Amino Acid And Peptide Synthesis

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Side Reactions in Peptide Synthesis

Yi Yang
Side Reactions in Peptide Synthesis Book PDF

Author : Yi Yang
Publisher : Academic Press
Page : 376 pages
File Size : 47,7 Mb
Release : 2015-09-01
Category : Science
ISBN : 9780128011812

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Side Reactions in Peptide Synthesis by Yi Yang Pdf

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction. Provides a systematic examination on how to troubleshoot and minimize the most frequent side reactions in peptide synthesis Gives chemists the background information and the practical tools they need to successfully troubleshoot and improve results Includes optimization-oriented analysis of side reactions in peptide synthesis for improved industrial process development in peptidyl API (active pharmaceutical ingredient) production Answers the growing, global need for improved, replicable processes to avoid impurities and maintain the integrity of the end product. Presents a thorough discussion of critical factors in peptide synthesis which are often neglected or underestimated by chemists Covers solid phase and solution phase methodologies, and provides abundant references for further exploration

Amino Acids and Peptides

G. C. Barrett,D. T. Elmore
Amino Acids and Peptides Book PDF

Author : G. C. Barrett,D. T. Elmore
Publisher : Cambridge University Press
Page : 246 pages
File Size : 40,5 Mb
Release : 1998-10-29
Category : Science
ISBN : 0521468272

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Amino Acids and Peptides by G. C. Barrett,D. T. Elmore Pdf

This text is suitable for advanced undergraduate and beginning graduate students in chemistry and biochemistry studying amino acids and peptides. The authors concentrate on amino acids and peptides without detailed discussions of proteins, although the book gives all the essential background chemistry, including sequence determination, synthesis and spectroscopic methods, to enable the reader to appreciate protein behaviour at the molecular level. The approach is intended to encourage the reader to cross classical boundaries, as in the later chapters on the biological roles of amino acids and the design of peptide-based drugs. For example, there is a section on the enzyme-catalysed synthesis of peptides, with suitable examples, an area often neglected in texts describing peptide synthesis. This modern text will be of value in the amino acid, peptide and protein field, to advanced undergraduates, graduate students and research workers.

Chemical Approaches to the Synthesis of Peptides and Proteins

Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt
Chemical Approaches to the Synthesis of Peptides and Proteins Book PDF

Author : Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt
Publisher : CRC Press
Page : 306 pages
File Size : 45,7 Mb
Release : 2020-08-18
Category : Cooking
ISBN : 9781000151688

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Chemical Approaches to the Synthesis of Peptides and Proteins by Paul Lloyd-Williams,Fernando Albericio,Ernest Giralt Pdf

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications. This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

Principles of Peptide Synthesis

M. Bodanszky
Principles of Peptide Synthesis Book PDF

Author : M. Bodanszky
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642967634

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Principles of Peptide Synthesis by M. Bodanszky Pdf

A look at the shelves of a major library awakens doubts in the author of this small volume about the importance of writing a new introduction to peptide synthesis. This rather narrow area of bio-organic chemistry already has received considerable attention. A whole series of books deals with the synthesis of peptides. Some of these are textbooks written to support lecture courses on peptide synthesis. Others try to help the beginner, otherwise well versed in organic chemistry, to embark on some experimental project that requires the construction of peptide chains. Not less useful are the monographs which were compiled to aid the adept practitioner and to provide him with references to the growing literature of a very active field. Is there any need for a new book on peptide synthesis? Should we add a new volume to an already impressive and certainly useful series? The answer is not obvious. The author has already participated in two similar en deavors. The first edition! of "Peptide Synthesis", with M. A. Ondetti as coauthor, was meant to serve as an introduction for the beginner. It was rather well received by researchers who joined the field of peptide chemistry and were looking for initiation. While working on the 2 second edition with Drs. Klausner and Ondetti, we became painfully aware of the impossibility of the task.

The Peptides

Eberhard Schröder,Klaus Lübke
The Peptides Book PDF

Author : Eberhard Schröder,Klaus Lübke
Publisher : Elsevier
Page : 510 pages
File Size : 53,5 Mb
Release : 2014-05-12
Category : Science
ISBN : 9781483261720

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The Peptides by Eberhard Schröder,Klaus Lübke Pdf

The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis of peptides by activation of the amino group, and peptide synthesis by activation of the carboxyl group. The manuscript elaborates on the synthesis of cyclic peptides, depsipeptides, peptoids, and the plastein reaction. Topics include synthesis of plastein-active peptides, glycopeptides, phosphopeptides, and S-peptides. The publication is a dependable source of data for readers interested in the methods of peptide synthesis.

