Alzheimer S Disease Past Present And Future

Author : Juan Daniels
Publisher : Unknown
Page : 222 pages
File Size : 41,9 Mb
Release : 2019-06-13
Category : Electronic
ISBN : 1632417405

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Alzheimer's Disease: Past, Present and Future by Juan Daniels Pdf

Alzheimer's disease (AD) is a chronic neurodegenerative disease, characterized by a gradual progression from short-term memory loss, disorientation, problems with language and mood swings to gradual loss of bodily function and death. AD is the cause of around 60-70% of all cases of dementia. In AD, there is a loss of neurons and synapses, in the cerebral cortex and in specific subcortical regions. This leads to neurodegeneration in the temporal and parietal lobe. It can be diagnosed on the basis of a person's medical history and review of neurological and neuropsychological symptoms. However, medical imaging can also be used to rule out other cerebral pathologies. The therapeutic approaches to the management of Alzheimer's disease are palliative in nature. Stimulation-oriented treatments such as pet, art and music therapies work to improve mood and behavior. A number of research directions have emerged over the years related to improved techniques for early diagnosis and drugs that target the underlying disease pathology. The effect of meditation for memory and cognitive function retrieval is also being studied. This book contains some path-breaking studies in Alzheimer's disease. It consists of contributions made by international experts. It is meant for students who are looking for an elaborate reference text on the traditional, current and potential approaches in the management of Alzheimer's disease.

Author : Jan Korabecny,Aradhana Verma,Matthew Zabel,Katarina Spilovska,Ondrej Soukup
Publisher : Unknown
Page : 0 pages
File Size : 42,6 Mb
Release : 2022-08-13
Category : Electronic
ISBN : 1642701769

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Alzheimer's Disease: Past, Present and Future by Jan Korabecny,Aradhana Verma,Matthew Zabel,Katarina Spilovska,Ondrej Soukup Pdf

Author : Ronald Sahyouni,Nolan J Brown,Jefferson William Chen
Publisher : World Scientific
Page : 426 pages
File Size : 41,9 Mb
Release : 2021-12-23
Category : Medical
ISBN : 9789811235122

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Alzheimer's Disease Decoded: The History, Present, And Future Of Alzheimer's Disease And Dementia (Second Edition) by Ronald Sahyouni,Nolan J Brown,Jefferson William Chen Pdf

This book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a 'global' perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world.Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research.Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease.Dr Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective.This book with appeal to a wide audience, regardless of their scientific or educational background.

Author : Ronald Sahyouni,Aradhana Verma,Jefferson Chen
Publisher : Unknown
Page : 426 pages
File Size : 44,9 Mb
Release : 2021
Category : Alzheimer's disease
ISBN : 9811235112

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Alzheimer's Disease Decoded by Ronald Sahyouni,Aradhana Verma,Jefferson Chen Pdf

Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research.

Author : Sylvain Lehmann,Charlotte Elisabeth Teunissen
Publisher : Frontiers Media SA
Page : 220 pages
File Size : 51,8 Mb
Release : 2016-11-10
Category : Electronic book
ISBN : 9782889450411

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Biomarkers of Alzheimer's Disease: The Present and the Future by Sylvain Lehmann,Charlotte Elisabeth Teunissen Pdf

Alzheimer disease (AD) is a neurodegenerative disorder characterized by significant cognitive deficits, behavioral changes, sleep disorders and loss of functional autonomy. AD represents the main cause of dementia and has become a major public health issue. In addition, the number of patients suffering from AD is growing rapidly as the population ages worldwide. Memory impairment is usually the earliest clinical and core symptom of this disease. The diagnosis at a late clinical stage is relatively easy. However, a delay in the diagnosis is damageable for the handling of patients in terms of optimal medical and social care. The actual interest of the scientific head-ways is to optimize the diagnosis in prodromal stage of the disease and to propose personalized therapeutic solutions to individual patients. New revised AD diagnostic criteria include early alteration of cerebrospinal fluid (CSF) biomarkers: decrease of amyloïd peptides (Aβ42), and increase in tau and phosphorylated-tau (p-tau) protein concentration. This recognition of CSF biological biomarkers for the diagnosis of AD is a major step towards the “molecular” diagnosis and follow-up of the disease. Many issues are however still subject of debate. This e-book provides a comprehensive overview of the state of the art of fluid biomarkers for AD, e.g. which novel biomarkers should be implemented in clinical practice for diagnosis or for monitoring treatment or side effects, which ones are new for AD or related dementias or what is the potential of peripheral blood markers. Moreover, the e-Book provides practical guidelines how to optimally and efficiently develop and validate novel biomarker assays, and to document and control pre-analytical variation.

