bolon,Mark Butt Pdf

This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

Author : G. Casadesus
Publisher : IOS Press
Page : 352 pages
File Size : 45,7 Mb
Release : 2011-07-05
Category : Medical
ISBN : 9781607507338

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Handbook of Animal Models in Alzheimer’s Disease by G. Casadesus Pdf

Animals have been used to model diseases or test new treatments since around 300 BC, and undoubtedly our ability to model disease in animals – including transgenic animals – has provided major breakthroughs in all fields of biomedical research. Due to their complexity and plurality of pathology and symptomatology, the study of neurodegenerative diseases relies heavily on animal models. These models have been developed in many species in the attempt to undercover the complex nature of the disease mechanisms involved. The ultimate goal is to test promising therapies and to manage, prevent or cure neurodegenerative disease. But because most animal models in this area do not reproduce the full phenotypical disease spectrum and the etiology and clinical presentation of neurodegenerative diseases differ from one patient to the next, the testing of these diseases in animal models often translates poorly to indices of efficacy when applied to the clinical population. Written by experts in the field with these advances and challenges in mind, this handbook provides an updated overview of the animal models being developed and used to study complex disease dynamics. The first part of the book presents an overview of animal models of various species and includes a review of new invertebrate animal models to study neurodegeneration. The second section presents the use of animal models to pinpoint disease mechanisms, and the last part of the handbook examines the various therapeutic interventions being used in models of neurodegenerative disease.

Author : Lüder Deecke,Peter Dal-Bianco
Publisher : Springer Science & Business Media
Page : 171 pages
File Size : 51,5 Mb
Release : 2013-03-13
Category : Medical
ISBN : 9783709191354

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Age-associated Neurological Diseases by Lüder Deecke,Peter Dal-Bianco Pdf

The papers compiled in this supplementum are a selection of the best con th tributions presented at the 19 Central-European Neurological Symposium (CNS 19) held on June 29 - July 1, 1989 in Vienna. The main topic of this conference was degenerative and age-associated neurological diseases. In recent decades life expectancy has dramatically increased, at least in the industrialized countries. This has led to extreme distortions of the so-called population pyramids that no longer look like such but begin to almost resemble cylinders. As a consequence of this "overaging" of the population, diseases that are associated with age have become much more common than before. It was thus more than reasonable to devote a congress of the CNS series to these important neurological diseases. The following fields of interest are covered: Age-associated memory impairment (AAMI), Alzheimer's and other dementias, Parkinson's disease and other movement disorders, stroke and others. Concerning the de men tias, some papers deal with diagnosis employing neuro-imaging methods such as MRI, CT, PET and SPECT, others using electrophysiological methods. An important aspect in the early preclinical diagnosis of dementia is the inclusion of neuropsychological tests to enhance the chance of effec tive early treatment. Also drugs that are now under clinical investigation are discussed and preliminary results are presented.

Author : Alistair S. Burns,Raymond A. Levy
Publisher : Springer
Page : 865 pages
File Size : 42,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781461568056

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Dementia by Alistair S. Burns,Raymond A. Levy Pdf

Author : Kurt A. Jellinger,Gernot Ladurner,Manfred Windisch
Publisher : Springer Science & Business Media
Page : 201 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783709193761

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New Trends in the Diagnosis and Therapy of Alzheimer’s Disease by Kurt A. Jellinger,Gernot Ladurner,Manfred Windisch Pdf

Alzheimer ́s Disease (AD), the most frequent cause of mental decline in the elderly represents one of the major health problems facing modern society. Despite considerable progress in the clinical diagnosis, epidemiology, structural basis, biochemistry, molecular genetics, and pharmacological aspects of AD, its etiology, molecular backgrounds, and treatment challenges are still poorly understood. This volume based on the 2nd International Symposium of EBEWE Research Initiative in October 1993 in Salzburg, Austria, is conceived as a review of our current knowledge of morphology, diagnostic clinical and imaging techniques, methodological approaches of cognitive assessment, trial designs, outcome variables and possibilities of therapy of AD and other neurodegenerative disorders. The book ́s coverage is broad and it should be of interest for investigators, clinicians, and researchers involved in the problems of AD.