Amino Acid and Peptide Synthesis

John Jones
Amino Acid and Peptide Synthesis Book PDF

Author : John Jones
Publisher : Oxford University Press, USA
Page : 104 pages
File Size : 48,5 Mb
Release : 1992
Category : Science
ISBN : UOM:39015029145375

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Amino Acid and Peptide Synthesis by John Jones Pdf

The principal methods for the synthesis of amino acids and peptides are outlined in this concise introduction. With its emphasis on chemical principles and strategies, the book should be of value to all undergraduate chemistry students.

The World of Peptides

Theodor Wieland,Miklos Bodanszky
The World of Peptides Book PDF

Author : Theodor Wieland,Miklos Bodanszky
Publisher : Springer Science & Business Media
Page : 311 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642758508

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The World of Peptides by Theodor Wieland,Miklos Bodanszky Pdf

Almost two centuries ago proteins were recognized as the primary materials (proteios = primary) oflife, but the significance and wide role of peptides (from pepsis = digestion) in practically all life pro cesses has only become apparent in the last few decades. Biologi cally active peptides are now being discovered at rapid intervals in the brain and in other organs including the heart, in the skin of amphibians and many other tissues. Peptides and peptide-like compounds are found among toxins and antibiotics. It is unlikely that this process, an almost explosive broadening of the field, will come to a sudden halt. By now it is obvious that Nature has used the combination of a small to moderate number of amino acids to generate a great variety of agonists with specific and often highly sophisticated functions. Thus, peptide chemistry must be regarded as a discipline in its own right, a major branch of biochemistry, fairly separate from the chemistry of proteins. Because of the important role played by synthesis both in the study and in the practical preparation of peptides, their area can be considered as belonging to bio-organic chemistry as well. The already overwhelming and still increasing body of know ledge renders an account of the history of peptide chemistry more and more difficult. It appears therefore timely to look back, to take stock and to recall the important stages in the development of a new discipline.

The Practice of Peptide Synthesis

Miklos Bodanszky,Agnes Bodanszky
The Practice of Peptide Synthesis Book PDF

Author : Miklos Bodanszky,Agnes Bodanszky
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 55,7 Mb
Release : 2013-11-11
Category : Science
ISBN : 9783642968358

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The Practice of Peptide Synthesis by Miklos Bodanszky,Agnes Bodanszky Pdf

During the years 1980-81, as guests of the Deutsches Woll forschungsinstitut in Aachen, Germany, we were working on a small book entitled, "Principles of Peptide Synthesis". In the library of the Institute we noted that the volumes of Houben-Weyl's Handbuch der Organischen Chemie dealing with peptide synthesis were so much in use that they were ready to fall apart because the researchers of the Institute consulted them with amazing regularity. They were looking for references, but even more for experimental details which could be adapted to the particular problem they happened to face. In planning a new synthetic endeavor they tried to lean on the experience of others in analogous situations. This suggested to us that a smaller and hence more tractable book may be needed, a volume which can be kept on or near the bench to make examples of funda mental methods readily available in the laboratory. Such a collection could save numerous short trips to the library, a point particularly important where a library well equipped with the sources of the literature of peptide synthesis is not near at hand. Also, we thought that the envisaged book may be welcome by those who are more versed in English than in German. To our best knowledge no similar publi cation is available.

Peptide Chemistry

Miklos Bodanszky
Peptide Chemistry Book PDF

Author : Miklos Bodanszky
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642978869

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Peptide Chemistry by Miklos Bodanszky Pdf

Analysis of peptides and determination of their primary structure. Conformational analysis: secondary-tertiary structure. Peptide synthesis: protection, activation and coupling, undesired reactions and their prevention, design of synthetic schemes.

Major Methods of Peptide Bond Formation

Erhard Gross,Johannes Meienhofer
Major Methods of Peptide Bond Formation Book PDF

Author : Erhard Gross,Johannes Meienhofer
Publisher : Elsevier
Page : 454 pages
File Size : 48,6 Mb
Release : 2014-05-10
Category : Science
ISBN : 9781483217963

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Major Methods of Peptide Bond Formation by Erhard Gross,Johannes Meienhofer Pdf

The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology. This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during peptide synthesis, strategies for minimizing racemization during amide-forming steps, and assays for chiral purity. This volume is suitable for students, specialists, and scientists from a broad range of disciplines concerned with peptides.