Author : Ronald Sahyouni,Nolan Brown,Jefferson Chen
Publisher : World Scientific Publishing Company
Page : 280 pages
File Size : 47,7 Mb
Release : 2021-12-23
Category : Medical
ISBN : 9811236224

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Alzheimer's Disease Decoded: The History, Present, and Future of Alzheimer's Disease and Dementia: 2nd Edition by Ronald Sahyouni,Nolan Brown,Jefferson Chen Pdf

This book aims to present, educate and inform individuals about Alzheimer's disease in a comprehensive manner. Its scope ranges from the discovery of the disease, epidemiology and basic biological principles underlying it, to advanced stem cell therapies used in the treatment of Alzheimer's. It adopts a "global" perspective on Alzheimer's disease, and include epidemiological data and science from countries around the world. Alzheimer's disease is a rapidly growing problem seen in every country around the world. This is the first and only comprehensive book to cover Alzheimer's disease, and includes the most updated literature and scientific progress in the field of dementia and Alzheimer's disease research. Most books on the market that focus on Alzheimer's disease are targeted at caregivers as practical advice on how to deal with loved ones with the disease. This book instead is a comprehensive and popular science book that can be read by anyone with an interest in learning more about the disease. Dr Jefferson Chen MD, PhD, co-author, participated in the world's first surgical clinical trial using shunts to treat Alzheimer's disease. His first-hand involvement in a clinical trial for patients with Alzheimer's disease and experience treating Normal Pressure Hydrocephalus (NPH) which is commonly misdiagnosed as Alzheimer's disease lends a unique perspective. This book with appeal to a wide audience, regardless of their scientific or educational background.

Author : Yildiz Dincer
Publisher : Unknown
Page : 128 pages
File Size : 47,8 Mb
Release : 2016-02-08
Category : Science
ISBN : 1632780674

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Alzheimer's Disease Current and Future Perspectives by Yildiz Dincer Pdf

Introduction to the eBookOver the past few decades global prevalence of Alzheimer¿s disease is increased and it became a major public health problem. Millions of elderly population have been suffering from Alzheimer¿s disease worldwide. Many efforts have been made aiming to prevent Alzheimer's disease due to its rising prevalence, the lack of a curative treatment and its high socio-economic cost. Although the study of Alzheimer's disease is moving ahead rapidly, cause of the disease has not been fully clarified yet. Alzheimer's disease is a slowly progressing brain disorder characterized by loss of synapses and neurons in cerebral cortex and in certain sub-cortical regions which leads to memory impairment, cognitive decline, and eventually death.

Author : Jason Karlawish
Publisher : St. Martin's Press
Page : 269 pages
File Size : 46,6 Mb
Release : 2021-02-23
Category : Health & Fitness
ISBN : 9781250218742

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The Problem of Alzheimer's by Jason Karlawish Pdf

A definitive and compelling book on one of today's most prevalent illnesses. In 2020, an estimated 5.8 million Americans had Alzheimer’s, and more than half a million died because of the disease and its devastating complications. 16 million caregivers are responsible for paying as much as half of the $226 billion annual costs of their care. As more people live beyond their seventies and eighties, the number of patients will rise to an estimated 13.8 million by 2050. Part case studies, part meditation on the past, present and future of the disease, The Problem of Alzheimer's traces Alzheimer’s from its beginnings to its recognition as a crisis. While it is an unambiguous account of decades of missed opportunities and our health care systems’ failures to take action, it tells the story of the biomedical breakthroughs that may allow Alzheimer’s to finally be prevented and treated by medicine and also presents an argument for how we can live with dementia: the ways patients can reclaim their autonomy and redefine their sense of self, how families can support their loved ones, and the innovative reforms we can make as a society that would give caregivers and patients better quality of life. Rich in science, history, and characters, The Problem of Alzheimer's takes us inside laboratories, patients' homes, caregivers’ support groups, progressive care communities, and Jason Karlawish's own practice at the Penn Memory Center.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Preventing Dementia and Cognitive Impairment
Publisher : National Academies Press
Page : 181 pages
File Size : 50,6 Mb
Release : 2017-10-05
Category : Medical
ISBN : 9780309459594

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Preventing Cognitive Decline and Dementia by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Preventing Dementia and Cognitive Impairment Pdf

Societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity to prevent or delay the onset of these conditions. Emerging evidence that the prevalence of dementia is declining in high-income countries offers hope that public health interventions will be effective in preventing or delaying cognitive impairments. Until recently, the research and clinical communities have focused primarily on understanding and treating these conditions after they have developed. Thus, the evidence base on how to prevent or delay these conditions has been limited at best, despite the many claims of success made in popular media and advertising. Today, however, a growing body of prevention research is emerging. Preventing Cognitive Decline and Dementia: A Way Forward assesses the current state of knowledge on interventions to prevent cognitive decline and dementia, and informs future research in this area. This report provides recommendations of appropriate content for inclusion in public health messages from the National Institute on Aging.