Chemistry of Peptide Synthesis

N. Leo Benoiton
Chemistry of Peptide Synthesis Book PDF

Author : N. Leo Benoiton
Publisher : CRC Press
Page : 304 pages
File Size : 54,7 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420027693

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Chemistry of Peptide Synthesis by N. Leo Benoiton Pdf

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather th

Peptide Synthesis and Applications

John Howl
Peptide Synthesis and Applications Book PDF

Author : John Howl
Publisher : Springer Science & Business Media
Page : 263 pages
File Size : 55,8 Mb
Release : 2008-02-02
Category : Science
ISBN : 9781592598779

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Peptide Synthesis and Applications by John Howl Pdf

Hands-on experts describe in step-by-step detail the key methodologies of contemporary peptide synthesis and illustrate their numerous applications. The techniques presented include protocols for chemical ligation, the synthesis of cyclic and phosphotyrosine-containing peptides, lipoamino acid- and sugar-conjugated peptides, and peptide purification and analyses. Additional chapters detail methodologies and instrumentation for high-throughput peptide synthesis, many different applications of peptides as novel research tools and biological probes, and the design and application of fluorescent substrate-based peptides that can be used to determine the selectivity and activity of peptidases. A practical guide to the identification of proteins using mass spectrometric analyses of peptide mixtures is also included.

Amino Acids and Peptides

J H Jones
Amino Acids and Peptides Book PDF

Author : J H Jones
Publisher : Royal Society of Chemistry
Page : 268 pages
File Size : 50,7 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847557414

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Amino Acids and Peptides by J H Jones Pdf

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

Studies on Chemical Synthesis of Peptides: Efficient Synthetic Methods for β-Amino Acids, Azides, Amino Acid Hydroxamates and Esters

Vasanthakumar Ganga Ramu
Studies on Chemical Synthesis of Peptides Efficient Synthetic Methods for Amino Acids Azides Amino Acid Hydroxamates and Esters Book PDF

Author : Vasanthakumar Ganga Ramu
Publisher : GRIN Verlag
Page : 180 pages
File Size : 54,9 Mb
Release : 2011-10-17
Category : Science
ISBN : 9783656030454

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Studies on Chemical Synthesis of Peptides: Efficient Synthetic Methods for β-Amino Acids, Azides, Amino Acid Hydroxamates and Esters by Vasanthakumar Ganga Ramu Pdf

Doctoral Thesis / Dissertation from the year 2004 in the subject Chemistry - Organic Chemistry, Bangalore University / Central College (Department of Studies in Chemistry), language: English, abstract: The importance of ß-amino acids has been focused, particularly in the past few decades. They are found as components of many biologically active peptidic and nonpeptidic natural products with antibiotic, antifungal, cytotoxic, and other pharmacological properties. ß-Amino acids are produced in humans, animals, microorganisms, marine organisms, and plants either in free state or as part of a peptide or depsipeptide. The importance of nonpeptidic ß-amino acids has been nfocused particularly on the ß-lactam antibiotics, since naturally occurring penicillin derivatives have been discovered as broad antibiotic active agents. Over the years, a large number of these compounds have been prepared and tested, and a variety of new ß-lactam ring systems have been introduced such as cephems, cephalosporins, oxacephems, penems, carbapenems, oxapenams as well as monocyclic and polycyclic ring systems. ß-Amino acids have been known to play an important role in primary and secondary metabolism also. [...]

Amino Acids, Peptides and Proteins

G C Barrett,J S Davies
Amino Acids Peptides and Proteins Book PDF

Author : G C Barrett,J S Davies
Publisher : Royal Society of Chemistry
Page : 458 pages
File Size : 49,9 Mb
Release : 2007-10-31
Category : Science
ISBN : 9781847557438

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Amino Acids, Peptides and Proteins by G C Barrett,J S Davies Pdf

In an ever-increasing domain of activity Amino Acids Peptides and Proteins provides an annual compilation of the world's research effort into this important area of biological chemistry. Volume 33 provides a review of literature published during 2000. Comprising a comprehensive review of significant developments at this biology/chemistry interface each volume opens with an overview of amino acids and their applications. Work on peptides is reviewed over several chapters ranging from current trends in their synthesis and conformational and structural analysis to peptidomimetics and the discovery of peptide-related molecules in nature. The application of advanced techniques in structural elucidation is incorporated into all chapters whilst periodic chapters on metal complexes of amino acids peptides and beta-lactams extend the scope of coverage. Efficient searching of specialist topics is facilitated by the sub-division of chapters into discrete subject areas allowing annual trends to be monitored. All researchers in the pharmaceutical and allied industries and at the biology/chemistry interface in academia will find this an indispensable reference source.