Author : National Academies of Sciences, Engineering, and Medicine,Division of Behavioral and Social Sciences and Education,Committee on Population
Publisher : National Academies Press
Page : 409 pages
File Size : 48,7 Mb
Release : 2018-07-21
Category : Social Science
ISBN : 9780309474108

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Future Directions for the Demography of Aging by National Academies of Sciences, Engineering, and Medicine,Division of Behavioral and Social Sciences and Education,Committee on Population Pdf

Almost 25 years have passed since the Demography of Aging (1994) was published by the National Research Council. Future Directions for the Demography of Aging is, in many ways, the successor to that original volume. The Division of Behavioral and Social Research at the National Institute on Aging (NIA) asked the National Academies of Sciences, Engineering, and Medicine to produce an authoritative guide to new directions in demography of aging. The papers published in this report were originally presented and discussed at a public workshop held in Washington, D.C., August 17-18, 2017. The workshop discussion made evident that major new advances had been made in the last two decades, but also that new trends and research directions have emerged that call for innovative conceptual, design, and measurement approaches. The report reviews these recent trends and also discusses future directions for research on a range of topics that are central to current research in the demography of aging. Looking back over the past two decades of demography of aging research shows remarkable advances in our understanding of the health and well-being of the older population. Equally exciting is that this report sets the stage for the next two decades of innovative researchâ€"a period of rapid growth in the older American population.

Author : Atta-ur-Rahman,Muhammad Iqbal Choudhary
Publisher : Elsevier
Page : 784 pages
File Size : 50,8 Mb
Release : 2015-06-27
Category : Science
ISBN : 9780128039601

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Drug Design and Discovery in Alzheimer’s Disease by Atta-ur-Rahman,Muhammad Iqbal Choudhary Pdf

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Author : Glenn E. Smith,Mark W. Bondi
Publisher : Oxford University Press
Page : 416 pages
File Size : 50,8 Mb
Release : 2013-03-21
Category : Medical
ISBN : 9780199764181

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Mild Cognitive Impairment and Dementia by Glenn E. Smith,Mark W. Bondi Pdf

This book reviews the neuropsychology of common and a few rare neurodegenerative conditions. The mild cognitive impairment prodrome of each condition is highlighted. Chapters include an autopsy-confirmed case presentation from the authors' files, current diagnostic criteria, epidemiology, neuropathology/neurophysiology, genetics, neuroimaging, associated clinical features, differential neuropsychological features and possible interventions.

Author : Peter J. Whitehouse,Konrad Maurer,Jesse F. Ballenger
Publisher : JHU Press
Page : 343 pages
File Size : 48,8 Mb
Release : 2003-05-27
Category : Health & Fitness
ISBN : 9780801877155

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Concepts of Alzheimer Disease by Peter J. Whitehouse,Konrad Maurer,Jesse F. Ballenger Pdf

As the essays in this volume show, conceptualizing dementia has always been a complex process. With contributions from noted professionals in psychiatry, neurology, molecular biology, sociology, history, ethics, and health policy, Concepts of Alzheimer Disease looks at the ways in which Alzheimer disease has been defined in various historical and cultural contexts. The book covers every major development in the field, from the first case described by Alois Alzheimer in 1907 through groundbreaking work on the genetics of the disease. Essays examine not only the prominent role that biomedical and clinical researchers have played in defining Alzheimer disease, but also the ways in which the perspectives of patients, their caregivers, and the broader public have shaped concepts.

Author : Harald Hampel,Maria C. Carrillo
Publisher : Karger Medical and Scientific Publishers
Page : 200 pages
File Size : 46,9 Mb
Release : 2012
Category : Medical
ISBN : 9783805598026

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Alzheimer's Disease by Harald Hampel,Maria C. Carrillo Pdf

How current biomarkers are modernizing the diagnosis of Alzheimer's disease Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer's disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the amyloid' or tau' hypotheses. This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.

Author : Han Yu
Publisher : Columbia University Press
Page : 487 pages
File Size : 48,7 Mb
Release : 2021-03-02
Category : Science
ISBN : 9780231552769

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Mind Thief by Han Yu Pdf

Alzheimer’s disease, a haunting and harrowing ailment, is one of the world’s most common causes of death. Alzheimer’s lingers for years, with patients’ outward appearance unaffected while their cognitive functions fade away. Patients lose the ability to work and live independently, to remember and recognize. There is still no proven way to treat Alzheimer’s because its causes remain unknown. Mind Thief is a comprehensive and engaging history of Alzheimer’s that demystifies efforts to understand the disease. Beginning with the discovery of “presenile dementia” in the early twentieth century, Han Yu examines over a century of research and controversy. She presents the leading hypotheses for what causes Alzheimer’s; discusses each hypothesis’s tangled origins, merits, and gaps; and details their successes and failures. Yu synthesizes a vast amount of medical literature, historical studies, and media interviews, telling the gripping stories of researchers’ struggles while situating science in its historical, social, and cultural contexts. Her chronicling of the trajectory of Alzheimer’s research deftly balances rich scientific detail with attention to the wider implications. In narrating the attempts to find a treatment, Yu also offers a critical account of research and drug development and a consideration of the philosophy of aging. Wide-ranging and accessible, Mind Thief is an important book for all readers interested in the challenge of Alzheimer’s.